BUSCADOR RECOLECTA

Supplementary research data from the poster titled “Unraveling the digestive behavior of flatbreads: impact of formulations and baking process” presented at the 17th ICC International Cereal and Bread Congress in Nantes, France, 2024., PRIMA program under grant agreement No. 2031, project Flat Bread of Mediterranean area: INnovation & Emerging process & technology (Flat Bread Mine)., Peer reviewed

Peer reviewed

[Description of methods used for collection/generation of data] The database provides discrete measurements of carbon system parameters in water samples collected at 13 stations during 5 campaigns conducted over 2020–2021. Geographic coordinates of sampling stations are provided. Some physical data (i.e. pressure, temperature and salinity) are also included. During the campaigns, temperature, salinity, conductivity, dissolved oxygen and pH were obtained with an EXO TM 2 multiparametric probe sonde. Surface seawater was subsequently collected for biogeochemical analysis. The biogeochemical variables shown in the database are pH in SWS and NBS scale (pH_SWS and pH_NBS), total alkalinity (AT), and inorganic nutrients (nitrite, nitrate, ammonium, silicate and phosphate), Dissolved Organic Carbon (DOC), Suspended Solid Matter (SSM), and chlorophyll a (Chla). · pH_NBS data were obtained by the EXO TM 2 multiparametric probe sonde and pH_SWS was measured with a Metrohm pH meter (model 780) at SWS scale that was calibrated according to DelValls & Dickson, (1998). · Samples for AT analysis were collected in 500-ml borosilicate bottles, and poisoned with 200 μl of HgCl2-saturated aqueous solution and stored until measurement in the laboratory. AT was measured by potential titration according to Mintrop et al. (2000) with a Titroprocessor (model Metrohm 794 for 2020 and model Metrothm 888 for 2021). · Water samples (5 mL, two replicates) for inorganic nutrients determination were taken, filtered immediately (Whatman GF/F, 0.7 μm) and stored frozen for later analyses in the shore-based laboratory. Nutrients concentrations were measured with a continuous flow auto-analyzer using standard colorimetric techniques (Hansen & Koroleff 1999). · Water samples for DOC and total dissolved nitrogen (TDN) determination were taken, filtered immediately (Whatman GF/F, 0.7 μm) and 100 μl of orthophosphoric acid (3:1) was added. Stored in fridge for later analyses in the laboratory. DOC and TDN concentrations were obtained by catalytic oxidation at high temperature (720°C) and chemiluminescence, respectively, applying the protocol described by Alvarez-Salgado & Miller, (1998). · SSM and the organic (particulate organic matter (POM) and inorganic (particulate inorganic matter (PIM)) fractions were determined by the loss on ignition method, filtering the water through pre-weighed Whatman 0.7 μm GF/F glass fibre filters pre-combusted at 450°C, with subsequent filter desiccation for 48 h and finally combustion. · Chla concentration was obtained by filtering water through Whatman 0.7 μm GF/F glass fibre filters that were maintained frozen and in the dark until analysis. The extract was measured by fluorometry following the method of Welschmeyer (1994)., This work was supported by the European Commission, [Fondo Europeo de Desarrollo Regional (FEDER)] through the project Apoio à gestão das zonas húmidas do litoral do Sudoeste Ibérico: interações entre Aquacultura e meio Ambiente na região transfronteiriça Alentejo-Algarve-Andaluzia 2 (AQUA&AMBI2) [ref: 0750_AQUA_AMBI_2_5_P]. SAV and AR were supported by a pre-doctoral grant from the Spanish Ministry of Science, Innovation and Universities [FPU19/04338 and FPU19/04557]. This work is a contribution to the CSIC Interdisciplinary Thematic Platform OCEANS+., Peer reviewed

General information, experimental details (no uncommon hazards are noted), and NMR, IR, and UV–vis spectra and structural analysis of complexes 2–5., Peer reviewed

Supplementary Tables: Table S1. Data imported from BPS for each patient: code and definition of the variable.-- Table S2: Log Hazard ratios obtained for the drugs tested, along with standard deviations (SDs), upper and lower coefficient intervals (CI), nominal and FDR-adjusted p-values. Also, Lymphocyte proliferation values (see Methods) along with standard deviations (SDs), upper and lower coefficient intervals (CI), nominal and FDR-adjusted p-values. The two last columns indicate the drugs used in the machine learning drug repurposing prediction study and the proteins targeted by the drug. Targets marked with an * were those analyzed in the machine learning drug repurposing., [Purpose] Despite the extensive vaccination campaigns in many countries, COVID-19 is still a major worldwide health problem because of its associated morbidity and mortality. Therefore, finding efficient treatments as fast as possible is a pressing need. Drug repurposing constitutes a convenient alternative when the need for new drugs in an unexpected medical scenario is urgent, as is the case with COVID-19., [Methods] Using data from a central registry of electronic health records (the Andalusian Population Health Database), the effect of prior consumption of drugs for other indications previous to the hospitalization with respect to patient outcomes, including survival and lymphocyte progression, was studied on a retrospective cohort of 15,968 individuals, comprising all COVID-19 patients hospitalized in Andalusia between January and November 2020., [Results] Covariate-adjusted hazard ratios and analysis of lymphocyte progression curves support a significant association between consumption of 21 different drugs and better patient survival. Contrarily, one drug, furosemide, displayed a significant increase in patient mortality., [Conclusions] In this study we have taken advantage of the availability of a regional clinical database to study the effect of drugs, which patients were taking for other indications, on their survival. The large size of the database allowed us to control covariates effectively., This research was funded by Spanish Ministry of Science and Innovation (grant PID2020-117979RB-I00), the Instituto de Salud Carlos III (ISCIII), co-funded with European Regional Development Funds (ERDF) (grant IMP/00019), and has also been funded by Consejería de Salud y Consumo, Junta de Andalucía (grants COVID-0012-2020, PS-2020-342 and IE19_259 FPS) and the postdoctoral contract of Carlos Loucera (PAIDI2020- DOC_00350) co-funded by the European Social Fund (FSE) 2014–2020., Peer reviewed

Raw data for the above-mentioned article that can be found in https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.202301040, Peer reviewed

Supporting Information of the manuscript " Cobalt-Catalyzed Intramolecular Cycloadditions of Alkenylidenecyclopropanes with Alkenes and Dienes", Peer reviewed

Reagents were acquired from J.T. Baker [borate (G23644), calcium chloride (0970-01), methanol (34,860/2L), Monopotassium phosphate (3246-01), magnesium chloride (2448-01),Sodium bicarbonate (JTB-3506-01), trichloroacetic acid (0414-01), potassium chloride (3040-01), potassium phosphate (3246-01)], Sigma-Aldrich [( +)-catechin (C1251-10 g), gallic acid (G7384-100 g), hydrochloric acid (C3878), 2,2-diphenyl-1-picrylhydrazyl (DPPH*; 257,621–100mg), ethanol (459,836/2L), Folin-Ciocalteu reagent (F9252-1L), lipase (L0777-50mL), linolenic acid (62240-25mL), magnesium chloride (M2670), nitroprusside sodium (71778-25g), thiobarbituric acid (T-5500), sodium chloride (S753), rutin (R5143), pepsin (P7000-100g), and Hycel [casein (55,695), α-amylase (10U/mg), β-carotene (C4582-10mg)], Meyer [Carbonate ammonium (8000-73-5), Hexane (V1020647), potassium iodide (J1220812), ferrous sulfate (7782-63-0)]., Peer reviewed

List of supplemental tables: Table I. Univariable risks for moderate or severe CED, by individual characteristics.-- Table II. Final models for CED levels (reference: no CED) with reperfusion classified into successful versus unsuccessful.-- Table III. Detailed data for the demonstration of effect modification by potential indicators of large infarct, using the final adjusted model., Peer reviewed

High pressure x-ray diffraction (HP-XRD) measurements were carried out at the 16-BM-D beamline of the Advanced Photon Source (APS), Argonne National Laboratory (ANL). HP-XRD data were recorded at T = 10 K and under pressures up to 50 GPa. Fine powder was loaded into the sample chamber (~90-µm hole in a Re gasket preindented to 30 µm) together with He gas as the quasihydrostatic pressure medium and a couple of ruby spheres and gold grains as the in situ pressure calibrants. A symmetric diamond anvil cell (DAC, Princeton) with 300-µm culet anvils was used for these measurements. Data were collected using x-ray radiation with lambda = 0.4016 Å (30.87 keV) and a MAR345 image plate. The two-dimensional diffractograms were integrated using the DIOPTAS software The long-range XAS spectra (EXAFS) at the Ir L3 absorption edge were recorded under applied high pressures (2.5–50 GPa) and at low temperature (10 K) at the ID24 beamline of the ESRF (Grenoble, France). ID24 energy dispersive spectrometer was used to perform the EXAFS measurements. The measurements were also performed in transmission by using a one-dimensional Hamamatsu CCD camera. We used nanopolycrystalline diamond anvils to avoid glitches (i.e.,strong Bragg peaks) from the anvils on the EXAFS spectra. Ruby chips were used as pressure markers and Ne gas was used as pressure transmitting medium. The short-range XAS (XANES) and XMCD measurements under high pressurewere carried out at beamline 4-ID-D of the Advanced PhotonSource, Argonne National Laboratory. The spectra were recorded at the Ir L2,3 absorption edges to probe the Ir 5d states. Circularly polarized x rays were generated using phase-retarding optics. Harmonic rejection was achieved by the combined effects of x-ray reflection from two Pd mirrors at 3.1 mrad incidence angle and detuning of the second crystal in the Si(111) double crystal monochromator. XMCD was measured by switching x-ray helicity (13.1 Hz) and detecting the related modulation in absorption coefficient with a lock-in amplifier. All the measurements were done in transmission geometry. For the high pressure measurements the powdered samples were loaded on copper-beryllium DACs fitted with 300-µm culet anvils and a Re gasket. Ne gas was used as the quasihydrostatic pressure transmitting medium. The samples were cooled in 4He vapor using the variable temperature insert of the superconducting magnet, and pressure was controlled remotely using a He-gas membrane., Spanish MICINN Projects No. PID2020-115159GBI00/AEI/10.13039/501100011033, MAT2017-83468-R (AEI/FEDER, UE) and MAT2017-84496-R (AEI/FEDER, UE; Regional Government of Aragon (Grant No. E12-20R RASMIA), Fig1a_Ir_L3edge_XMCD_vs_HP_SNIO.dat Fig1b_Ir_L2edge_XMCD_vs_HP_SNIO.dat Fig1c_Ir_L3edge_XMCD_vs_HP_SZIO.dat Fig2a_Ir_L3edge_XAS_vs_HP_SNIO.dat Fig2a_Ir_L2edge_XAS_vs_HP_SNIO.dat Fig2b_Ir_L3edge_XAS_vs_HP_SZIO.dat Fig3_XRD_vs_HP_SNIO.dat FigIr_L3edge_EXAFS_vs_HP_SNIO.dat, Peer reviewed