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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations, Background COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. At the time this clinical trial was planned, there were no available vaccine or therapeutic agents with proven efficacy, but the severity of the condition prompted the use of several pharmacological and non-pharmacological interventions. It has long been hypothesized that the use of convalescent plasma (CP) from infected patients who have developed an effective immune response is likely to be an option for the treatment of patients with a variety of severe acute respiratory infections (SARI) of viral etiology. The aim of this study is to assess the efficacy and safety of convalescent plasma in adult patients with severe COVID-19 pneumonia. Methods/design The ConPlas-19 study is a multicenter, randomized, open-label controlled trial. The study has been planned to include 278 adult patients hospitalized with severe COVID-19 infection not requiring mechanical ventilation (invasive or non-invasive). Subjects are randomly assigned in a 1:1 ratio (139 per treatment arm), stratified by center, to receive intravenously administered CP (single infusion) plus SOC or SOC alone, and are to be followed for 30 days. The primary endpoint of the study is the proportion of patients that progress to category 5, 6, or 7 (on the 7-point ordinal scale proposed by the WHO) at day 15. Interim analyses for efficacy and/or futility will be conducted once 20%, 40%, and 60% of the planned sample size are enrolled and complete D15 assessment. Discussion This clinical trial is designed to evaluate the efficacy and safety of passive immunotherapy with convalescent plasma for the treatment of adult patients hospitalized with COVID-19. The results of this study are expected to contribute to establishing the potential place of CP in the therapeutics for a new viral disease. Trial registration ClinicalTrials.gov NCT04345523. Registered on 30 March, 2020. First posted date: April 14, 2020, This research is funded by the Government of Spain, Ministry of Science and Innovation, Instituto de Salud Carlos III, grant n° COV20/00072 (Royal Decree-Law 8/2020, of 17 March, on urgent extraordinary measures to deal with the economic and social impact of COVID-19), co-financed by the European Regional Development Fund (FEDER) “A way to make Europe,” and supported by SCReN (Spanish Clinical Research Network), ISCIII, project PT17/0017/0009. The funding institutions do not have any role in the design of the study, data collection, analysis, or interpretation of data, nor in writing the manuscript

Este documento se trata de la base de datos (en inglés) utilizada para la elaboración del manuscrito "Persistence of submerged macrophytes in a drying world: unravelling the timing and the environmental drivers for the production of drought-resistant propagules", elaborado por S. Calero, L.P.C. Morellato y M.A. Rodrigo, y que será próximamente publicado en la revista internacional Aquatic Conservation: Marine and Freshwater Ecosystems., This dataset contains two years of data about the sexual reproductive phenology of three charophyte species (Chara hispida, Chara aspera and Nitella hyalina) growing in different depth and salinity conditions in two Mediterranean brackish shallow ponds. The first sheet contains all metadata. From the second to the seventh sheets, raw data from each population are shown. From the eighth to the thirteenth sheets, grouped and transformed data from each population -ready to perform circular statistics- are shown. In the last sheet, environmental and phenological variables from one population are shown. More information about the acquisition, analyses and discussion of these data is available in the manuscript: Calero, S., Morellato, L.P.C. & Rodrigo, M.A. Persistence of submerged macrophytes in a drying world: unravelling the timing and the environmental drivers for the production of drought-resistant propagules. Aquatic Conservation: Marine and Freshwater Ecosystems., Esta base de datos contiene dos años de datos sobre la fenología reproductiva de tres especies de carófitos (Chara hispida, Chara aspera y Nitella hyalina) que crecen en distintas condiciones de profundidad y salinidad en dos charcas mediterráneas (someras y de agua salobre). La primera hoja de cálculo contiene todos los metadatos. De la segunda a la séptima hoja, se muestran los datos en bruto de cada población. De la octava a la decimotercera hoja, se muestran los datos agrupados y transformados de cada población. En la última hoja, se muestran las variables ambientales y fenológicas correspondientes a una población. Puede encontrarse más información sobre la adquisición, el análisis y la discusión de estos datos en el manuscrito: Calero, S., Morellato, L.P.C. & Rodrigo, M.A. Persistence of submerged macrophytes in a drying world: unravelling the timing and the environmental drivers for the production of drought-resistant propagules. Aquatic Conservation: Marine and Freshwater Ecosystems.

This dataset contains the results for the Social Progress Adjusted GDPpc Indicator elaborated in Picazo-Tadeo, A.J.; Gianmoena, L.; Peiró-Palomino, J.; Rios, V. (2024). Building a social progress-adjusted indicator of GDP per capita for the European Union’s regions. Social Indicators Research, in press (https://doi.org/10.1007/s11205-023-03267-7), Ministerio de Ciencia e Innovación