Resultados totales (Incluyendo duplicados): 35611
Encontrada(s) 3562 página(s)
Encontrada(s) 3562 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311571
Dataset. 2022
SUPPLEMENTARY INFORMATION FROM PHENOLOGICAL SENSITIVITY AND SEASONAL VARIABILITY EXPLAIN CLIMATE-DRIVEN TRENDS IN MEDITERRANEAN BUTTERFLIES
- Colom, Pau
- Ninyerola, Miquel
- Pons, Xavier
- Traveset, Anna
- Stefanescu, Constantí
38 pages. -- Includes: Supplementary text S1 to S3; Figures S1 to S2; Tables S1 to S5; SI References, Supporting information on ecological traits calculation, flight peak selection and data refinement and supplementary figures and tables., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/311571
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311571
HANDLE: http://hdl.handle.net/10261/311571
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311571
PMID: http://hdl.handle.net/10261/311571
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311571
Ver en: http://hdl.handle.net/10261/311571
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311571
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311573
Dataset. 2022
CONTROL OF RNA POLYMERASE II PROMOTER-PROXIMAL PAUSING BY DNA SUPERCOILING [RNA-SEQ]
- Herrero-Ruiz, Andrés
- Martínez-García, Pedro Manuel
- Terrón-Bautista, José
- Jimeno-González, Silvia
- Cortés-Ledesma, Felipe
Expression profiling by high throughput sequencing.--2 RNA-seq experiments in human RPE cells were generated, each one consisting on 2 conditions (control VS merbarone treatment): 1) Control VS 30m merbarone: 30m vehicle treatment (3 replicates) and 30m merbarone treatment (3 replicates); 2) Control VS 2h merbarone: Untreated (2 replicates) and 2h merbarone treatment (2 replicates)., Resources available on the publisher's site: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE141799, During transcription, DNA supercoiling generated by the advance of RNA polymerase II (Pol II) is resolved by DNA topoisomerases, enzymes that bind chromatin and produce transient breaks to relax DNA. Recently, this idea of mere facilitators of transcription progression is changing, as topoisomerases are being assigned new functions in regulating the expression of specific genes. In fact, mammalian type II topoisomerases, both the [Symbol] (TOP2A) and [Symbol] (TOP2B) paralogs, are enriched at promoter regions, where they have been proposed to trigger transcription through the generation of DNA double-strand breaks (DSBs). However, this is difficult to reconcile with the intrinsic catalytic properties of TOP2 and the high risk of genome instability that continuous production and repair of DSBs implies. Here, we show that TOP2A enforces promoter-proximal pausing of Pol II by removing transcription-associated negative DNA supercoiling. Interestingly, this topological balance and its disruption is essential for the transcriptional control of Immediate Early Genes (IEGs) and their typical bursting behaviour in response to stimulus. We therefore uncover a novel layer of transcriptional regulation that relies on canonical functions of TOP2A that are independent of aberrant DSB formation, providing a topological framework for the control of promoter-proximal pausing and the tight regulation of IEGs., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/311573
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311573
HANDLE: http://hdl.handle.net/10261/311573
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311573
PMID: http://hdl.handle.net/10261/311573
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311573
Ver en: http://hdl.handle.net/10261/311573
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311573
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311575
Dataset. 2022
IMAGE_1_A TROPICAL MACROALGA (HALIMEDA INCRASSATA) ENHANCES DIVERSITY AND ABUNDANCE OF EPIFAUNAL ASSEMBLAGES IN MEDITERRANEAN SEAGRASS MEADOWS.TIF
- Mateo, Miguel Ángel
- Máñez-Crespo, Julia
- Royo, Laura
- Tuya, Fernando
- Castejón-Silvo, Inés
- Hernán, Gema
- Pereda-Briones, Laura
- Terrados, Jorge
- Tomàs, Fiona
1 figure., The introduction and successful expansion of tropical species into temperate systems is being exacerbated by climate change, and it is particularly important to identify the impacts that those species may have, especially when habitat-forming species are involved. Seagrass meadows are key shallow coastal habitats that provide critical ecosystem services worldwide, and they are threatened by the arrival of non-native macroalgae. Here, we examined the effects of Halimeda incrassata, a tropical alga that has recently colonized the Mediterranean Sea, on epifaunal assemblages associated with Cymodocea nodosa seagrass meadows of Mallorca Island (Western Mediterranean Sea). This invasive macroalga is an ecological engineer and thus has a high potential of modifying native habitats. A seagrass meadow colonized by H. incrassata exhibited important changes on associated epifaunal assemblages, with an increase in abundance and diversity, particularly driven by higher abundances of Gammaridae, Polychaeta, Copepoda and Caprellidae. Given the key ecological contribution of epifauna to food webs, these alterations will likely have important implications for overall food web structure and ecosystem functioning of native ecosystems., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/311575
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311575
HANDLE: http://hdl.handle.net/10261/311575
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311575
PMID: http://hdl.handle.net/10261/311575
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311575
Ver en: http://hdl.handle.net/10261/311575
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311575
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311580
Dataset. 2021
DELIBERATIVE STRUCTURES AND THEIR IMPACT ON VOTING UNDER ECONOMIC CONFLICT [DATASET]
- Brandts, Jordi
- Gerhards, Leonie
- Mechtenberg, Lydia
We conduct a laboratory experiment to investigate how different deliberative structures of varying inclusiveness affect collective decisions in the presence of economic conflict. An electorate consists of two groups, one informed and one uninformed about an uncertain state of the economy. This state affects payoffs differently for the two groups. We study three deliberative structures that vary in how the uninformed are included in pre-vote communication. Compared with a setting without any communication, we find that communication in all three deliberation treatments leads to more frequent votes for the efficient policies. The most inclusive deliberative structure motivates more truthfulness, more trust, more cooperativeness (i.e. refraining from protest votes), and more votes for the efficient policies, than the least inclusive structure. However, comparison among the deliberation treatments reveals that the most inclusive deliberative structure is not the one that generates the highest degree of truthfulness. The dynamics of communication lead to a general deterioration of truth-telling and cooperativeness, reinforced by the use of disrespectful and uncooperative language., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/311580
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311580
HANDLE: http://hdl.handle.net/10261/311580
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311580
PMID: http://hdl.handle.net/10261/311580
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311580
Ver en: http://hdl.handle.net/10261/311580
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311580
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311581
Dataset. 2022
ADDITIONAL FILE 1 OF GENETICALLY PREDICTED TELOMERE LENGTH AND ALZHEIMER’S DISEASE ENDOPHENOTYPES: A MENDELIAN RANDOMIZATION STUDY
- Rodríguez-Fernández, Blanca
- Vilor-Tejedor, Natalia
- Arenaza-Urquijo, Eider M.
- Sánchez-Benavides, Gonzalo
- Suárez-Calvet, Marc
- Operto, Grégory
- Minguillón, Carolina
- Fauria, Karine
- Kollmorgen, Gwendlyn
- Suridjan, Ivonne
- Castro de Moura, Manuel
- Piñeyro, David
- Esteller, Manel
- Blennow, Kaj
- Zetterberg, Henrik
- De Vivo, Immaculata
- Molinuevo, José Luis
- Navarro, Arcadi
- Gispert, Juan Domingo
- Sala-Vila, Aleix
- Crous-Bou, Marta
Additional file 1: Supplementary Table 1. Characteristics of Single Nucleotide Polymorphisms (SNPs) associated with longer telomere length. The effect allele refers to the allele that is associated with longer telomere length. Chromosomal position of the SNPs (genome assembly GRCh37 (hg19)) according to the public archive for genetic variation within and across different species developed and hosted by the National Center for Biotechnology Information (NCBI) in collaboration with the National Human Genome Research Institute (NHGRI) (dbSNP)., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/311581
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311581
HANDLE: http://hdl.handle.net/10261/311581
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311581
PMID: http://hdl.handle.net/10261/311581
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311581
Ver en: http://hdl.handle.net/10261/311581
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311581
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311588
Dataset. 2022
ADDITIONAL FILE 2 OF GENETICALLY PREDICTED TELOMERE LENGTH AND ALZHEIMER’S DISEASE ENDOPHENOTYPES: A MENDELIAN RANDOMIZATION STUDY
- Rodríguez-Fernández, Blanca
- Vilor-Tejedor, Natalia
- Arenaza-Urquijo, Eider M.
- Sánchez-Benavides, Gonzalo
- Suárez-Calvet, Marc
- Operto, Grégory
- Minguillón, Carolina
- Fauria, Karine
- Kollmorgen, Gwendlyn
- Suridjan, Ivonne
- Castro de Moura, Manuel
- Piñeyro, David
- Esteller, Manel
- Blennow, Kaj
- Zetterberg, Henrik
- De Vivo, Immaculata
- Molinuevo, José Luis
- Navarro, Arcadi
- Gispert, Juan Domingo
- Sala-Vila, Aleix
- Crous-Bou, Marta
Additional file 2: Supplementary Table 1. Linear regression estimates for cognition outcomes in the entire sample. All models are adjusted for covariates: age, sex, education, and APOE status. Supplementary Table 2. Linear regression estimates for neuroimaging outcomes (i.e., Alzheimer’s disease and aging signatures) outcome in the entire sample. All models are adjusted for covariates: age, sex, education, and APOE status. Supplementary Table 3. Linear regression estimates for CSF biomarkers outcomes in the entire sample. All models are adjusted for covariates: age, sex, education, and APOE status. Supplementary Table 4. Linear regression estimates for cognition outcomes in APOE-ɛ4 carriers. All models are adjusted for covariates: age, sex, and education. Supplementary Table 5. Linear regression estimates for neuroimaging outcomes (i.e., Alzheimer’s disease and aging signatures) in APOE-ɛ4 carriers. All models are adjusted for covariates: age, sex, and education. Supplementary Table 6. Linear regression estimates for CSF biomarkers outcomes in APOE-ɛ4 carriers. All models are adjusted for covariates: age, sex, and education. Supplementary Table 7. Linear regression estimates for cognition outcomes in APOE-ɛ4 non-carriers. All models are adjusted for covariates: age, sex, and education. Supplementary Table 8. Linear regression estimates for neuroimaging outcomes (i.e., Alzheimer’s disease and aging signatures) in APOE-ɛ4 non-carriers. All models are adjusted for covariates: age, sex, and education. Supplementary Table 9. Linear regression estimates for CSF biomarkers outcomes in APOE-ɛ4 carriers. All models are adjusted for covariates: age, sex, and education. Supplementary Table 10. Linear regression estimates for cognition outcomes among individuals at high genetic predisposition to AD. All models are adjusted for covariates: age, sex, and education. Supplementary Table 11. Linear regression estimates for neuroimaging outcomes (i.e., Alzheimer’s disease and aging signatures) among individuals at high genetic predisposition to AD. All models are adjusted for covariates: age, sex, and education. Supplementary Table 12. Linear regression estimates for CSF biomarkers outcomes (i.e., Alzheimer’s disease and aging signatures) among individuals at high genetic predisposition to AD. All models are adjusted for covariates: age, sex, and education. Supplementary Table 13. Linear regression estimates for cognition outcomes among individuals at low genetic predisposition to AD. All models are adjusted for covariates: age, sex, and education. Supplementary Table 14. Linear regression estimates for neuroimaging outcomes (i.e., Alzheimer’s disease and aging signatures) among individuals at low genetic predisposition to AD. All models are adjusted for covariates: age, sex, and education. Supplementary Table 15. Linear regression estimates for CSF biomarkers outcomes among individuals at low genetic predisposition to AD. All models are adjusted for covariates: age, sex, and education., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/311588
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311588
HANDLE: http://hdl.handle.net/10261/311588
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311588
PMID: http://hdl.handle.net/10261/311588
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311588
Ver en: http://hdl.handle.net/10261/311588
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311588
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311625
Dataset. 2022
ADDITIONAL FILE 3 OF GENETICALLY PREDICTED TELOMERE LENGTH AND ALZHEIMER’S DISEASE ENDOPHENOTYPES: A MENDELIAN RANDOMIZATION STUDY
- Rodríguez-Fernández, Blanca
- Vilor-Tejedor, Natalia
- Arenaza-Urquijo, Eider M.
- Sánchez-Benavides, Gonzalo
- Suárez-Calvet, Marc
- Operto, Grégory
- Minguillón, Carolina
- Fauria, Karine
- Kollmorgen, Gwendlyn
- Suridjan, Ivonne
- Castro de Moura, Manuel
- Piñeyro, David
- Esteller, Manel
- Blennow, Kaj
- Zetterberg, Henrik
- De Vivo, Immaculata
- Molinuevo, José Luis
- Navarro, Arcadi
- Gispert, Juan Domingo
- Sala-Vila, Aleix
- Crous-Bou, Marta
Additional file 3: Supplementary Table 1. Characteristics of the study participants with information for cognition outcomes. Mean and SD are shown for continuous variables. Supplementary Table 2. Characteristics of the study participants with information for neuroimaging outcomes. Mean and SD are shown for continuous variables. Supplementary Table 3. Characteristics of the study participants with information for CSF biomarkers. Mean and SD are shown for continuous variables., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/311625
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311625
HANDLE: http://hdl.handle.net/10261/311625
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311625
PMID: http://hdl.handle.net/10261/311625
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311625
Ver en: http://hdl.handle.net/10261/311625
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311625
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311628
Dataset. 2022
ADDITIONAL FILE 4 OF GENETICALLY PREDICTED TELOMERE LENGTH AND ALZHEIMER’S DISEASE ENDOPHENOTYPES: A MENDELIAN RANDOMIZATION STUDY
- Rodríguez-Fernández, Blanca
- Vilor-Tejedor, Natalia
- Arenaza-Urquijo, Eider M.
- Sánchez-Benavides, Gonzalo
- Suárez-Calvet, Marc
- Operto, Grégory
- Minguillón, Carolina
- Fauria, Karine
- Kollmorgen, Gwendlyn
- Suridjan, Ivonne
- Castro de Moura, Manuel
- Piñeyro, David
- Esteller, Manel
- Blennow, Kaj
- Zetterberg, Henrik
- De Vivo, Immaculata
- Molinuevo, José Luis
- Navarro, Arcadi
- Gispert, Juan Domingo
- Sala-Vila, Aleix
- Crous-Bou, Marta
Additional file 4: Supplementary Table 1. Results of the effect of genetically predicted longer telomere length on AD endophenotypes in the entire sample. Supplementary Table 2. Results of the effect of genetically predicted longer telomere length on AD endophenotypes among APOE-ɛ4 carriers. Supplementary Table 3. Results of the effect of genetically predicted longer telomere length on AD endophenotypes among APOE-ɛ4 non-carriers. Supplementary Table 4. Results of the effect of genetically predicted longer telomere length on AD endophenotypes among individuals at high genetic predisposition to Alzheimer's disease. Supplementary Table 5. Results of the effect of genetically predicted longer telomere length on AD endophenotypes among individuals at low genetic predisposition to Alzheimer's disease., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/311628
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311628
HANDLE: http://hdl.handle.net/10261/311628
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311628
PMID: http://hdl.handle.net/10261/311628
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311628
Ver en: http://hdl.handle.net/10261/311628
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311628
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311633
Dataset. 2022
ADDITIONAL FILE 5 OF GENETICALLY PREDICTED TELOMERE LENGTH AND ALZHEIMER’S DISEASE ENDOPHENOTYPES: A MENDELIAN RANDOMIZATION STUDY
- Rodríguez-Fernández, Blanca
- Vilor-Tejedor, Natalia
- Arenaza-Urquijo, Eider M.
- Sánchez-Benavides, Gonzalo
- Suárez-Calvet, Marc
- Operto, Grégory
- Minguillón, Carolina
- Fauria, Karine
- Kollmorgen, Gwendlyn
- Suridjan, Ivonne
- Castro de Moura, Manuel
- Piñeyro, David
- Esteller, Manel
- Blennow, Kaj
- Zetterberg, Henrik
- De Vivo, Immaculata
- Molinuevo, José Luis
- Navarro, Arcadi
- Gispert, Juan Domingo
- Sala-Vila, Aleix
- Crous-Bou, Marta
Additional file 5: Supplementary Figure 1. Leave-one-out permutation analysis plot for AD signature among individuals at high genetic predisposition to AD obtained by leaving out the SNP indicated and repeating the Inverse-Variance Weighted method with the rest of the instrumental variables. Supplementary Figure 2. Leave-one-out permutation analysis plot for Aging signature among individuals at high genetic predisposition to AD, obtained by leaving out the SNP indicated and repeating the Inverse-Variance Weighted method with the rest of the instrumental variables. Supplementary Figure 3. Leave-one-out permutation analysis plot for Aβ ratio among APOE-ɛ4 non-carriers obtained by leaving out the SNP indicated and repeating the Inverse-Variance Weighted method with the rest of the instrumental variables. Supplementary Figure 4. Leave-one-out permutation analysis plot for NfL among APOE-ɛ4 non-carriers obtained by leaving out the SNP indicated and repeating the Inverse-Variance Weighted method with the rest of the instrumental variables. Supplementary Figure 5. Leave-one-out permutation analysis plot for p-tau among individuals at high genetic predisposition to AD, obtained by leaving out the SNP indicated and repeating the Inverse-Variance Weighted method with the rest of the instrumental variables., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/311633
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311633
HANDLE: http://hdl.handle.net/10261/311633
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311633
PMID: http://hdl.handle.net/10261/311633
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311633
Ver en: http://hdl.handle.net/10261/311633
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311633
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311638
Dataset. 2022
ONLINE APPENDIX OF ACADEMIC INTEGRITY IN ON-LINE EXAMS: EVIDENCE FROM A RANDOMIZED FIELD EXPERIMENT
- Klijn, Flip
- Mdaghri Alaoui, Mehdi
- Vorsatz, Marc
Contents:
• Online Appendix A: Course structure and screenshots of the final exam
• Online Appendix B: Subject pool information
• Online Appendix C: Analysis of order effect for individual questions
• Online Appendix D: Instant order effects
• Online Appendix E: Analysis of informativeness of exam grades
• Online Appendix F: Additional figures
• Online Appendix G: Exam questions
• References, Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/311638
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311638
HANDLE: http://hdl.handle.net/10261/311638
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311638
PMID: http://hdl.handle.net/10261/311638
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311638
Ver en: http://hdl.handle.net/10261/311638
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311638
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