BUSCADOR RECOLECTA

Web tool for the selection of SNPs from the STAR project with potential functional effect. Més informació: funcSTAR (web) http://bg.upf.edu/funcSTAR/

Mutations, genes and pathways involved in tumorigenesis across 4,623 cancer genomes/exomes from 13 cancer sites. 1 SQL (Structured Query Language) file and 1 WAR (Web application ARchive) file.

Database of human genes prioritized for their probability of involvement in dominant or recessive hereditary diseases.

Raw data of PM2.5 and CO from an indoor wood-combustion experiment. We evaluated the performance of two low-cost sensors measuring fine particulate matter (PM2.5) (HAPEX Nano, Climate Solutions Consulting, and TZOA-R Model RD02, MyTZOA) and one measuring carbon monoxide (CO) (EL-USB-CO, Lascar Electronics Ltd.) in a real-world wood-combustion experiment. PM2.5 devices were compared against a DustTrak (Model 8534, TSI Inc.) and a BGI pump (BGI4004, BGI Inc.) and the EL-USB-CO data-logger was compared against a Q-Trak (Model 7575, TSI Inc.). Sampling was conducted in a single-family house in Terrassa (Spain) during five non-consecutive days. All devices were co-located 1 meter away from an indoor fireplace and 0.6 meters above the ground. Fire was set once per day with hardwood logs and kept burning for 12 hours including a minimum of 2 hours with an opened window. The data provided is the raw output from all the devices tested for the 5 sampling days aiming interested researchers to play with the data and reproduce our findings.

Long noncoding RNAs (lncRNAs, which comprise 68% of the human transcriptome with average length of 1,000 nt) interact with various RNA-binding proteins (RBPs) to mediate cellular functions. Here we introduce Global Score as a tool to predict protein interactions with lncRNAs (http://service.tartaglialab.com/new_submission/globalscore). We used enhanced CLIP (eCLIP) to test the binding of the lncRNA Xist to the RBPs HnrnpK (Global Score of 0.99), Ptbp1 (0.99), Lbr (0.79), HnrnpU (Saf-A) (0.66), Spen (Sharp) (0.59) and negative control Dkc1 (0.01). Global Score prediction correlates with the eCLIP binding profile (Pearson correlation = 0.93). As for the binding sites, Spen and HnrnpK, Ptbp1, and Lbr interact respectively with Xist A, B, and E repeats and adjacent regions, while HnrnpU binds across the whole transcript, and Dkc1 does not interact with Xist.

This database contains information on the genes identified as drivers in Rubio-Perez and Tamborero et al. (2015). It contains information on driver identification at mutational, CNA and gene fusion level. Additional ancillary information about the role and major clonality of drivers is also included. A table is also provided with the list of datasets used for mutational driver identification.

The effects on growth performance of supplementation of four different AA combinations in a milk replacer (MR, 25.4% CP and 20.3% fat) based on skimmed milk powder and whey protein concentrate were evaluated in 76 Holstein male calves (3 ± 1.7 d old). The 4 MR were: CTRL with no AA supplementation; PG supplying additional 0.3% Pro and 0.1% Gly; FY supplying additional 0.2% Phe and 0.2% Tyr; KMT providing additional 0.62% Lys, 0.22% Met, and 0.61% Thr. All calves were fed the same milk allowance program and were weaned at 56 d of study. Concentrate intake was limited to minimize interference of potential differences in solid feed intake among treatments. Animals were weighed weekly, intakes recorded daily, and blood samples obtained at 2, 5, and 7 wk of study to determine serum urea and plasma AA concentrations. The file presents data of the backwards selection process to assess the model that fitted better ADG with the study variables (performance, intake, plasma AA balances). Data was collected at Torre Marimon IRTA calf facilities (Caldes de Montbui, Spain) during 2017

This file lists the High Confidence Drivers identified as part of the pan-cancer12 initiative, published in the paper Comprehensive identification of mutational cancer driver genes across 12 tumor types" Scientific Reports 3:2650, 2013, doi:10.1038/srep02650

Genes and pathways affected by expression and copy number changes in tumors across projects and cancer types.

Bioinformatics method to identify individual driver mutations.