Resultados totales (Incluyendo duplicados): 35619
Encontrada(s) 3562 página(s)
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135143
Dataset. 2023

FAIR DATA FOR COMPOUNDS INCLUDED IN THE ARTICLE "REACTIVITY OF GLUTACONAMIDES WITHIN [2]ROTAXANES: MECHANICAL BOND CONTROLLED CHEMOSELECTIVE SYNTHESIS OF HIGHLY REACTIVE Α-KETOAMIDES AND THEIR LIGHT-TRIGGERED CYCLIZATION" ANGEW. CHEM. INT. ED. 2023, E202302681

  • Perez, Jesus de Maria
  • Alajarin, Mateo
  • Martinez-Cuezva, Alberto
  • Berna, Jose

Proyecto: //
DOI: http://hdl.handle.net/10201/135143
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135143
HANDLE: http://hdl.handle.net/10201/135143
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135143
PMID: http://hdl.handle.net/10201/135143
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135143
Ver en: http://hdl.handle.net/10201/135143
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135143

DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135164
Dataset. 2023

FAIR DATA FOR COMPUNDS INCLUDED IN THE ARTICLE "CONTROL OF THE ASSEMBLY OF A CYCLIC HETERO[4]PSEUDOROTAXANE FROM A SELF-COMPLEMENTARY [2]ROTAXANE"

  • Saura-Sanmartin, Adrian
  • Nicolas-Garcia, Tomas
  • Pastor, Aurelia
  • Quiñonero, David
  • Alajarin, Mateo
  • Martinez-Cuezva, Alberto
  • Berna, Jose

Proyecto: //
DOI: http://hdl.handle.net/10201/135164
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135164
HANDLE: http://hdl.handle.net/10201/135164
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135164
PMID: http://hdl.handle.net/10201/135164
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135164
Ver en: http://hdl.handle.net/10201/135164
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135164

DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/131523
Dataset. 2023

EFFECT OF SILK FIBROIN MICROPARTICLES ON CELLULAR IMMUNITY AND LIVER OF GILTHEAD SEABREAM (SPARUS AURATA L.) WITH AND WITHOUT EXPERIMENTAL SKIN INJURIES

  • Albaladejo-Riad, Nora
  • Espinosa-Ruiz, Cristóbal
  • Esteban Abad, María Ángeles
Silk fibroin microparticles (SF) were administered in the diet of gilthead seabream with or without experimental skin wounds to study the effects on cellular immunity and liver. A commercial diet was enriched with different SF contents: 0, 50 and 100 mg kg-1 (control, SF50 and SF100 diet, respectively). The animals were fed for 30 days and half of them were sampled. Similar experimental wounds were then performed to the rest of fish and they continued to be fed the same diet. At 7 days post-wounding, samples were taken from the wounded fish. Cellular immunity was studied on head kidney leucocytes (phagocytosis, respiratory and peroxidase content) and liver status (histological study and gene expression) were studied. Our results showed that experimental wounds affect both cellular immunity (by decreasing leucocyte respiratory burst and peroxidase activity) and altered liver histology (by inducing vascularization and congestion of blood vessels). In addition, it affects the expression of genes indicative of oxidative stress, endoplasmic reticulum stress and apoptosis. More specifically, it was the highest dose of silk fibroin (SF100) that significantly increased the phagocytic capacity of leucocytes as well as vascularization in the liver. In addition, increased expression of antioxidant genes (cat and gsr) and decreased expression of genes related to reticulum endoplasmic stress (grp94 and grp170) and apoptosis (nos and jnk) were detected in these fish fed with SF100 and wounded. In conclusion, fed fish with SF100 had many beneficial effects as cellular immunostimulant and hepatoprotection in wounded fish. Its use could be of great interest for stress management in farmed fish conditions.

Proyecto: //
DOI: http://hdl.handle.net/10201/131523
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/131523
HANDLE: http://hdl.handle.net/10201/131523
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/131523
PMID: http://hdl.handle.net/10201/131523
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/131523
Ver en: http://hdl.handle.net/10201/131523
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/131523

DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/131623
Dataset. 2023

USE OF CARRAGEENAN IN THE SCREENING OF NATURAL ANTI-INFLAMMATORY MOLECULES IN FISH: IN VITRO EFFECTS OF CHILIADENUS GLUTINOSUS EXTRACTS

  • Campos-Sánchez, Jose Carlos
  • Guardiola, Francisco A.
  • Esteban, María Ángeles
Carrageenan, a high molecular weight sulphated polysaccharide, has been used in the screening of anti-inflammatory molecules in mammals. In this sense, Chiliadenus glutinosus (L.) Fourr., an endemic species of plant has been reported in the Spanish popular medicine due to their anti-inflammatory properties in humans. However, their properties have poorly been studied in fish. In this assay, different concentrations (0, 0.001, 0.01, 0.125, 0.25, 0.5 and 1 mg mL-1) of aqueous, ethanolic and methanolic extracts of this plant were elaborated, and the antioxidant, bactericidal (against four marine fish pathogen) and cytotoxic activity, as well as several immunological parameters in head-kidney leucocytes (HKLs) of gilthead seabream (Sparus aurata) were evaluated in a first experiment to determinate the extract with the best properties. Our results showed a dose-dependent antioxidant activity of each plant extract increasing with the concentration, a species- and extract-specific bactericidal activity, as well as a cytotoxic activity against the PLHC1 tumour cell line by the ethanolic and methanolic extracts. However, taking into account the cytotoxic effects of these two extracts on HKLs and the strong immunosuppressive effects on the immunological parameters assayed (peroxidase, respiratory burst activity and phagocytic capacity), a second experiment was developed by using only adjusted doses of the aqueous extract (0, 0.25 and 0.5 mg mL-1), in which immune parameters, cell morphology and inflammatory-related genes were studied in HKLs stimulated with λ-carrageenan. The present results offer a detailed view of the biological effects of C. glutinosus extracts, which could be interesting to the aquaculture sector due to their possible anti-inflammatory effects.

Proyecto: //
DOI: http://hdl.handle.net/10201/131623
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/131623
HANDLE: http://hdl.handle.net/10201/131623
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/131623
PMID: http://hdl.handle.net/10201/131623
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/131623
Ver en: http://hdl.handle.net/10201/131623
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/131623

DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/132143
Dataset. 2023

DATA OF THE WORK ENTITLED: ABILITY OF SHORT-CHAIN FATTY ACIDS TO REDUCE INFLAMMATION AND ATTRACT LEUCOCYTES TO THE INFLAMED SKIN OF GILTHEAD SEABREAM (SPARUS AURATA L.)

  • Albaladejo-Riad, Nora
  • El qendouci, Mouna
  • Cuesta, Alberto
  • Esteban, Mª Ángeles

Proyecto: //
DOI: http://hdl.handle.net/10201/132143
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/132143
HANDLE: http://hdl.handle.net/10201/132143
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/132143
PMID: http://hdl.handle.net/10201/132143
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/132143
Ver en: http://hdl.handle.net/10201/132143
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/132143

DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/132703
Dataset. 2023

GENE EXPRESSION RAW DATA OF THE WORK ENTITLLED: "EVOLUTION OF A GILTHEAD SEA BREAM (SPARUS AURATA L.) CAUDAL FIN SKIN EXPLANT"

  • Albaladejo-Riad, Nora
  • Esteban Abad, María Ángeles
  • Cuesta, Alberto
  • García-Álvarez, Miguel Ángel
  • Marín-Parra, Claudia

Proyecto: //
DOI: http://hdl.handle.net/10201/132703
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/132703
HANDLE: http://hdl.handle.net/10201/132703
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/132703
PMID: http://hdl.handle.net/10201/132703
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/132703
Ver en: http://hdl.handle.net/10201/132703
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/132703

DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/133203
Dataset. 2023

EXPERIMENTAL STUDY DESIGN: GENE SILENCING MODEL USING SIRNAS IN MICE WITH CARDIOTOXICITY.

  • Lax Pérez, Antonio Manuel
  • Asensio López, Maria del Carmen
Se adjunta esquema del procedimiento experimental tipo para estudiar el efecto del silenciamiento génico mediante siRNAs en modelo animal con Cardiotoxicidad basada en el uso de antraciclinas.

Proyecto: //
DOI: http://hdl.handle.net/10201/133203
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/133203
HANDLE: http://hdl.handle.net/10201/133203
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/133203
PMID: http://hdl.handle.net/10201/133203
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/133203
Ver en: http://hdl.handle.net/10201/133203
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/133203

DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/133205
Dataset. 2023

SOLUBLE SST2 ISOFORM IS RELATED TO CARDIOTOXICITY

  • Lax Pérez, Antonio Manuel
  • Asensio López, Maria del Carmen
Soluble sST2 isoform is related to cardiotoxicity. Led by the Lax´s team, preliminary data have identified for first time a relationship between higher sST2 levels and YY1 with CIC, using an in vitro translational model

Proyecto: //
DOI: http://hdl.handle.net/10201/133205
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/133205
HANDLE: http://hdl.handle.net/10201/133205
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/133205
PMID: http://hdl.handle.net/10201/133205
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/133205
Ver en: http://hdl.handle.net/10201/133205
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/133205

DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135930
Dataset. 2023

IN VITRO IMMUNE-DEPRESSION AND ANTI-INFLAMMATORY ACTIVITIES OF CANTHARIDIN ON GILTHEAD SEABREAM (SPARUS AURATA) LEUCOCYTES ACTIVATED BY Λ-CARRAGEENAN

  • Campos-Sánchez, Jose Carlos
  • Guardiola, Francisco A.
  • Esteban, María Ángeles
Cantharidin is a natural compound with known therapeutic applications in humans. However, its properties have hardly been studied in fish. The aim of this study was to investigate the in vitro effects of cantharidin on gilthead seabream (Sparus aurata) head kidney leucocytes (HKL) stimulated with λ-carrageenan. Thus, HKLs were incubated for 24 h with cantharidin (0, 2.5 and 5 μg mL-1) and λ-carrageenan (0 and 1,000 μg mL-1) and cell viability and morphology, immunological parameters and several selected genes related to inflammation and apoptosis were evaluated. The results showed that cantharidin only decreased HKL viability when incubated with the highest dose (5 μg mL-1) and in combination with λ-carrageenan. As for the immunological parameters studied, cantharidin increased the peroxidase activity of HKLs only when incubated in combination with λ-carrageenan, but inhibited the respiratory burst and phagocytic activities even after being previously increased by λ-carrageenan. Furthermore, cantharidin induced morphological changes in HKLs with apoptotic and vacuolization signs that were enhanced when incubated in combination with λ-carrageenan. Considering the analysis of gene expression in HKLs, although λ-carrageenan up-regulated the expression of the proinflammatory gene il1b, cantharidin down-regulated its expression in HKLs exposed to both λ-carrageenan and cantharidin. In addition, cantharidin up-regulated casp3 and casp9 expression, which was down-regulated in HKLs incubated with both molecules. This combination also up-regulated casp1 expression. The present results provide detailed insight into the immune-depressive and anti-inflammatory properties of cantharidin on immune cells, which could be of interest to the aquaculture sector.

Proyecto: //
DOI: http://hdl.handle.net/10201/135930
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135930
HANDLE: http://hdl.handle.net/10201/135930
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135930
PMID: http://hdl.handle.net/10201/135930
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135930
Ver en: http://hdl.handle.net/10201/135930
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/135930

DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/138151
Dataset. 2021

CONJUNTO DE DATOS DEL ARTÍCULO ANÁLISIS DOCUMENTAL SOBRE LOS RIESGOS Y LAS POSIBILIDADES DE INTERNET PARA LOS MENORES. PAUTAS EDUCATIVAS DIRIGIDAS A FAMILIAS.

  • López Vicent, Patricia
  • Hernández Prados, María de los Ángeles
  • Gamboa Gil de Sola, Gonzalo
Se trata del conjunto de datos del artículo Análisis documental sobre los riesgos y las posibilidades de internet para los menores. Pautas educativas dirigidas a familias https://doi.org/10.6018/riite.430341, Item en revisión. Pendiente de cumplimentar metadatos.

Proyecto: //
DOI: http://hdl.handle.net/10201/138151
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/138151
HANDLE: http://hdl.handle.net/10201/138151
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/138151
PMID: http://hdl.handle.net/10201/138151
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/138151
Ver en: http://hdl.handle.net/10201/138151
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
oai:digitum.um.es:10201/138151

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