BUSCADOR RECOLECTA

Details on sample preparation and precharacterization (Notes S1 to S3), the near-field optical data analysis (Note S4), the noise figure in the experiment (Note S5), the dispersion back bending (Note S6), three-dimensional representation of the PhP field distributions (Note S7), the rotation of the l = 1 mode (Note S8), the PhP canalization (Note S9), the impact of excitation bandwidth on the PhP properties (Note S10), the PhP group velocity (Note S11), and related supplementary references., Peer reviewed

Details about the membranes’ specifications, frequency tracking setup, and biological sample preparation, Peer reviewed

Methods, STM data of 1, STM data of 1 after hydrogenation, STM data of a sample after thermally triggered dehydrogenation, STM data of ketone-functionalized molecules at various dehydrogenation stages, temperature-dependent Kondo resonance analysis of 6, calculated ionization energies, conductance maps of 7 with Cl-functionalized probes, DFT-calculated wavefunctions of molecular orbitals of 7 in different charging states, STM data of 7 on Ag(111), and bias-dependent conductance maps of 7 on Ag(111) ., Peer reviewed

Figure S1. Impedance spectra of the Pt/LCO/CGO/LCO/Pt symmetrical cell (black solid line) and blank Pt/CGO/Pt (red solid line) at (a) 200 °C and (b) 600 °C., Peer reviewed

7 pages. -- Content: 1. Chemical and biological reagents; 2. BiMW interferometer sensor; 2.1. The BiMW device; 2.2. BiMW sensor chips cleaning and silanization; 3. Data analysis; 4. Figures S1-S4 S-4; 5. Lung cancer clinical samples. Table S-1., The rapid diagnosis of cancer, especially in its early stages, is crucial for on-time medical treatment and for increasing the patient survival rate. Lung cancer shows the highest mortality rate and the lowest 5-year survival rate due to the late diagnosis in advanced cancer stages. Providing rapid and reliable diagnostic tools is a top priority to address the problem of a delayed cancer diagnosis. We introduce a nanophotonic biosensor for the direct and real-time detection in human plasma of the microRNA-21-5p biomarker related to lung cancer. The biosensor employs a silicon photonic bimodal interferometric waveguide that provides a highly sensitive detection in a label-free format. We demonstrate a very competitive detectability for direct microRNA-21-5p biomarker assays in human plasma samples (estimated LOD: 25 pM). The diagnostic capability of our biosensor was validated by analyzing 40 clinical samples from healthy individuals and lung cancer patients, previously analyzed by reverse-transcription quantitative polymerase chain reaction (qRT-PCR). We could successfully identify and quantify the levels of microRNA in a one-step assay, without the need for DNA extraction or amplification steps. The study confirmed the significance of implementing this biosensor technique compared to the benchmarking molecular analysis and showed excellent agreement with previous results employing the traditional qRT-PCR. This work opens new possibilities for the true implementation of point-of-care biosensors that enable fast, simple, and efficient early diagnosis of cancer diseases., Peer reviewed

List of sequences used in this work, FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids, digestion of DNA duplexes and DNA/RNA hybrids mediated by BanI and FokI, working principle of the FokI-assisted digestion method, design of target DNA/RNA sequences and reporter oligonucleotides, LOD of the proposed reactions, enhanced detection of individual SARS-CoV-2 sequences, FokI-assisted signal amplification allows the simultaneous detection of multiple targets, FokI-assisted signal amplification discriminates between known SARS-CoV-2 variants, and specificity and LOD of the RCA-enhanced reaction., Peer reviewed

Procedures used to synthesize ligands and complexes, 1H and 13C NMR spectra of the ligands in CD2Cl2, thermogravimetric analyses of complexes 2 and 2a, analyses of X-ray crystal structures of L2 and complex 2, magnetometry studies of 1 and 2 performed at a scan rate of 5 K min–1, and small- and wide-angle X-ray scattering (SWAXS) studies of complexes 2 and 2a., Peer reviewed

Data1_MuñozGallegoetal2022Ecology: Data used to analyze the effects of moth herbivory and goat herbivory on inflorescence production and pollinator abundance. -- Data2_MuñozGallegoetal2022Ecology: Data used to analyze the effects of moth herbivory and goat herbivory on fruit initiation and fruit development. -- Data3_MuñozGallegoetal2022Ecology: Unpublished data from the PF (Platja de Formentor, Mallorca, Balearic Islands) dwarf palm population. -- Data4_ MuñozGallegoetal2022Ecology: Results of the generalized linear mixed models (GLMMs) testing the isolated and combined effects (interaction) of moth herbivory and goat herbivory on palm reproduction. -- Metadata_MuñozGallegoetal2022Ecology: Metada related to Data1, Data2, Data3 and Data4., Data1_MuñozGallegoetal2022Ecology.csv, Data2_MuñozGallegoetal2022Ecology.csv, Data3_MuñozGallegoetal2022Ecology.xlsx, Data4_ MuñozGallegoetal2022Ecology.xlsx, Peer reviewed

Table S1: Synthesis conditions used for hybrid samples; Table S2: Synthesis conditions used for non-hybrid samples; Figure S1: Isotherms and pore size distribution of xerogels samples; title; Table S3: Thermal conductivity of hybrid xerogels., Peer reviewed

Analysis of the effect of damping on spin-wave dynamics; explanation of wavevector shift in dispersion relations of different magnetization components., Peer reviewed