Buscador

Encontrado(s) 2203151 resultado(s)
Encontrada(s) 220316 página(s)

La demonización del comunismo durante la II Guerra Mundial en Mundo: Revista de Política Exterior y Economía

  • Pich i Mitjana, Josep, 1967-
  • Contreras, Josep
  • Pastrana Piñero, Juan
El discurso en política exterior del franquismo durante los años 1941-1945 resaltó las diferencias ideológicas con el comunismo, hasta el punto de demonizar al régimen de la Unión Soviética, presentándolo como una amenaza mundial y, en especial, para la civilización de la Europa Occidental. Mundo: Revista de Política Exterior y Economía, por la composición de su plantilla de redactores, entre los que figuraban gran número de altos funcionarios y personalidades relacionadas con el régimen del general Franco, constituye un ejemplo ilustrativo de dicho discurso. A través del análisis de los editoriales publicados entre 1941 y 1945, los autores del artículo pretendemos mostrar las líneas argumentales básicas de dicho discurso, extrapolable a la postura del régimen, examinando si las tesis defendidas en los textos analizados sufrieron variaciones significativas en el período contemplado. El análisis de dichos textos viene complementado por el de los redactores de la publicación, así como las variaciones sufridas por ésta durante el período considerado., Francoist foreign policy discourse throughout the 1941-1945 period highlighted the ideological differences with communism, to the point of demonizing the Soviet Union’ regime in order to picture it as a world menace to Eastern Europe civilization. Mundo: Revista de Política Exterior y Economía, with an editorial staff which featured a large number of senior Francoist officials and personalities, is an illustrative example of this discourse. In this article we attempt to set out the basic lines of arguments of this discourse, which can be extrapolated to the overall stance of regime. Through an analysis of its editorials published between 1941 and 1945. We also focus on studying whether the theses defended in the articles analyzed witnessed significant changes throughout the period examined. The analysis of the texts is supplemented by a study of this weekly’s staff and the changes the publication saw over the period in question.
Proyecto:


Las Humanidades Digitales: principios, valores y prácticas

  • Rojas Castro, Antonio
El objetivo de este artículo es introducir al lector español en algunos debates recientes de la comunidad de humanistas digitales de habla inglesa. En lugar de intentar definir la disciplina en términos absolutos, se ha optado por una aproximación diacrónica aunque se ha puesto el acento en algunos principios como la interdisciplinariedad y la construcción de modelos, valores como el acceso y el código abierto, y prácticas como la minería de datos y la colaboración., This article aims to introduce the Spanish reader to the current debates in the English speaking community of Digital Humanities. Rather than trying to define the discipline in absolute terms the approach is broadly diachronic though some principles as interdisciplinarity and modeling, values as openness and practices as data mining and collaboracion are emphasized., Proyecto de investigación TODO GÓNGORA II [I+D+I FFI2010-17349]
Proyecto:


Una primera aproximació a la comunitat jueva dels Encants del Mercat de Sant Antoni de Barcelona, 1882-1939

  • Ojeda Mata, Maite
No hi ha cap recerca sobre els jueus i les jueves del Mercat de Sant Antoni de Barcelona. Certament són pocs els estudis sobre els jueus i jueves a l’Espanya contemporània. D’aquests, només tres mencionen l’existència d’una comunitat jueva a la zona del Mercat de Sant Antoni de Barcelona: el llibre de José Antonio Lisbona, Retorno a Sefarad, 1993;2 la compilació de la història oral de la Comunitat Israelita de Barcelona (CIB)3 de Martine Berthelot, Memorias Judías, 2001;4 i la meva tesi doctoral, La España contemporánea, l@s sefardíes y la Shoah: entre esencias y ambivalencias, identidades y derechos políticos, 2008, Vull expressar el meu agraïment al Centre de Promoció de la Cultura Popular i Tradicional Catalana per finançar aquesta recerca
Proyecto:


Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

  • Guerra, Carmen
  • Mijimolle, Nieves
  • Dhawahir, Alma
  • Dubus, Pierre
  • Barradas, Marta
  • Serrano, Manuel
  • Campuzano Uceda, María Victoria
  • Barbacid, Mariano
We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprotein along with a marker protein (beta-geo) from a single bicistronic transcript. Expression of this oncogenic allele requires removal of a knocked in STOP transcriptional cassette by Cre recombinase. Primary mouse embryonic fibroblasts expressing this K-ras(V12) allele do not undergo proliferative senescence and proliferate as immortal cells. In mice, expression of K-ras(V12) throughout the body fails to induce unscheduled proliferation or other growth abnormalities for up to eight months. Only a percentage of K-ras(V12)-expressing lung bronchiolo-alveolar cells undergo malignant transformation leading to the formation of multiple adenomas and adenocarcinomas. These results indicate that neoplastic growth induced by an endogenous K-ras oncogene depends upon cellular context, This work was supported by grants from the V Framework Programme of the EU (to M.B. and M.S.), Ministerio de Ciencia y Tecnologı́a (to M.B.), Ministerio de Sanidad y Consumo and Comunidad Autónoma de Madrid (to C.G.), and Ligue contre le Cancer (Comité de Dordogne) and INSERM (to P.D.). N.M. was supported by a Beca de Formación para la Investigación (BEFI, Fondo de Investigación Sanitaria) and A.D. by a fellowship from the Programa de Formación de Personal Investigador (FPI, Ministerio de Ciencia y Tecnología)
Proyecto:


Characterization of large structural genetic mosaicism in human autosomes

  • Machiela, Mitchell J.
  • Real, Francisco X.
  • Rodríguez Santiago, Benjamín
  • Pérez Jurado, Luis Alberto
  • Chanock, Stephen J.
Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 × 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population., Some individuals, studies, and centers received individual support. The grant numbers are: Addiction (U01HG004422, NIAAA: U10AA008401, NCI: P01CA089392, NIDA: R01DA013423, R01DA019963); Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (U.S. Public Health Service contracts: N01-CN-45165, N01-RC-45035, N01-RC-37004, NCI contract: HHSN261201000006C); Birth weight (U01HG004415); Blood clotting (R37 HL 039693); Broad Center for Genotyping and Analysis (U01HG04424); Cancer Prevention Study-II (American Cancer Society); Center for Inherited Disease Research (U01HG004438, HHSN268200782096C); Cleft lip/palate (NIDCR: U01DE018993 and R01DE016148, NIH contract: HHSN268200782096C); Dental Caries (NIDCR:U01DE018903 and R01DE014899, NIH CIDR contract: HHSN268200-782096C); Endometrial cancer (R01 CA134958); Fudan Lung Cancer Study (Ministry of Health (201002007); Ministry of Science and Technology (2011BAI09B00); National S&T Major Special Project (2011ZX09102-010-01); China National High-Tech Research and Development Program (2012AA02A517, 2012AA02A518); National Science Foundation of China (30890034); National Basic Research Program (2012CB944600); Scientific and Technological Support Plans from Jiangsu Province (BE2010715)); Gene-Environment Association Studies (Coordinating Center :U01 HG004446, Manuscript preparation: P01-GM099568); Genes and Environment in Lung Cancer, Singapore Study (National Medical Research Council Singapore grant (NMRC/0897/2004, NMRC/1075/2006); Agency for Science, Technology and Research (A*STAR) of Singapore); Genetic Epidemiological Study of Lung Adenocarcinoma (National Research Program on Genomic Medicine in Taiwan (DOH98-TD-G-111-015); National Research Program for Biopharmaceuticals in Taiwan (DOH 100-TD-PB-111-TM013); National Science Council,Taiwan (NSC 100-2319-B-400-001)); Glaucoma (NHGRI: U01HG004728, NEI: R01EY015473, NEI: R01EY015872, Harvard Medical School Distinguished Ophthalmology Scholar Award: Louis Pasquale); Guangdong Study (Foundation of Guangdong Science and Technology Department (2006B60101010, 2007A032000002, 2011A030400010); Guangzhou Science and Information Technology Bureau (2011Y2-00014); Chinese Lung Cancer Research Foundation; National Natural Science Foundation of China (81101549); Natural Science Foundation of Guangdong Province (S2011010000792)); Health Professionals Follow-up Study (UM1 CA167552, R01 HL35464); Hong Kong Study (General Research Fund of Research Grant Council, Hong Kong (781511M)); Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH; Intramural Research Program of the NIH, National Library of Medicine; Intramural Research Program of the National Institute for Occupational Safety and Health; Japanese Female Lung Cancer Collaborative Study (Grants-in-Aid from the Ministry of Health, Labor, and Welfare for Research on Applying Health Technology and for the 3rd-term Comprehensive 10-year Strategy for Cancer Control; National Cancer Center Research and Development Fund; Grant-in-Aid for Scientific Research on Priority Areas and on Innovative Area from the Ministry of Education, Science, Sports, Culture and Technology of Japan; NCI (R01-CA121210)); Lung cancer (Z01CP010200); Lung health (U01HG004738); Ministry of Health (201002007); Ministry of Science and Technology (2011BAI09B00); Melanoma (NCI R29CA70334, R01CA100264, P50CA093459); NLCS (China National High-Tech Research and Development Program Grant (2009AA022705); Priority Academic Program Development of Jiangsu Higher Education Institution; National Key Basic Research Program Grant (2011CB503805)); Nurses’ Health Study (P01 CA87969, R01 CA49449); Nurses’ Health Study II (UM1 CA176726, R01, 67262); OpPancreatic cancer (Mayo Clinic SPORE in Pancreatic Cancer: P50CA102701); Prematurity (U01HG004423); Prostate cancer (U01HG004726, NCI: CA63464, CA54281, CA1326792, RC2 CA148085); Shanghai Women’s Health Cohort Study (National Institutes of Health (R37 CA70867); National Cancer Institute intramural research program; NCI Intramural Research Program contract (N02 CP1101066)); Shenyang Lung Cancer Study (National Nature Science Foundation of China (81102194); Liaoning Provincial Department of Education (LS2010168); China Medical Board (00726)); Singapore Chinese Health Study (NIH grants: NCI R01 CA55069, R35 CA53890, R01 CA80205, and R01 CA144034); South Korea Multi-Center Lung Cancer Study (National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (2011-0016106); National R&D Program for Cancer Control, Ministry of Health &Welfare, Republic of Korea (0720550-2); (A010250)); Tianjin Lung Cancer Study (Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT); China (IRT1076), Tianjin Cancer Institute and Hospital, National Foundation for Cancer Research US); Venous thromboembolism (U01HG004735); Wuhan lung cancer study (National Key Basic Research and Development Program (2011CB503800)) and Yunnan Lung Cancer Study (Intramural program of U.S. National Institutes of Health; National Cancer Institute). Additionally, K.C.B. was supported in part by the Mary Beryl Patch Turnbull Scholar Program. The GENEVA consortium thanks the participants and the staff of all GENEVA studies for their important contributions. Support for the GENEVA genome-wide association studies was provided through the NIH Genes, Environment and Health Initiative (GEI).
Proyecto:


Masked polycythaemia vera: presenting features, response to treatment and clinical outcomes.

  • Álvarez Larrán, Alberto
  • Angona Figueras, Anna
  • Ancochea Serra, Agueda
  • García-Pallarols, Francesc
  • Fernández Rodríguez, M. Concepción
  • Longarón Rozalen, Raquel
  • Bellosillo Paricio, Beatriz
  • Besses Raebel, Carles
Masked polycythaemia vera (PV) has been proposed as a new entity with poorer outcome than overt PV. In this study, the initial clinical and laboratory characteristics, response to treatment and outcome of masked and overt PV were compared using red cell mass and haemoglobin or haematocrit levels for the distinction between both entities. Sixty-eight of 151 PV patients (45%) were classified as masked PV according to World Health Organisation diagnostic criteria, whereas 16 (11%) were classified as masked PV using the British Committee for Standards in Haematology (BCSH). In comparison with overt PV, a higher platelet count and a lower JAK2V617F allele burden at diagnosis were observed in masked PV. Patients with masked PV needed lower phlebotomies and responded faster to hydroxcarbamide than those with overt PV. Complete haematological response was more frequently achieved in masked than in overt PV (79% vs. 58%, P = 0.001). There were no significant differences in the duration of haematological response, the rate of resistance or intolerance to hydroxycarbamide and the probability of molecular response according to type of PV (masked vs. overt). Overall survival, rate of thrombosis and major bleeding, and probability of transformation was superimposable among patients with masked and overt PV., This work was supported by grants from the Spanish Health Ministry ‘Fondo de Investigación Sanitaria’, PI10/01807,PI13/00557, PI13/00393, AECC Cataluña 2011, Instituto de Salud Carlos III FEDER RD12/0036/0010, SGR2014 567,the ‘Xarxa de Bancs de Tumors sponsored by Pla Director d’Oncologia de Catalunya (XBTC)’. Anna Angona is currently supported by a research grant from RETICS RD12/0036/0010.
Proyecto:


Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort.

  • Iñiguez, Carmen
  • Esplugues, Ana
  • Sunyer Deu, Jordi
  • Basterrechea, Mikel
  • Fernández Somoano, Ana
  • Costa, Olga
  • Estarlich, Marisa
  • Aguilera Jiménez, Inmaculada, 1977-
  • Lertxundi, Aitana
  • Tardón, Adonina
  • Guxens, Mònica
  • Murcia, Mario
  • Lopez-Espinosa, Maria-José
  • Ballester Díez, Ferran
  • NMA Project
BACKGROUND: Air pollution exposure during pregnancy has been associated with impaired fetal growth. However, few studies have measured fetal biometry longitudinally, remaining unclear as to whether there are windows of special vulnerability. OBJECTIVE: The aim was to investigate the impact of nitrogen dioxide (NO2) exposure on fetal and neonatal biometry in the Spanish INMA study. METHODS: Biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), and estimated fetal weight (EFW) were evaluated for up to 2,478 fetuses in each trimester of pregnancy. Size at 12, 20, and 34 weeks of gestation and growth between these points, as well as anthropometry at birth, were assessed by SD scores derived using cohort-specific growth curves. Temporally adjusted land-use regression was used to estimate exposure to NO2 at home addresses for up to 2,415 fetuses. Associations were investigated by linear regression in each cohort and subsequent meta-analysis. RESULTS: A 10-μg/m3 increase in average exposure to NO2 during weeks 0-12 was associated with reduced growth at weeks 0-12 in AC (-2.1%; 95% CI: -3.7, -0.6) and EFW (-1.6%; 95% CI: -3.0, -0.3). The same exposure was inversely associated with reduced growth at weeks 20-34 in BPD (-2.6%; 95% CI: -3.9, -1.2), AC (-1.8%; 95% CI: -3.3, -0.2), and EFW (-2.1%; 95% CI: -3.7, -0.2). A less consistent pattern of association was observed for FL. The negative association of this exposure with BPD and EFW was significantly stronger in smoking versus nonsmoking mothers. CONCLUSIONS: Maternal exposure to NO2 in early pregnancy was associated with reduced fetal growth based on ultrasound measures of growth during pregnancy and measures of size at birth., This study was funded by grants from the European Union: NEWGENERIS FP6-2003-Food-3-A-016320, FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1; and by grants from Spain: Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0031, and FIS-FEDER PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI04/2018, PI04/1436, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI08/1151, PI09/02647, PI09/02311, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/02429, PI14/0891, PI14/1687, and Miguel Servet CP11/00178 and MS13/00054), Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya (CIRIT 1999SGR 00241), Diputación Foral de Guipúzcoa (DFG/004), Departamento de Sanidad y Consumo Gobierno Vasco (2005111093), Obra Social Cajastur, and Oviedo University.
Proyecto:


Chorion formation in panoistic ovaries requires windei and trimethylation of histone 3 lysine 9

  • Herráiz Yebes, Alba, 1984-
  • Bellés, Xavier, 1952-
  • Piulachs i Bagà, M. Dolors
Epigenetic modifications play key roles in transcriptional regulation. Trimethylation of histone 3 lysine 9 (H3K9me3) is one of the most widely studied histone post-translational modifications, and has been linked to transcriptional repression. In Drosophila melanogaster, Windei is needed for H3K9me3 in female germ line cells. Here, we report the occurrence of a D. melanogaster Windei (Wde) ortholog in the ovary of the hemimetabolous insect Blattella germanica, which we named BgWde. Depletion of BgWde by RNAi reduced H3K9me3 in follicular cells, which triggered changes in transcriptional regulation that led to the prevention of chorion gene expression. In turn, this impaired oviposition (and the formation of the ootheca) and, therefore, prevented reproduction. Windei and H3K9me3 have already been reported in follicular cells of D. melanogaster, but this is the first time that the function of these modifications has been demonstrated in the said cells. This is also the first time that an epigenetic marker is reported as having a key role in choriogenesis., Support for this research was provided by the Spanish Ministry of Science and Innovation (Grant nos. BFU2011-22404 to MDP and CGL2008-03517/BOS to XB), by the CSIC (Grant no. 2010TW0019, Formosa program) and from FEDER funds to XB. Support from Generalitat de Catalunya (Grant no. 2005 SGR 00053) and LINC-Global is also gratefully acknowledged. AH received a pre-doctoral research grant (JAE-LINCG program) from the CSIC, and The European Social Fund (ESF).
Proyecto:


Ligand-dependent Notch signaling strength orchestrates lateral induction and lateral inhibition in the developing inner ear

  • Petrovic, Jelena, 1983-
  • Formosa Jordán, Pau
  • Luna Escalante, Juan C.
  • Abelló Sumpsi, Gina, 1980-
  • Ibañes, Marta
  • Neves, Joana
  • Giráldez, Fernando
During inner ear development, Notch exhibits two modes of operation: lateral induction, which is associated with prosensory specification, and lateral inhibition, which is involved in hair cell determination. These mechanisms depend respectively on two different ligands, jagged 1 (Jag1) and delta 1 (Dl1), that rely on a common signaling cascade initiated after Notch activation. In the chicken otocyst, expression of Jag1 and the Notch target Hey1 correlates well with lateral induction, whereas both Jag1 and Dl1 are expressed during lateral inhibition, as are Notch targets Hey1 and Hes5. Here, we show that Jag1 drives lower levels of Notch activity than Dl1, which results in the differential expression of Hey1 and Hes5. In addition, Jag1 interferes with the ability of Dl1 to elicit high levels of Notch activity. Modeling the sensory epithelium when the two ligands are expressed together shows that ligand regulation, differential signaling strength and ligand competition are crucial to allow the two modes of operation and for establishing the alternate pattern of hair cells and supporting cells. Jag1, while driving lateral induction on its own, facilitates patterning by lateral inhibition in the presence of Dl1. This novel behavior emerges from Jag1 acting as a competitive inhibitor of Dl1 for Notch signaling. Both modeling and experiments show that hair cell patterning is very robust. The model suggests that autoactivation of proneural factor Atoh1, upstream of Dl1, is a fundamental component for robustness. The results stress the importance of the levels of Notch signaling and ligand competition for Notch function., The work was supported by grants from Ministerio de Ciencia e Innovacion (MICINN)/n[BFU-2011-24057, PLE-2009-0098, FIS2012-37655-C02-02] and Generalitat de/nCatalunya (GENCAT) [2009SGR14], Spain; fellowships SFRH/BPD/70691/2010 to/nJ.N. from Fundação para a Ciência e a Tecnologia (FCT), Portugal; FPU-AP2008-/n03325 to P.F.-J. from Ministerio de Educación (MEC); and BES-2009-022286 to J.P./nfrom MICINN, Spain
Proyecto:


Olive oil polyphenols decrease LDL concentrations and LDL atherogenicity in men in a randomized controlled trial.

  • Hernáez, Álvaro
  • Remaley, Alan T.
  • Farràs Mañé, Marta
  • Fernández-Castillejo, Sara
  • Subirana Cachinero, Isaac
  • Schröder, Helmut, 1958-
  • Fernández-Mampel, Mireia
  • Muñoz Aguayo, Daniel
  • Sampson, Maureen
  • Solà, Rosa
  • Farré Albaladejo, Magí
  • Torre Fornell, Rafael de la
  • López Sabater, M. Carmen
  • Nyyssönen, Kristiina
  • Zunft, Hans-Joachim F.
  • Covas Planells, Maria Isabel
  • Fitó Colomer, Montserrat
BACKGROUND: Olive oil polyphenols have shown protective effects on cardiovascular risk factors. Their consumption decreased oxidative stress biomarkers and improved some features of the lipid profile. However, their effects on LDL concentrations in plasma and LDL atherogenicity have not yet been elucidated. OBJECTIVE: Our objective was to assess whether the consumption of olive oil polyphenols could decrease LDL concentrations [measured as apolipoprotein B-100 (apo B-100) concentrations and the total number of LDL particles] and atherogenicity (the number of small LDL particles and LDL oxidizability) in humans. METHODS: The study was a randomized, cross-over controlled trial in 25 healthy European men, aged 20-59 y, in the context of the EUROLIVE (Effect of Olive Oil Consumption on Oxidative Damage in European Populations) study. Volunteers ingested 25 mL/d raw low-polyphenol-content olive oil (LPCOO; 366 mg/kg) or high-polyphenol-content olive oil (HPCOO; 2.7 mg/kg) for 3 wk. Interventions were preceded by 2-wk washout periods. Effects of olive oil polyphenols on plasma LDL concentrations and atherogenicity were determined in the sample of 25 men. Effects on lipoprotein lipase (LPL) gene expression were assessed in another sample of 18 men from the EUROLIVE study. RESULTS: Plasma apo B-100 concentrations and the number of total and small LDL particles decreased (mean ± SD: by 5.94% ± 16.6%, 11.9% ± 12.0%, and 15.3% ± 35.1%, respectively) from baseline after the HPCOO intervention. These changes differed significantly from those after the LPCOO intervention, which resulted in significant increases of 6.39% ± 16.6%, 4.73% ± 22.0%, and 13.6% ± 36.4% from baseline (P < 0.03). LDL oxidation lag time increased by 5.0% ± 10.3% from baseline after the HPCOO intervention, which was significantly different only relative to preintervention values (P = 0.038). LPL gene expression tended to increase by 26% from baseline after the HPCOO intervention (P = 0.08) and did not change after the LPCOO intervention. CONCLUSION: The consumption of olive oil polyphenols decreased plasma LDL concentrations and LDL atherogenicity in healthy young men. This trial was registered at www.controlled-trials.com as ISRCTN09220811., his work was funded by the AGAUR (2014-SGR-240), the CICYT-FEDER (AGL2009-13517-C03-01), the European Commission (QLRT-2001-00287), FIS programs (PI070759 and PI11/01647), FPI fellowship program (BES-2010-040766), FPU fellowship program (FPU12/01318) and Miguel Servet’s contract (CP06/00100). The CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN)is an initiative of the Instituto de Salud Carlos III, Madrid, Spain
Proyecto:


Buscador avanzado