Resultados totales (Incluyendo duplicados): 34416
Encontrada(s) 3442 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346119
Dataset. 2020

THE 2014 GREENLAND-PORTUGAL GEOVIDE BOTTLE DATA (GO-SHIP A25 AND GEOTRACES GA01)

  • Pérez, Fiz F.
  • Tréguer, Paul
  • Branellec, Pierre
  • García-Ibáñez, Maribel I.
  • Lherminier, Pascale
  • Sarthou, Géraldine
This dataset reports for the classical rosette bottle data for the following Essential Ocean Variables: salinity, dissolved oxygen, total alkalinity, pH, nitrates and silicic acid. It also reports on the measurements of the CTD-O2 probe at the bottle levels: pressure, temperature, salinity and dissolved oxygen, The GEOVIDE cruise was carried out coast to coast between Portugal and Newfoundland via the south tip of Greenland, following the OVIDE line in the eastern part and crossing the Labrador Sea in the western part. The classical hydrographic rosette was cast 163 times at 78 different geographical positions called stations. While the CTD-O2 probe acquired continuous profiles of the “physical” variables (pressure, temperature, salinity and dissolved oxygen), 22 Niskin bottles were closed at different levels during the upcast to provide samples for biogeochemical analysis. After calibration, we find precisions for pressure, temperature, salinity and dissolved oxygen that fit the GO-SHIP international quality requirements. In parallel, but not simultaneously, a trace-metal rosette (TMR) was cast 53 times, also acquiring profiles of physical variables, and equipped with 24 Go-Flo bottles adapted for the sampling of trace metals. Depending on the number of operations, stations were identified as “Short” (one single CTD cast), “Large” (3 CTD casts), “XLarge” (up to 6) and “Super” (up to 11). All along the track of the ship, current magnitude and direction was measured by Ship Acoustic Doppler Current Profilers, down to 1000m depth, No

Proyecto: //
DOI: http://hdl.handle.net/10261/346119
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346119
HANDLE: http://hdl.handle.net/10261/346119
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346119
PMID: http://hdl.handle.net/10261/346119
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346119
Ver en: http://hdl.handle.net/10261/346119
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346119

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346142
Dataset. 2018

SUPPORTING INFORMATION - DUAL ROLE OF MAGNETIC NANOPARTICLES AS INTRACELLULAR HOTSPOTS AND EXTRACELLULAR MATRIX DISRUPTORS TRIGGERED BY MAGNETIC HYPERTHERMIA IN 3D CELL CULTURE MODELS

  • Beola, Lilianne
  • Asín, Laura
  • Fratila, Raluca M.
  • Herrero, Vanessa
  • Fuente, Jesús M. de la
  • Grazú, Valeria
  • Gutiérrez, Lucía
Table S1. Hydrodynamic size and ζ-potential of magnetic nanoparticles. Table S2. Iron concentration located inside the cells. Figure S1. Sterility assay. Figure S2. MNP toxicity assay in 2D cell cultures. Figure S3. MNP toxicity evaluated in 3D models. Figure S4. Magnetic characterization of the 3D models., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/346142
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346142
HANDLE: http://hdl.handle.net/10261/346142
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346142
PMID: http://hdl.handle.net/10261/346142
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346142
Ver en: http://hdl.handle.net/10261/346142
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346142

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346154
Dataset. 2020

SUPPORTING INFORMATION - THE INTRACELLULAR NUMBER OF MAGNETIC NANOPARTICLES MODULATES THE APOPTOTIC DEATH PATHWAY AFTER MAGNETIC HYPERTHERMIA TREATMENT

  • Beola, Lilianne
  • Asín, Laura
  • Roma-Rodrigues, Catarina
  • Fernández-Afonso, Yilian
  • Fratila, Raluca M.
  • Serantes, David
  • Ruta, Sergiu
  • Chantrell, Roy W.
  • Fernandes, Alexandra R.
  • Baptista, Pedro V.
  • Fuente, Jesús M. de la
  • Grazú, Valeria
  • Gutiérrez, Lucía
(Figure S1) Characterization of the MNP glucose functionalization efficacy; (Figure S2) cell viability studies; (Figure S3) hysteresis loop simulating the experimental conditions in water measurements; (Figure S4) hysteresis loops simulating the experimental conditions in vitro; (Computational details) extended description of the calculations performed for the analysis of the local termal effects occuring during the AMF exposure; and (Figure S5) Bid expression analysis., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/346154
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346154
HANDLE: http://hdl.handle.net/10261/346154
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346154
PMID: http://hdl.handle.net/10261/346154
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346154
Ver en: http://hdl.handle.net/10261/346154
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346154

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346280
Dataset. 2023

SUPPORTING INFORMATION - TWO SYNTHETIC TOOLS TO DEEPEN THE UNDERSTANDING OF THE INFLUENCE OF STEREOCHEMISTRY ON THE PROPERTIES OF IRIDIUM(III) HETEROLEPTIC EMITTERS

  • Babón, Juan C.
  • Boudreault, Pierre-Luc T.
  • Esteruelas, Miguel A.
  • Gaona, Miguel A.
  • Izquierdo, Susana
  • Oliván, Montserrat
  • Oñate, Enrique
  • Tsai, Jui-Yi
  • Vélez, Andrea
General information for the experimental section, structural analysis of complexes 3, 5, 9a, 9b, and 11a, computational details, energies of optimized structures, observed and calculated UV–vis spectra of 3 and a and b isomers of 9–12, analysis of computed UV–vis data, theoretical analysis of molecular orbitals, cyclic voltammograms of 3 and a and b isomers of 9–12, photophysical studies, and NMR spectra (PDF). Atomic coordinates of optimized complexes (XYZ)., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/346280
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346280
HANDLE: http://hdl.handle.net/10261/346280
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346280
PMID: http://hdl.handle.net/10261/346280
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346280
Ver en: http://hdl.handle.net/10261/346280
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346280

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346403
Dataset. 2023

CRISPR/DCAS9-MEDIATED DNA DEMETHYLATION SCREEN IDENTIFIES DRIVER EPIGENETIC DETERMINANTS OF COLORECTAL CANCER (PROCESSED DATA)

  • Tejedor, Juan Ramón
  • Peñarroya, Alfonso
  • Gancedo-Verdejo, Javier
  • Santamarina-Ojeda, Pablo
  • Pérez, Raúl F.
  • López-Tamargo, Sara
  • Díez-Borge, Ana
  • Alba-Linares, Juan J.
  • González-Del-Rey, Nerea
  • Urdinguio, Rocío G.
  • Mangas, Cristina
  • Roberti, Annalisa
  • López, Virginia
  • Morales-Ruiz, Teresa
  • Ariza, Rafael R.
  • Roldán-Arjona, Teresa
  • Meijón, Mónica
  • Valledor, Luis
  • Cañal, María Jesús
  • Fernández-Martínez, Daniel
  • Fernández-Hevia, María
  • Jiménez-Fonseca, Paula
  • García-Flórez, Luis J.
  • Fernández, Agustín F.
  • Fraga, Mario F.
[Background]: Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorectal cancer (CRC). However, whether this epigenetic mechanism is an actual driver of cancer or is a mere consequence of the carcinogenic process remains to be elucidated., [Results]: In this work we performed an integrative multi -omic approach to identify gene candidates with strong correlations between DNA methylation and gene expression in human CRC samples and a set of 8 colon cancer cell lines. As a proof of concept, we combined recent CRISPR-Cas9 epigenome editing tools (dCas9-TET1, dCas9-TET-IM) with a custom arrayed gRNA library to modulate the DNA methylation status of 56 promoters previously linked with strong epigenetic repression in CRC, and we monitored the potential functional consequences of such DNA methylation loss by means of a high-content cell proliferation screen. Overall, the epigenetic modulation of most of these DNA methylated regions had a mild impact in the reactivation of gene expression and in the viability of cancer cells. Interestingly, we found that epigenetic reactivation of RSPO2 in the tumour context was associated with a significant impairment in cell proliferation in p53-/- cancer cell lines and further validation with human samples demonstrated that the epigenetic silencing of RSPO2 is a mid-late event in the adenoma to carcinoma sequence., [Conclusions]: These results highlight the potential role of DNA methylation as a driver mechanism of CRC and open up the venue for the identification of novel therapeutic windows based on the epigenetic reactivation of certain tumour suppressor genes., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/346403
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346403
HANDLE: http://hdl.handle.net/10261/346403
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346403
PMID: http://hdl.handle.net/10261/346403
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346403
Ver en: http://hdl.handle.net/10261/346403
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346403

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346411
Dataset. 2024

RNA-SEQ DATA SET OF PENNYCRESS SEED MATURATION

  • Alfonso Lozano, Miguel
  • Claver Lacasa, Ana
  • Luján Serrano, María Ángeles
  • López Sánchez, María Victoria
[EN] A single excel file containing 4 different sheets. Each sheet corresponds to the compared gene expression analysis between each of the different seed maturation stages with respect to the initial GREEN one. Each sheet contains the raw data, log2fold change, p-values, pdaj and FPKM values for each identified 20,016 genes in the pennycress genome. No specific software is needed to read the .xls files. [ES] Un único fichero Excel que contiene 4 hojas independientes. Cada hoja corresponde al análisis comparado de la expresión génica de cada uno de los estadios de maduración con respecto al estadio VERDE inicial. Cada hoja contiene los datos brutos de expresión, cambios en el Log2fold change, p-values, pdaj y valores FPKM para cada uno de los 20.016 genes identificados en nuestro análisis en el genoma de Pennycress. No se necesita ningún software específico para leer los archivos .xls. This dataset is covered by a Creative Commons Licence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)., [EN] This dataset contains the results obtained from a RNA-Seq analysis performed on five (5) different seed maturation stages of Pennycress (Thlaspi arvense), corresponding to GREEN, GREEN-YELLOW, YELLOW-GREEN, YELLOW and MATURE seed maturation stages. Gene comparisons were performed with respect to the initial GREEN stage. Data show the expression of 20,016 genes encoding proteins., [ES] Este conjunto de datos corresponde a un estudio de RNA-Seq llevado a cabo en cinco (5) estadios de maduración diferentes de Pennycress (Thalspi arvense), que corresponden al estadio VERDE, VERDE-AMARILLO; AMARILLO-VERDE; AMARILLO y MADURO. Los datos muestran la expresión de 20.016 genes que codifican proteína., Grant PDI2021-1265630-B100 funded by MCIN/AEI/, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/346411
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346411
HANDLE: http://hdl.handle.net/10261/346411
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346411
PMID: http://hdl.handle.net/10261/346411
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346411
Ver en: http://hdl.handle.net/10261/346411
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346411

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346426
Dataset. 2023

SUPPLEMENTAL INFORMATION FOR DPPA3-HIF1Α AXIS CONTROLS COLORECTAL CANCER CHEMORESISTANCE BY IMPOSING A SLOW CELL-CYCLE PHENOTYPE

  • Cuesta-Borràs, Estefania
  • Salvans, Cándida
  • Arqués, Oriol
  • Chicote, Irene
  • Ramírez, Lorena
  • Cabellos, Laia
  • Martínez-Quintanilla, Jordi
  • Mur-Espinosa, Alex
  • García-Álvarez, Alejandro
  • Hernando, Jorge
  • Tejedor, Juan Ramón
  • Mirallas, Oriol
  • Élez, Elena
  • Fraga, Mario F.
  • Tabernero, Josep
  • Nuciforo, Paolo
  • Capdevila, Jaume
  • Palmer, Héctor G.
  • Puig, Isabel
Document S1. Figures S1–S6 and Tables S2, S6, and S7. Table S1. CRC cohort clinical characteristics, related to Figure 1. Clinical characteristics of CRC patients corresponding to the paired primary tumor and metastasis samples analyzed for DPPA3 expression. Table S3. DPPA3-overexpressing cell model gene-expression profile, related to Figure 3. Microarray analysis of SW1222 CTRL and DPPA3 cells cultured in 3D. FC, fold change. Table S4. DPPA3_CELL_CYCLE_DW gene set, related to Figure 3. List of gene sets related to DNA replication and cell cycle differentially negatively enriched in SW1222 DPPA3 versus control cells grown in 3D. This list is used to generate the DPPA3_CELL_CYCLE_DW gene set. NES, normalized enrichment score. Table S5. DPPA3_HYPOXIA_UP gene set, related to Figure 5. List of gene sets associated with hypoxia differentially positively enriched in SW1222 DPPA3 versus control cells. This list is used to generate the DPPA3_HYPOXIA_UP gene set. NES, normalized enrichment score. Document S2. Article plus supplemental information., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/346426
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346426
HANDLE: http://hdl.handle.net/10261/346426
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346426
PMID: http://hdl.handle.net/10261/346426
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346426
Ver en: http://hdl.handle.net/10261/346426
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346426

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346449
Dataset. 2023

SUPPLEMENTARY INFORMATION FOR "DUAL-BAND COUPLING OF PHONON AND SURFACE PLASMON POLARITONS WITH VIBRATIONAL AND ELECTRONIC EXCITATIONS IN MOLECULES"

  • Bylinkin, Andrei
  • Calavalle, Francesco
  • Barra-Burillo, María
  • Kirtaev, Roman V.
  • Nikulina, Elizaveta
  • Modin, Evgeny
  • Janzen, Eli
  • Edgar, James H.
  • Casanova, Fèlix
  • Hueso, Luis E.
  • Volkov, Valentyn S.
  • Vavassori, Paolo
  • Aharonovich, Igor
  • Alonso-González, Pablo
  • Hillenbrand, Rainer
  • Nikitin, Alexey Y.
The dielectric functions of materials. SEM images of the Al ribbons. Analysis of the polaritonic modes in the nanoresonator heterostructure. Data processing of nanoimaging experiments. Comparison between the experimental and simulated extinction spectra. Details of the coupled classical harmonic oscillator fits., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/346449
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346449
HANDLE: http://hdl.handle.net/10261/346449
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346449
PMID: http://hdl.handle.net/10261/346449
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346449
Ver en: http://hdl.handle.net/10261/346449
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346449

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346474
Dataset. 2023

SUPPORTING INFORMATION - MULTI-OMIC INTEGRATION OF DNA METHYLATION AND GENE EXPRESSION DATA REVEALS MOLECULAR VULNERABILITIES IN GLIOBLASTOMA

  • Santamarina-Ojeda, Pablo
  • Tejedor, Juan Ramón
  • Pérez, Raúl F.
  • López, Virginia
  • Roberti, Annalisa
  • Mangas, Cristina
  • Fernández, Agustín F.
  • Fraga, Mario F.
Fig. S1. Optimization of multi-omics factor analysis models. Fig. S2. Clinical correlations observed in the factors identified by the multi-omics factor analysis model. Fig. S3. Differential Gene Expression analyses of Glioblastoma Stem Cells. Fig. S4. Gene sets and molecular pathways enriched in the different Glioblastoma clusters identified in the co-expression analysis approach. Fig. S5. Differential Methylation changes observed in Glioblastoma Stem Cells. Fig. S6. Chromatin state and TFBS enrichments on pd-GBSC data. Fig. S7. Correlation between SMAD3 and CEBPs expression levels and the epigenetic status of their cognate putative binding sites. Fig. S8. Validation of candidate TF using single-cell Glioblastoma Stem Cell data. Data S1. Legends., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/346474
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346474
HANDLE: http://hdl.handle.net/10261/346474
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346474
PMID: http://hdl.handle.net/10261/346474
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346474
Ver en: http://hdl.handle.net/10261/346474
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346474

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346528
Dataset. 2023

SUPPORTING INFORMATION FOR "TERAHERTZ TWISTOPTICS-ENGINEERING CANALIZED PHONON POLARITONS"

  • Obst, Maximilian
  • Nörenberg, Tobias
  • Álvarez-Pérez, Gonzalo
  • Oliveira, Thales V. A. G. de
  • Taboada-Gutiérrez, Javier
  • Feres, Flávio H.
  • Kaps, Felix G.
  • Hatem, Osama
  • Luferau, Andrei
  • Nikitin, Alexey Y.
  • Klopf, J. Michael
  • Alonso-González, Pablo
  • Kehr, Susanne C.
  • Eng, Lukas M.
Details on α-MoO3 THz permittivity data, additional measurements at all mentioned frequencies, details on data processing, the extraction of HPhP confinements and quality factors from line profiles, and an overview of extracted properties as well as a remark on the influence of sample thickness, sample preparation, and FEL and setup parameters., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/346528
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346528
HANDLE: http://hdl.handle.net/10261/346528
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346528
PMID: http://hdl.handle.net/10261/346528
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346528
Ver en: http://hdl.handle.net/10261/346528
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/346528

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