BUSCADOR RECOLECTA

Deuterostomes are a monophyletic group of animals that includes Hemichordata, Echinodermata (together called Ambulacraria), and Chordata. The diversity of deuterostome body plans has made it challenging to reconstruct their ancestral condition and to decipher the genetic changes that drove the diversification of deuterostome lineages. Here, we generate chromosome-level genome assemblies of 2 hemichordate species, Ptychodera flava and Schizocardium californicum, and use comparative genomic approaches to infer the chromosomal architecture of the deuterostome common ancestor and delineate lineage-specific chromosomal modifications. We show that hemichordate chromosomes (1N = 23) exhibit remarkable chromosome-scale macrosynteny when compared to other deuterostomes and can be derived from 24 deuterostome ancestral linkage groups (ALGs). These deuterostome ALGs in turn match previously inferred bilaterian ALGs, consistent with a relatively short transition from the last common bilaterian ancestor to the origin of deuterostomes. Based on this deuterostome ALG complement, we deduced chromosomal rearrangement events that occurred in different lineages. For example, a fusion-with-mixing event produced an Ambulacraria-specific ALG that subsequently split into 2 chromosomes in extant hemichordates, while this homologous ALG further fused with another chromosome in sea urchins. Orthologous genes distributed in these rearranged chromosomes are enriched for functions in various developmental processes. We found that the deeply conserved Hox clusters are located in highly rearranged chromosomes and that maintenance of the clusters are likely due to lower densities of transposable elements within the clusters. We also provide evidence that the deuterostome-specific pharyngeal gene cluster was established via the combination of 3 pre-assembled microsyntenic blocks. We suggest that since chromosomal rearrangement events and formation of new gene clusters may change the regulatory controls of developmental genes, these events may have contributed to the evolution of diverse body plans among deuterostomes., Peer reviewed

[Introduction]: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer., [Methods]: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease., [Results and discussion]: CD20+ T cells were more represented within the CD8+ T cell compartment and they showed a predominant memory Tc1 phenotype. CD20+ T cells were less represented in MBL and CLL patients vs healthy controls, particularly among those with unmutated IGVH gene. The expansion of malignant B cells was accompanied by phenotypic and functional changes in CD20+ T cells, including an increase in follicular helper CD4+ CD20+ T cells and CD20+ Tc1 cells, in addition to the expansion of the TCR Vβ 5.1 in CD4+ CD20+ T cells in CLL., Peer reviewed

Detailed composition for each substrate-binding pocket in AmiA:peptide 5 complex., Peer reviewed

Detailed composition for each substrate-binding pocket in AliB:peptide 4 complex., Peer reviewed

Mapes sobre diferents tipus d’impactes en tot el Mar Mediterrani. Dades primàries (mapes) associades a un article acceptat per la revista Scientific Reports (2018). Publicat a: https://doi.org/10.1038/s41598-018-33237-w, Dades primàries (mapes) associades a un article publicat a la revista Scientific Reports, 2018, vol. 8. http://doi.org/10.1038/s41598-018-33237-w

Dades associades a l'article: Vicente Royuela, Paolo Veneri & Raul Ramos (2018): The short-run relationship between inequality and growth: evidence from OECD regions during the Great Recession, Regional Studies, DOI: 10.1080/00343404.2018.1476752, This dataset is the basis of the work titled “The short-run relationship between inequality and growth: evidence from OECD regions during the Great Recession”, published in Regional Studies (DOI: 10.1080/00343404.2018.1476752). This paper provides evidence on the relationship between income inequality and economic growth in Organisation for Economic Co-operation and Development (OECD) regions during the decade 2003–13. It combines household survey data and macroeconomic databases, covering over 200 comparable regions in 15 OECD countries. The econometric results, based on two alternative sets of instruments, highlight a general negative association between inequalities and economic growth since the start of the economic crisis. This relationship is sensitive to the type of urban structure. Higher inequalities seem to be more detrimental for growth in regions characterized by medium to large-sized cities, while regions characterized by small cities and rural areas are less affected.

Dades primàries associades a un article pendent de publicació: Navas-Fernández, Miguel; Abadal, Ernest (2018). "Les revistes científiques de Catalunya 2014-2017". Anuari de l'Observatori de Biblioteques, Llibres i Lectura, vol 5., Podeu consultar l'article resultat al camp recurs relacionat

Dades primàries associades a un article sotmès per publicació a la revista PLOS ONE, Raw data from the study Functioning in Schizophrenia from the Perspective of Psychologists: A Worldwide Study. The study aimed to explore the content validity of the International Classification of Functioning, Disability and Health (ICF) Core Sets for schizophrenia from the perspective of psychologists. The results support the content validity of the ICF Core Sets for schizophrenia from the perspective of psychologists and suggest that they are an appropriate framework for describing functioning and disability in individuals with schizophrenia.

We provide the code for producing Functional Urban Areas by means of using OSM and Google maps data., Dades associades a l'article: Obaco A., Moisés; Royuela Mora, Vicente (2019): Identifying functional urban areas in Ecuador using a varying travel time approach,. Publicat a: Geographical Analysis, 2020, vol. 52, n. 1. (https://onlinelibrary.wiley.com/doi/10.1111/gean.12190). DOI: https://doi.org/10.1111/gean.12190., Podeu consultar l'article associat a: http://hdl.handle.net/2445/154578, Identifying integrated urban areas is an important issue for urban analysis and policy evaluation. In this paper, we provide a set of FUAs suitable for monitoring urbanization in Ecuador, a less developed country without commuting data. We do so substituting such socioeconomic flows by available information on road structure, which allow us to work with accessibility based on a varying travel time. In order to build Ecuadorean FUAs, we calibrate our methodology considering Colombian data. We perform several sensitivity analysis and robustness checks to Ecuador with alternative sources of socioeconomic flows. We conclude that the use of GIS data and the calibrated thresholds provide a set of FUAs close to the ones that would result of using commuting information.

Dades associades a l'article: Laura García-Otero, Marta López, Mariona Guitart-Mampel, Constanza Morén, Anna Goncé, Carol Esteve, Laura Salazar, Olga Gómez, Josep María Martínez, Berta Torres, Sergi César, Glòria Garrabou, Fàtima Crispi, Eduard Gratacós. (2019): Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment., Article publicat a la revista PLOS ONE, http://doi.org/10.1371/journal.pone.0213279 i al Dipòsit Digital de la UB http://hdl.handle.net/2445/148934, Mitochondrial toxicity related to intrauterine exposure to maternal HIV and combined antiretroviral treatment (cART) may have an impact on the heart of the uninfected offspring. The objective of the study was to evaluate fetal cardiovascular and mitochondrial biomarkers in HIV pregnancies.