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Dimensionamento de plataformas offshore de concreto utilizando a teoria de cascas de tres camadas

  • Friaca, C.P.P.
  • Barbosa, M.P.
  • Bittencourt, T.N.
  • Machado, M.
The concrete ffshore platforms, which are subjected a several loading combinations and, thus, requires an analysis more generic possible, can be designed using the concepts adopted to shell elements, but the resistance must be verify in particular cross- sections to shear forces. This work about design of shell elements will be make using the three-layer shell theory. The elements are subject to combined loading of membrane and plate, totalizing eight components of internal forces, which are three membrane forces, three moments (two out-of-plane bending moments and one in-plane,or torsion, moment) and two shear forces. The design method adopted, utilizing the iterative process proposed by Lourenço & Figueiras (1993) obtained from equations of equilibrium developed by Gupta (1896), will be compared to results of experimentally tested shell elements found in the literature using the program DIANA.

Personalised news services: user study of Avui.cat newspaper readers

  • Frías-Castillo, Amparo
  • Rey-Martín, Carina
User studies permit online media to ask users various questions directly, in this case about the benefits to them of personalised news services. The satisfaction survey of Avui.cat readers has revealed how personalised services enhance and increase interest in news information and dedication to reading news, buying the newspaper, or subscribing to other news services.

Spheres and expressions of violence against women and girls: Survey-based evidences

  • Frías, Sonia
This paper present evidence of some of the multiple expressions of violence against Mexican women. The lack of analyses tha use representative samples about violence against women hinders its visualization and jeopardizes women’s right to live a life without violence. By using recent surveys, this paper summarizes data about the prevalence of violence against women and children across their lifespan –childhood, adolescence, and adulthood– in family settings: forced marriage, selling of women, and violence perpetrated by women’s relatives. In school and work settings data about sexual harassment and bullying, as well as the prevalence of pregnancy screenings are presented. Regarding women’s experiences of institutional violence, their experiences upon seeking formal help for partner violence or rape in public institutions are examined. It is argued that social construction of gender inequalities support these expressions of violence. However, their analyses need to be studied as the result of the intersection of gender, race, class and sexuality systems.

Severe anaphylactic reaction to mediterranean jellyfish (Ropilhema nomadica ) envenomation: Case report

  • Friedel, Nadav
  • Scolnik, Dennis
  • Adir, Dikla
  • Glatstein, Miguel
We present a 15-year-old female patient with an anaphylactic reaction to a jellyfish sting, sustained while surfing in the Mediterranean Sea. She experienced immediate difficulty in breathing, hoarseness and itching and was taken by ambulance to the emergency department, receiving intramuscular adrenaline on the way. She presented with periorbital swelling and facial edema and improved with systemic steroids and antihistamines. She was discharged 2 days later with allergy service follow up at our institution. This is the first case report documenting anaphylaxis due to Mediterranean jellyfish envenomation.

Artful Resources: Adaptation and Reconstruction in Drama

  • Friedman, Edward
There is an obvious relation between the imitation and adaptation of literary works. The focus of the essay is the adaptation of early Spanish modern works —including Don Quijote and plays by Cervantes, Lope de Vega, and Juan Ruiz de Alarcón— and Miguel de Unamuno’s Niebla into dramatic texts in English. Adaptation becomes a method of reading, analysis, and interpretation, as well as a form of communication among authors.

I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model

  • W. Friedrich, Felix
  • Hannieh Sotoud, Hannieh Sotoud
  • Birgit Geertz, Birgit Geertz
  • Silvio Weber, Silvio Weber
  • Frederik Flenner, Frederik Flenner
  • Silke Reischmann, Silke Reischmann
  • Thomas Eschenhagen, Thomas Eschenhagen
  • Lucie Carrier, Lucie Carrier
  • Ali El-Armouche, Ali El-Armouche
Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, diastolic dysfunction and increased interstitial fibrosis. Current treatment is based on beta-adrenoceptor (AR) and calcium channel blockers. Since mice deficient of protein phosphatase-1 inhibitor-1 (I-1), an amplifier in beta-AR signalling, were protected from pathological adrenergic stimulation in vivo, we hypothesized that I-1 ablation could result in an improved outcome in a HCM mouse model. We crossed mice deficient of I-1 with homozygous myosin-binding protein C knock-out (Mybpc3 KO) mice exhibiting cardiac dilatation and reduced survival. Unexpectedly, survival time was shorter in double I-1/Mybpc3 KO than in single Mybpc3 KO mice. Longitudinal echocardiographic assessment revealed lower fractional area change, and higher diastolic left ventricular inner dimensions and end-diastolic volumes in Mybpc3 KO than in WT mice. In comparison to Mybpc3 KO, double I-1/Mybpc3 KO presented higher left ventricular end-diastolic volumes, inner dimensions and ventricular surface areas with increasing differences over time. Phosphorylation levels of PKA-downstream targets and mRNA levels of hypertrophic markers did not differ between I-1/Mybpc3 KO and single Mybpc3 KO mice, except a trend towards higher beta-myosin heavy chain levels in double I-1/Mybpc3 KO. The data indicate that interference with beta-AR signalling has no long-term benefit in this severe MYBPC3-related cardiomyopathy mouse model.

Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer

  • Friedrich, Teresa
  • Söhn, Michaela
  • Gutting, Tobias
  • Janssen, Klaus-Peter
  • Behrens, Hans-Michael
  • Röcken, Christoph
  • Ebert, Matthias
  • Burgermeister, Elke
Full-length (FL) docking protein-1 (DOK1) is an adapter protein which inhibits growth factor and immune response pathways in normal tissues, but is frequently lost in human cancers. Small DOK1 variants remain in cells of solid tumors and leukemias, albeit, their functions are elusive. To assess the so far unknown role of DOK1 in colorectal cancer (CRC), we generated DOK1 mutants which mimic the domain structure and subcellular distribution of DOK1 protein variants in leukemia patients. We found that cytoplasmic DOK1 activated peroxisome-proliferator-activated-receptor-gamma (PPARγ) resulting in inhibition of the c-FOS promoter and cell proliferation, whereas nuclear DOK1 was inactive. PPARγ-agonist increased expression of endogenous DOK1 and interaction with PPARγ. Forward translation of this cell-based signaling model predicted compartmentalization of DOK1 in patients. In a large series of CRC patients, loss of DOK1 protein was associated with poor prognosis at early tumor stages (*p = 0.001, n = 1492). In tumors with cytoplasmic expression of DOK1, survival was improved, whereas nuclear localization of DOK1 correlated with poor outcome, indicating that compartmentalization of DOK1 is critical for CRC progression. Thus, DOK1 was identified as a prognostic factor for non-metastatic CRC, and, via its drugability by PPARγ-agonist, may constitute a potential target for future cancer treatments.

A test of the Social Identity Model of Cessation Maintenance: The content and role of social control

  • Frings, Daniel
  • Michael Collins, Michael Collins
  • Gavin Long, Gavin Long
  • R. Pinto, Isabel
  • P. Albery, Ian
Engagement with self-help groups is a predictor of positive outcomes for those attempting to control their addictive behaviours. In common with other groups, self-help groups have to manage non-normative (‘deviant’) behaviour to ensure the social values of the group remain preserved, and the group can fulfil its aims. These processes may protect group members from relapse. Drawing on the Social Identity Model of Cessation Maintenance, the current study asked a number (n = 44) of attendees of fellowship (AA/NA/CA) and of SMART groups to list behaviours they saw as normative and deviant, and rate a variety of responses to deviant behaviours. Costs of relapse to both the self and the group were also measured alongside self-efficacy regarding cessation and identity as both an active addict and as a member of a self-help group. Results suggest that social control responses to deviance grouped into education, punishment and avoidant type responses. More social control was perceived by highly identifying self-help group members. Educational responses were seen as used by groups more extensively than other responses. Punishment responses were mediated by the perceived costs an individuals relapse incurred on the rest of the group. These findings inform our understanding of what standards of normative and deviant behaviour self-help groups hold, and how they react to violations of such norms. They also have a number of implications for practitioners and facilitators in regard to using social identities as part of the treatment process.

Implicit and explicit drinker identities interactively predict in-the-moment alcohol placebo consumption

  • Frings, Daniel
  • Lucinda Melichar, Lucinda Melichar
  • P. Albery, Ian
Having an identity as a ‘drinker’ has been linked to increased alcohol-related harm, self-reported consumption and self-reported intention to engage in risky drinking behavior. These effects have been observed when identities have been measured using explicit measures (e.g. via questionnaires) and implicitly (e.g. using Implicit Association Tests [IATs] adapted to measure identity). Little research has used actual behavioral measures to measure alcohol consumption in-the-moment, nor compared the effects of implicit and explicit identities directly. Participants' (n = 40) implicit and explicit identities associated with being a drinker were measured. Attitudes towards ones own drinking were measured explicitly. Participants completed a Pouring Taste Preference Task [PTPT] involving the consumption and rating of non-alcoholic wine. This provided a behavioral measure of intention (pouring), a behavioral measure of consumption and a measure of the implementation of intention into behavior. Results showed an interactive effect of implicit and explicit identities on attitudes and behavior. Explicit identities predicted attitudes towards drinking, but not behavior. Neither identity predicted the amount poured. Implicit identities predicted the amount consumed. A greater proportion of wine poured was predicted by higher implicit identities when explicit identities were absent. These results suggest that explicit identities may be associated more with those beliefs about drinking that one is aware of than behavioral intention. In addition, explicit identities may not predict behavioral enactment well. Implicit identity shows effects on actual behavior and not behavioral intention. Together this highlights the differential influence of reflective (explicit) and impulsive (implicit) identity in-the-moment behavior.

A phase I clinical study to evaluate safety of orally administered, genetically engineered Salmonella enterica serovar Typhimurium for canine osteosarcoma

  • Fritz, Sara
  • Henson, Michael
  • Greengard, Emily
  • Winter, Amber
  • Stuebner, Kathleen
  • Yoon, Una
  • Wilk, Vicki
  • Borgatti, Antonella
  • Augustin, Lance
  • Modiano, Jaime
  • Saltzman, Daniel
We conducted a prospective phase I study to evaluate safety of an orally administered Salmonella encoding IL-2 (SalpIL2) in combination with amputation and adjuvant doxorubicin for canine appendicular osteosarcoma. Efficacy was assessed as a secondary measure. The first dose of SalpIL2 was administered to 19 dogs on Day 0; amputation was done after 10 days with chemotherapy following 2 weeks later. SalpIL2 was administered concurrent with chemotherapy, for a total of five doses of doxorubicin and six doses of SalpIL2. There were six reportable events prior to chemotherapy, but none appeared due to SalpIL2. Dogs receiving SalpIL2 had significantly longer disease-free interval (DFI) than a comparison group of dogs treated with doxorubicin alone. Dogs treated using lower doses of SalpIL2 also had longer DFI than dogs treated using the highest SalpIL2 dose. The data indicate that SalpIL2 is safe and well tolerated, which supports additional testing to establish the potential for SalpIL2 as a novel form of adjuvant therapy for dogs with osteosarcoma.

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