Resultados totales (Incluyendo duplicados): 45302
Encontrada(s) 4531 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329975
Dataset. 2022

PROGRAMMED CELL DEATH AND AUTOPHAGY IN AN IN VITRO MODEL OF SPONTANEOUS NEURORETINAL DEGENERATION [DATASET]

  • Puertas-Neyra, Kevin
  • Galindo-Cabello, Nadia
  • Hernández-Rodríguez, Leticia A.
  • González-Pérez, Fernando
  • Rodríguez-Cabello, José Carlos
  • González-Sarmiento, Rogelio
  • Pastor, José Carlos
  • Usategui-Martín, Ricardo
  • Fernández-Bueno, Iván
Retinal neurodegenerative diseases are the leading causes of visual impairment and irreversible blindness worldwide. Although the retinal response to injury remains closely similar between different retinal neurodegenerative diseases, available therapeutic alternatives are only palliative, too expensive, or very specific, such as gene therapy. In that sense, the development of broad-spectrum neuroprotective therapies seems to be an excellent option. In this regard, it is essential to identify molecular targets involved in retinal degeneration, such as cell death mechanisms. Apoptosis has been considered as the primary cell death mechanism during retinal degeneration; however, recent studies have demonstrated that the only use of anti-apoptotic drugs is not enough to confer good neuroprotection in terms of cell viability and preservation. For that reason, the interrelationship that exists between apoptosis and other cell death mechanisms needs to be characterized deeply to design future therapeutic options that simultaneously block the main cell death pathways. In that sense, the study aimed to characterize the programmed cell death (in terms of apoptosis and necroptosis) and autophagy response and modulation in retinal neurodegenerative diseases, using an in vitro model of spontaneous retinal neurodegeneration. For that purpose, we measured the mRNA relative expression through qPCR of a selected pool of genes involved in apoptosis (BAX, BCL2, CASP3, CASP8, and CASP9), necroptosis (MLKL, RIPK1, and RIPK3), and autophagy (ATG7, BCLIN1, LC3B, mTOR, and SQSTM1); besides, the immunoexpression of their encoding proteins (Casp3, MLKL, RIPK1, LC3B, and p62) were analyzed using immunohistochemistry. Our results showed an increase of pro-apoptotic and pro-necroptotic related genes and proteins during in vitro retinal neurodegeneration. Besides, we describe for the first time the modulation between programmed cell death mechanisms and autophagy in an in vitro retinal neurodegeneration model. This study reinforces the idea that cell death mechanisms are closely interconnected and provides new information about molecular signaling and autophagy along the retinal degeneration process., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329975
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329975
HANDLE: http://hdl.handle.net/10261/329975
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329975
PMID: http://hdl.handle.net/10261/329975
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329975
Ver en: http://hdl.handle.net/10261/329975
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329975

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329981
Dataset. 2022

SUPPLEMENTARY INFORMATION EFFECT OF CRYSTALLINITY AND THICKNESS ON THERMAL TRANSPORT IN LAYERED PTSE2

  • Sachat, Alexandros el
  • Xiao, Peng
  • Donadio, Davide
  • Bonell, Fréderic
  • Sledzinska, Marianna
  • Marty, Alain
  • Vergnaud, Céline
  • Boukari, Hervé
  • Jamet, Matthieu
  • Arregui, Guillermo
  • Chen, Zekun
  • Alzina, Francesc
  • Sotomayor Torres, C. M.
  • Chávez-Angel, Emigdio
15 pages. -- Supplementary Figure 1. Reflection high energy electron diffraction (RHEED) measurements and the final structure of the PtSe2 wedge sample. -- Supplementary Figure 2. X-ray diffraction measurements in PtSe2. -- Supplementary Figure 3. AFM measurements. -- Supplementary Note 1: FDTR sensitivity analysis. -- Supplementary Figure 4. Phase sensitivity analysis for thin PtSe2 films. -- Supplementary Figure 5. Phase sensitivity analysis for bulk PtSe2. -- Supplementary Note 2: Spot size measurements. -- Supplementary Figure 6. Spot size measurements. -- Supplementary Note 3: Three omega measurements. -- Supplementary Figure 7. Three omega measurements. -- Supplementary Note 4: Raman thermometry measurements. -- Supplementary Table 1. Measured cross-plane thermal conductivity obtained by Raman thermometry and FDTR. -- Supplementary Figure 8. Raman thermometry measurements. -- Supplementary Note 5: Fourier transform from ASOPS data. -- Supplementary Figure 9. Fast Fourier transform of the layered breathing modes. -- Supplementary Figure 10. DFT calculations. -- Supplementary Figure 11. FDTR data from bulk PtSe2 crystal and the best model fit in a low frequency range (20 kHz - 1 MHz) for a ratio kr/kz = 9. -- Supplementary Figure 12. (a) XRD radial scans in the polycrystalline wedge sample showing the polycrystalline nature of the PtSe2 film. -- Supplementary Figure 13. Interface thermal resistance measurements. -- Supplementary Figure 14. Raman line scan between 1 and 3 ML PtSe2 in the crystalline wedge sample., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329981
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329981
HANDLE: http://hdl.handle.net/10261/329981
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329981
PMID: http://hdl.handle.net/10261/329981
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329981
Ver en: http://hdl.handle.net/10261/329981
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329981

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329995
Dataset. 2022

ADDITIONAL FILE 10 OF USE OF BAYES FACTORS TO EVALUATE THE EFFECTS OF HOST GENETICS, LITTER AND CAGE ON THE RABBIT CECAL MICROBIOTA

  • Velasco‐Galilea, María
  • Piles, Miriam
  • Ramayo-Caldas, Yuliaxis
  • Varona, Luis
  • Sánchez, Juan Pablo
Additional file 10: Table S10. Bayes factors, marginal posterior means and standard deviations of cage variance ratio for OTU influenced by cage effects together with the associated probability of these estimates being higher than 0.10. The frequency among the rabbit samples and the taxonomic assignment are also provided for each OTU., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Horizon 2020 Framework Programme Ministerio de Ciencia, Innovación y Universidades, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329995
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329995
HANDLE: http://hdl.handle.net/10261/329995
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329995
PMID: http://hdl.handle.net/10261/329995
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329995
Ver en: http://hdl.handle.net/10261/329995
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329995

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330015
Dataset. 2023

DATA SUPPORTING THE RESULTS PUBLISHED IN THE PAPER ENTITLED "THE YEAST MRNA-BINDING PROTEIN CTH2 POST-TRANSCRIPTIONALLY MODULATES ERGOSTEROL BIOSYNTHESIS IN RESPONSE TO IRON DEFICIENCY"

  • Jordá, Tania
  • Rozès, Nicolas
  • Martínez-Pastor, María Teresa
  • Puig,Sergi
The dataset is made available under the Open Database License. Any rights in individual contents of the database are licensed under the Database Contents License. Please, read the full ODbL 1.0 license text for the exact terms that apply. Users of the dataset are free to: Share: copy, distribute and use the database, either commercially or non-commercially. Create: produce derivative works from the database. Adapt: modify, transform and build upon the database. Under the following conditions: Attribution: You must attribute any public use of the database, or works produced from the database. For any use or redistribution of the database, or works produced from it, you must make clear to others the license of the original database. Share-Alike: If you publicly use any adapted version of this database, or works produced from an adapted database, you must also offer that adapted database under the ODbL, This work was supported by grants PID2020-116940RB-I00 and CEX2021-001189-S funded by MCIN/AEI/10.13039/501100011033. T. J. received the ACIF/2019/214 predoctoral fellowship from “Generalitat Valenciana”., With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX 2021-001189-S), Peer reviewed

DOI: http://hdl.handle.net/10261/330015
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330015
HANDLE: http://hdl.handle.net/10261/330015
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330015
PMID: http://hdl.handle.net/10261/330015
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330015
Ver en: http://hdl.handle.net/10261/330015
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330015

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330003
Dataset. 2022

ADDITIONAL FILE 1 OF USE OF BAYES FACTORS TO EVALUATE THE EFFECTS OF HOST GENETICS, LITTER AND CAGE ON THE RABBIT CECAL MICROBIOTA

  • Velasco‐Galilea, María
  • Piles, Miriam
  • Ramayo-Caldas, Yuliaxis
  • Varona, Luis
  • Sánchez, Juan Pablo
1 table., Additional file 1: Table S1. Metadata associated with the 425 rabbit cecal samples analyzed in this study., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Horizon 2020 Framework Programme Ministerio de Ciencia, Innovación y Universidades, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/330003
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330003
HANDLE: http://hdl.handle.net/10261/330003
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330003
PMID: http://hdl.handle.net/10261/330003
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330003
Ver en: http://hdl.handle.net/10261/330003
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330003

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330010
Dataset. 2022

ADDITIONAL FILE 2 OF USE OF BAYES FACTORS TO EVALUATE THE EFFECTS OF HOST GENETICS, LITTER AND CAGE ON THE RABBIT CECAL MICROBIOTA

  • Velasco‐Galilea, María
  • Piles, Miriam
  • Ramayo-Caldas, Yuliaxis
  • Varona, Luis
  • Sánchez, Juan Pablo
1 table., Additional file 2: Table S2. Table of filtered and CSS-normalized OTU., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Horizon 2020 Framework Programme Ministerio de Ciencia, Innovación y Universidades, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/330010
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330010
HANDLE: http://hdl.handle.net/10261/330010
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330010
PMID: http://hdl.handle.net/10261/330010
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330010
Ver en: http://hdl.handle.net/10261/330010
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330010

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330019
Dataset. 2022

ADDITIONAL FILE 4 OF USE OF BAYES FACTORS TO EVALUATE THE EFFECTS OF HOST GENETICS, LITTER AND CAGE ON THE RABBIT CECAL MICROBIOTA

  • Velasco‐Galilea, María
  • Piles, Miriam
  • Ramayo-Caldas, Yuliaxis
  • Varona, Luis
  • Sánchez, Juan Pablo
1 figure., Additional file 4: Figure S1. Geweke z-statistics for genetic, litter and cage variance ratios computed for the microbial traits that were better adjusted with the normal linear mixed model., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Horizon 2020 Framework Programme Ministerio de Ciencia, Innovación y Universidades, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/330019
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330019
HANDLE: http://hdl.handle.net/10261/330019
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330019
PMID: http://hdl.handle.net/10261/330019
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330019
Ver en: http://hdl.handle.net/10261/330019
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330019

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330047
Dataset. 2022

EIGENVALUE SPECTRA AND STABILITY OF DIRECTED COMPLEX NETWORKS. SUPPLEMENTAL MATERIAL

  • Baron, Joseph W.
This document contains additional information about the calculations performed to obtain the results detailed in the main paper., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/330047
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330047
HANDLE: http://hdl.handle.net/10261/330047
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330047
PMID: http://hdl.handle.net/10261/330047
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330047
Ver en: http://hdl.handle.net/10261/330047
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330047

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330048
Dataset. 2022

SUPPLEMENTAL MATERIAL FOR “CORRELATIONS OF NETWORK TRAJECTORIES”

  • Lacasa, Lucas
  • Rodríguez-García, Jorge Pablo
  • Eguíluz, Víctor M.
Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/330048
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330048
HANDLE: http://hdl.handle.net/10261/330048
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330048
PMID: http://hdl.handle.net/10261/330048
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330048
Ver en: http://hdl.handle.net/10261/330048
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330048

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330061
Dataset. 2022

ADDITIONAL FILE 5 OF USE OF BAYES FACTORS TO EVALUATE THE EFFECTS OF HOST GENETICS, LITTER AND CAGE ON THE RABBIT CECAL MICROBIOTA

  • Velasco‐Galilea, María
  • Piles, Miriam
  • Ramayo-Caldas, Yuliaxis
  • Varona, Luis
  • Sánchez, Juan Pablo
1 figure., Additional file 5: Figure S2. Geweke z-statistics for genetic, litter and cage variance ratios computed for the microbial traits that were better adjusted with the zero-inflated Poisson model., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Horizon 2020 Framework Programme Ministerio de Ciencia, Innovación y Universidades, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/330061
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330061
HANDLE: http://hdl.handle.net/10261/330061
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330061
PMID: http://hdl.handle.net/10261/330061
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330061
Ver en: http://hdl.handle.net/10261/330061
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330061

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