Resultados totales (Incluyendo duplicados): 44423
Encontrada(s) 4443 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235054
Dataset. 2020

ACSAPPLMATERINTERFACES2020_12_44195_CEAMANOS_FIGS2

  • Ceamanos, Lorena
  • Kahveci, Zehra
  • López-Valdeolivas, María
  • Liu, Danqing
  • Broer, Dirk, J.
  • Sánchez-Somolinos, Carlos
Dataset corresponding to the underlying data of PRIME scientific publications - Publication title: Four-Dimensional Printed Liquid Crystalline Elastomer Actuators with Fast Photoinduced Mechanical Response toward Light-Driven Robotic Functions - Publication reference: ACS Appl. Mater. Interfaces 2020, 12, 39, 44195. - Publication DOI: 10.1021/acsami.0c13341 - Figure S2 caption: Photoresponse of a dog-bone shaped LCE strip with uniaxial orientation. Peak force measurement at maximum under a sequence of ten pulses (pulse duration of 1 s with a periodicity of 11s) of UV light (365 nm) at 50 mW/cm2. PRIME. Advanced and versatile PRInting platform for the next generation of active Microfluidic dEvices., PRIME has received Funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No. 829010 and VIBRATE - Self-sustaining vibration and mechanical resonance effects in stimuli responsive liquid crystal polymer coatings and membranes (Vibrate) (669991)., Peer reviewed

DOI: http://hdl.handle.net/10261/235054
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235054
HANDLE: http://hdl.handle.net/10261/235054
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235054
PMID: http://hdl.handle.net/10261/235054
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235054
Ver en: http://hdl.handle.net/10261/235054
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oai:digital.csic.es:10261/235054

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235114
Dataset. 2020

MAGNETISM OF TOPOLOGICAL BOUNDARY STATES INDUCED BY BORON SUBSTITUTION IN GRAPHENE NANORIBBONS

  • Friedrich, Niklas
  • Brandimarte, Pedro
  • Li, Jingcheng
  • Saito, Shohei
  • Yamaguchi, Shigehiro
  • Pozo, Iago
  • Peña, Diego
  • Frederiksen, Thomas
  • Garcia-Lekue, Aran
  • Sánchez-Portal, Daniel
  • Pascual, José I.
OPEN DATA related to the research publication: Niklas Friedrich, Pedro Brandimarte, Jingcheng Li, Shohei Saito, Shigehiro Yamaguchi, Iago Pozo, Diego Peña, Thomas Frederiksen, Aran Garcia-Lekue, Daniel Sánchez-Portal, and José Ignacio Pascual, Magnetism of Topological Boundary States Induced by Boron Substitution in Graphene Nanoribbons, Phys. Rev. Lett. 125, 146801 (2020) [arXiv:2004.10280], Graphene nanoribbons (GNRs), low-dimensional platforms for carbon-based electronics, show the promising perspective to also incorporate spin polarization in their conjugated electron system. However, magnetism in GNRs is generally associated with localized states around zigzag edges, difficult to fabricate and with high reactivity. Here we demonstrate that magnetism can also be induced away from physical GNR zigzag edges through atomically precise engineering topological defects in its interior. A pair of substitutional boron atoms inserted in the carbon backbone breaks the conjugation of their topological bands and builds two spin-polarized boundary states around them. The spin state was detected in electrical transport measurements through boron-substituted GNRs suspended between the tip and the sample of a scanning tunneling microscope. First-principle simulations find that boron pairs induce a spin 1, which is modified by tuning the spacing between pairs. Our results demonstrate a route to embed spin chains in GNRs, turning them into basic elements of spintronic devices., We acknowledge funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 863098 (FET-Open project "SPRING")., Peer reviewed

Proyecto: EC/H2020/863098
DOI: http://hdl.handle.net/10261/235114
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235114
HANDLE: http://hdl.handle.net/10261/235114
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235114
PMID: http://hdl.handle.net/10261/235114
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235114
Ver en: http://hdl.handle.net/10261/235114
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oai:digital.csic.es:10261/235114

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235116
Dataset. 2020

EFFECT OF SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES ON GLUCOSE HOMEOSTASIS ON TYPE 2 DIABETES EXPERIMENTAL MODEL

  • Ali, L. M. A.
  • Shaker, Sara A.
  • Piñol, Rafael
  • Millán, Ángel
  • Hanafy, Mervat Y.
  • Helmy, Madiha H.
  • Kamel, Maher A.
  • Mahmoud, Shimaa A.
The data correspond to figures in the paper by Ali, L.M.A. et al. Life Sciences 245 (2020) 117361. doi:10.1016/j.lfs.2020.117361., European Commission: NanoTBTech - Nanoparticles-based 2D thermal bioimaging technologies (801305) HOTZYMES - Redesigning biocatalysis: Thermal-tuning of one-pot multienzymatic cascades by nanoactuation (829162), Peer reviewed

DOI: http://hdl.handle.net/10261/235116
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235116
HANDLE: http://hdl.handle.net/10261/235116
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235116
PMID: http://hdl.handle.net/10261/235116
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235116
Ver en: http://hdl.handle.net/10261/235116
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oai:digital.csic.es:10261/235116

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235122
Dataset. 2021

CONSERVATION OF AGING AND CANCER EPIGENETIC SIGNATURES ACROSS HUMAN AND MOUSE

  • Pérez, Raúl F.
  • Tejedor, Juan Ramón
  • Santamarina-Ojeda, Pablo
  • López, Virginia
  • Urdinguio, Rocío G.
  • Villamañán, Lucía
  • Candiota, Ana Paula
  • Vidal Sarró, Noemí
  • Barradas, Marta
  • Fernández-Marcos, Pablo José
  • Serrano, Manuel
  • Fernández, Agustín F.
  • Fraga, Mario F.
This dataset contains information related to dataframes, databases, scripts and supplementary material mentioned in the original manuscript., Aging and cancer are two interrelated biological processes, with aging being one of the most important risk factors for the development of cancer. Parallel epigenetic alterations have been described for both, although differences, especially within the DNA hypomethylation scenario, have also been identified in recent literature. While many of these observations arise from the use of mouse models, there is a lack of systematic and single-base resolution comparisons of human and mouse epigenetic patterns in the context of disease. However, such comparisons are especially significant with respect to the DNA methylation alterations found independently in the two species as they allow to establish the extent to which some of the observed similarities or differences arise from pre-existing species-specific epigenetic traits. Here, we have used reduced representation bisulfite sequencing to profile the brain methylomes of young and old, tumoral and non-tumoral brain samples from human and mouse. We first characterized the baseline epigenomic patterns of the species and subsequently focused on the DNA methylation alterations associated with cancer and aging. Next, we described the functional genomic and epigenomic context associated with the alterations, and finally we integrated our data in order to study interspecies DNA methylation levels at specific CpG sites. Globally, we found robust evidence for the conservation of cancer and aging-associated epigenomic patterns in both species, and our observations point towards the preservation of the functional consequences of these alterations at multiple levels of genomic regulation., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/235122
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235122
HANDLE: http://hdl.handle.net/10261/235122
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235122
PMID: http://hdl.handle.net/10261/235122
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235122
Ver en: http://hdl.handle.net/10261/235122
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Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235126
Dataset. 2017

DISTINCT CHROMATIN SIGNATURES OF DNA HYPOMETHYLATION IN AGING AND CANCER (DATASETS AND ADDITIONAL FILES)

  • Pérez, Raúl F.
  • Tejedor, Juan Ramón
  • Bayón, Gustavo F.
  • Fernández, Agustín F.
  • Fraga, Mario F.
Provided datasets correspond to the supplementary material generated for Perez RF et al (2018)., Distinct chromatin signatures of DNA hypomethylation in aging and cancer. Raúl F, Pérez et al. (DOI: 10.1111/acel.12744), Cancer is an aging-associated disease but the underlying molecular links between these processes are still largely unknown. Gene promoters that become hypermethylated in aging and cancer share a common chromatin signature in ES cells. In addition, there is also global DNA hypomethylation in both processes. However, any similarities of the regions where this loss of DNA methylation occurs is currently not well characterized, nor is it known whether such regions also share a common chromatin signature in aging and cancer. To address this issue we analysed TCGA DNA methylation data from a total of 2,311 samples, including control and cancer cases from patients with breast, kidney, thyroid, skin, brain and lung tumors and healthy blood, and integrated the results with histone, chromatin state and transcription factor binding site data from the NIH Roadmap Epigenomics and ENCODE projects. We identified 98,857 CpG sites differentially methylated in aging, and 286,746 in cancer. Hyper- and hypomethylated changes in both processes each had a similar genomic distribution across tissues and displayed tissue-independent alterations. The identified hypermethylated regions in aging and cancer shared a similar bivalent chromatin signature. In contrast, hypomethylated DNA sequences occurred in very different chromatin contexts. DNA hypomethylated sequences were enriched at genomic regions marked with the activating histone posttranslational modification H3K4me1 in aging, whilst in cancer, loss of DNA methylation was primarily associated with the repressive H3K9me3 mark., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/235126
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235126
HANDLE: http://hdl.handle.net/10261/235126
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235126
PMID: http://hdl.handle.net/10261/235126
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235126
Ver en: http://hdl.handle.net/10261/235126
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oai:digital.csic.es:10261/235126

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235128
Dataset. 2020

RADIOMAG INTERLABORATORY COMPARISON OF MAGNETIC HYPERTHERMIA CHARACTERISATION MEASUREMENTS: DATA

  • Wells, J. W.
  • Ortega, Daniel
  • Steinhoff, Uwe
  • Dutz, Silvio
  • Garaio, Eneko
  • Sandre, Olivier
  • Natividad, Eva
  • Cruz, M. M.
  • Brero, Francesca
  • Southern, Paul
  • Pankhurst, Quentin A.
  • Spassov, Simo
These files contain the raw measurement data reported for the Radiomag interlaboratory comparison of magnetic hyperthermia characterisation measurements. Each heating curve for samples containing magnetic nanoparticles is presented in a separate excel file detailing the corrected-slope technique (CST) recalculation of the specific loss power and intrinsic loss power for that measurement as described in the manuscript. The measurements are organised into separate folders for Rounds 1 and 2 of the interlaboratory study, with further subfolders dividing the results for samples 1 and 2. Round 2 also includes the results for the “blank” pure water sample which was included in this Round. For each laboratory there is 3 repeated measurements of each sample during each round the study., This data is based upon work supported by the COST action (RADIOMAG TD1402), supported by COST (European Cooperation in Science and Technology). The financial support of the DFG research grants "quantMPI: Establishment of quantitative Magnetic Particle Imaging (MPI) application oriented phantoms for preclinical investigations" (TR 408/9-1) and "Matrix in Vision" (SFB 1340/1 2018, no 372486779, projects A02 and B02) are also gratefully acknowledged. Additional financial support was received from the Spanish Ministry of Economy and Competitiveness through the grants RED2018-102626-T, MAT2017-85617-R, MAT2017-86826-R and the "Severo Ochoa" Program for Centers of Excellence in R&D (SEV-2016-0686). Additional financial support was received from the Portuguese Foundation for Science and Technology (FCT) under UID/MULTI/04046/2013 (BioISI)., Peer reviewed

DOI: http://hdl.handle.net/10261/235128
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235128
HANDLE: http://hdl.handle.net/10261/235128
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235128
PMID: http://hdl.handle.net/10261/235128
Digital.CSIC. Repositorio Institucional del CSIC
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Ver en: http://hdl.handle.net/10261/235128
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Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235136
Dataset. 2021

TAILORING SUPERCONDUCTIVITY IN LARGE-AREA SINGLE-LAYER NBSE2 VIA SELF-ASSEMBLED MOLECULAR ADLAYERS

  • Calavalle, Francesco
  • Dreher, Paul
  • Surdendran, Ananthu P.
  • Wan, Wen
  • Timpel, Melanie
  • Verucchi, Roberto
  • Rogero, Celia
  • Bauch, Thilo
  • Lombardi, Floriana
  • Casanova, Félix
  • Vittorio Nardi, Marco
  • Ugeda, Miguel M.
  • Hueso, Luis E.
  • Gobbi, Marco
Two-dimensional transition metal dichalcogenides (TMDs) represent an ideal testbench for the search of materials by design, because their optoelectronic properties can be manipulated through surface engineering and molecular functionalization. However, the impact of molecules on intrinsic physical properties of TMDs, such as superconductivity, remains largely unexplored. In this work, the critical temperature (TC) of large-area NbSe2 monolayers is manipulated, employing ultrathin molecular adlayers. Spectroscopic evidence indicates that aligned molecular dipoles within the self-assembled layers act as a fixed gate terminal, collectively generating a macroscopic electrostatic field on NbSe2. This results in an ∼55% increase and a 70% decrease in TC depending on the electric field polarity, which is controlled via molecular selection. The reported functionalization, which improves the air stability of NbSe2, is efficient, practical, up-scalable, and suited to functionalize large-area TMDs. Our results indicate the potential of hybrid 2D materials as a novel platform for tunable superconductivity., This work was supported by the Spanish MICINN under the Maria de Maeztu Units of Excellence Programme (Grant No. MDM-2016-0618), under project Grant Nos. MAT2015-65159-R, RTI2018-094861-B-100, and MAT2017-82071-ERC, and by the European Union H2020 under the Marie Curie Actions (Grant Nos. 794982-2DSTOP and 766025-QuESTech)., Peer reviewed

DOI: http://hdl.handle.net/10261/235136
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235136
HANDLE: http://hdl.handle.net/10261/235136
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235136
PMID: http://hdl.handle.net/10261/235136
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235136
Ver en: http://hdl.handle.net/10261/235136
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oai:digital.csic.es:10261/235136

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235141
Dataset. 2017

EPIGENOME-WIDE ANALYSIS REVEALS SPECIFIC DNA HYPERMETHYLATION OF T CELLS DURING HUMAN HEMATOPOIETIC DIFFERENTIATION

  • Tejedor, Juan Ramón
  • Bueno, Clara
  • Cobo, Isabel
  • Bayón, Gustavo F.
  • Prieto López, Cristina
  • Mangas, Cristina
  • Pérez, Raúl F.
  • Santamarina-Ojeda, Pablo
  • Urdinguio, Rocío G.
  • Menéndez, Pablo
  • Fraga, Mario F.
  • Fernández, Agustín F.
Supplementary figures and supplementary data tables from MethylationEPIC arrays (Tejedor et al), plus a compiled dataset including raw methylation intensities, processed β-values and Phenotypic data from HumanMethylation450 arrays collected from datasets GSE63409, GSE49618, GSE88824 and GSE49031, and HumanMethylationEPIC arrays deposited in E-MTAB-6315 entry from ArrayExpress., Epigenetic regulation plays an important role in cellular development and differentiation. A detailed map of the DNA methylation dynamics that occur during cell differentiation would contribute to decipher the molecular networks governing cell fate commitment. In this study we used the most recent Illumina MethylationEPIC Beadchip platform to describe the genome-wide DNA methylation changes observed throughout hematopoietic maturation by analyzing multiple hematopoietic cell types at different developmental stages., Grants: European Commission: INFANTLEUKEMIA - GENOMIC, CELLULAR AND DEVELOPMENTAL RECONSTRUCTION OFINFANT MLL-AF4+ ACUTE LYMPHOBLASTIC LEUKEMIA (646903)., Peer reviewed

Proyecto: EC/H2020/646903
DOI: http://hdl.handle.net/10261/235141
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235141
HANDLE: http://hdl.handle.net/10261/235141
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235141
PMID: http://hdl.handle.net/10261/235141
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235141
Ver en: http://hdl.handle.net/10261/235141
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oai:digital.csic.es:10261/235141

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235151
Dataset. 2018

CHROMATIN REGULATION BY HISTONE H4 ACETYLATION AT LYSINE 16 DURING CELL DEATH AND DIFFERENTIATION IN THE MYELOID COMPARTMENT

  • Urdinguio, Rocío G.
  • López, Virginia
  • Bayón, Gustavo F.
  • Díaz de la Guardia, Rafael
  • Sierra, Marta I.
  • García-Toraño, Estela
  • Pérez, Raúl F.
  • García, María G.
  • Carella, Antonella
  • Pruneda, Patricia C.
  • Prieto López, Cristina
  • Dmitrijeva, Marija
  • Santamarina-Ojeda, Pablo
  • Belmonte, Thalia
  • Mangas, Cristina
  • Diaconu, Elena
  • Ferrero, Cecilia
  • Tejedor, Juan Ramón
  • Fernández-Morera, Juan L.
  • Bravo, Cristina
  • Bueno, Clara
  • Sanjuan-Pla, Alejandra
  • Rodríguez López, Ramón María
  • Suárez-Álvarez, Beatriz
  • López-Larrea, Carlos
  • Bernal, Teresa
  • Colado, Enrique
  • Balbín, Milagros
  • García-Suarez, Olivia
  • Chiara, María-Dolores
  • Sáenz-de-Santa-María, Inés
  • Rodríguez Hernández, Francisco José
  • Pando-Sandoval, Ana
  • Rodrigo, Luis
  • Santos, Laura
  • Salas, Ana
  • Vallejo-Díaz, Jesús
  • Carrera, Ana C.
  • Rico, Daniel
  • Hernández-López, Inmaculada
  • Vayá, Amparo
  • Ricart, José M.
  • Seto, Edward
  • Sima-Teruel, Núria
  • Vaquero, Alejandro
  • Valledor, Luis
  • Cañal, María Jesús
  • Pisano, David G.
  • Graña-Castro, Osvaldo
  • Thomas, Tim
  • Voss, Anne K.
  • Menéndez, Pablo
  • Villar-Garea, Ana
  • Deutzmann, Rainer
  • Fernández, Agustín F.
  • Fraga, Mario F.
Supplementary data files corresponding to manuscript: Urdinguio, Lopez et al., Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. Here we show that this lysine is massively hyperacetylated in peripheral neutrophils. Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functional experiments, supported a role for this histone post-translational modification in the regulation of cell differentiation and apoptosis in the hematopoietic system. Furthermore, in neutrophils, H4K16ac was enriched at specific DNA repeats. These DNA regions presented an accessible chromatin conformation and were associated with the cleavage sites that generate the 50 kb DNA fragments during the first stages of programmed cell death. Our results thus suggest that H4K16ac plays a dual role in myeloid cells as it not only regulates differentiation and apoptosis, but it also exhibits a non-canonical structural role in poising chromatin for cleavage at an early stage of neutrophil cell death., European Commission: INFANTLEUKEMIA - GENOMIC, CELLULAR AND DEVELOPMENTAL RECONSTRUCTION OFINFANT MLL-AF4+ ACUTE LYMPHOBLASTIC LEUKEMIA (646903), Peer reviewed

Proyecto: EC/H2020/646903
DOI: http://hdl.handle.net/10261/235151
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235151
HANDLE: http://hdl.handle.net/10261/235151
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235151
PMID: http://hdl.handle.net/10261/235151
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235151
Ver en: http://hdl.handle.net/10261/235151
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oai:digital.csic.es:10261/235151

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235497
Dataset. 2021

CHARACTERIZATION OF A LOW-COST FPGA-BASED TIME-TO-DIGITAL CONVERTER WITH MAXIMIZED READOUT SPEED

  • Parsakordasiabi, Mojtaba
  • Vornicu, Ion
  • Rodríguez-Vázquez, Ángel
  • Carmona-Galán, R.
This dataset reports the specifications of a low-cost FPGA-based TDC whose readout speed is maximized. The evaluated TDC is composed of a toggling input stage to shape the hit signal and maximize the readout speed, a coarse counter to count the number of clocks between start and stop signals, a tuned tapped delay line to achieve high resolution, a dual-mode counter-based encoder to convert the output of the delay line to a binary number, a controller to determine the encoding mode, and a bin-width calibration to improve the TDC performance. To measure the exact bin widths and calculate the DNL and INL of the TDC, the code density test that is a statistical estimation approach, is hired., This dataset includes: (i) code density test results obtained from 116272 collected samples; (ii) Differential and integral nonlinearities (DNL and INL) of uncalibrated and calibrated outputs calculated from estimated widths of delay elements; and (iii) Graphs of measured bin widths, bin width distribution, comparison of ideal, uncalibrated, and calibrated transfer functions, uncalibrated DNL and INL, and calibrated DNL and INL., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/235497
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235497
HANDLE: http://hdl.handle.net/10261/235497
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235497
PMID: http://hdl.handle.net/10261/235497
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/235497
Ver en: http://hdl.handle.net/10261/235497
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