BUSCADOR RECOLECTA

Figure S1: Differences in the composition of each donor attributed to protocol variations; Table S1: Abundance matrix displaying viral counts across samples. Table S2: Relative abundance of the viral families identified for each sample in the study, used for Figure 3., Peer reviewed

The incorporation of novel, functional, and sustainable foods in human diets is increasing because of their beneficial effects and environmental-friendly nature. Chia (Salvia hispanica L.) has proved to be a suitable source of bioactive peptides via enzymatic hydrolysis. These peptides could be responsible for modulating several physiological processes if able to reach the target organ. The bioavailable peptides contained in a hydrolysate obtained with Alcalase, as functional foods, were identified using a transwell system with Caco-2 cell culture as the absorption model. Furthermore, 20 unique peptides with a molecular weight lower than 1000 Da and the higher statistical significance of the peptide-precursor spectrum match (−10 log P) were assessed by in silico tools to suggest which peptides could be those exerting the demonstrated bioactivity. From the characterized peptides, considering the molecular features and the results obtained, the peptides AGDAHWTY, VDAHPIKAM, PNYHPNPR, and ALPPGAVHW are anticipated to be contributing to the antioxidant and/or ACE inhibitor activity of the chia protein hydrolysates., Peer reviewed

1 file, The Greenland-Portugal A25 OVIDE line is carried out biennially since 2002. The section is composed of 98 stations where hydrographic, biogeochemical and current measurements are carried out down to the bottom. OVIDE is a contribution to the international programs Go-Ship, IOCCP, and CLIVAR. This data set contains the final (adjusted) CTDO2 data, Peer reviewed

Supplementary Table S1. Maternal age, maternal weight status, mode of delivery, gestational age, birth weight, gender, and human milk sampling time of entire study group and subgroups., Peer reviewed

Supplementary Table 1. The intersecting circRNAs from current published data via a Venn map.-- Supplementary Figure 1. Dysregulated circRNAs in NAFLD from 7 published studies. (A) The nomenclature of circRNAs was converted to gene names, which is the most commonly used method in circRNAs publications (the complete data set of differentially expressed circRNAs was used if available in the original article or supplementary information; otherwise, the top circRNAs expression profiles in the original article was used); (B) Aligent data from original data.-- Supplementary Figure 2. CircRNAs predicted solely through bioinformatics analysis, but the underlying mechanism were not verified by in vitro or in vivo experiment. NAFLD, nonalcoholic fatty liver disease; UCP2, uncoupling protein 2; SLC1A5 (ASCT2), solute carrier family 1 member 5; PLP2, proteolipid protein 2; CPEB1, CPE-binding protein1; LPIN1, Lipin 1; SIRT1, sirtuin 1; PEG10, paternally expressed gene 10., Nonalcoholic fatty liver disease (NAFLD), which affects approximately 25% of the global population, is an urgent health issue leading to various metabolic comorbidities. Circular RNAs (circRNAs), covalently closed RNA molecules, are characterized by ubiquity, diversity, stability, and conservatism. Indeed, they participate in various biological processes via distinct mechanisms that could modify the natural history of NAFLD. In this review, we briefly introduce the biogenesis, characteristics, and biological functions of circRNAs. Furthermore, we summarize circRNAs expression profiles in NAFLD by intersecting seven sequencing data sets and describe the cellular roles of circRNAs and their potential advantages as biomarkers of NAFLD. In addition, we emphatically discuss the exosomal non-coding RNA sorting mechanisms and possible functions in recipient cells. Finally, we extensively discuss the potential application of targeting disease-related circRNAs and competing endogenous RNA networks through gain-of-function and loss-of-function approaches in targeted therapy of NAFLD., This work was supported by the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (No. ZYGD20009); Sichuan Science and Technological Program (No. 2022YFS0338); Post-Doctor Research Project of West China Hospital of Sichuan University (2020HXBH079); Chengdu Science and Technology innovation project (2021-YF05-00800-SN); National Natural Science Foundation of China (No. 81900512 and No. 81802468)., Peer reviewed

Wheat-dependent exercise-induced anaphylaxis (WDEIA) is one of the most severe forms of wheat allergy. It occurs in patients when they exercise after ingesting wheat-containing foods. Nowadays, the only possible alternative for WDEIA patients is to avoid such foods. This study investigated the potential of six RNA of interference (RNAi) wheat lines with low-prolamin content as alternatives for WDEIA patients. For that purpose, a high performance-liquid chromatography (HPLC) analysis was performed to evaluate differences in gluten protein fractions among these lines. Next, western blots were conducted to measure the immunoglobulin E (IgE) reactivity to wheat proteins in sera from five WDEIA patients. Additionally, monoclonal antibodies (moAb) recognition sites and the IgE binding sites were searched in all peptides identified by LC-MS/MS after protein digestion. The results showed a 61.4%–81.2% reduction in the gliadin content of the RNAi lines, accompanied by an increase in their high-molecular weight (HMW) glutenin content compared to the wild type bread wheat line (WT). In all cases, the reduction in gliadin content correlated with a decrease in IgE reactivity observed in the sera of WDEIA patients, highlighting the E82 and H320 lines. These two RNAi lines exhibited a ≤90% reduction in IgE reactivity. This reduction could be attributed to an absence of IgE binding sites associated with α- and ω5-gliadins, which were present in the WT. Overall, these lines offer a potential alternative for foodstuff for individuals with WDEIA., Peer reviewed

Strategic Action in Health of the Institute of Health Carlos III Department of Regional Health of the Castilla y Léon Government Consejería de Educación, Junta de Castilla y León, Peer reviewed

Strategic Action in Health of the Institute of Health Carlos III Department of Regional Health of the Castilla y Léon Government Consejería de Educación, Junta de Castilla y León, Peer reviewed

Additional file 1: Supplementary Material 1. Minor Revision. Supplementary Material 2. DSMB. Supplementary Material 3. Full protocol., Peer reviewed

Figure S1: GenBank codes for the partial COI sequences of the Aedes albopictus lines used in this study; Figure S2: Mean female fecundity (left) and mean egg fertility (right) in Ae. albopictus ARwPL, ARwPBA, ARwPBN, and BN., Peer reviewed