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Andalucía : revista mensual, n. 12 (mayo 1917)

Fondo de la Real Academia de Córdoba de Ciencias, Bellas Letras y Nobles Artes
Proyecto:


Synthesis of bioactive compounds. Studies of their attachment to nanoparticles

  • Lucena-Serrano, Cristina
  • Lucena-Serrano, Ana
  • López-Romero, Juan Manuel
  • Díaz, Amelia
  • Valpuesta-Fernandez, Maria
The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of 1-aryl tetrahydroisoquinoline are used for the treatment of neurodegenerative diseases such as Parkinson´s and Alzheimer´s diseases since also act as dopaminergic antagonists and N-methyl-D-aspartate receptor antagonist. [1] The 1-substituted tetrahydro-3-benzazepines have also been studied for their affinity to the Phencylclidine binding site of the NMDA receptor as well as for their affinity to the dopaminergic receptors. [2] In the last years, various methods have been carried out to satisfy the demand of novel tetrahydroisoquinolines and tetrahydro-3-benzazepines. We have synthesized nor-1-aryl tetrahydroisoquinolines with different substituents in the aryl group of C-1 (H, NMe2, SMe, NO2, NH2). In addition to this, we have performed the synthesis of nor-tetrahydro-3-benzazepinas by different routes, obtaining the best results via opening of epoxides by arylphenethylamines and subsequent cyclization. The nor-tetrahydroisoquinolines and nor-tetrahydro-3-benzazepines have been derivatized to obtain appropiate adsorbates which can be attached to nanoparticles. This fact is crutial in drug delivery systems as well as in the improvement of the biocompatibility of these compounds. Literature: [1] Toshiaki Saitoh, Eur. J. Med. Chem. 2006, 41, 241. Mattias Ludwig, Eur. J. Med. 2006, 41, 1003. [2] Olaf Krull, Bioorg. Med. Chem. 2004, 12, 1439., Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
Proyecto:


Carta de Alberto Ghiraldo a Miguel de Unamuno. Madrid, 30 de enero de 1917

  • Ghiraldo, Alberto, 1875-1946
Carta del escritor argentino Alberto Ghiraldo a Miguel de Unamuno, remitiéndole sus últimos libros y la dirección que tiene en Madrid, ya que es corresponsal de “La Razón” en España. También le informa de que ha mandado para Buenos Aires una crónica que ha hecho sobre su discurso para que se publique en “La Razón”.
Proyecto:


Carta de Rodríguez del Busto a Miguel de Unamuno. Tucumán (Argentina), 30 de julio de 1917

  • Rodríguez del Busto, N.
Carta del abogado y escritor Rodríguez del Busto a Miguel de Unamuno en la que le adjunta el ejemplar de un libro suyo.
Proyecto:


Carta de Luis Rueda a Miguel de Unamuno. Buenos Aires, 21 de agosto de 1917

  • Rueda, Luis
Carta del empresario Luis Rueda, emigrante español en Argentina, a Miguel de Unamuno confesándole que lleva mucho tiempo queriendo escribirle y que lee sus trabajos, ya que le viene a la memoria recuerdos de su amistad. Le comenta además que se ha enterado por un telegrama de España que ha sido detenido, enviándole su más sincero cariño y deseo de que no sea cierta la noticia. Además le manda saludos a su esposa, Concha Lizarraga.
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