Resultados de investigación

Insectos, anfibios y reptiles. Pájaros. Animales domésticos. Mamíferos. Depredadores. La caza., Insetos, anfíbios e répteis. Aves. Animais domésticos. Mamíferos. Predadores. A caça., Insects, amphibians and reptiles. Birds. Domestic animals. Mammals. Predators. The hunt.

Project developed by Giovanni Federico (Università di Pisa) and Antonio Tena Junguito (Universidad Carlos III de Madrid). This data base outlines changes in world trade from 1800 to 2016. Dataset: Dutch Guiana - Suriname

Project developed by Giovanni Federico (Università di Pisa) and Antonio Tena Junguito (Universidad Carlos III de Madrid). This data base outlines changes in world trade from 1800 to 2016. Dataset: America

The reemergence of China is changing the world, and that EU needs to develop a long-term approach based on research-based knowledge in order to engage strategically with an increasingly assertive China.

This dataset consists of a semi-structured interview with a person of Chinese nationality, carried out in Chinese and transcribed in Chinese language.

Project developed by Christopher Absell (University Gothenburg and Instituto Figuerola) Giovanni Federico (New York University Dubai) and Antonio Tena Junguito (Universidad Carlos III de Madrid and Instituto Figuerola). Dataset: Montenegro

El presente estudio pretende mostrar un mapa global y general de la producción científica relacionada con los programas grupales de educación parental., Metodología: Revisión sistemática

Daily quotations of stocks corresponding to several biopharmaceutical companies which produced Covid-19 vaccines. These data are detailed and analyzed in the following paper: Diaz, R. F., Herrador-Alcaide, T. C., & Sanchez-Robles, B. (2023). COVID-19 Vaccines, Healthcare Policies and Stock Markets: Are There Winners and Losers? Risk Management and Healthcare Policy, 16, 971–989. https://doi.org/10.2147/RMHP.S406216

Project developed by Giovanni Federico (Università di Pisa) and Antonio Tena Junguito (Universidad Carlos III de Madrid). This data base outlines changes in world trade from 1800 to 2016. Dataset: Iraq

Project developed by Giovanni Federico (New York University Abu Dhabi) and Antonio Tena Junguito (Universidad Carlos III de Madrid). Dataset: Palestine (Ottoman Empire)

The dataset comprises a database including 1556 chronic hepatitis C patients with sustained virologic response after treatment with direct acting antivirals. These patients have been followed up for a median of 74 months after development of hepatocelular carcinoma, death from other cause or the last appointment. Besides the dependent (hepatocelular carcinoma development) and independent variable (metformin treatment), other possible confounders to check the protective role of metformin on HCC development are also recorded.

Background: Metformin may protect against hepatocellular carcinoma (HCC) in chronic hepatitis C (CHC) patients with advanced fibrosis after sustained virologic response (SVR) by enhancing immune response and altering tumour metabolism. Aim: To assess HCC incidence based on FIB-4 levels and evaluate metformin’s protective effect in CHC patients post-SVR. Methods: A retrospective analysis of prospectively collected data was conducted in a multicentre cohort of 1,556 CHC patients with SVR after direct-acting antivirals (DAAs). Patients were followed for a median of 74 months. HCC incidence was stratified by FIB-4, type 2 diabetes mellitus (T2DM), clinically significant portal hypertension (CSPH), and metformin use. A multivariate Cox model assessed the association between metformin use and HCC risk, adjusted for confounders, and validated via Random Survival Forest (RSF) and SHapley Additive exPlanations (SHAP). Results: HCC incidence increased with higher FIB-4, reaching 1.8 per 100 patient-years in the FIB-4 >3.25 group. Within this group, CSPH and T2DM were associated with higher HCC incidence, while metformin use was associated with a reduction to levels comparable to those in the intermediate FIB-4 group. In multivariate analysis, FIB-4, cirrhosis, CSPH, smoking, and older age were independently associated with higher HCC risk, whereas metformin use was consistently associated with HCC hazard reduction. These findings were confirmed by RSF and SHAP analyses, which particularly highlighted the potential benefit of metformin in patients with advanced fibrosis and CSPH. Conclusions: FIB-4 effectively stratifies HCC risk post-SVR. Metformin significantly lowers HCC risk, particularly in high-risk CHC patients with CSPH, T2DM, cirrhosis or smoking habit supporting its role in HCC prevention strategies.