BUSCADOR RECOLECTA

Results of the beta regression, assessing the effect of NewAlters on the Abstract Similarity Score., Peer reviewed

Additional file 10. BED file with stable and differential HiChIP loops in neural retina and RPE/choroid, with annotation of interacting cis-regulatory elements (CREs, from [4])., Ghent University European Commission Research Foundation - Flanders Junta de Andalucía, Peer reviewed

Same conditions as in S1 Table. We found Cbk1 described interactions in cdc15-2 cells in the absence (A “cdc15-2 vs. control”), the presence of rapamycin (B “cdc15-2 + rapa vs. ctrl”), and TOR1-1 cdc15-2 cells after the addition of rapamycin (C “TOR1-1 cdc15-2 + rapa vs. ctrl”). In all cases, cells were arrested in late anaphase after having been grown at 37 °C. Three biological replicates of each described cells and conditions were performed and compared with 3 biological replicates of untagged control cells (ctrlCounts). Cbk1 interactions can be found in: https://thebiogrid.org/35668/summary/saccharomyces-cerevisiae/cbk1.html., Peer reviewed

Peer reviewed

Deuterostomes are a monophyletic group of animals that includes Hemichordata, Echinodermata (together called Ambulacraria), and Chordata. The diversity of deuterostome body plans has made it challenging to reconstruct their ancestral condition and to decipher the genetic changes that drove the diversification of deuterostome lineages. Here, we generate chromosome-level genome assemblies of 2 hemichordate species, Ptychodera flava and Schizocardium californicum, and use comparative genomic approaches to infer the chromosomal architecture of the deuterostome common ancestor and delineate lineage-specific chromosomal modifications. We show that hemichordate chromosomes (1N = 23) exhibit remarkable chromosome-scale macrosynteny when compared to other deuterostomes and can be derived from 24 deuterostome ancestral linkage groups (ALGs). These deuterostome ALGs in turn match previously inferred bilaterian ALGs, consistent with a relatively short transition from the last common bilaterian ancestor to the origin of deuterostomes. Based on this deuterostome ALG complement, we deduced chromosomal rearrangement events that occurred in different lineages. For example, a fusion-with-mixing event produced an Ambulacraria-specific ALG that subsequently split into 2 chromosomes in extant hemichordates, while this homologous ALG further fused with another chromosome in sea urchins. Orthologous genes distributed in these rearranged chromosomes are enriched for functions in various developmental processes. We found that the deeply conserved Hox clusters are located in highly rearranged chromosomes and that maintenance of the clusters are likely due to lower densities of transposable elements within the clusters. We also provide evidence that the deuterostome-specific pharyngeal gene cluster was established via the combination of 3 pre-assembled microsyntenic blocks. We suggest that since chromosomal rearrangement events and formation of new gene clusters may change the regulatory controls of developmental genes, these events may have contributed to the evolution of diverse body plans among deuterostomes., Peer reviewed

[Introduction]: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer., [Methods]: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease., [Results and discussion]: CD20+ T cells were more represented within the CD8+ T cell compartment and they showed a predominant memory Tc1 phenotype. CD20+ T cells were less represented in MBL and CLL patients vs healthy controls, particularly among those with unmutated IGVH gene. The expansion of malignant B cells was accompanied by phenotypic and functional changes in CD20+ T cells, including an increase in follicular helper CD4+ CD20+ T cells and CD20+ Tc1 cells, in addition to the expansion of the TCR Vβ 5.1 in CD4+ CD20+ T cells in CLL., Peer reviewed

Detailed composition for each substrate-binding pocket in AmiA:peptide 5 complex., Peer reviewed

Detailed composition for each substrate-binding pocket in AliB:peptide 4 complex., Peer reviewed

Mapes sobre diferents tipus d’impactes en tot el Mar Mediterrani. Dades primàries (mapes) associades a un article acceptat per la revista Scientific Reports (2018). Publicat a: https://doi.org/10.1038/s41598-018-33237-w, Dades primàries (mapes) associades a un article publicat a la revista Scientific Reports, 2018, vol. 8. http://doi.org/10.1038/s41598-018-33237-w

Dades associades a l'article: Vicente Royuela, Paolo Veneri & Raul Ramos (2018): The short-run relationship between inequality and growth: evidence from OECD regions during the Great Recession, Regional Studies, DOI: 10.1080/00343404.2018.1476752, This dataset is the basis of the work titled “The short-run relationship between inequality and growth: evidence from OECD regions during the Great Recession”, published in Regional Studies (DOI: 10.1080/00343404.2018.1476752). This paper provides evidence on the relationship between income inequality and economic growth in Organisation for Economic Co-operation and Development (OECD) regions during the decade 2003–13. It combines household survey data and macroeconomic databases, covering over 200 comparable regions in 15 OECD countries. The econometric results, based on two alternative sets of instruments, highlight a general negative association between inequalities and economic growth since the start of the economic crisis. This relationship is sensitive to the type of urban structure. Higher inequalities seem to be more detrimental for growth in regions characterized by medium to large-sized cities, while regions characterized by small cities and rural areas are less affected.