BUSCADOR RECOLECTA

Supplementary Tables and Figures., This phase II clinical trial evaluated the combination of ibrutinib with rituximab, gemcitabine, and oxaliplatin (R-GemOx) in patients with nongerminal center B-cell–like (non-GCB) diffuse large B-cell lymphoma (DLBCL). The IBDCL trial (NCT02692248) included patients with histologic diagnosis of non-GCB DLBCL with relapsed or refractory disease and non-candidates for stem-cell transplantation. Patients received an induction treatment consisting of six or eight cycles of R-GemOx at standard doses every 2 weeks, in combination with ibrutinib (560 mg daily), followed by a maintenance treatment with ibrutinib for a maximum of 2 years. The primary objective was to evaluate the overall response rate after four cycles. Sixty-four patients were included, 72% of them refractory to the last regimen. The overall response rate and complete remission rate after the fourth cycle were 53% [95% confidence interval (CI), 41–65] and 34% (95% CI, 24–46), respectively. Twenty-four (37%) patients started maintenance, and 7 (11%) completed the planned 2 years. After a median follow-up of 29.7 months (range: 0.4–48.6), the estimated 2-year progression-free survival and overall survival were 18% (95% CI, 8–28) and 26% (95% CI, 14–37), respectively. The most common grade ≥3 treatment-related adverse events were thrombocytopenia (44%), neutropenia (30%), and anemia (14%). Grade ≥3 infectious and cardiovascular treatment-related adverse events were reported in 6 (9%) and 1 (2%) patient, respectively. Ibrutinib in combination with R-GemOx, followed by ibrutinib maintenance, demonstrated encouraging antitumor activity with durable responses and a manageable toxicity in patients with non-GCB DLBCL., Peer reviewed

Supplementary material, Peer reviewed

This study reports the discovery of a sensor domain that is specific for purine compounds and found in many different types of bacterial receptors., Peer reviewed

Peer reviewed

Peer reviewed

The present study aimed to investigate the effects of (R)-(−)-1-isothiocyanato-6-(methylsulfinyl)-hexane [(R)-6-HITC], the major isothiocyanate present in wasabi, in an ex vivo model of inflammation using lipopolysaccharide-stimulated murine peritoneal macrophages. (R)-6-HITC improved the immune response and mitigated oxidative stress, which involved suppression of reactive oxygen species, nitric oxide, and pro-inflammatory cytokines (IL-1β, IL-6, IL-17, IL-18, and TNF-α) production and downregulation of pro-inflammatory enzymes such as inducible nitric oxide synthase, COX-2, and mPGES-1. In addition, (R)-6-HITC was able to activate the Nrf2/HO-1 axis while simultaneously inhibiting key signaling pathways, including JAK2/STAT3, mitogen-activated protein kinases, and canonical and noncanonical inflammasome pathways, orchestrating its potent immunomodulatory effects. Collectively, these findings demonstrate the potential of (R)-6-HITC as a promising nutraceutical for the management of immuno-inflammatory diseases and justify the need for further in vivo validation studies., Peer reviewed

This file contains 13 supplementary Tables and 7 supplementary Figures, Peer reviewed

Contents of this file: Table S1. List of CMIP6 GCMs and the availability of runoff, salinity, and SST in historical simulations and projections four SSPs, covering the period of 1850-2100. -- Figure S1. Results from the diagnostics of the overimputation in the PCA. The overimputed values for the different measured biogeochemical properties show that they are in acceptable range (i.e., values are close to the diagnostic slope). The data included in the PCA were organic carbon (oc), C:N-ratio (cn) and stable isotopes of C (d13c) and N (d15n), XRF-elements (Cl, Br, Zr, Sr, Ca, Rb, Fe, K, Mn, and Ti), n-alkanes (average chain length, MCL), mean sediment grain-size distribution (MEAN) and sorting (SORTING), and magnetic susceptibility (MS_x). -- Figure S2. Sediment age models based on cumulative mass vs. combined 210Pb and 14C ages obtained with Bacon for (A) Gåsö S and (B) Gåsö N. The solid lines show the best “fitted” model based on 210Pb-derived ages and calibrated 14C-dates and the dashed lines are 2 σ range (equal to 0.95). Note the difference in scale on the axes. In the above panels, iteration is the number of Markov Chain Monte Carlo (MCMC) runs that was performed to assess the accumulation rate and produce the age model, acc. rate is the gamma distribution of the accumulation rate and memory shows the variability of the accumulation rate before (green curve) and after (grey box) the model was run. -- Table S2. Radiocarbon dates used for estimating sediment age models in Gåsö S and N. AMS = Accelerator Mass Spectrometry. BP = Before present. -- Figure S3. Mean (±SD) n-alkane (µg g dry weight sediment-1) signature of Zostera marina above- and belowground biomass based on analysis of three replicates for each of the above- and belowground plant parts., Peer reviewed

Dataset for "A 2,000-year record of eelgrass (Zostera marina L.) colonization shows substantial gains in blue carbon storage and nutrient retention", containing biogeochemical data used in the study., Peer reviewed

Birds and ants are among the most ubiquitous taxa co-occurring in terrestrial ecosystems, but how they mutually interact is almost unknown. Here, the main features of this neglected interaction are synthetized in a systematic literature review. Interaction with ants has been recorded in 1122 bird species (11.2% of extant species) belonging to 131 families widely distributed across the globe and the avian phylogeny. On the other hand, 47 genus of ants (14.4% of extant genus) belonging to eight subfamilies interact with birds. Interactions include competition, antagonism (either ant–bird mutual predation or parasitism) and living together commensally or mutualistically. Competition (48.9%) and antagonism (36.1%) were the most common reported interactions. The potential for engaging in commensalism and competition with ants has a phylogenetic structure in birds and was present in the bird's ancestor. Interaction is better studied in the tropics, in where the network is less dense and more nested than in temperate or arid biomes. This review demonstrates that ant–bird interactions are a pervasive phenomenon across ecological domains, playing a key role in ecosystem function. Future studies need to combine sensible experimentation within anthropogenic disturbance gradients in order to achieve a better understanding of this interaction., Peer reviewed