Resultados totales (Incluyendo duplicados): 45302
Encontrada(s) 4531 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311375
Dataset. 2022

IMAGE_2_KNOCK-OUT OF CMNAC-NOR AFFECTS MELON CLIMACTERIC FRUIT RIPENING.TIF

  • Liu, Bin
  • Santo Domingo, Miguel
  • Mayobre, Carlos
  • Martín-Hernández, Ana Montserrat
  • Pujol, Marta
  • García-Mas, Jordi
1 figure., Fruit ripening is an important process that affects fruit quality. A QTL in melon, ETHQV6.3, involved in climacteric ripening regulation, has been found to be encoded by CmNAC-NOR, a homologue of the tomato NOR gene. To further investigate CmNAC-NOR function, we obtained two CRISPR/Cas9-mediated mutants (nor-3 and nor-1) in the climacteric Védrantais background. nor-3, containing a 3-bp deletion altering the NAC domain A, resulted in ~8 days delay in ripening without affecting fruit quality. In contrast, the 1-bp deletion in nor-1 resulted in a fully disrupted NAC domain, which completely blocked climacteric ripening. The nor-1 fruits did not produce ethylene, no abscission layer was formed and there was no external color change. Additionally, volatile components were dramatically altered, seeds were not well developed and flesh firmness was also altered. There was a delay in fruit ripening with the nor-1 allele in heterozygosis of ~20 days. Our results provide new information regarding the function of CmNAC-NOR in melon fruit ripening, suggesting that it is a potential target for modulating shelf life in commercial climacteric melon varieties., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/311375
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311375
HANDLE: http://hdl.handle.net/10261/311375
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311375
PMID: http://hdl.handle.net/10261/311375
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311375
Ver en: http://hdl.handle.net/10261/311375
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311375

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311387
Dataset. 2022

SUPPLEMENTARY FILES OF THE ARTICLE "CRISPR/CAS9‐DIRECTED GENE TRAP CONSTITUTES A SELECTION SYSTEM FOR CORRECTED BCR/ABL LEUKEMIC CELLS IN CML" [DATASET]

  • Vuelta, Elena
  • Ordóñez, José Luis
  • Sanz, David J.
  • Ballesteros, Sandra
  • Hernández, Jesús M.
  • Méndez-Sánchez, Lucía
  • Sánchez-Martín, M.
  • García-Tuñón, Ignacio
The promoter‐less CRISPR‐Trap system efficiently the specific integration of the gene trap donor in BCR/ABL but is not a robust reporter system to select corrected cells. As a first approach, we generate a dsDNA donor by PCR amplification containing a SAT2A‐ Venus interfering cassette (Figure S1A). The K562 cell line was divided into three experimental groups according to the conditions for their subsequent electroporation: a) with the donor dsDNA (donor), b) with the donor DNA and Cas9 nuclease without sgRNA (Cas9 + donor) and c) with the donor DNA, Cas9 nuclease and the specific BCR/ABL sgRNA (CRISPR/Cas9 + donor). Twenty‐four hours after electroporation, no fluorescent cells (Venus + cells) were observed in any of the three groups (Figure S1B). The result of the site‐unspecific PCR (In 5´F/Venus R, Table 1) which amplify a region contained entirely in the donor HDR dsDNA, showed a band of the expected size in the Cas9 + donor and CRISPR/Cas9 + donor groups, but not in the donor group (Figure S1C), implying that all donor HDR dsDNA not integrated in the genome was fully degraded. In contrast, the sitespecific PCR (Out 5´F/Venus R, Table 1) corroborated the correct insertion of the donor HDR dsDNA at the BCR/ABL target sequence only in the CRISPR/Cas9 + donor group, with no sitespecific integration detected in any of the controls (Figure S1C). These results were corroborated by Sanger sequencing of the PCR products, supporting the HDR‐mediated insertion of the donor dsDNA into the CRISPR/Cas9 + donor group., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/311387
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311387
HANDLE: http://hdl.handle.net/10261/311387
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311387
PMID: http://hdl.handle.net/10261/311387
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311387
Ver en: http://hdl.handle.net/10261/311387
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311387

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311433
Dataset. 2022

IMAGE_1_KNOCK-OUT OF CMNAC-NOR AFFECTS MELON CLIMACTERIC FRUIT RIPENING.TIF

  • Liu, Bin
  • Santo Domingo, Miguel
  • Mayobre, Carlos
  • Martín-Hernández, Ana Montserrat
  • Pujol, Marta
  • García-Mas, Jordi
1 figure., Fruit ripening is an important process that affects fruit quality. A QTL in melon, ETHQV6.3, involved in climacteric ripening regulation, has been found to be encoded by CmNAC-NOR, a homologue of the tomato NOR gene. To further investigate CmNAC-NOR function, we obtained two CRISPR/Cas9-mediated mutants (nor-3 and nor-1) in the climacteric Védrantais background. nor-3, containing a 3-bp deletion altering the NAC domain A, resulted in ~8 days delay in ripening without affecting fruit quality. In contrast, the 1-bp deletion in nor-1 resulted in a fully disrupted NAC domain, which completely blocked climacteric ripening. The nor-1 fruits did not produce ethylene, no abscission layer was formed and there was no external color change. Additionally, volatile components were dramatically altered, seeds were not well developed and flesh firmness was also altered. There was a delay in fruit ripening with the nor-1 allele in heterozygosis of ~20 days. Our results provide new information regarding the function of CmNAC-NOR in melon fruit ripening, suggesting that it is a potential target for modulating shelf life in commercial climacteric melon varieties., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/311433
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311433
HANDLE: http://hdl.handle.net/10261/311433
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311433
PMID: http://hdl.handle.net/10261/311433
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311433
Ver en: http://hdl.handle.net/10261/311433
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311433

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311451
Dataset. 2022

DATASHEET1_THE EMERGENCE OF GENOME EDITING—INNOVATION NETWORK DYNAMICS OF ACADEMIC PUBLICATIONS, PATENTS, AND BUSINESS ACTIVITIES.DOCX

  • Laibach, Natalie
  • Bröring, Stefanie
Supplementary Table S1: Databases and corresponding search strings for data retrieval., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/311451
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311451
HANDLE: http://hdl.handle.net/10261/311451
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311451
PMID: http://hdl.handle.net/10261/311451
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311451
Ver en: http://hdl.handle.net/10261/311451
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311451

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311458
Dataset. 2022

TABLE_4_THE LACK OF ALTERNATIVE OXIDASE 1A RESTRICTS IN VIVO RESPIRATORY ACTIVITY AND STRESS-RELATED METABOLISM FOR LEAF OSMOPROTECTION AND REDOX BALANCING UNDER SUDDEN ACUTE WATER AND SALT STRESS IN ARABIDOPSIS THALIANA.DOCX

  • Saz, Néstor F. del
  • Iglesias-Sanchez, Ariadna
  • Alonso-Forn, David
  • López-Gómez, Miguel
  • Palma, Francisco
  • Clemente-Moreno, María José
  • Fernie, Alisdair R.
  • Ribas-Carbó, Miquel
  • Florez-Sarasa, Igor
1 table. -- Supplemental Table 4. Primers used in the qPCR analyses performed in this study., In plants salt and water stress result in an induction of respiration and accumulation of stress-related metabolites (SRMs) with osmoregulation and osmoprotection functions that benefit photosynthesis. The synthesis of SRMs may depend on an active respiratory metabolism, which can be restricted under stress by the inhibition of the cytochrome oxidase pathway (COP), thus causing an increase in the reduction level of the ubiquinone pool. However, the activity of the alternative oxidase pathway (AOP) is thought to prevent this from occurring while at the same time, dissipates excess of reducing power from the chloroplast and thereby improves photosynthetic performance. The present research is based on the hypothesis that the accumulation of SRMs under osmotic stress will be affected by changes in folial AOP activity. To test this, the oxygen isotope-fractionation technique was used to study the in vivo respiratory activities of COP and AOP in leaves of wild-type Arabidopsis thaliana plants and of aox1a mutants under sudden acute stress conditions induced by mannitol and salt treatments. Levels of leaf primary metabolites and transcripts of respiratory-related proteins were also determined in parallel to photosynthetic analyses. The lack of in vivo AOP response in the aox1a mutants coincided with a lower leaf relative water content and a decreased accumulation of crucial osmoregulators. Additionally, levels of oxidative stress-related metabolites and transcripts encoding alternative respiratory components were increased. Coordinated changes in metabolite levels, respiratory activities and photosynthetic performance highlight the contribution of the AOP in providing flexibility to carbon metabolism for the accumulation of SRMs., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/311458
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311458
HANDLE: http://hdl.handle.net/10261/311458
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311458
PMID: http://hdl.handle.net/10261/311458
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311458
Ver en: http://hdl.handle.net/10261/311458
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311458

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311464
Dataset. 2022

TABLE_3_THE LACK OF ALTERNATIVE OXIDASE 1A RESTRICTS IN VIVO RESPIRATORY ACTIVITY AND STRESS-RELATED METABOLISM FOR LEAF OSMOPROTECTION AND REDOX BALANCING UNDER SUDDEN ACUTE WATER AND SALT STRESS IN ARABIDOPSIS THALIANA.DOCX

  • Saz, Néstor F. del
  • Iglesias-Sanchez, Ariadna
  • Alonso-Forn, David
  • López-Gómez, Miguel
  • Palma, Francisco
  • Clemente-Moreno, María José
  • Fernie, Alisdair R.
  • Ribas-Carbó, Miquel
  • Florez-Sarasa, Igor
Supplemental Table 3. Absolute metabolite levels in leaves of WT and AOX1a plants under control conditions and after 1 day of severe (300 mM) NaCl and Mannitol treatments as measured by GC-MS (see material and methods for details). Data is presented as means ± SE for 4 to 6 biological replicates. Bold numbers denote significant differences (P < 0.05) to the control condition in each genotype separately. Asterisks denote significant differences (P < 0.05) between WT and aox1a plants in each experimental condition. †Denotes metabolites detected only in one replicate in WT at control conditions. ‘n.d.’ denotes cases for not detected metabolites., In plants salt and water stress result in an induction of respiration and accumulation of stress-related metabolites (SRMs) with osmoregulation and osmoprotection functions that benefit photosynthesis. The synthesis of SRMs may depend on an active respiratory metabolism, which can be restricted under stress by the inhibition of the cytochrome oxidase pathway (COP), thus causing an increase in the reduction level of the ubiquinone pool. However, the activity of the alternative oxidase pathway (AOP) is thought to prevent this from occurring while at the same time, dissipates excess of reducing power from the chloroplast and thereby improves photosynthetic performance. The present research is based on the hypothesis that the accumulation of SRMs under osmotic stress will be affected by changes in folial AOP activity. To test this, the oxygen isotope-fractionation technique was used to study the in vivo respiratory activities of COP and AOP in leaves of wild-type Arabidopsis thaliana plants and of aox1a mutants under sudden acute stress conditions induced by mannitol and salt treatments. Levels of leaf primary metabolites and transcripts of respiratory-related proteins were also determined in parallel to photosynthetic analyses. The lack of in vivo AOP response in the aox1a mutants coincided with a lower leaf relative water content and a decreased accumulation of crucial osmoregulators. Additionally, levels of oxidative stress-related metabolites and transcripts encoding alternative respiratory components were increased. Coordinated changes in metabolite levels, respiratory activities and photosynthetic performance highlight the contribution of the AOP in providing flexibility to carbon metabolism for the accumulation of SRMs., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/311464
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311464
HANDLE: http://hdl.handle.net/10261/311464
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311464
PMID: http://hdl.handle.net/10261/311464
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311464
Ver en: http://hdl.handle.net/10261/311464
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311464

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311468
Dataset. 2022

SUPPLEMENTARY FILES OF THE ARTICLE &QUOT;DECIPHERING BIOMARKERS FOR LEPTOMENINGEAL METASTASIS IN MALIGNANT HEMOPATHIES (LYMPHOMA/LEUKEMIA) PATIENTS BY COMPREHENSIVE MULTIPRONGED PROTEOMICS CHARACTERIZATION OF CEREBROSPINAL FLUID&QUOT; [DATASET]

  • Juanes-Velasco, Pablo
  • Galicia, N.
  • Pin, Elisa
  • Jara-Acevedo, Ricardo
  • Carabias-Sánchez, Javier
  • García-Valiente, R.
  • Lécrevisse, Quentin
  • Pedreira, C. E.
  • Góngora, Rafael
  • Sanchez-Santos, Jose Manuel
  • Lorenzo-Gil, Héctor
  • Landeira-Viñuela, Alicia
  • Bareke, Halin
  • Orfao, Alberto
  • Nilsson, Peter
  • Fuentes, Manuel
The following are available online at https://www.mdpi.com/article/10.3390/cancers14020449/s1. Supplementary Figures. Figure S1: Distribution of pathological CSF samples (without healthy ones) among each phase of study and the different groups according to the incidence of the pathology, depending on the infiltration (CSF +/− LM) and the primary tumor (hematologic and solid tumor). Figure S2: Quality control images of the planar protein microarrays generated. Figure S3: A quantile normalization in planar protein microarrays. Figure S4: Coomasie gels which indicate protein distribution across samples. Figure S5: Venn diagrams of total identified proteins with LC-MS/MS. Figure S6: Plots showing the functional proteins using the Reactome for different conditions. Figure S7: Differential protein profiles within CSF + LM according to primary tumor (Lymphoma) by protein microarrays. Figure S8: Differential protein profiles within CSF + LM according to primary tumor (Leukemia) by protein microarrays. Figure S9: Differential protein profiles within CSF + LM according to primary tumor (Lymphoma) by affinity proteomics. Figure S10: Differential protein profiles within CSF + LM according to primary tumor (Leukemia) by affinity proteomics. Figure S11: Summary of the multipronged proteomics characterization among the different phases of study. Supplementary Tables. Table S1: Table of clinical-biological characteristics from the whole CSF samples used in the study. Table S2: Antibodies list used in Planar Protein Microarrays. Table S3: Antibodies list used in Beads Suspension Microarrays. Table S4: Protein identification with LC-MS/MS among the different strategies and their emPAI quantification. Table S5: Boxplots of the protein identified in validation and confirmation phases, respectively, comparing the different groups of study. Table S6: Intensity data results from Planar Protein Microarrays. Table S7: Intensity data results from Beads Suspension Microarrays. Table S8: ROC analysis list of potential biomarker panel on CSF +/− LM and the different comparisons by protein arrays and affinity proteomics., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/311468
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311468
HANDLE: http://hdl.handle.net/10261/311468
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311468
PMID: http://hdl.handle.net/10261/311468
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311468
Ver en: http://hdl.handle.net/10261/311468
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311468

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311469
Dataset. 2022

TABLE_2_THE LACK OF ALTERNATIVE OXIDASE 1A RESTRICTS IN VIVO RESPIRATORY ACTIVITY AND STRESS-RELATED METABOLISM FOR LEAF OSMOPROTECTION AND REDOX BALANCING UNDER SUDDEN ACUTE WATER AND SALT STRESS IN ARABIDOPSIS THALIANA.DOCX

  • Saz, Néstor F. del
  • Iglesias-Sanchez, Ariadna
  • Alonso-Forn, David
  • López-Gómez, Miguel
  • Palma, Francisco
  • Clemente-Moreno, María José
  • Fernie, Alisdair R.
  • Ribas-Carbó, Miquel
  • Florez-Sarasa, Igor
1 table. -- Supplemental Table 2. Relative metabolite levels in leaves of WT and aox1a plants under control conditions and after 1 day of severe (300 mM) NaCl and Mannitol treatments as measured by GC-MS (see material and methods for details). Data is presented as means ± SE for 4 to 6 biological replicates normalized to the mean level of the WT plants under control conditions. Bold numbers denote significant differences (P < 0.05) to the control condition in each genotype separately. Asterisks denote significant differences (P < 0.05) between WT and aox1a plants in each experimental condition. †Denotes metabolites detected only in one replicate in WT at control conditions. ‘n.d.’ denotes cases for not detected metabolites., In plants salt and water stress result in an induction of respiration and accumulation of stress-related metabolites (SRMs) with osmoregulation and osmoprotection functions that benefit photosynthesis. The synthesis of SRMs may depend on an active respiratory metabolism, which can be restricted under stress by the inhibition of the cytochrome oxidase pathway (COP), thus causing an increase in the reduction level of the ubiquinone pool. However, the activity of the alternative oxidase pathway (AOP) is thought to prevent this from occurring while at the same time, dissipates excess of reducing power from the chloroplast and thereby improves photosynthetic performance. The present research is based on the hypothesis that the accumulation of SRMs under osmotic stress will be affected by changes in folial AOP activity. To test this, the oxygen isotope-fractionation technique was used to study the in vivo respiratory activities of COP and AOP in leaves of wild-type Arabidopsis thaliana plants and of aox1a mutants under sudden acute stress conditions induced by mannitol and salt treatments. Levels of leaf primary metabolites and transcripts of respiratory-related proteins were also determined in parallel to photosynthetic analyses. The lack of in vivo AOP response in the aox1a mutants coincided with a lower leaf relative water content and a decreased accumulation of crucial osmoregulators. Additionally, levels of oxidative stress-related metabolites and transcripts encoding alternative respiratory components were increased. Coordinated changes in metabolite levels, respiratory activities and photosynthetic performance highlight the contribution of the AOP in providing flexibility to carbon metabolism for the accumulation of SRMs., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/311469
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311469
HANDLE: http://hdl.handle.net/10261/311469
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311469
PMID: http://hdl.handle.net/10261/311469
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311469
Ver en: http://hdl.handle.net/10261/311469
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311469

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311473
Dataset. 2022

SUPPLEMENTARY MATERIAL FROM &QUOT;FLIGHT OR PROTECTION: THE GENES ULTRABITHORAX AND APTEROUS IN THE DETERMINATION OF MEMBRANOUS AND SCLEROTIZED WINGS IN INSECTS&QUOT;

  • Elias-Neto, Moysés
  • Álvarez, Niuska
  • Ventós-Alfonso, Alba
  • Bellés, Xavier
Present-day pterygote insects have two pairs of wings, one in the mesothorax (T2), the other in the metathorax (T3), and both have diverged in structure and function in different groups. Studies in endopterygote and paraneopteran species have shown that the gene Ultrabithorax (Ubx) specifies the identity and wing structure in T3, whereas the gene apterous (ap) significantly contributes to forming modified T2 wings. We wondered whether these Ubx and ap mechanisms operate in the lineage of polyneopterans. To explore this possibility, we used the cockroach Blattella germanica (Polyneoptera and Blattodea), in which the T2 wings are sclerotized (tegmina), whereas those of the T3 are membranous. We found that Ubx determines the structure of T3 and the membranous wing, while ap significantly contributes to form the sclerotized T2 tegmina. These results along with the studies carried out on the beetle Tribolium castaneum by Tomoyasu and collaborators suggest that ap plays an important role in the sclerotization and melanization of the T2 wings in neopteran groups that have sclerotized forewings. In turn, the sclerotizing properties of ap demonstrated in beetles and cockroaches suggest that the origin of this function goes back to the emergence of Neoptera, in the mid Devonian., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/311473
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311473
HANDLE: http://hdl.handle.net/10261/311473
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311473
PMID: http://hdl.handle.net/10261/311473
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311473
Ver en: http://hdl.handle.net/10261/311473
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311473

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311479
Dataset. 2022

TABLE S1;TABLE S2;FIG. S1 FROM FLIGHT OR PROTECTION: THE GENES ULTRABITHORAX AND APTEROUS IN THE DETERMINATION OF MEMBRANOUS AND SCLEROTIZED WINGS IN INSECTS

  • Elias-Neto, Moysés
  • Álvarez, Niuska
  • Ventós-Alfonso, Alba
  • Bellés, Xavier
Primers used to measure transcript levels by qPCR in Blattella germanica tissues and to prepare the dsRNA for RNAi experiments.;Summary of the experiments carried out to study the effects of RNAi targeting Ultrabithorax (Ubx) or apterous-A (ap-A) and apterous-B (ap-B) on wing development in Blattella germanica.;Alignment of the homeodomain of Apterous proteins., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/311479
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311479
HANDLE: http://hdl.handle.net/10261/311479
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311479
PMID: http://hdl.handle.net/10261/311479
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311479
Ver en: http://hdl.handle.net/10261/311479
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311479

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