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Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275586
Dataset. 2022

[DATASET] PRECIPITATION FATE AND TRANSPORT IN A MEDITERRANEAN CATCHMENT THROUGH MODELS CALIBRATED ON PLANT AND STREAM WATER ISOTOPE DATA

  • Sprenger, Matthias
  • Llorens, Pilar
  • Gallart Gallego, Francesc
  • Benettin, Paolo
  • Allen, S. T.
  • Latron, Jérôme
Files 1. Calibration2015_2017_model_Input. csv The input data for the modeling of the timer periods 2015 to 2017 for calibration 2. Validation2011_2013_model_Input.csv The input data for the modeling of the timer periods 2011 to 2013 for the validation 3. dO18_Xylem_ET.csv The raw xylem isotope data, the evaporation corrected xylem and the weighted average over 30 days prior to each xylem sampling, and the estimated total ET isotope ratios 4. CalibrationResults.csv The calibration results (all parameter combinations that we tested and the respective goodness of fit) 5. d18O_SimResults.csv The results of the d18O simulations for the best model run 6. MedWaterAges.csv The water ages for the best model run 7. Readme.csv A readme file that explains the column names for each file, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/275586, https://doi.org/10.20350/digitalCSIC/14700
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275586
HANDLE: http://hdl.handle.net/10261/275586, https://doi.org/10.20350/digitalCSIC/14700
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275586
PMID: http://hdl.handle.net/10261/275586, https://doi.org/10.20350/digitalCSIC/14700
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275586
Ver en: http://hdl.handle.net/10261/275586, https://doi.org/10.20350/digitalCSIC/14700
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275586

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275763
Dataset. 2022

OCCUPANCY DATA IMPROVES PARAMETER PRECISION IN SPATIAL CAPTURE-RECAPTURE MODELS [DATASET]

  • Jiménez, José
  • Díaz-Ruiz, Francisco
  • Monterroso, Pedro S.
  • Tobajas, Jorge
  • Ferreras, Pablo
Stone marten data (Cabañeros National Park) and R+Nimble code for fiting the integrated SCR-occupancy-telemetry model from the paper "Occupancy data improves parameter precision in spatial capture-recapture models" (Ecology and Evolution)., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/275763, https://doi.org/10.20350/digitalCSIC/14701
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275763
HANDLE: http://hdl.handle.net/10261/275763, https://doi.org/10.20350/digitalCSIC/14701
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275763
PMID: http://hdl.handle.net/10261/275763, https://doi.org/10.20350/digitalCSIC/14701
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275763
Ver en: http://hdl.handle.net/10261/275763, https://doi.org/10.20350/digitalCSIC/14701
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275763

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275769
Dataset. 2022

PUBLICACIONES CIENTÍFICAS RELATIVAS AL PARQUE NATURAL SIERRAS DE CAZORLA, SEGURA Y LAS VILLAS, JAÉN, ANDALUCÍA, ESPAÑA. II. ECOLOGÍA, SCIENTIFIC PUBLICATIONS REFERRED TO THE NATURAL PARK SIERRAS DE CAZORLA, SEGURA Y LAS VILLAS, JAÉN PROVINCE, SE SPAIN. II. ECOLOGY

  • Herrera, Carlos M.
  • Núñez-Carbajal, Alejandro
  • Alonso, Conchita
[ES] En la disciplina de la Ecología, se reúnen 247 referencias de libros o capítulos de libros, tesis, ponencias y artículos de revista publicados entre 1981 y 2021. Las referencias se presentan ordenadas alfabéticamente por el apellido del primer autor. En cada referencia constan los autores, el título de la publicación, el título de la revista, el año de publicación, volumen y páginas. En los casos en los que ha sido posible se incluye el enlace web dónde se puede encontrar el documento, esto resulta más complicado para la literatura antigua., [EN] In the discipline of Ecology, there are 247 references of books or book chapters, thesis, papers and journal articles published between 1981 and 2021. The references are presented in alphabetical order by the first author's last name. Each reference includes the authors, the title of the publication, the title of the journal, the year of publication, volume and pages. In the cases in which it has been possible, the web link where the document can be found is included, this is more complicated for old literature., [ES] El acceso a la información preexistente es clave para el desarrollo científico. Las publicaciones científicas referidas a una temática concreta o un lugar constituyen un repositorio esencial del conocimiento adquirido para ese tema o lugar. Se presenta aquí una colección de literatura científica publicada desde principio del s. XX que contiene información de referencia o datos relativos al Parque Natural Sierras de Cazorla, Segura y Las Villas (Jaén) en la disciplina de la Ecología. La colección completa consta de tres catálogos sobre Botánica, Ecología y Zoología. Este trabajo es fruto de la labor pionera de recopilación bibliográfica llevada a cabo por uno de sus autores, Carlos M Herrera, revisando revistas de ámbito nacional e internacional durante décadas y facilitando su difusión en su página web. El catálogo se presenta aquí en dos formatos (xml, pdf) para hacerlo accesible a la comunidad científica de forma estandarizada. La colección de documentos permanece además como recurso accesible para uso docente y de investigación en la web: www.plant-animal.es., [EN] Access to available data is key for scientific development. Scientific publications referring to a specific topic or geographical region constitute an essential repository of the knowledge acquired for that topic or region. We present here a collection of scientific literature published since the beginning of the 20th century that contains reference information or data related to the Natural Park Sierras de Cazorla, Segura and Las Villas (Jaén) in the discipline of Ecology. The complete collection consists of three catalogs of Botany, Ecology and Zoology. This work is the result of the pioneering bibliographic compilation work carried out by one of the authors, Carlos M Herrera, who reviewed national and international journals for decades and facilitated the way to access these publications through his website. The catalogue is presented in two formats (xml, pdf) to make it accessible to the scientific community in a standardized way. The collection of documents remains also as an accessible resource for teaching and research use on the web: www.plant-animal.es., This study was partially funded by MICINN through European Regional Development Fund [SUMHAL, LIFEWATCH-2019-09-CSIC-13, POPE 2014-2020], Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/275769, https://doi.org/10.20350/digitalCSIC/14703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275769
HANDLE: http://hdl.handle.net/10261/275769, https://doi.org/10.20350/digitalCSIC/14703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275769
PMID: http://hdl.handle.net/10261/275769, https://doi.org/10.20350/digitalCSIC/14703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275769
Ver en: http://hdl.handle.net/10261/275769, https://doi.org/10.20350/digitalCSIC/14703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275769

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275773
Dataset. 2022

PUBLICACIONES CIENTÍFICAS RELATIVAS AL PARQUE NATURAL SIERRAS DE CAZORLA, SEGURA Y LAS VILLAS, JAÉN, ANDALUCÍA, ESPAÑA. III. ZOOLOGÍA, SCIENTIFIC PUBLICATIONS REFERRED TO THE NATURAL PARK SIERRAS DE CAZORLA, SEGURA Y LAS VILLAS, JAÉN PROVINCE, SE SPAIN. III. ZOOLOGY

  • Herrera, Carlos M.
  • Núñez-Carbajal, Alejandro
  • Alonso, Conchita
[ES] En la disciplina de la Zoología, se reúnen 262 referencias de libros o capítulos de libros, tesis, ponencias y artículos de revista publicados entre 1902 y 2021. Las referencias se presentan ordenadas alfabéticamente por el apellido del primer autor. En cada referencia constan los autores, el título de la publicación, el título de la revista, el año de publicación, volumen y páginas. En los casos en los que ha sido posible se incluye el enlace web dónde se puede encontrar el documento, esto resulta más complicado para la literatura antigua., [EN] In the discipline of Zoology, there are 262 references of books or book chapters, thesis, papers and journal articles published between 1902 and 2021. The references are presented in alphabetical order by the first author's last name. Each reference includes the authors, the title of the publication, the title of the journal, the year of publication, volume and pages. In the cases in which it has been possible, the web link where the document can be found is included, this is more complicated for old literature., [ES] El acceso a la información preexistente es clave para el desarrollo científico. Las publicaciones científicas referidas a una temática concreta o un lugar constituyen un repositorio esencial del conocimiento adquirido para ese tema o lugar. Se presenta aquí una colección de literatura científica publicada desde principio del s. XX que contiene información de referencia o datos relativos al Parque Natural Sierras de Cazorla, Segura y Las Villas (Jaén) en la disciplina de la Ecología. La colección completa consta de tres catálogos sobre Botánica, Ecología y Zoología. Este trabajo es fruto de la labor pionera de recopilación bibliográfica llevada a cabo por uno de sus autores, Carlos M Herrera, revisando revistas de ámbito nacional e internacional durante décadas y facilitando su difusión en su página web. El catálogo se presenta aquí en dos formatos (xml, pdf) para hacerlo accesible a la comunidad científica de forma estandarizada. La colección de documentos permanece además como recurso accesible para uso docente y de investigación en la web: www.plant-animal.es., [EN] Access to available data is key for scientific development. Scientific publications referring to a specific topic or geographical region constitute an essential repository of the knowledge acquired for that topic or region. We present here a collection of scientific literature published since the beginning of the 20th century that contains reference information or data related to the Natural Park Sierras de Cazorla, Segura and Las Villas (Jaén) in the discipline of Ecology. The complete collection consists of three catalogs of Botany, Ecology and Zoology. This work is the result of the pioneering bibliographic compilation work carried out by one of the authors, Carlos M Herrera, who reviewed national and international journals for decades and facilitated the way to access these publications through his website. The catalogue is presented in two formats (xml, pdf) to make it accessible to the scientific community in a standardized way. The collection of documents remains also as an accessible resource for teaching and research use on the web: www.plant-animal.es., This study was partially funded by MICINN through European Regional Development Fund [SUMHAL, LIFEWATCH-2019-09-CSIC-13, POPE 2014-2020]., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/275773, https://doi.org/10.20350/digitalCSIC/14704
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275773
HANDLE: http://hdl.handle.net/10261/275773, https://doi.org/10.20350/digitalCSIC/14704
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275773
PMID: http://hdl.handle.net/10261/275773, https://doi.org/10.20350/digitalCSIC/14704
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275773
Ver en: http://hdl.handle.net/10261/275773, https://doi.org/10.20350/digitalCSIC/14704
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275773

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275789
Dataset. 2022

NATAL EFFECTS OF CLIMATE ON A LONG-LIVED PREDATOR

  • Sergio, Fabrizio
  • Blas, Julio
  • Tanferna, Alessandro
  • Hiraldo, F.
The data are organized into 10 spreadsheets within a single Excel file on the impact of drought on: prey availability, nestlings' provisioning rates, probability of breeding, clutch size, hatching success, brood reduction, predation rate, number of young fledged per breeding pair, number of young fledged per territorial pair, body condition, body size., Part of the study was funded by Foundation Jaime González-Gordon and by the research projects 1602/2015 of the Spanish Ministry of Agriculture, Food and the Environment (Autonomous Organism of National Parks), PGC2018-095860-B-I00 of the Ministry of Science, Innovation and Universities with Feder Funds, and P18-FR-4239 of the Andalucía Autonomous Region (Consejería de Economía, Conocimiento, Empresas y Universidad)., Peer reviewed

DOI: http://hdl.handle.net/10261/275789, https://doi.org/10.20350/digitalCSIC/14705
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275789
HANDLE: http://hdl.handle.net/10261/275789, https://doi.org/10.20350/digitalCSIC/14705
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275789
PMID: http://hdl.handle.net/10261/275789, https://doi.org/10.20350/digitalCSIC/14705
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275789
Ver en: http://hdl.handle.net/10261/275789, https://doi.org/10.20350/digitalCSIC/14705
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275789

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275792
Dataset. 2022

HEAD-CT 2D/3D IMAGES WITH AND WITHOUT ICH PREPARED FOR DEEP LEARNING

  • Pérez del Barrio, Amaia
  • Menéndez Fernández-Miranda, Pablo
  • Sanz Bellón, Pablo
  • Esteve Domínguez, Anna
  • Lloret Iglesias, Lara
  • Marqués Fraguela, Enrique
  • Rodríguez González, David
For the "ICH detection" part, radiologists selected parients according to inclusion and exclusion criteria. - Images with HIC: - Inclusion criteria: Diagnosis of an ICH between 2010 and 2015. - Exclusion criteria: Significant motion artifact Significant postsurgical changes. - Images without ICH (healthy): - Inclusion criteria: Having done a head-CT between 2010 and 2015 reported as “normal” or “ICH is ruled out”. - Exclusion criteria: Significant motion artifact. Other major diagnoses (such as tumors). For the "prognosis" part, only the pathological head-CTs were used. All images are de-identified., In order to access this dataset, it is necessary to send an email to amaia.pdb@gmail.com specifying the intended use. Commercial use is prohibited under license: Creative Commons Attribution-NonCommercial-ShareAlike (CC-BY-NC-SA)., Para poder acceder a este dataset es necesario enviar un email a amaia.pdb@gmail.com especificando el uso que se le va a dar. Se prohíbe su uso comercial bajo la licencia Creative Commons Attribution-NonCommercial-ShareAlike (CC-BY-NC-SA)., [EN] This dataset contains two sets of images and tabular data anonymised and prepared for its use in the training and/or validation of artificial neural networks. The first set of images includes 3322 JPG files with 2D images of head computed tomography (CT) scans with and without intracranial hemorrhage (ICH), as well as a CSV with demographic data (age and gender) associated to each file. The second set of images consists of 262 NPY files with 3D images of head-CT scans with ICH, together with a CSV that includes clinical data related to each image., [ES] Este dataset contiene dos conjuntos de imágenes y datos tabulares anonimizados y preparados para su uso en el entrenamiento o validación de redes neuronales artificiales. El primer conjunto de imágenes incluye 3322 archivos JPG con imágenes 2D de tomografías computarizadas (TCs) craneales sin y con hemorragia intracranial (HIC), así como un CSV con datos demográficos (edad y sexo) asociados a cada archivo. El segundo conjunto de imágenes consiste en 262 archivos NPY con imágenes 3D de TCs con HIC junto con un CSV que incluye varios datos clínicos asociados a las imágenes., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/275792, https://doi.org/10.20350/digitalCSIC/14706
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275792
HANDLE: http://hdl.handle.net/10261/275792, https://doi.org/10.20350/digitalCSIC/14706
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275792
PMID: http://hdl.handle.net/10261/275792, https://doi.org/10.20350/digitalCSIC/14706
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275792
Ver en: http://hdl.handle.net/10261/275792, https://doi.org/10.20350/digitalCSIC/14706
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275792

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275818
Dataset. 2022

ACETOXYMETHYL-BODIPY DYES NMR DATASET

  • Blázquez-Moraleja, Alberto
  • Maierhofer, L.
  • Mann, Enrique
  • Prieto Montero, Ruth
  • Oliden-Sánchez, Ainhoa
  • Celada, Lucía
  • Martínez, Virginia
  • Chiara, María D.
  • Chiara, José Luis
Proton and carbon-13 nuclear magnetic resonance (1H NMR or 13C NMR) spectra were recorded on a Bruker Avance III-400 (400 and 100 MHz, respectively) or a Varian System 500 (500 and 125 MHz, respectively) spectrometers. Chemical shifts are expressed in parts per million (? scale) downfield from tetramethylsilane and are referenced to residual peaks of the deuterated NMR solvent used. Weighted Fourier transform and phase and baseline adjustment processing using the program MestReNova version 14.1.2-25024, Current methods for the preparation of functional small-molecule fluorophores generally require labor-intensive, multi-step synthetic routes for all the major chromophore groups. In spite of recent significant contributions from numerous laboratories, the paucity of rapid, straightforward and wide-scope synthetic strategies in this field is limiting the development of advanced probes for bioimaging, sensing and therapeutic applications. We describe herein a general and robust methodology for the one-step fluorescent labeling of a wide variety of molecules having C-, N-, P-, O-, S-, or halide-nucleophilic centers, using stable and readily available acetoxymethyl-BODIPYs as reagents in the presence of an acid catalyst. This modular methodology allows a very facile preparation of mono- and di-functional probes incorporating a broad assortment of biomolecules, enzyme cofactors, natural products, and other chromophores, as well as chemical functionalities for a wide range of applications including bioorthogonal conjugation, polymerization, and supramolecular chemistry, among others. The photophysical properties and preliminary applications of the new probes in live-cell imaging were also studied. The described strategy enables the high-throughput engineering of novel BODIPY dyes with diverse functionalities for basic and applied science with potential for innovative technological applications., Instituto de Salud Carlos III/FEDER A way to make Europe/Investing in your future" (project 20/01754), MCIN/AEI/10.13039/501100011033 (projects PID2020-114347RB-C31 and PID2020-114347RB-C32), Gobierno Vasco-Eusko Jaurlaritza (project IT1639-22). A.B.-M. and L.C. thank MICIN for a FPI (BES-2015-073571) and a FPU (FPU2017-01317) predoctoral contract, respectively. R.P.M thanks MIU and NGEU for a postdoctoral contract (MARSA21/71). A.O.S. thanks UPV-EHU for a predoctoral fellowship, Peer reviewed

DOI: http://hdl.handle.net/10261/275818, https://doi.org/10.20350/digitalCSIC/14707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275818
HANDLE: http://hdl.handle.net/10261/275818, https://doi.org/10.20350/digitalCSIC/14707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275818
PMID: http://hdl.handle.net/10261/275818, https://doi.org/10.20350/digitalCSIC/14707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275818
Ver en: http://hdl.handle.net/10261/275818, https://doi.org/10.20350/digitalCSIC/14707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275818

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275833
Dataset. 2022

[DATASET] INDUCED SEISMICITY AT THE BASEL (SWITZERLAND) ENHANCED GEOTHERMAL SYSTEM

  • Boyet, Auregan
  • De Simone, Silvia
  • Ge, Shemin
  • Vilarrasa, Víctor
This dataset corresponds to the model made from the EGS project of Basel (2006, Switzerland). The model solves the coupled hydro-mechanical problem for a 2D fault network on a surface of 1 km2, located at 4630-m deep coinciding with the injection depth in the crystalline basement at Basel. A set of faults is embedded in a rock matrix, with the fault network derived from the induced seismicity that was monitored in the range of 3750 and 4750-m deep. The maximum principal stress S_Hmax is aligned with y-axis (S_Hmax=160 MPa, S_hmin=84 MPa, S_v=115 MPa). The hydrostatic pressure is set at 45 MPa following a hydrostatic profile and the temperature at the depth of the reservoir is set at 190°C. Stimulation parameters are inputs as wellhead pressure based on the injection strategy from Häring et al. (2008). The injection fluid is water. This dataset includes the following files: - “ .gid” is the Code_Bright file with the model of Basel. The file “_gen.dat” contains the input data of the model (including material properties, initial and boundary conditions and the time intervals). The file “_gri.dat” includes the information on the mesh. The “root.dat” includes the name of the model. To run simulations, execute the Code_Bright executable “Cb_2020_21.exe” in a folder that contains the three input files and the executable.  V13_C_elastic.gid corresponds to the model in which the faults have an elastic behavior.  V13_C_F245_D5_P1.gid corresponds to the model in which the faults have an viscoplastic behavior, and fault C has a slip weakening of 5°. - “Deichmann_et_al_2014_cluster.txt” is the file proposed by Deichmann et al. (2014). Seismic events are sorted by clusters, in function of the location and focal mechanisms., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/275833, https://doi.org/10.20350/digitalCSIC/14710
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275833
HANDLE: http://hdl.handle.net/10261/275833, https://doi.org/10.20350/digitalCSIC/14710
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275833
PMID: http://hdl.handle.net/10261/275833, https://doi.org/10.20350/digitalCSIC/14710
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275833
Ver en: http://hdl.handle.net/10261/275833, https://doi.org/10.20350/digitalCSIC/14710
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275833

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275973
Dataset. 2022

[DATASET] PHYSICS-BASED MODELING TO UNDERSTAND AND FORECAST INDUCED SEISMICITY

  • Boyet, Auregan
  • De Simone, Silvia
  • Vilarrasa, Víctor
This dataset corresponds to the model made based on the EGS project of Basel (2006, Switzerland). The model is solving coupled hydro-mechanical problem for isotropic and heterogeneous 2D models on a surface of 16 km2, located at 4630-meters depth coinciding with the injection depth in the crystalline basement at Basel. The heterogeneous domain is crossed by a fault zone with a length of 1200 meters and a width of 30 meters, oriented at 20° from the maximum horizontal stress. The maximum principal stress S_Hmax is aligned with y-axis (SHmax=160 MPa, Shmin=84 MPa, Sv=115 MPa). The hydrostatic pressure is set at 45 MPa following a hydrostatic profile and the temperature at the depth of the reservoir is set at 190°C. Stimulation parameters are inputs as wellhead pressure based on the injection strategy from Häring et al. (2008), injection fluid is water. - “ .gid” is the Code_Bright folder with the model of Basel. The file “_gen.dat” contains the input data of the model (including material properties, initial and boundary conditions and the time intervals). The file “_gri.dat” includes the information on the mesh. The “root.dat” includes the name of the model. To run simulations, execute the Code_Bright executable “Cb_2020_21.exe” in a folder that contains the three input files and the executable.  V13_isotropic.gid corresponds to the model with isotropic domain.  V13_inclined.gid corresponds to the model with the domain crossed by the fault zone., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/275973, https://doi.org/10.20350/digitalCSIC/14713
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275973
HANDLE: http://hdl.handle.net/10261/275973, https://doi.org/10.20350/digitalCSIC/14713
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275973
PMID: http://hdl.handle.net/10261/275973, https://doi.org/10.20350/digitalCSIC/14713
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275973
Ver en: http://hdl.handle.net/10261/275973, https://doi.org/10.20350/digitalCSIC/14713
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/275973

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/276267
Dataset. 2022

DATA OF MANUSCRIPT TRANSCRIPTIONAL REGULATION OF ERGOSTEROL BIOSYNTHESIS GENES IN RESPONSE TO IRON DEFICIENCY

  • Jordá,Tania
  • Barba-Aliaga, Marina
  • Rozès, Nicolas
  • Alepuz, Paula
  • Martínez-Pastor, María Teresa
  • Puig, Sergi
The dataset is made available under the Open Database License. Any rights in individual contents of the database are licensed under the Database Contents License. Please, read the full ODbL 1.0 license text for the exact terms that apply. Users of the dataset are free to: Share: copy, distribute and use the database, either commercially or non-commercially. Create: produce derivative works from the database. Adapt: modify, transform and build upon the database. Under the following conditions: Attribution: You must attribute any public use of the database, or works produced from the database. For any use or redistribution of the database, or works produced from it, you must make clear to others the license of the original database. Share-Alike: If you publicly use any adapted version of this database, or works produced from an adapted database, you must also offer that adapted database under the ODbL., Iron participates as an essential cofactor in the biosynthesis of critical cellular components, including DNA, proteins and lipids. The ergosterol biosynthetic pathway, which is an important target of antifungal treatments, depends on iron in four enzymatic steps. Our results in the model yeast Saccharomyces cerevisiae show that the expression of ergosterol biosynthesis (ERG) genes is tightly modulated by iron availability probably through the iron-dependent variation of sterol and heme levels. Whereas, the transcription factors Upc2 and Ecm22 are responsible for the activation of ERG genes upon iron deficiency, the heme-dependent factor Hap1 triggers their Tup1-mediated transcriptional repression. The combined regulation by both activating and repressing regulatory factors allows for the fine-tuning of ERG transcript levels along the progress of iron deficiency, avoiding the accumulation of toxic sterol intermediates and enabling efficient adaptation to rapidly changing conditions. The lack of these regulatory factors leads to changes in the yeast sterol profile upon iron-deficient conditions. Both environmental iron availability and specific regulatory factors should be considered in ergosterol antifungal treatments, This research was supported by grant PID2020-116940RB-I00 funded by MCIN/AEI/10.13039/501100011033 to Sergi Puig, and grants PID2020-120066RB-I00 funded by MCIN/AEI/10.13039/501100011033 and AICO/2020/086 by “Generalitat Valenciana” to Paula Alepuz. Tania Jordá was a recipient of a predoctoral fellowship ACIF/2019/214 funded by “Generalitat Valenciana”, and Marina Barba-Aliaga was a recipient of a predoctoral fellowship (FPU2017/03542) funded by MCIN/AEI/10.13039/501100011033 and by ESF-Investing in your future., Peer reviewed

DOI: http://hdl.handle.net/10261/276267, https://doi.org/10.20350/digitalCSIC/14714
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/276267
HANDLE: http://hdl.handle.net/10261/276267, https://doi.org/10.20350/digitalCSIC/14714
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/276267
PMID: http://hdl.handle.net/10261/276267, https://doi.org/10.20350/digitalCSIC/14714
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/276267
Ver en: http://hdl.handle.net/10261/276267, https://doi.org/10.20350/digitalCSIC/14714
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/276267

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