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Video game addiction in gambling disorder: clinical, psychopathological, and personality correlates

  • Jiménez-Murcia, Susana
  • Fernández Aranda, Fernando
  • Granero, Roser
  • Chóliz, Mariano
  • La Verde, Melania
  • Aguglia, Eugenio
  • Signorelli, Maria S.
  • Sá, Gustavo M.
  • Aymamí, Maria Neus
  • Gómez-Peña, Mónica
  • Del Pino Gutiérrez, Amparo
  • Moragas, Laura
  • Fagundo, Ana Beatriz
  • Sauchelli, Sarah
  • Fernández Formoso, José Antonio
  • Menchón Magriñá, José Manuel
Objective: We studied the prevalences of video game use (VGU) and addiction (VGA) in gambling disorder (GD) patients and compared them with subjects with non-video game use (non-VGU) in relation to their gambling behavior, psychopathology, and personality characteristics. Method: A sample of 193 GD patients (121 non-VGU, 43 VGU, and 29 VGA) consecutively admitted to our pathological gambling unit participated in the study. Assessment: Measures included the video game dependency test (VDT), symptom checklist-90-revised, and the temperament and character inventory-revised, as well as a number of other GD indices. Results: In GD, the observed prevalence of VG (use or addiction) was 37.3% (95%CI:30.7% ÷ 44.3),VGU 22.3% (95%CI:17.0% ÷ 28.7), and VGA 15% (95%CI:10.7% ÷ 20.7). Orthogonal polynomial contrast into logistic regression showed positive linear trends for VG level and GD severity and other measures of general psychopathology. After structural equation modeling, higher VG total scores were associated with younger age, general psychopathology, and specific personality traits, but not with GDseverity. Patients" sex and age were involved in the mediational pathways between personality traits and VG impairment. Conclusions: GD patients with VG are younger and present more dysfunctional personality traits, and more general psychopathology. The presence of VG did not affect the severity of GD

Development of a genetic tool for functional screening of anti-malarial bioactive extracts in metagenomic libraries

  • Mongui, Alvaro
  • Pérez-Llanos, Francy J.
  • Yamamoto, Marcio M.
  • Lozano, Marcela
  • Zambrano, Maria M.
  • Portillo, Patricis Del
  • Fernández Becerra, Carmen
  • Restrepo, Silvia
  • Junca, Howard
BACKGROUND: The chemical treatment of Plasmodium falciparum for human infections is losing efficacy each year due to the rise of resistance. One possible strategy to find novel anti-malarial drugs is to access the largest reservoir of genomic biodiversity source on earth present in metagenomes of environmental microbial communities. METHODS: A bioluminescent P. falciparum parasite was used to quickly detect shifts in viability of microcultures grown in 96-well plates. A synthetic gene encoding the Dermaseptin 4 peptide was designed and cloned under tight transcriptional control in a large metagenomic insert context (30 kb) to serve as proof-of-principle for the screening platform. RESULTS: Decrease in parasite viability consistently correlated with bioluminescence emitted from parasite microcultures, after their exposure to bacterial extracts containing a plasmid or fosmid engineered to encode the Dermaseptin 4 anti-malarial peptide. CONCLUSIONS: Here, a new technical platform to access the anti-malarial potential in microbial environmental metagenomes has been developed.

Increased opioid dependence in a mouse model of panic disorder

  • Gallego, Xavier
  • Murtra, Patricia
  • Zamalloa, Teresa
  • Canals i Coll, Josep M.
  • Pineda, Joseba
  • Amador-Arjona, Alejandro
  • Maldonado, Rafael, 1961-
  • Dierssen, Mara
Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high-affinity receptor for neurotrophin-3, is a key molecule involved in panic disorder and opiate dependence, using a transgenic mouse model (TgNTRK3). Constitutive TrkC overexpression in TgNTRK3 mice dramatically alters spontaneous firing rates of locus coeruleus (LC) neurons and the response of the noradrenergic system to chronic opiate exposure, possibly related to the altered regulation of neurotrophic peptides observed. Notably, TgNTRK3 LC neurons showed an increased firing rate in saline-treated conditions and profound abnormalities in their response to met5-enkephalin. Behaviorally, chronic morphine administration induced a significantly increased withdrawal syndrome in TgNTRK3 mice. In conclusion, we show here that the NT-3/TrkC system is an important regulator of neuronal firing in LC and could contribute to the adaptations of the noradrenergic system in response to chronic opiate exposure. Moreover, our results indicate that TrkC is involved in the molecular and cellular changes in noradrenergic neurons underlying both panic attacks and opiate dependence and support a functional endogenous opioid deficit in panic disorder patients.

Las referencias bibliográficas sobre 'nursing diagnosis' en Medline (1994-2000)

  • Icart Isern, M. Teresa (Maria Teresa)
  • Icart Isern, M. Carmen
  • Pulpón Segura, Anna M.
  • Esteve, Carme
  • Coll, Margarita
  • Granollers Mercader, Sílvia
  • Ferrer, Iona
  • Asensi, Xavier
  • Espelt, Pilar
  • Ondiviella, Angels
  • Manito Lorite, Isabel
  • Basora, Imma
Para conocer las características bibliométricas y metodológicas de los documentos sobre diagnósticos de enfermería indexados en la base Medline entre 1994 y 2000, se realizó un estudio en la Unidad de Salud Pública (Escuela Universitaria de Enfermería, Universitat de Barcelona) y en el Instituto Catalán de la Salud (Generalitat de Catalunya). Se empleó un diseño observacional, descriptivo y transversal. El material estudiado corresponde a 204 referencias bibliográficas (RB) que contenían los términos «nursing diagnosis» en el título e identificadas en la base Medline (1994-2000). Se concluye que la mayor parte de las RB estudiadas corresponde a artículos de tipo teórico; sus autores son del ámbito académico y desarrollan su actividad en el mundo anglosajón. Destaca el hecho de que en las RB estudiadas no constan algunas de las variables que se pretendían analizar en el presente estudio: filiación de los autores, lugar donde se realiza el estudio, número de sujetos estudiados, etcétera.

Leaving the Dark ages with AMIGA

  • Manrique Oliva, Alberto
  • Salvador Solé, Eduard
  • Juan, Enric
  • Hatziminaoglou, Evanthia
  • Rozas, José María
  • Sagristà, Antoni
  • Casteels, Kevin
  • Bruzual, Gustavo
  • Magris, Gladis
We present an Analytic Model of Intergalactic-medium and GAlaxy (AMIGA) evolution since the dark ages. AMIGA is in the spirit of the popular semi-analytic models of galaxy formation, although it does not use halo merger trees but interpolates halo properties in grids that are progressively built. This strategy is less memory-demanding and allows one to start modeling at sufficiently high redshifts and low halo masses to have trivial boundary conditions. The number of free parameters is minimized by making a causal connection between physical processes usually treated as independent of each other, which leads to more reliable predictions. However, the strongest points of AMIGA are the following: (1) the inclusion of molecular cooling and metal-poor, population III (Pop III) stars with the most dramatic feedback and (2) accurate follow up of the temperature and volume filling factor of neutral, singly ionized, and doubly ionized regions, taking into account the distinct halo mass functions in those environments. We find the following general results. Massive Pop III stars determine the intergalactic medium metallicity and temperature, and the growth of spheroids and disks is self-regulated by that of massive black holes (MBHs) developed from the remnants of those stars. However, the properties of normal galaxies and active galactic nuclei appear to be quite insensitive to Pop III star properties due to the much higher yield of ordinary stars compared to Pop III stars and the dramatic growth of MBHs when normal galaxies begin to develop, which cause the memory loss of the initial conditions.

Geofluid behaviour in successive extensional and compressional events: a case study from the southwestern end of the Vallès-Penedès Fault (Catalan Coastal Ranges, NE Spain)

  • Baqués, V.
  • Travé i Herrero, Anna
  • Roca i Abella, Eduard
  • Marín, M.
  • Cantarero Abad, Irene
The structural position of the Upper Jurassic-Lower Cretaceous carbonates located in the central part of the Catalan Coastal Ranges corresponds to the southwestern end of the Vallès-Penedès Fault. This fault was reactivated at different times during successive extensional and compressional events and several generations of fractures and cementations were formed.

Efficient reconstruction of linear baryon acoustic oscillations in galaxy surveys

  • Burden, Angela
  • Percival, W.J.
  • Manera, Marc
  • Cuesta, Antonio J.
  • Vargas Magana, Mariana
  • Ho, Shirley
Reconstructing an estimate of linear baryon acoustic oscillations (BAO) from an evolved galaxy field has become a standard technique in recent analyses. By partially removing non-linear damping caused by bulk motions, the real-space BAO peak in the correlation function is sharpened, and oscillations in the power spectrum are visible to smaller scales. In turn these lead to stronger measurements of the BAO scale. Future surveys are being designed assuming that this improvement has been applied, and this technique is therefore of critical importance for future BAO measurements. A number of reconstruction techniques are available, but the most widely used is a simple algorithm that decorrelates large-scale and small-scale modes approximately removing the bulk-flow displacements by moving the overdensity field. We consider the practical implementation of this algorithm, looking at the efficiency of reconstruction as a function of the assumptions made for the bulk-flow scale, the shot-noise level in a random catalogue used to quantify the mask and the method used to estimate the bulk-flow shifts. We also examine the efficiency of reconstruction against external factors including galaxy density, volume and edge effects, and consider their impact for future surveys. Throughout we make use of the mocks catalogues created for the Baryon Oscillation Spectroscopic Survey (BOSS) Date Release 11 samples covering 0.43 < z < 0.7 (CMASS) and 0.15 < z < 0.43 (LOWZ), to empirically test these changes.

Refráns meteorolóxicos e atlas románicos, paremioloxía e territorio

  • Gargallo Gil, José Enrique
Tras unha presentación da Base de datos sobre refranes del calendario y meteorológicos en la Romania (BADARE) e do progresivo baleirado nela de diversos atlas lingüísticos da Romania, preséntanse tres mostras da variación diatópica deste tipo de refráns no espazo iberorromance: (1) coa implicación do arco da vella, (2) dos roibéns e (3) das imaxes de ceo ovellado e afíns. Cómpre destacar o grande interese dos materiais contidos nos atlas románicos, que se poden complementar cos doutras obras vinculadas á lingua e ao territorio: repertorios paremiográficos, monografías dialectais, achegas diversas. Aínda que non parece factible un grande atlas paremiolóxico romance nin sequera de segunda xeración, pois os refráns (meteorolóxicos o de outros tipos) son nos atlas de primeira xeración unha propina ocasional, coidamos que mediante a base de datos BADARE se poden administrar eses materiais de xeito que faciliten o estudo da paremioloxía románica ligada ao territorio.

Beyond the work-life balance: family and international mobility of the highly skilled

  • Vergés Bosch, Núria
  • González Ramos, Ana M.
International mobility of the highly skilled has become one of the cornerstones of development in the current knowledge society. Correspondingly, highly skilled personnel are impelled to move abroad in order to improve their competences and build influential professional networks. Mobility implies some advantages involving personal, social and family opportunities when movers experience handicaps in their country of origin. For movers, mobility becomes a new challenge beyond the work-family balance, particularly for women who usually take on the lion's share of childcare and domestic tasks within the family. The literature exploring the gender dimension in relation to international mobility points to complex outcomes. Firstly, women are taking on a more active role in international mobility processes, even when they have family. Secondly, family and international mobility are interrelated both for men and for women, although family could become a hindrance, particularly for women. Thirdly, international mobility and women's career development may interfere with family formation or modify traditional family values. Finally, families moving abroad constitute a challenge for public policy, since they present a new area of problems. We aim to analyse the relationship between international mobility and family based on in-depth interviews from a purposive sample of highly skilled personnel in science and technology. The results of our research suggest that international mobility of the highly skilled has effects on the family and vice versa; however, while international mobility and family are compatible, measures and policies to reconcile them are still insufficient.

A birth cohort study in the Middle East: the Qatari birth cohort study (QBiC) phase I

  • Sadoun, Eman
  • Leventakou, Vasiliki
  • Casas, Maribel
  • Ahmed, Heba Fawzy
  • Kogevinas, Manolis
  • Fthenou, Eleni
BACKGROUND: The latest scientific reports raise concerns about the rapidly increasing burden of chronic diseases in the state of Qatar. Pregnant Qatari women often confront complications during pregnancy including gestational diabetes, hypertension, abortion and stillbirth. The investigation of early life environmental, genetic, nutritional and social factors that may affect lifelong health is of great importance. Birth cohort studies offer a great opportunity to address early life hazards and their possible long lasting effects on health. METHODS/DESIGN: The Qatari Birth Cohort study is the first mother-child cohort study in the Middle East Area that aims to assess the synergetic role of environmental exposure and genetic factors in the development of chronic disease and monitor woman and child health and/or obstetric characteristics with high prevalence. The present manuscript describes the recruitment phase of the study (duration: 2 years; expected number: 3000 families), where the pregnant Qatari women and their husbands are being contacted before the 15th week of gestation at the Primary Health Care Centers. The consented participants are interviewed to obtain information on several factors (sociodemographic characteristics, dietary habits, occupational/environmental exposure) and maternal characteristics are assessed based on anthropometric measurements, spirometry, and blood pressure. Pregnant women are invited to provide biological samples (blood and urine) in each trimester of their pregnancy, as well as cord blood at delivery. Fathers are also asked to provide biological samples. DISCUSSION: The present study provides invaluable insights into a wide range of early life factors affecting human health. With a geographical focus on the Middle East, it will be a resource for information to the wider scientific community and will allow the formulation of effective policies with a primary focus on public health interventions for maternal and child health.

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