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18 pages. -- PDF file includes: Experimental Section. -- Table S1. Complete list of samples produced and characterized, including name, precursors and processing conditions. -- Figure S1. SEM images of a) ZIF-67, b) Co3O4, c) Mo-Co MOFs-1h, d) MoCoxOy-100-1h, e) Mo-Co MOFs-3h, f) MoCoxOy-100-3h, g) Mo-Co MOFs-12h, and h) MoCoxOy-100-12h. -- Figure S2. SEM images of a) Co3O4, b) MoCoxOy-50, c) MoCoxOy-100 and d) MoCoxOy-200. -- Figure S3. (a-d) TEM and (e-f) HAADF STEM images of MoCoxOy-100. -- Figure. S4. EELS chemical composition maps obtained from the red squared area of the STEM micrograph of MoCoxOy-100. Individual Mo M4,5-edges at 227 eV (red), Co L2,3-edges at 779 eV (green), O K-edge at 532 eV and C K-edge at 284 eV (grey) and composites of Co-O and Mo-Co-O. -- Figure S5. XRD patterns of a) Mo-Co MOFs produced using different stirring times, b) MoCoxOy-100 samples obtained from the annealing of Mo-Co MOFs produced with different stirring times and c) MoCoxOy-100 after different annealing temperature. -- Figure S6. XRD patterns of a) Na2MoO4-ZIF-67 and b) Na2MoO4-CoOx after 350 °C calcination. -- Figure S7. a) SEM images of Na2MoO4-ZIF-67. b-c) SEM images and d) EDX spectrum of Na2MoO4-CoOx after 350 °C calcination. -- Figure S8. a-c) SEM images and b) EDX spectrum of MoCoxOy-50 after 350 °C calcination. -- Figure S9. a-c) SEM images and d) EDX spectrum of MoCoxOy-100 after 350 °C calcination. -- Figure S10. a-c) SEM images and d) EDX spectrum of MoCoxOy-200 after 350 °C calcination. -- Figure S11. a-c) SEM images and d) EDX spectrum of MoCoxOy-100 after 450 °C calcination. -- Figure S12. a-c) SEM images and d) EDX spectrum of MoCoxOy-100 after 550 °C calcination. -- Figure S13. Pore size distribution for a) Co3O4 and b) MoCoxOy-100. -- Figure S14. a-d) Co 2p high-resolution XPS spectra of Co3O4 and MoCoxOy with different molybdenum contents. -- Figure S15. a-d) O 1s high-resolution XPS spectra of Co3O4 and MoCoxOy with different molybdenum contents. -- Table S2. Surface ratios of Co and Mo chemical states, ratio of adsorved vs. lattice oxygen, and Mo/Co ratio as obtained from the XPS analysis. -- Table S3. Comparison of OER activity of obtained catalyst. -- Figure S16. Cyclic voltammograms for a) Mo-Co MOFs; b) IrO2; c) Co3O4 and d) MoCoxOy50; e) MoCoxOy-100; f) MoCoxOy-200 in the non-faradaic region of 0.90-1.00 V vs. RHE at various scan rates. -- Table S4. Cdl and ECSAs of various catalysts. -- Figure S17. a) OER polarization curves for MoCoOx-100 annealed at different tempratures and Na2MoO4-CoOx. b) ECSA-normalized OER polarization curves for Mo-Co MOFs, IrO2, Co3O4, MoCoxOy-50, MoCoxOy-100 and MoCoxOy-200 in 1.0 M KOH. -- Figure S18. OER polarization curves of a) MoCoxOy-100 before and after 2000 cycles. b) Co3O4 at different pH values. -- Figure S19. Time-dependent concentration of Mo and Co ions dissolved in the electrolyte during of MoCoxOy-100 a 18h chronoamperometric test at 282 mV vs. RHE. -- Table S5. Comparison of OER activity of amorphous MoCoxOy-100 nanosheets with recently reported Co-based electrocatalysts in alkaline electrolyte., Peer reviewed

Supplementary Data 1. Protein content of whole ww saliva. Supplementary Data 2. Proteins in the wax worm saliva. Protein content of ion exchange (peak 1, 2c and 3), and size exclusion (peak 5) chromatographic column peaks. The protein content of whole saliva is included in the incorporated file (icon above) Supplementary Data 3. BLAST search of the NCBI proteins with sequence identity (> 50%) with Demetra. Supplementary Data 4. BLAST search of the NCBI proteins with sequence identity (> 50%) with Ceres., Peer reviewed

S1 Fig. Immunoblot analysis of Pedem::GFP expression in young animals. (A) Quantitative real-time PCR (qPCR) of edem-3 mRNA. WT and edem-3 mutant worms treated with empty vector or edem-3 RNAi; expression were normalized to that of cdc-42 and pmp-3. (B) Total protein lysates derived from WT Pedem::GFP transgenic animals subjected to the indicated treatment were separated by SDS-PAGE and immunoblotted with anti-GFP polyclonal antisera; tubulin was used as loading control. NS- non-treated, TM- tunicamycin, HS-heat stress, OS- osmotic stress. The histograms show the densitometry values of Pedem::GFP bands normalized to the value of of NS condition (n=3 ± SEM, t test), *P<0.05; **P<0.01; ***P<0.001; ns, not significant. (C) RNAi downregulation of edem triggered accumulation of CPL-1* in intestinal cells. To overrule a significant contribution of autofluorescent stress granules to the GFP fluorescence, images captured with Diode laser were included. Scale bar: 20 μm., Peer reviewed

Series temporales por países del mundo, [EN] This database includes the representative Standardized Precipitation Evapotranspiration Index (SPEI) series for the different countries of the world from 1901 at the time scales from 1 to 48 months. The data is based on the average precipitation and reference evapotranspiration series from the Climatic Research Unit (last version) for the different world countries., [ES] Esta base de datos incluye la serie representativa del Índice Estandarizado de Precipitación y Evapotranspiración (SPEI) para los diferentes países del mundo desde 1901 en las escalas de tiempo de 1 a 48 meses. Los datos se basan en las series de precipitación media y evapotranspiración de referencia de la Unidad de Investigación Climática (última versión) para los diferentes países del mundo., No

S2 Fig. EDEM-1 and EDEM-2 are required for CPL-1* degradation (A) Fluorescence intensities of WT animals carrying the CPL-1* transgene treated with indicated concentrations of kifunensine. Values in scatter gram represent mean fluorescence/µm2 x 1000 in arbitrary units (AU). The red bars indicate the average ±SEM. ****P<0.0001; one way ANOVA with Dunnett post test. (B) Immunoblot analysis of CPL-1* degradation in edem-1 and edem-2 mutants carrying the rescuing EDEM-1::mCherry and EDEM-2::mCherry transgenes, respectively. Total protein lysates derived from edem-1 and edem-2 mutants carrying the CPL-1* and rescuing transgenes were separated by SDS-PAGE and immunoblotted with anti-GFP polyclonal antisera. Tubulin was used as loading control. (C) Histogram showing the densitometry values of the bands presented in (B) normalized to the value of WT condition (n=3 ± SEM, one way ANOVA with Fisher test), *P<0.05; **P<0.01)., Peer reviewed

S3 Fig. EDEM depletion mitigates ER stress. (A) Representative confocal images of WT(EV) control or indicated RNAi depleted young adults carrying the Phsp-4::GFP transgene under non ER-stress conditions (upper panel), treatment with 5 μg/ml tunicamycin for 12h (middle panel), and heat shock, and 5 μM thapsigargin treatment (lower panel). TM-tunicamycin, HS-heat shock, TG-thapsigargin. The worms were outlined for better visualization. Images were obtained using the same confocal settings. Exposure adjustments were uniformly applied. Scale bar: 50 μm. (B) Quantitative RT-PCR measurements of Phsp-4::mRNA levels in indicated strains under non stress and treatment with 5 μg/ml tunicamycin (n = 3 independent experiments). (C) Quantitative RT-PCR measurements of Phsp-4::mRNA levels in indicated strains under non stress and heat stress treatment (n = 3 independent experiments). In (B) and (C) quantifications were normalized relative to WT non stress conditions. ****P<0.0001, ns, not significant. Quantifications were normalized relative to WT non stress conditions. (D) Representative confocal images of WT control and edem-2 mutants carrying the PC12C8.1::GFP transgene under non ER-stress conditions. The left panels show fluorescence images and the right panels DIC images., Peer reviewed

S4 Fig. edem response to thapsigargin. (A) Quantitative RT-PCR measurements of edem mRNA levels in WT young animals under non stress (NS) and treatment with 5 μM thapsigargin (TG), (n = 3 independent experiments). (B) Percentage of eggs that developed into L4 larvae after 3 days on 10 μM thapsigargin. Each strain was scored in three independent experiments in triplicates. (C) Quantification of WT (EV) or RNAi-treated day one adults carrying Phsp-4::GFP transgene, treated or not with 5 μM thapsigargin. The worms were kept on RNAi plates for one generation before exposure to ER stress treatments. Values represent mean fluorescence/µm2 x 1000. The red bars indicate the average ±SEM. (D) Analysis of xbp-1 spliced/unspliced ratio from young adults of indicated strains. Total RNA was isolated, reverse transcribed and used for PCR analysis of xbp-1 splicing forms., Peer reviewed

S1 Table. Strains used in this study., Peer reviewed

S2 Table. Primers used in this study., Peer reviewed

S3 Table. Raw numerical data of all the figures., Peer reviewed