BUSCADOR RECOLECTA

This dataset is supplementary material for the paper: "Pappalysins and stanniocalcins and their relationship with the peripheral IGF axis in newborns and during development". It countains 4 figures and 2 tables,

Background: Pappalysins (PAPP-A, PAPP-A2) modulate body growth by increasing IGF-I bioavailability through cleavage of IGFBPs and are inhibited by stanniocalcins (STC1, STC2). Normative data of these novel factors, as well as of free IGF-I and uncleaved fractions of IGFBPs are not well established.

Objective: To determine serum concentrations of PAPP-A, PAPP-A2, STC1 and STC2, in relationship with other GH-IGF axis parameters during development.

Patients and methods: Full-term newborns (150; gestational age: 39.30 ± 1.10 weeks), 40 preterm newborns (30.87 ± 3.35 weeks) and 1071 healthy individuals (1-30 years old) were included in the study and divided according to their Tanner stages (males and females): I:163 males, 154 females; II:100 males, 75 females; III:83 males, 96 females; IV: 77 males, 86 females; and V:109 males,128 females.

Results: Serum concentrations of total and free IGF-I, IGF-II, total IGFBP-3 and ALS rose gradually during development peaking in Tanner stages III-IV. Concentrations of IGFBP-4 and IGFBP-5 were lower in prepubertal children. PAPP-A, PAPP-A2, STC1, STC2, IGFBP-2, total IGFBP-4 and total IGFBP-5 were elevated at birth and declined throughout childhood. In postnatal life, PAPP-A2 concentrations decreased progressively in concomitance with the free/total IGF-I ratio; however, stanniocalcin concentrations remained stable. PAPP-A2 concentrations positively correlated with the free/total IGF-I ratio (r=+0.28 p<0.001) and negatively with the intact/total IGFBP-3 ratio (r=-0.23, p<0.001). PAPP-A concentrations inversely correlated with intact/total IGFBP-4 ratio (r=-0.21, p<0.001), with PAPP-A concentrations being lower in females at all ages.

Conclusion: This study provides reference values of pappalysins and stanniocalcins, which modulate IGF-I activity by changing the concentrations of uncleaved IGFBPs.

Entrevista a informante 1 en Esperança. Enumeración de algunos animales del ganado (cabras, cerdos, vacas). Las crías. Animales de carga. Canga. El informante da designaciones españolas y portuguesas y señala sobre algunas diferencias entre países. Había ovejas, pero no era lo tradicional, fue introducción reciente. Rebaños y pastores de cada tipo de ganado. Preparación del queso. La matanza. La carne de antes era de mucha mejor calidad que ahora. Comidas con el chorizo y los derivados de la matanza., Enumeração de alguns animais de criação (cabras, porcos, vacas). As crias. Animais de cárrega. Canga. O informante dá designações em espanhol e português e indica algumas diferenças entre os países. Havia ovelhas, mas não era tradicional, era uma introdução recente. Rabanhos e pastores de cada tipo de gado. Preparação do queijo. Matança. A carne de antes era de muito melhor qualidade do que agora. Refeições com o chouriço e os derivados da matança., Enumeration of some livestock animals (goats, pigs, cows). The babies. Animals of load. Canga. The informant gives Spanish and Portuguese designations and reports on some differences between countries. There were sheep, but it was not traditional, it was a recent introduction. Flocks and shepherds of each type of cattle. Preparation of the cheese. The slaughter. The meat from before was of much better quality than now. Meals with the chorizo and the products of the slaughter.

Labrar la tierra. El arado y sus partes. Tipos de terreno, huerta, marcos y lindes, barbecho. Frutas. Musgo y setas. La uva y el vino., Lavrar a terra. O arado e suas partes. Tipos de terra, pomares, estruturas e limites, pousio. Frutas. Musgo e cogumelos. A uva e o vinho., Till the land. The plow and its parts. Types of land, garden, frames and boundaries, fallow. Fruits. Moss and mushrooms. The grape and the wine.

Entrevista a Informante 1 y 2 en La Alamedilla. Semejanzas y diferencias con las localidades limítrofes, a ambos lados de la frontera. ¿Cómo se hablan el castellano y el portugués en la zona? Intercomprensión, Semelhanças e diferenças com as localidades limítrofes, a ambos lados da fronteira. Como se falam o português e o castelhano na zona? Intercompreensão, Similarities and differences with regard to neighbouring localities, at both sides of the border. Characteristics of Spanish and Portuguese spoken at the area. Mutual understanding

Project developed by Giovanni Federico (Università di Pisa) and Antonio Tena Junguito (Universidad Carlos III de Madrid). This data base outlines changes in world trade from 1800 to 2016. Dataset: Rhodesia - Zimbabwe

Project developed by Christopher Absell (University Gothenburg and Instituto Figuerola) Giovanni Federico (New York University Dubai) and Antonio Tena Junguito (Universidad Carlos III de Madrid and Instituto Figuerola). Dataset: Saint Vincent

Project developed by Christopher Absell (University Gothenburg and Instituto Figuerola) Giovanni Federico (New York University Dubai) and Antonio Tena Junguito (Universidad Carlos III de Madrid and Instituto Figuerola). Dataset: Rwanda

Cuadras. Fuentes y manantiales. Partes de la casa. Utensilios domésticos. Partes del cuerpo. Parentesco. Mocear. Partes del día., Estábulos. Fontes e nascentes. Partes da casa. Utensílios domésticos. Partes do corpo. Relacionamento. Namoro. Partes do dia., Stables. Fountains and springs. Parts of the house. Domestic utensils. Parts of the body. Relationship. Parts of the day.

This project focuses on developing a reliable, 3D-printed test specimen that replicates the mechanical behavior of biodegradable metallic stents. By combining additive manufacturing, mechanical testing, and finite element simulations, the goal is to create a standardized and cost-effective method to evaluate stent materials and designs, improving the development process for cardiovascular implants. Methodology: Design novel test specimen and fabricated using additive manufacturing (AM) techniques. Tensile tests were conduced on the printed samples and in parallel, developed finite element (FE) models to simulate the mechanical response

This is the dataset used for the study entitled "Developmental Trajectory of a Toddler with PACS1 Syndrome: A Longitudinal Descriptive Case Study". This dataset contains the results obtained in the different standardized tests and questionnaires employed in the study in each evaluation moment. The study aimed to conduct a detailed characterization of the profile of early psychological development in PACS1 syndrome. It also sought to raise awareness of this rare syndrome. A boy with PACS1 syndrome was longitudinally assessed at 24, 30, 36, 42 and 48 months of age. His cognitive, motor, linguistic and socio-communicative development, as well as his adaptative behaviour and sensory profile. At 51 months, symptoms compatible with Autism Spectrum Disorder (ASD) were also explored.