Resultados totales (Incluyendo duplicados): 34354
Encontrada(s) 3436 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329505
Dataset. 2022

TABLE_5_GENOMIC MAPPING OF COPY NUMBER VARIATIONS INFLUENCING IMMUNE RESPONSE IN BREAST CANCER.XLSX [DATASET]

  • López-Cade, Igor
  • García-Barberán, Vanesa
  • Cabañas, Esther
  • Díaz-Tejeiro, Cristina
  • Saiz-Ladera, Cristina
  • Sanvicente, Adrián
  • Pérez-Segura, Pedro
  • Pandiella, Atanasio
  • Győrffy, Balázs
  • Ocaña, Alberto
Identification of genomic alterations that influence the immune response within the tumor microenvironment is mandatory in order to identify druggable vulnerabilities. In this article, by interrogating public genomic datasets we describe copy number variations (CNV) present in breast cancer (BC) tumors and corresponding subtypes, associated with different immune populations. We identified regulatory T-cells associated with the Basal-like subtype, and type 2 T-helper cells with HER2 positive and the luminal subtype. Using gene set enrichment analysis (GSEA) for the Type 2 T-helper cells, the most relevant processes included the ERBB2 signaling pathway and the Fibroblast Growth Factor Receptor (FGFR) signaling pathway, and for CD8+ T-cells, cellular response to growth hormone stimulus or the JAK-STAT signaling pathway. Amplification of ERBB2, GRB2, GRB7, and FGF receptor genes strongly correlated with the presence of type 2 T helper cells. Finally, only 8 genes were highly upregulated and present in the cellular membrane: MILR1, ACE, DCSTAMP, SLAMF8, CD160, IL2RA, ICAM2, and SLAMF6. In summary, we described immune populations associated with genomic alterations with different BC subtypes. We observed a clear presence of inhibitory cells, like Tregs or Th2 when specific chromosomic regions were amplified in basal-like or HER2 and luminal groups. Our data support further evaluation of specific therapeutic strategies in specific BC subtypes, like those targeting Tregs in the basal-like subtype., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329505
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329505
HANDLE: http://hdl.handle.net/10261/329505
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329505
PMID: http://hdl.handle.net/10261/329505
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329505
Ver en: http://hdl.handle.net/10261/329505
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329505

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329507
Dataset. 2022

TABLE_6_GENOMIC MAPPING OF COPY NUMBER VARIATIONS INFLUENCING IMMUNE RESPONSE IN BREAST CANCER.XLSX [DATASET]

  • López-Cade, Igor
  • García-Barberán, Vanesa
  • Cabañas, Esther
  • Díaz-Tejeiro, Cristina
  • Saiz-Ladera, Cristina
  • Sanvicente, Adrián
  • Pérez-Segura, Pedro
  • Pandiella, Atanasio
  • Győrffy, Balázs
  • Ocaña, Alberto
Identification of genomic alterations that influence the immune response within the tumor microenvironment is mandatory in order to identify druggable vulnerabilities. In this article, by interrogating public genomic datasets we describe copy number variations (CNV) present in breast cancer (BC) tumors and corresponding subtypes, associated with different immune populations. We identified regulatory T-cells associated with the Basal-like subtype, and type 2 T-helper cells with HER2 positive and the luminal subtype. Using gene set enrichment analysis (GSEA) for the Type 2 T-helper cells, the most relevant processes included the ERBB2 signaling pathway and the Fibroblast Growth Factor Receptor (FGFR) signaling pathway, and for CD8+ T-cells, cellular response to growth hormone stimulus or the JAK-STAT signaling pathway. Amplification of ERBB2, GRB2, GRB7, and FGF receptor genes strongly correlated with the presence of type 2 T helper cells. Finally, only 8 genes were highly upregulated and present in the cellular membrane: MILR1, ACE, DCSTAMP, SLAMF8, CD160, IL2RA, ICAM2, and SLAMF6. In summary, we described immune populations associated with genomic alterations with different BC subtypes. We observed a clear presence of inhibitory cells, like Tregs or Th2 when specific chromosomic regions were amplified in basal-like or HER2 and luminal groups. Our data support further evaluation of specific therapeutic strategies in specific BC subtypes, like those targeting Tregs in the basal-like subtype., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329507
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329507
HANDLE: http://hdl.handle.net/10261/329507
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329507
PMID: http://hdl.handle.net/10261/329507
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329507
Ver en: http://hdl.handle.net/10261/329507
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329507

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329512
Dataset. 2022

SUPPORTING INFORMATION FOR PHONON-ENHANCED MID-INFRARED CO2 GAS SENSING USING BORON NITRIDE NANORESONATORS

  • Bareza, Nestor Jr.
  • Paulillo, Bruno
  • Slipchenko, Tetiana
  • Autore, Marta
  • Dolado, Irene
  • Liu, Song
  • Edgar, James H.
  • Vélez, Saul
  • Martín-Moreno, Luis
  • Hillenbrand, Rainer
  • Pruneri, Valerio
(S1) Thin PEI film characterizations such as thickness, surface morphology and deposited layer profile. (S2) Differential resonant extinction contour plots as functions of hBN damping and ribbon geometry. (S3) Sensing of bare hBN nanoribbons with varying CO2 concentration. (S4) Fit of PEI permittivity model from experimental transmission spectrum as a function of CO2 concentration. (S5) Simulated response of different hBN ribbon geometry in varying CO2 concentration. (S6) Sensing of hBN nanoribbons and 30 nm PEI coating with varying CO2 concentration., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329512
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329512
HANDLE: http://hdl.handle.net/10261/329512
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329512
PMID: http://hdl.handle.net/10261/329512
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329512
Ver en: http://hdl.handle.net/10261/329512
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329512

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329513
Dataset. 2022

SUPPORTING INFORMATION FOR PIM-1 MEMBRANES CONTAINING POSS - GRAPHENE OXIDE FOR CO2 SEPARATION

  • Mohsenpour, Sajjad
  • Ameen, Ahmed W.
  • Leaper, Sebastian
  • Skuse, Clara
  • Almansour, Faiz
  • Budd, Peter M.
  • Gorgojo, Patricia
Supplementary data 1: 1. Experimental details of POSS functionalized GO (GO-POSS) 2. Thickness and labelling of the prepared membranes 3. N2 adsorption and desorption isotherms of PIM-1 4. 1H Nuclear Magnetic Resonance (1H NMR) of PIM-1 5. (MALDI-TOF) mass spectroscopy of PIM-1 6. XPS spectra of GO-POSS and GO 7. FTIR spectra of GO-POSS and POSS 8. GO-POSS flake size distribution 9. AFM and height profile of GO-POSS samples 10. TEM images of GO and GO-POSS 11. FTIR spectra of MMMs 12. XRD spectra of 48PGP and PP MMMs 13. Cross-sectional and surface SEM images of selected MMMs 14. Single gas permeation test 15. CO2 permeability prediction for 48PGP membranes according to Maxwell equation 16. CO2/CH4 separation performance of the neat PIM-1 membrane and the MMMs prepared with GO-POSS72 and rGO-POSS72 as fillers 17. Effect of feed composition on CO2/CH4 separation performance of selected 48PGP MMMs 18. Effect of feed pressure on CO2/CH4 separation performance of selected 48PGP MMMs 19. H2/N2 separation performance of the selected membranes, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329513
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329513
HANDLE: http://hdl.handle.net/10261/329513
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329513
PMID: http://hdl.handle.net/10261/329513
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329513
Ver en: http://hdl.handle.net/10261/329513
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329513

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329517
Dataset. 2022

ELECTRONIC SUPPLEMENTARY INFORMATION FOR PYRANYLIDENE/TRIFLUOROMETHYLBENZOIC ACID-BASED CHROMOPHORES FOR DYE SENSITIZED SOLAR CELLS

  • Royo, Raquel
  • Domínguez-Celorrio, Amelia
  • Franco, Santiago
  • Andreu, Raquel
  • Orduna, Jesús
1. General experimental methods 2. Device preparation and characterization 3. NMR spectra for new compounds (Figures S-1 to S-36) 4. Computational procedures (Figures S-37 to S40) 5. Dye-load studies (Figure S-41) 6. Calibration lines (UV-visible) (Figures S-42 to S-46) 7. UV-visible spectra of films at different immersion times (Figures S-47 to S-51) 8. Spectrum (UV-visible) of the OSRAM 930 lamp (Figure S-52) 9. J/V curves measured with the OSRAM 930 lamp (Figure S-53), Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329517
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329517
HANDLE: http://hdl.handle.net/10261/329517
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329517
PMID: http://hdl.handle.net/10261/329517
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329517
Ver en: http://hdl.handle.net/10261/329517
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329517

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329518
Dataset. 2022

SUPPLEMENTAL MATERIAL FOR "QUANTUM KERNELS TO LEARN THE PHASES OF QUANTUM MATTER"

  • Sancho-Lorente, Teresa
  • Román-Roche, Juan
  • Zueco, David
Additional figures that complete Fig. 1 in the main text., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329518
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329518
HANDLE: http://hdl.handle.net/10261/329518
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329518
PMID: http://hdl.handle.net/10261/329518
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329518
Ver en: http://hdl.handle.net/10261/329518
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329518

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329521
Dataset. 2022

SUPPORTING INFORMATION FOR SAFE EXTENDED-RANGE CYCLING OF LI4TI5O12-BASED ANODES FOR ULTRA-HIGH CAPACITY THIN-FILM BATTERIES

  • Siller, Valerie
  • Gonzalez-Rosillo, Juan Carlos
  • Nuñez Eroles, Marc
  • Stchakovsky, Michel
  • Arenal, Raúl
  • Morata, Alex
  • Tarancón, Albert
Multimedia component 1. The supporting information includes the following: Description of the multilayering approach in the PLD (Fig. S1); STEM-HAADF images and EEL spectra (Figs. S2 and S3); structural, optical, and electrochemical properties of LTO (Fig. S4, Eqs. S1 – S2); spectroscopic Ellipsometry raw data and modeling description using the Bruggeman EMA and optical models based on dispersion formulas (Fig. S5, Eqs. S3 – S4); optical properties of the thin films dependent on the Li2O content (Fig. S6); charge–discharge profiles of the operando experiment (Fig. S7); first charge–discharge profiles of each cut-off voltage series (Fig. S8); thickness and mass calculations (Table S1); and Raman spectroscopy analysis (Table S2)., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329521
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329521
HANDLE: http://hdl.handle.net/10261/329521
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329521
PMID: http://hdl.handle.net/10261/329521
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329521
Ver en: http://hdl.handle.net/10261/329521
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329521

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329525
Dataset. 2022

TABLE_7_GENOMIC MAPPING OF COPY NUMBER VARIATIONS INFLUENCING IMMUNE RESPONSE IN BREAST CANCER.XLSX [DATASET]

  • López-Cade, Igor
  • García-Barberán, Vanesa
  • Cabañas, Esther
  • Díaz-Tejeiro, Cristina
  • Saiz-Ladera, Cristina
  • Sanvicente, Adrián
  • Pérez-Segura, Pedro
  • Pandiella, Atanasio
  • Győrffy, Balázs
  • Ocaña, Alberto
Identification of genomic alterations that influence the immune response within the tumor microenvironment is mandatory in order to identify druggable vulnerabilities. In this article, by interrogating public genomic datasets we describe copy number variations (CNV) present in breast cancer (BC) tumors and corresponding subtypes, associated with different immune populations. We identified regulatory T-cells associated with the Basal-like subtype, and type 2 T-helper cells with HER2 positive and the luminal subtype. Using gene set enrichment analysis (GSEA) for the Type 2 T-helper cells, the most relevant processes included the ERBB2 signaling pathway and the Fibroblast Growth Factor Receptor (FGFR) signaling pathway, and for CD8+ T-cells, cellular response to growth hormone stimulus or the JAK-STAT signaling pathway. Amplification of ERBB2, GRB2, GRB7, and FGF receptor genes strongly correlated with the presence of type 2 T helper cells. Finally, only 8 genes were highly upregulated and present in the cellular membrane: MILR1, ACE, DCSTAMP, SLAMF8, CD160, IL2RA, ICAM2, and SLAMF6. In summary, we described immune populations associated with genomic alterations with different BC subtypes. We observed a clear presence of inhibitory cells, like Tregs or Th2 when specific chromosomic regions were amplified in basal-like or HER2 and luminal groups. Our data support further evaluation of specific therapeutic strategies in specific BC subtypes, like those targeting Tregs in the basal-like subtype., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329525
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329525
HANDLE: http://hdl.handle.net/10261/329525
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329525
PMID: http://hdl.handle.net/10261/329525
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329525
Ver en: http://hdl.handle.net/10261/329525
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329525

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329529
Dataset. 2022

SUPPORTING INFORMATION FOR SALDI-MS AND SERS MULTIMODAL IMAGING: ONE NANOSTRUCTURED SUBSTRATE TO RULE THEM BOTH

  • Iakab, Stefania-Alexandra
  • Baquer, Gerard
  • Lafuente, Marta
  • Pina, María Pilar
  • Ramírez, José Luis
  • Ràfols, Pere
  • Correig-Blanchar, Xavier
  • García-Altares, María
Comparison between SERS imaging, SALDI MSI, and multimodal imaging on AuBSi; physico-chemical characterization of the AuBSi substrate; AuBSi performance for SALDI-MSI and SERS imaging; coregistration strategy; and tentative annotation of bands (SERS) and ions (SALDI) detected from the same fingerprint sweat on AuBSi., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329529
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329529
HANDLE: http://hdl.handle.net/10261/329529
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329529
PMID: http://hdl.handle.net/10261/329529
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329529
Ver en: http://hdl.handle.net/10261/329529
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329529

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329532
Dataset. 2022

SUPPLEMENTARY MATERIALS STUDY OF MELAMINE-FORMALDEHYDE/PHASE CHANGE MATERIAL MICROCAPSULES FOR THE PREPARATION OF POLYMER FILMS BY EXTRUSION

  • García-Viñuales, Sara
  • Rubio, César
  • Martínez-Izquierdo, Lidia
  • Zornoza, Beatriz
  • Piera, Elena
  • Caballero, Miguel A.
  • Téllez, Carlos
Figure S1: TGA of the MF/n-eicosane microcapsules synthesized during the scaling process, Figure S2: Microcapsules MC1 washed in different conditions: (a) TGA; (b) DSC, Figure S3: Cross-section view of polyamide 6 films made at 235 °C and 90 bar with 17 wt.% MF/n-eicosane MCs, Figure S4: Cross-section view of polyamide 6 films made at 235 °C and 90 bar with 9 wt.% MF/n-eicosane MCs, Figure S5: Polyamide 6 film made at 256 °C and 50 bar: (a) surface view without MCs, (b) surface view with 10 wt.% MF/n-eicosane MCs, and (c) cross-section view with 10 wt.% MF/n-eicosane MCs, Figure S6: Cross section view of low density polyethylene film made at 133 °C and 181 bar with 10 wt.% MF/n-eicosane MCs., n-Eicosane-melamine formaldehyde microcapsules of an average size of 1.1 μm and latent heat of fusion of 146.2 ± 5.3 J/g have been prepared. They have been characterized by scanning electron microscopy, FTIR spectroscopy, calorimetric techniques, and thermogravimetric analyses. Under processing conditions, the microcapsules apparently preserved their properties, also maintaining their n-eicosane loading and heat storage capacity under washing conditions (water with detergent at 60 °C). The microcapsules synthesis has been scaled up for the fabrication of functional films by extrusion. For that, polymer films containing 10 wt.% of microcapsules were prepared at a pilot plant level. In those films, even though a fraction of the n-eicosane loading was lost during the extrusion process, the microcapsules showed good compatibility within the polyamide. The percentage of PCM in the polyamide 6 films was estimated by TGA, verifying also the heat storage capacity predicted by DSC (2.6 ± 0.7 J/g)., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329532
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329532
HANDLE: http://hdl.handle.net/10261/329532
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329532
PMID: http://hdl.handle.net/10261/329532
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329532
Ver en: http://hdl.handle.net/10261/329532
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329532

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