BUSCADOR RECOLECTA

Zeta potential of AuNPs and silica-coated AuNPs (Figure S1); low magnification TEM images of different samples of AuNPs (Figure S2); low magnification bright-field TEM images of non-centrifuged AuNPs (Figure S3); photographs of Au@SiO2 NP precipitates and re-dispersions obtained from different centrifuge speeds (Figure S4); size distribution of core diameter and shell thickness (Figure S5); percentage of aggregated AuNPs and single AuNPs present in Au@SiO2 NPs obtained from 2000, 4000, and 6000 rpm centrifugation (Figure S6); TEM images and SERS spectra with 10–5 M Rh6G of Au@SiO2 NPs with thick silica shell (Figure S7); HRTEM image of a single-Au@SiO2 NP (Figure S8); high-magnification TEM images of multi-Au@SiO2 NPs (Figure S9); TEM images showing the heat effect of electron beam of TEM (Figure S10); effect of ionic strength on the NPs (Figure S11); effect of adding Rh6G to the NPs (Figure S12); calculation of SERS enhancement factor (Table S1); FDTD simulation for AuNPs (Figure S13); cyclic voltammetry with different scan rates (Figure S14); reproducibility, long-term stability, repeatability, and selectivity of Au@SiO2_2000/GCE for glucose sensing (Figure S15)., Peer reviewed

Additional file 1: Supplementary Fig. 1. Study design and Flow-chart., Consejería de Transformación Económica, Industria, Conocimiento y Universidades Instituto de Salud Carlos III Consejería de Salud y Familias, Junta de Andalucía, Peer reviewed

Additional file 2: Supplementary Table 1. Demographical and anthropometrics characteristics of the study population., Consejería de Transformación Económica, Industria, Conocimiento y Universidades Instituto de Salud Carlos III Consejería de Salud y Familias, Junta de Andalucía, Peer reviewed

Additional file 3: Supplementary Table 2. Comorbidities and behavioral factors of residents from the Santa Caridad Nursing Home., Consejería de Transformación Económica, Industria, Conocimiento y Universidades Instituto de Salud Carlos III Consejería de Salud y Familias, Junta de Andalucía, Peer reviewed

Additional file 4: Supplementary Table 3.Thymic activity, Biochemical, Inflammatory and Immunological profiles of the study populations one month after the second dose (T1)., Consejería de Transformación Económica, Industria, Conocimiento y Universidades Instituto de Salud Carlos III Consejería de Salud y Familias, Junta de Andalucía, Peer reviewed

Details of synthetic procedures and characterization, NMR spectra, crystallographic data, electrochemical data, photochemical data, QCM details, XPS details, conductance details, example conductance trances, 2D histogram data, and details for theoretical calculations., Peer reviewed

Additional file 5: Supplementary Fig. 2. Levels of Thymosin-α1 in higher vs. lower responders of the older group., Consejería de Transformación Económica, Industria, Conocimiento y Universidades Instituto de Salud Carlos III Consejería de Salud y Familias, Junta de Andalucía, Peer reviewed

Additional file 6: Supplementary Fig. 3. Correlations among Log of anti-S antibody titers at all different study points., Consejería de Transformación Económica, Industria, Conocimiento y Universidades Instituto de Salud Carlos III Consejería de Salud y Familias, Junta de Andalucía, Peer reviewed

Additional file 7: Supplementary Fig. 4. Factors associated with the magnitude of the initial response to the BNT162B2 vaccine at T1 by age-groups., Consejería de Transformación Económica, Industria, Conocimiento y Universidades Instituto de Salud Carlos III Consejería de Salud y Familias, Junta de Andalucía, Peer reviewed

Additional file 8. Detailed methodology., Consejería de Transformación Económica, Industria, Conocimiento y Universidades Instituto de Salud Carlos III Consejería de Salud y Familias, Junta de Andalucía, Peer reviewed