Resultados totales (Incluyendo duplicados): 42083
Encontrada(s) 4209 página(s)
Encontrada(s) 4209 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336569
Set de datos (Dataset). 2009
CUENCA. SEMINARIO DE SAN JULIÁN. INSCRIPCIÓN DE LA FACHADA PRINCIPAL
- Cañas Reillo, José Manuel
Es la inscripción situada en la fachada de la Plaza de la Merced, de la 1ª mitad del siglo XVIII. Está grabada sobre una cartela de mármol de color azul claro con una cita en latín del salmo 110, v. 9 (según la inscripción, en realidad v. 19), CSIC. Proyecto intramural: “Epigrafía latina inédita de los siglos XV al XVIII en monumentos civiles y eclesiásticos de la provincia de Cuenca (2006-2007). Referencia: 2006 | 0| 011., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/336569, https://doi.org/10.20350/digitalCSIC/15622
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336569
HANDLE: http://hdl.handle.net/10261/336569, https://doi.org/10.20350/digitalCSIC/15622
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336569
PMID: http://hdl.handle.net/10261/336569, https://doi.org/10.20350/digitalCSIC/15622
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336569
Ver en: http://hdl.handle.net/10261/336569, https://doi.org/10.20350/digitalCSIC/15622
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336569
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336575
Set de datos (Dataset). 2023
FRUGIVORY CAMTRAP: A DATASET OF PLANT-ANIMAL INTERACTIONS RECORDED WITH CAMERA TRAPS
- Villalva, Pablo
- Arroyo-Correa, Blanca
- Calvo, Gemma
- Homet, Pablo
- Isla, Jorge
- Mendoza, Irene
- Moracho, Eva
- Quintero, Elena
- Rodríguez-Sánchez, Francisco
- Jordano, Pedro
[Description of methods used for collection/generation of data] Over a span of 5 years (four complete fruiting seasons; 2018-11-21 to 2023-04-17), we monitored 339 plant individuals belonging to 13 distinct fleshy-fruited plant species with camera traps. Uur approach involved the strategic placement of camera traps in front of specific plant individuals, referred to as focal plants. These cameras were set in video mode, providing valuable insights for identifying animal species, but also annotating specific foraging behaviors and estimating fruit consumption rates for certain species, as well as fruit-picking and fruit handling behaviors. We deployed a total of 70 cameras, including 50 Browning Dark Ops®, 10 Bushnell Trophy® cam Aggressor, and 10 GoPro® cameras. These cameras were strategically positioned towards different plant individuals bearing fleshy fruits. Sensor-triggered camera traps were used for 12 plant species, while continuous recording with GoPro® cameras was used for sampling Pistacia lentiscus. Regular checks of the camera traps were conducted at regular intervals, either weekly or biweekly, depending on the plant species and the specific period of the year, [Methods for processing the data] We developed an image processing workflow specifically designed for integrating video recordings and creating extensive and accurate databases of frugivore interactions using camera traps. We leverage Megadetector and Time-lapse, an AI model for eliminating blank images and enhanced visualisation software respectively., The goal of this repository is to contain and facilitate access to the data associated to the datapaper FRUGIVORY CAMTRAPS: A dataset of plant-animal interactions recorded with camera traps, Ecological interactions are a key component of biodiversity, essential for understanding ecosystem services and functioning. Recording and quantifying ecological interactions is challenging, frequently requiring complex logistics and substantial effort in the field. Camera traps are routinely used in ecology for various applications and have proven to be an excellent method for passive and non-invasive sampling of plant-animal interactions. We implemented a standardized camera trap protocol to monitor frugivory interactions between fleshy-fruited plant species and vertebrate frugivores in Doñana National Park, SW Spain. The central objective was to inventory the diversity of plant-animal ecological interactions providing seed dispersal services. We recorded pairwise interactions between plant individuals and vertebrate frugivore species from 2018 to 2023, reporting both qualitative information (presence-absence of the interaction) and quantitative data (frequency of visits). Each record in the dataset contains information of a visit by an individual animal to an individual plant, resulting in any form of fleshy-fruit use and provides information on visitation phenology, visit length and feeding behavior. The dataset presented here includes 10,659 frugivory interactions for 59 vertebrate species (46 birds, 13 mammals) recorded on 339 plant individuals from 13 different plant species which dominate the fleshy-fruited plant assemblage in the Doñana National Park. The most recorded animal species consuming fruits and playing a legitimate seed dispersal role was Curruca melanocephala (1678 records) among birds and Vulpes vulpes among mammals (751 records). On the other hand, Cervus elaphus was the most recorded mammal species (1508 records), but it is a fruit consumer with a marginal role as legitimate seed disperser. Avian frugivores, particularly those from the Sylviidae and Turdidae families, are widespread in the region, and play a crucial role in maintaining the dispersal service for the fleshy-fruited plant populations in the area. The dataset offers highly versatile quantitative information that can be used to investigate frugivory from the highest resolution scale, the interaction event between pairs of individuals. In addition, information can be extracted about the timing of interactions of animals and plants (their phenological couplings), activity periods of the animals, behavior during the events and preferences for individual plants within populations., This study was funded by MICINN through the European Regional Development Fund [SUMHAL, LIFEWATCH-2019-09-CSIC-4, POPE 2014-2020], with additional funding (PJ) from grant PID2022-136812NB-I00 by MCIN/AEI/10.13039/501100011033. IM was supported by the grant PID2020-115129RJ-I00 by MCIN/AEI/10.13039/501100011033., Peer reviewed
DOI: http://hdl.handle.net/10261/336575, https://doi.org/10.20350/digitalCSIC/15623
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336575
HANDLE: http://hdl.handle.net/10261/336575, https://doi.org/10.20350/digitalCSIC/15623
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336575
PMID: http://hdl.handle.net/10261/336575, https://doi.org/10.20350/digitalCSIC/15623
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336575
Ver en: http://hdl.handle.net/10261/336575, https://doi.org/10.20350/digitalCSIC/15623
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336575
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336578
Set de datos (Dataset). 2023
HOME RANGE SIZE OF DOMESTIC CATS IN SPAIN
- Palomares, Francisco
- Sanglas, Ariadna
[Description of methods used for collection/generation of data] Sixty-four different domestic cats were tagged with three different types of devices (Tractive IKATI GPS-GPM collars (https://tractive.com), 48 cats; backpack-GPS-datalogger CatLog2 (http://www.mr-lee.com/science.htm), 14 cats; and e-Obs GPS collars 1A (https://e-obs.de/products.html), two cats. Every type of device had its own tracking schedule. Tractive collars can not be programmed, and they, in normal conditions, take one location every 3 minutes, but it varies depending on animal activity and movement (see https://help.tractive.com/hc/es for more details). Backpack GPS dataloggers were programmed to take fixes every 10 min. Finally, e-Obs collars were programmed to take fixes every 4 hours.
Cats tagged with Tractive collars were managed by volunteers over Spain, who wished to participate in the study by tagging their cats. Every volunteer fit the collar to its cats and charged the collar battery when necessary. These cats were tracked during a period ranging between 10 and 66 days, but for different reasons, collar batteries were not continuously working, so the number of effective days of tracking ranged between 10 and 34 days. Three cats were tracked in two different periods. Backpack dataloggers were used to track the movements of an unattended cat colony in the municipality of Abla (Almería province), on the border of the Sierra Nevada Natural Park, and one free-ranging isolated individual living in the Sierra Aracena y Picos de Aroche Natural Park in the municipality of Jabugo (Huelva province). These cats were trapped with trap boxes baited with commercial pellet cat food, and immobilized with Ketamine (Imalgene 100mg/ml) and Medetomidine hydrochloride (Domtor 1mg/ml) according to manufacturer dosage instructions, before installing or removing the backpacks. The effect of anaesthesia was reverted with Antisedan 5mg/ml. For these cats, the tracking period ranged between 8 and 58 days. Finally, two cats living in an isolated house inside the Sierra Nevada Natural Park were tagged with e-Obs collars for 49 and 82 days. These cats were tame, so we managed to put the collars without trapping and immobilizing them.
The study was undertaken with the correspondent permissions (including the bioethics one) of the Consejería de Agricultura, Ganadería, Pesca y Desarrollo Sostenible of the Junta de Andalucía, the Sierra Nevada National and Natural Park, and the Dirección General de la Producción Agrícola y Ganadera of the Junta de Andalucía., [Methods for processing the data] All home range estimation analysis was carried out in the program RStudio (Posit team 2023) using the ‘adehabitatHR’ package (Calenge 2023; version 0.4.21). We calculated home range sizes by minimum convex polygon (mcp) methods using 100% and 95% of valid fixes (see below) and by the kernel methods using 95% and 50% of valid fixes for each individual cat. These different home range estimations allow comparisons with the most often used methods in the literature. In all cases, we used the default settings within the package ‘adehabitatHR’., [EN] This dataset describes the home range size of 64 domestic cats living in different sites in Spain during the years 2021, 2022 and 2023. Cats were tracked with three different types of devices during periods ranging from 8 and 82 days, and they were owned cats living associated with a house (50 individuals), colony unattended cats (13 individuals), and one isolated unattended cats living in a natural area. Four estimates of home range size are presented: Minimum convex polygon method using 100% and 95% of valid fixes, and kernel estimates using 95% and 50% of valid fixes. Additional information on the number of tracking days, date of tracking, number of fixes, or details on cat individuals are also provided., [ES] Este conjunto de datos describe el tamaño del área de campeo de 64 gatos domésticos que vivieron en diferentes lugares de España durante los años 2021, 2022 y 2023. Los gatos fueron rastreados con tres tipos diferentes de dispositivos durante períodos que oscilaron entre 8 y 82 días, y eran gatos con dueño, viviendo asociado a una casa (50 individuos), de una colonia de gatos desatendida (13 individuos) y un gato desatendido que vivía en un área natural. Se presentan cuatro estimas del tamaño del área de campeo: método del polígono convexo mínimo utilizando el 100 % y el 95 % de las localizaciones válidas, y el método de kernel usando el 95% y el 50 % de las localizaciones válidas. También se proporciona información adicional sobre el número de días de seguimiento, las fechas de seguimiento, el número de localizaciones o detalles sobre los gatos., This study was funded by MICINN through the European Regional Development Fund [SUMHAL, LIFEWATCH-2019-09-CSIC-04, POPE 2014-2020]., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/336578, https://doi.org/10.20350/digitalCSIC/15624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336578
HANDLE: http://hdl.handle.net/10261/336578, https://doi.org/10.20350/digitalCSIC/15624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336578
PMID: http://hdl.handle.net/10261/336578, https://doi.org/10.20350/digitalCSIC/15624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336578
Ver en: http://hdl.handle.net/10261/336578, https://doi.org/10.20350/digitalCSIC/15624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336578
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336588
Set de datos (Dataset). 2023
RAW DATA FOR DETECTING THE SPIN-POLARIZATION OF EDGE STATES IN GRAPHENE NANORIBBONS
- Brede, Jens
- Merino-Díez, Nestor
- Berdonces-Layunta, Alejandro
- Sanz, Sofía
- Domínguez-Celorrio, Amelia
- Lobo-Checa, Jorge
- Vilas-Varela, Manuel
- Peña, Diego
- Frederiksen, Thomas
- Pascual, José I.
- García de Oteyza, Dimas
- Serrate, David
Colección de datos originales necesarios para la elaboración del artículo al que hace referencia el título. Incluye imágenes en formato binario *.sxm, datos ascii enformato *.txt o *.dat, archivos de origin *.opj, e imágenes *.bmp, Low dimensional carbon-based materials can show intrinsic magnetism associated to p-electrons in open-shell $\pi$-conjugated systems. Chemical design provides atomically precise control of the $\pi$-electron cloud, which makes them promising for nanoscale magnetic devices. However, direct verification of their spatially resolved spin-moment remains elusive. Here, we report the spin-polarization of chiral graphene nanoribbons (one-dimensional strips of graphene with alternating zig-zag and arm-chair boundaries), obtained by means of spin-polarized scanning tunnelling microscopy. We extract the energy-dependent spin-moment distribution of spatially extended edge states with $\pi$-orbital character, thus beyond localized magnetic moments at radical or defective carbon sites. Guided by mean field Hubbard calculations, we demonstrate that electron correlations are responsible for the spin-splitting of the electronic structure. Our versatile platform utilizes a ferromagnetic substrate that stabilizes the organic magnetic moments against thermal and quantum fluctuations, while being fully compatible with on-surface synthesis of the rapidly growing class of nanographenes., We acknowledge financial support from the Spanish Ministry of Science and Innovation MICIN through grant nos. PID2019-107338RB-C64, PID2019-107338RB-C61, PID2019-107338RB-C62, PID2019-107338RB-C63, PID2020–115406GB-I00 funded by AEI/10.13039/501100011033; grant no. PCI2019-111933-2; and red tem\'{a}tica RED2018-102833-T. This work was also supported by European Regional Development Fund (ERDF) under the program Interreg V-A España-Francia-Andorra (grant no. EFA194/16 TNSI), the European Union (EU) H2020 program through the FET-Open project SPRING (Grant Agreement No. 863098), the Maria de Maeztu Units of Excellence Program CEX2020-001038-M, the Aragon Government (E13-20R and E12-20R), the Programa Red Guipuzcoana de Ciencia, Tecnología e Innovación 2021 (Grant No. 2021-CIEN-000069-01. Gipuzkoa Next), the Basque Departmente of Educatioon (PRE-2021-2-0190 and PIBA-2020-1-0014), and the Xunta de Galicia (Centro de Investigación accreditation 2019–2022, ED431G2019/03), Peer reviewed
DOI: http://hdl.handle.net/10261/336588, https://doi.org/10.20350/digitalCSIC/15625
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336588
HANDLE: http://hdl.handle.net/10261/336588, https://doi.org/10.20350/digitalCSIC/15625
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336588
PMID: http://hdl.handle.net/10261/336588, https://doi.org/10.20350/digitalCSIC/15625
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336588
Ver en: http://hdl.handle.net/10261/336588, https://doi.org/10.20350/digitalCSIC/15625
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336588
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336624
Set de datos (Dataset). 2023
SUPPORTING INFORMATION CORRELATIVE RADIOIMAGING AND MASS SPECTROMETRY IMAGING: A POWERFUL COMBINATION TO STUDY 14C-GRAPHENE OXIDE IN VIVO BIODISTRIBUTION
- Cazier, Hélène
- Malgorn, Carole
- Georgin, Dominique
- Fresneau, Nathalie
- Beau, Fabrice
- Kostarelos, Kostas
- Bussy, Cyrill
- Campidelli, Stéphane
- Pinault, Mathieu
- Mayne-L'Hermite, Martine
- Taran, Frédéric
- Junot, Christophe
- Fenaille, François
- Sallustrau, Antoine
- Colsch, Benoit
14 pages. -- PDF file includes: 1. Characterization. -- 2. Methods. -- 3. Biodistribution. -- Figures, Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/336624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336624
HANDLE: http://hdl.handle.net/10261/336624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336624
PMID: http://hdl.handle.net/10261/336624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336624
Ver en: http://hdl.handle.net/10261/336624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336624
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336632
Set de datos (Dataset). 2023
SUPPORTING INFORMATION FOR ADV. ELECTRON. MATER., DOI: 10.1002/AELM.202201224 DEVICE-TO-MATERIALS PATHWAY FOR ELECTRON TRAPS DETECTION IN AMORPHOUS GESE-BASED SELECTORS
- Slassi, Amine
- Medondjio, Linda-Sheila
- Padovani, Andrea
- Tavanti, Francesco
- He, Xu
- Clima, Sergiu
- Garbin, Daniele
- Kaczer, Ben
- Larcher, Luca
- Ordejón, Pablo
- Calzolari, Arrigo
13 pages. -- S1. Device characterization and Experimental data. -- Table S2. RPERI modules with varying number of fingers, and hence a varying perimeter, but a fixed total area. -- Figure S1. Leakage current measured as a function of the temperature on TiN/10nm Ge60Se40/TiN (D16). -- Figure S2. TiN/10nm Ge60Se40/TiN (D16) C-V-f and G-V-f vs Temperature (T). -- Figure S3. Leakage current measured as a function of the temperature on TiN/20nm Ge50Se50/TiN (D21) in the (left) +/-2V and (right) +/-5V voltage ranges. -- Figure S4. TiN/20nm Ge50Se50/TiN (D21) C-V-f and G-V-f vs Temperature (T). -- Figure S5. Leakage current measured as a function of the temperature in TiN/20nmGe60Se40/TiN (D22). -- Figure S6. TiN/20nmGe60Se40/TiN (D22) C-V-f and G-V-f vs Temperature (T). -- S2. DFT accuracy tests. -- Table S3. Basis set convergence. -- Figure S7. Density of states of representative models of amorphous Ge50Se50. -- Figure S8. Density of states of representative models of amorphous Ge50Se50. -- S3 Electronic structure analysis. -- Figure S9. Total (black line) and Ge- (blue) and Se-projected (green) DOS for the twelve
simulation boxes obtained from DFT relaxation for the Ge40Se60 system. -- Figure S10. Total (black line) and Ge- (blue) and Se-projected (green) DOS for the twelve simulation boxes obtained from DFT relaxation for the Ge50Se50 system. -- Figure S11. Total (black line) and Ge- (blue) and Se-projected (green) DOS for the twelve
simulation boxes obtained from DFT relaxation for the Ge60Se40 system. -- Figure S12. Density of states of representative models of amorphous GexSe100-x at different Ge concentration (x). -- Figure S13. (a) Density of States (DOS) plot for Se-rich Ge40Se60 compound. (b) Single-particle charge density isosurface of a trap state in the mobility gap of Ge40Se60. Gray polyhedrons indicate ordered 3-fold and 4-fold local-order
structures centered on Ge atoms., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/336632
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336632
HANDLE: http://hdl.handle.net/10261/336632
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336632
PMID: http://hdl.handle.net/10261/336632
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336632
Ver en: http://hdl.handle.net/10261/336632
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336632
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336645
Set de datos (Dataset). 2023
SUPPORTING INFORMATION FOR CHRONIC DEGRADATION OF SEASONALLY DRY TROPICAL FORESTS INCREASES THE INCIDENCE OF GENOTOXICITY IN BIRDS
- Cevallos-Solorzano, Gabriela
- Bailón-Moscoso, Natalia
- Ordóñez-Delgado, Leonardo
- Jara, Paul
- Tomás, Gustavo
- Espinosa, Carlos Iván
Tabla S1. Number of birds sampled from each species studied in Zapotillo, Ecuador., The mean and standard deviation (SD) of micronucleus and nuclear alterations for all included bird species are provided in this supporting information. These alterations were analyzed in the main article., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/336645
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336645
HANDLE: http://hdl.handle.net/10261/336645
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336645
PMID: http://hdl.handle.net/10261/336645
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336645
Ver en: http://hdl.handle.net/10261/336645
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336645
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336646
Set de datos (Dataset). 2023
MICRONUCLEUS AND ABNORMALITY NUCLEAR IN BIRDS OF SEASONALLY DRY TROPICAL FORESTS
- Ordóñez-Delgado, Leonardo
- Bailón-Moscoso, Natalia
- Cevallos-Solorzano, Gabriela
- Tomás, Gustavo
- Espinosa, Carlos Iván
- Jara, Paul
For the detection of micronuclei and nuclear abnormalities, blood smears were prepared and stained with Giemsa. A total of 10,000 erythrocytes were counted on each slide., We are interested in understanding how the degradation of the dry forest in the Tumbesian region is related to an increase in genotoxic damage in birds. Our research hypothesis posited that the degradation of the dry forest would be associated with a higher frequency of micronuclei and nuclear abnormalities in the birds inhabiting these areas.
To test our hypothesis, we conducted safe captures of birds in three different types of forests: natural forests, semi-natural forests, and shrub-dominated forests in the Tumbesian region. We collected blood samples from the captured birds and conducted tests for micronuclei and nuclear abnormalities in the laboratory. These genotoxic markers are sensitive indicators of DNA damage and provide information about the genetic health of the birds. This dataset is the basis of our findings., Universidad Técnica Particular de Loja PROY_CCNN_1256 PROY_CCNN_1054., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/336646
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336646
HANDLE: http://hdl.handle.net/10261/336646
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336646
PMID: http://hdl.handle.net/10261/336646
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336646
Ver en: http://hdl.handle.net/10261/336646
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336646
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336720
Set de datos (Dataset). 2022
EFFICIENT TUMOR ERADICATION AT ULTRALOW DRUG CONCENTRATION VIA EXTERNALLY CONTROLLED AND BOOSTED METALLIC IRON MAGNETOPLASMONIC NANOCAPSULES [DATASET]
- Fluksman, Arnon
- Lafuente, Aritz
- Li, Zhi
- Sort, Jordi
- Lope-Piedrafita, Silvia
- Esplandiú, María J.
- Nogués, Josep
- Roca, Alejandro G.
- Benny, Ofra
- Sepúlveda, Borja
8 pages. -- Figure S1. MAPSULES structural and colloidal characterization and drug release. -- Figure S2. Magnetic trapping experimental conditions. -- Figure S3. MAPSULES degradation evolution. -- Figure S4. Theoretical analysis of the absorption and scattering cross-sections and parameters for the calculation of the photothermal efficiency. -- Figure S5. In vivo biodistribution analysis by mass spectrometry. -- Figure S6. In vivo analysis of the photothermal effects without injected MAPSULES. -- Figure S7. In vivo safety analysis. -- Figure S8. Tumor progression., With the aim to locally enhance the efficacy of cancer nanotherapies, here we present metal iron based magnetoplasmonic drug-loaded nanocapsules (MAPSULES), merging powerful external magnetic concentration in the tumor and efficient photothermal actuation to locally boost the drug therapeutic action at ultralow drug concentrations. The MAPSULES are composed of paclitaxel-loaded polylactic-co-glycolic acid (PLGA) nanoparticles partially coated by a nanodome shape iron/silica semishell. The iron semishell has been designed to present a ferromagnetic vortex for incorporating a large quantity of ferromagnetic material while maintaining high colloidal stability. The large iron semishell provides very strong magnetic manipulation via magnetophoretic forces, enabling over 10-fold higher trapping efficiency in microfluidic channels than typical superparamagnetic iron oxide nanoparticles. Moreover, the iron semishell exhibits highly damped plasmonic behavior, yielding intense broadband absorbance in the near-infrared biological windows and photothermal efficiency similar to the best plasmonic nanoheaters. The in vivo therapeutic assays in a mouse xenograft tumor model show a high amplification of the therapeutic effects by combining magnetic concentration and photothermal actuation in the tumor, leading to a complete eradication of the tumors at ultralow nanoparticle and drug concentration (equivalent to only 1 mg/kg PLGA nanoparticles containing 8 μg/kg of paclitaxel, i.e., 100–500-fold lower than the therapeutic window of the free and PLGA encapsulated drug and 13–3000-fold lower than current nanotherapies combining paclitaxel and light actuation). These results highlight the strength of this externally controlled and amplified therapeutic approach, which could be applied to locally boost a wide variety of drugs for different diseases., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/336720
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336720
HANDLE: http://hdl.handle.net/10261/336720
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336720
PMID: http://hdl.handle.net/10261/336720
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336720
Ver en: http://hdl.handle.net/10261/336720
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336720
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336829
Set de datos (Dataset). 2023
EMERGENT SPIN FRUSTRATION IN NEUTRAL MIXED-VALENCE 2D CONJUGATED POLYMERS: A POTENTIAL QUANTUM MATERIALS PLATFORM [DATASET]
- Alcón, Isaac
- Ribas-Ariño, Jordi
- Moreira, Ibério de P. R.
- Bromley, Stefan T.
12 pages. -- Fig. S1. Electronic band structures (top) and periodic atomic structures (bottom). -- Fig. S2. Atomically-resolved spin population maps (spin-up: blue; spin-down: red) for B-mv-2DCP. -- Fig. S3. Electronic density of states (DOS) plots for in the FM (left) and AFM (right) configurations for N-mv-2DCP. -- Fig. S4. Atomically-resolved spin population maps. -- Fig. S5. Atomically-resolved spin population maps for cyclo-para-phenylmethine (analog molecular cycle of C-2DCP). -- Fig. S6. Singly occupied natural orbitals (SONO) for the singlet ground state of the CB- model with two magnetic centres. -- Fig. S7. Average of the absolute atomically-partitioned αC spin population, 〈|𝜇𝛼𝐶|〉, during 3 ps of an ab initio molecular dynamics (AIMD) simulation of N-mv-2DCP at 300 K using the PBE0 functional. -- Fig. S8. Z-view (top) and y-view (bottom) of the fully optimized atomic structures (both atomic coordinates and cell parameters) for the ox-N-mv-2DCP, N-mv-2DCP and Cl-N-mv-2DCP. -- Fig. S9. Species-projected electronic density of states (PDOS) plots for: ox-N-mv-2DCP (left), N-mv-2DCP (middle) and Cl-N-mv-2DCP (right) per unit cell for the FM solution. -- Fig. S10. Estimated variance of U/t in ox-N-mv-2DCP, N-mv-2DCP and Cl-N-mv-2DCP assuming a single band Hubbard model on a 2D triangular lattice (i.e. the emergent lattice of αC centres). -- Magnetic coupling constant calculations. -- Fig. S11. Magnetic solutions used to extract the magnetic coupling constants described in the text. -- Rationalizing of CN- and CB- differences via molecular orbital diagrams., Two-dimensional conjugated polymers (2DCPs)organic 2D materials composed of arrays of carbon sp2 centers connected by π-conjugated linkersare attracting increasing attention due to their potential applications in device technologies. This interest stems from the ability of 2DCPs to host a range of correlated electronic and magnetic states (e.g., Mott insulators). Substitution of all carbon sp2 centers in 2DCPs by nitrogen or boron results in diamagnetic insulating states. Partial substitution of C sp2 centers by B or N atoms has not yet been considered for extended 2DCPs but has been extensively studied in the analogous neutral mixed-valence molecular systems. Here, we employ accurate first-principles calculations to predict the electronic and magnetic properties of a new class of hexagonally connected neutral mixed-valence 2DCPs in which every other C sp2 nodal center is substituted by either a N or B atom. We show that these neutral mixed-valence 2DCPs significantly energetically favor a state with emergent superexchange-mediated antiferromagnetic (AFM) interactions between C-based spin-1/2 centers on a triangular sublattice. These AFM interactions are surprisingly strong and comparable to those in the parent compounds of cuprate superconductors. The rigid and covalently linked symmetric triangular AFM lattice in these materials thus provides a highly promising and robust basis for 2D spin frustration. As such, extended mixed-valence 2DCPs are a highly attractive platform for the future bottom-up realization of a new class of all-organic quantum materials, which could host exotic correlated electronic states (e.g., unusual magnetic ordering, quantum spin liquids)., Peer reviewed
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DOI: http://hdl.handle.net/10261/336829
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336829
HANDLE: http://hdl.handle.net/10261/336829
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336829
PMID: http://hdl.handle.net/10261/336829
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336829
Ver en: http://hdl.handle.net/10261/336829
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/336829
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