Resultados totales (Incluyendo duplicados): 33785
Encontrada(s) 3379 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331162
Dataset. 2022

ASSESSMENT OF NEUROPSYCHOLOGICAL FUNCTION IN BRAIN TUMOUR TREATMENT: A COMPARISON OF TRADITIONAL NEUROPSYCHOLOGICAL ASSESSMENT WITH APP-BASED COGNITIVE SCREENING. SUPPLEMENTARY MATERIAL

  • Romero García, Rafael
  • Owen, Mallory
  • McDonald, Alexa
  • Woodberry, Emma
  • Assem, Moataz
  • Coelho, Pedro
  • Morris, Rob C.
  • Price, Stephen J.
  • Santarius, Thomas
  • Suckling, John
  • Manly, Tom
  • Erez, Yaara
  • Hart, Michael G.
Figure S1. Distribution of z-scores for individual items across patients grouped by major domains (i.e., each count represents the score of one item in one of the patients’ assessment) Values less than 0 indicate items where brain tumour patients showed lower performance than healthy controls. Table S1. Individual cognitive tests included in the OCS-Bridge assessment and the traditional neuropsychology battery. Table S2. Combined domains across neuropsychological testing and OCS-Bridge testing. Table S3. OCS-Bridge screening and neuropsychological assessments completed by each participant. Table S4. Average total number of cognitive deficits and standard deviations across patients for each domain and assessment. A positive T value indicates a larger number of deficits detected by traditional neuropsychology compared with OCS-BRIDGE., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331162
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331162
HANDLE: http://hdl.handle.net/10261/331162
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331162
PMID: http://hdl.handle.net/10261/331162
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331162
Ver en: http://hdl.handle.net/10261/331162
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oai:digital.csic.es:10261/331162

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331166
Dataset. 2022

TABLE_1_BIOCHEMICAL FEATURES AND MODULATION OF DIGESTIVE ENZYMES BY ENVIRONMENTAL TEMPERATURE IN THE GREATER AMBERJACK, SERIOLA DUMERILI.DOCX

  • Navarro-Guillén, Carmen
  • Yúfera, Manuel
  • Perera, Erick
1 table. -- Real activity (measured at physiological conditions) and total activity (measured at optimal enzymatic conditions) of the major digestive enzymes in the stomach (pepsin) and pyloric caeca (trypsin, chymotrypsin, leucine aminopeptidase and lipase) of S. dumerili., The study of fish digestive biochemistry is essential to understand factors that affect the net efficiency of food transformation and growth, and therefore aquaculture profitability. The aim of the present study was to assess the activity and functional characteristics of key digestive enzymes in juveniles of greater amberjack (Seriola dumerili), as well as the possible modulation of their relative importance by water temperature. For that, a combination of biochemical assays and substrate-SDS-PAGE were used. Under physiological conditions pepsin activity was negligible. Chymotrypsin was the most active enzyme in the digestive tract of the greater amberjack, while lipase was the enzyme with lower activity, though both enzymes in addition to trypsin were responsive to water temperature as revealed by discriminant analysis. Seriola dumerili showed to have pH-sensitive and, except for chymotrypsin, thermally robust proteases. Inhibition assays showed the major importance of serine proteases and revealed inverse trypsin and chymotrypsin responses to environmental temperature, with higher trypsin contribution in 26°C-fish while higher chymotrypsin contribution in 18°C-fish. Zymograms revealed three isotrypsin and three isochymotrypsin enzymes, with no variation in the presence of particular isoforms among rearing temperatures. However, they confirmed the role of chymotrypsin activity in providing digestive plasticity, with one of the isoforms being more active at lower temperatures. Thus, results indicate that variation in the relative contribution of chymotrypsin isoenzymes to a particular environmental temperature occurs due to different physic-chemical features of isoforms as a source of functional flexibility. This study assessed for the first time the effects of rearing temperature on greater amberjack digestive enzymes, increasing the knowledge on its digestive biochemistry, and aiding in the improvement of management practices for this species industrialization., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331166
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331166
HANDLE: http://hdl.handle.net/10261/331166
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331166
PMID: http://hdl.handle.net/10261/331166
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331166
Ver en: http://hdl.handle.net/10261/331166
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oai:digital.csic.es:10261/331166

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331167
Dataset. 2022

ELECTRONIC SUPPLEMENTARY INFORMATION FOR: STOICHIOMETRIC NETWORK ANALYSIS IN REACTION NETWORKS YIELDING SPONTANEOUS MIRROR SYMMETRY BREAKINGIN PREBIOTIC ATMOSPHERE

  • Bourdon-García, Rubén Danilo
  • Ágreda, Jesús
  • Burgos-Salcedo, Javier
  • Hochberg, David
  • Ribó, Josep M.
  • Bargueño, Pedro
  • Estupiñan Salamanca, Andrés
The extreme currents matrix E and the explicite xtreme currents of KNS-LES, KNSCI and KNSCI-LES models., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331167
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331167
HANDLE: http://hdl.handle.net/10261/331167
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331167
PMID: http://hdl.handle.net/10261/331167
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331167
Ver en: http://hdl.handle.net/10261/331167
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331167

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331170
Dataset. 2022

IMAGE_1_BIOCHEMICAL FEATURES AND MODULATION OF DIGESTIVE ENZYMES BY ENVIRONMENTAL TEMPERATURE IN THE GREATER AMBERJACK, SERIOLA DUMERILI.TIF

  • Navarro-Guillén, Carmen
  • Yúfera, Manuel
  • Perera, Erick
1 figure. -- Effect of Ph on the stability of trypsin (TRY), chymotripsin (CHY), leucine aminopeptidase (LAP), lipase (LIP) and pepsin (PP) activities from pyloric caeca and stomach of S. Dumerili adapted to different rearing temperatures (18, 22 and 26º C)., The study of fish digestive biochemistry is essential to understand factors that affect the net efficiency of food transformation and growth, and therefore aquaculture profitability. The aim of the present study was to assess the activity and functional characteristics of key digestive enzymes in juveniles of greater amberjack (Seriola dumerili), as well as the possible modulation of their relative importance by water temperature. For that, a combination of biochemical assays and substrate-SDS-PAGE were used. Under physiological conditions pepsin activity was negligible. Chymotrypsin was the most active enzyme in the digestive tract of the greater amberjack, while lipase was the enzyme with lower activity, though both enzymes in addition to trypsin were responsive to water temperature as revealed by discriminant analysis. Seriola dumerili showed to have pH-sensitive and, except for chymotrypsin, thermally robust proteases. Inhibition assays showed the major importance of serine proteases and revealed inverse trypsin and chymotrypsin responses to environmental temperature, with higher trypsin contribution in 26°C-fish while higher chymotrypsin contribution in 18°C-fish. Zymograms revealed three isotrypsin and three isochymotrypsin enzymes, with no variation in the presence of particular isoforms among rearing temperatures. However, they confirmed the role of chymotrypsin activity in providing digestive plasticity, with one of the isoforms being more active at lower temperatures. Thus, results indicate that variation in the relative contribution of chymotrypsin isoenzymes to a particular environmental temperature occurs due to different physic-chemical features of isoforms as a source of functional flexibility. This study assessed for the first time the effects of rearing temperature on greater amberjack digestive enzymes, increasing the knowledge on its digestive biochemistry, and aiding in the improvement of management practices for this species industrialization., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331170
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331170
HANDLE: http://hdl.handle.net/10261/331170
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331170
PMID: http://hdl.handle.net/10261/331170
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331170
Ver en: http://hdl.handle.net/10261/331170
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331170

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331172
Dataset. 2022

SUPPLEMENTAL ONLINE CONTENT. ASSOCIATION OF RARE APOE MISSENSE VARIANTS V236E AND R251G WITH RISK OF ALZHEIMER DISEASE

  • Le Guen, Yann
  • Belloy, Michael E
  • Grenier-Boley, Benjamin
  • de Rojas, Itziar
  • Castillo-Morales, Atahualpa
  • Jansen, Iris
  • Nicolas, Aude
  • Bellenguez, Céline
  • Dalmasso, Carolina
  • Küçükali, Fahri
  • Eger, Sarah J
  • Nicolas, Gael
  • Olaso, Robert
  • Papenberg, Goran
  • Parnetti, Lucilla
  • Pasquier, Florence
  • Peters, Oliver
  • Pijnenburg, Yolande A L
  • Popp, Julius
  • Rainero, Innocenzo
  • Ramakers, Inez
  • Riedel-Heller, Steffi
  • Scarmeas, Nikolaos
  • Scheltens, Philip
  • Scherbaum, Norbert
  • Schneider, Anja
  • Seripa, Davide
  • Soininen, Hilkka
  • Solfrizzi, Vincenzo
  • Spalletta, Gianfranco
  • Squassina, Alessio
  • van Swieten, John
  • Tegos, Thomas J
  • Tremolizzo, Lucio
  • Verhey, Frans
  • Vyhnalek, Martin
  • Wiltfang, Jens
  • Boada, Mercè
  • García-González, Pablo
  • Puerta, Raquel
  • Real, Luis Miguel
  • Álvarez, Victoria
  • Bullido, María J.
  • Clarimón, Jordi
  • García-Alberca, José María
  • Mir, Pablo
  • Moreno, Fermín
  • Pastor, Pau
  • Piñol-Ripoll, Gerard
  • Molina-Porcel, Laura
  • Pérez-Tur, Jordi
  • Rodríguez Martínez, Eloy
  • Royo, Jose Luís
  • Sánchez-Valle, Raquel
  • Dichgans, Martin
  • Rujescu, Dan
  • Rasmussen, Katrine Laura
  • Thomassen, Jesper Qvist
  • Deleuze, Jean-François
  • He, Zihuai
  • Napolioni, Valerio
  • Amouyel, Philippe
  • Jessen, Frank
  • Kehoe, Patrick G.
  • van Duijn, Cornelia
  • Tsolaki, Magda
  • Sánchez-Juan, Pascual
  • Sleegers, Kristel
  • Ingelsson, Martin
  • Rossi, Giacomina
  • Hiltunen, Mikko
  • Sims, Rebecca
  • van der Flier, Wiesje M.
  • Ramírez, Alfredo
  • Andreassen, Ole A.
  • Frikke-Schmidt, Ruth
  • Williams, Julie
  • Ruiz, Agustín
  • Lambert, Jean-Charles
  • Greicius, Michael D
  • Arosio, Beatrice
  • Benussi, Luisa
  • Boland, Anne
  • Borroni, Barbara
  • Caffarra, Paolo
  • Daian, Delphine
  • Daniele, Antonio
  • Debette, Stéphanie
  • Dufouil, Carole
  • Düzel, Emrah
  • Galimberti, Daniela
  • Giedraitis, Vilmantas
  • Grimmer, Timo
  • Graff, Caroline
  • Grünblatt, Edna
  • Hanon, Olivier
  • Hausner, Lucrezia
  • Heilmann-Heimbach, Stefanie
  • Holstege, Henne
  • Hort, Jakub
  • Jürgen, Deckert
  • Kuulasmaa, Teemu
  • van der Lugt, Aad
  • Masullo, Carlo
  • Mecocci, Patrizia
  • Mehrabian, Shima
  • de Mendonça, Alexandre
  • Moebus, Susanne
  • Nacmias, Benedetta
eAppendix. Additional acknowledgments eMethods. eFigure 1. Flowchart describing the number of individuals remaining at each filtering steps eFigure 2. V236E and R251G are associated with decreased AD risk across dataset in APOE-stratified sensitivity analyses eFigure 3. APOE ε3/ε3[V236E] individuals have a lower AD risk than APOE ε2/ε3 individuals and APOE ε3/ε4[R251G] have a risk equivalent to ε2/ε3 carriers despite carrying 1 ε4 allele, regardless of the EUR ancestry cutoff for admixed Europeans and Europeans eTable 1. Queried cohort overview to identify admixed and European ancestry individuals in the ADSP discovery and ADGC internal replication eTable 2. Overview of ADSP studies with whole-exome sequencing (WES) and/or whole-genome sequencing (WGS) available at NIAGADS DSS (NG00067) eTable 3. Demographic characteristics of the cohorts queried for discovery and internal replication samples eTable 4. Missense variants on the APOE canonical transcript reported in gnomADv.3.1 eTable 5. Demographic characteristics per cohort in ADSP discovery and ADGC internal replication after ancestry selection, quality control, and duplicates removal eTable 6. APOE missense variants rs769452-C (APOE[L28P]), rs199768005-A (APOE[V236E]), and rs267606661-G (APOE[R251G]) allelic breakdown by APOE main genotype eTable 7. V236E and R251G association in primary and secondary analyses, nonstratified and APOE stratified eTable 8. Nonstratified sensitivity analyses at various European ancestry cutoffs eTable 9. Sensitivity analysis, including all dementia in the CCHS and CGPS data set, slightly strengthens the V236E and R251G associations with decreased AD risk eTable 10. Sensitivity analysis, excluding the UK Biobank proxy-AD phenotype from the meta-analysis, results in slight worsening of the P values of the V236E and R251G associations with decreased AD risk eReferences. Supplemental Online Content: Nonauthor Collaborators., Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331172
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331172
HANDLE: http://hdl.handle.net/10261/331172
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331172
PMID: http://hdl.handle.net/10261/331172
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331172
Ver en: http://hdl.handle.net/10261/331172
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oai:digital.csic.es:10261/331172

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331175
Dataset. 2022

IMAGE_2_BIOCHEMICAL FEATURES AND MODULATION OF DIGESTIVE ENZYMES BY ENVIRONMENTAL TEMPERATURE IN THE GREATER AMBERJACK, SERIOLA DUMERILI.TIF

  • Navarro-Guillén, Carmen
  • Yúfera, Manuel
  • Perera, Erick
1 figure. -- Effect of Ph on the stability of trypsin (TRY), chymotripsin (CHY), leucine aminopeptidase (LAP), lipase (LIP) and pepsin (PP) activities from pyloric caeca and stomach of S. Dumerili adapted to different rearing temperatures (18, 22 and 26º C)., The study of fish digestive biochemistry is essential to understand factors that affect the net efficiency of food transformation and growth, and therefore aquaculture profitability. The aim of the present study was to assess the activity and functional characteristics of key digestive enzymes in juveniles of greater amberjack (Seriola dumerili), as well as the possible modulation of their relative importance by water temperature. For that, a combination of biochemical assays and substrate-SDS-PAGE were used. Under physiological conditions pepsin activity was negligible. Chymotrypsin was the most active enzyme in the digestive tract of the greater amberjack, while lipase was the enzyme with lower activity, though both enzymes in addition to trypsin were responsive to water temperature as revealed by discriminant analysis. Seriola dumerili showed to have pH-sensitive and, except for chymotrypsin, thermally robust proteases. Inhibition assays showed the major importance of serine proteases and revealed inverse trypsin and chymotrypsin responses to environmental temperature, with higher trypsin contribution in 26°C-fish while higher chymotrypsin contribution in 18°C-fish. Zymograms revealed three isotrypsin and three isochymotrypsin enzymes, with no variation in the presence of particular isoforms among rearing temperatures. However, they confirmed the role of chymotrypsin activity in providing digestive plasticity, with one of the isoforms being more active at lower temperatures. Thus, results indicate that variation in the relative contribution of chymotrypsin isoenzymes to a particular environmental temperature occurs due to different physic-chemical features of isoforms as a source of functional flexibility. This study assessed for the first time the effects of rearing temperature on greater amberjack digestive enzymes, increasing the knowledge on its digestive biochemistry, and aiding in the improvement of management practices for this species industrialization., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331175
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331175
HANDLE: http://hdl.handle.net/10261/331175
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331175
PMID: http://hdl.handle.net/10261/331175
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331175
Ver en: http://hdl.handle.net/10261/331175
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oai:digital.csic.es:10261/331175

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331178
Dataset. 2022

IMAGE_3_BIOCHEMICAL FEATURES AND MODULATION OF DIGESTIVE ENZYMES BY ENVIRONMENTAL TEMPERATURE IN THE GREATER AMBERJACK, SERIOLA DUMERILI.TIF

  • Navarro-Guillén, Carmen
  • Yúfera, Manuel
  • Perera, Erick
1 figure. -- 13% substrate SDS-PAGE showing caseinolysc activity bands in pyloric caeca extracts of individual S. dumerili adapted to different rearing temperatures (18, 22 and 26º C). Get incubation temperature 37º C., The study of fish digestive biochemistry is essential to understand factors that affect the net efficiency of food transformation and growth, and therefore aquaculture profitability. The aim of the present study was to assess the activity and functional characteristics of key digestive enzymes in juveniles of greater amberjack (Seriola dumerili), as well as the possible modulation of their relative importance by water temperature. For that, a combination of biochemical assays and substrate-SDS-PAGE were used. Under physiological conditions pepsin activity was negligible. Chymotrypsin was the most active enzyme in the digestive tract of the greater amberjack, while lipase was the enzyme with lower activity, though both enzymes in addition to trypsin were responsive to water temperature as revealed by discriminant analysis. Seriola dumerili showed to have pH-sensitive and, except for chymotrypsin, thermally robust proteases. Inhibition assays showed the major importance of serine proteases and revealed inverse trypsin and chymotrypsin responses to environmental temperature, with higher trypsin contribution in 26°C-fish while higher chymotrypsin contribution in 18°C-fish. Zymograms revealed three isotrypsin and three isochymotrypsin enzymes, with no variation in the presence of particular isoforms among rearing temperatures. However, they confirmed the role of chymotrypsin activity in providing digestive plasticity, with one of the isoforms being more active at lower temperatures. Thus, results indicate that variation in the relative contribution of chymotrypsin isoenzymes to a particular environmental temperature occurs due to different physic-chemical features of isoforms as a source of functional flexibility. This study assessed for the first time the effects of rearing temperature on greater amberjack digestive enzymes, increasing the knowledge on its digestive biochemistry, and aiding in the improvement of management practices for this species industrialization., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331178
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331178
HANDLE: http://hdl.handle.net/10261/331178
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331178
PMID: http://hdl.handle.net/10261/331178
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331178
Ver en: http://hdl.handle.net/10261/331178
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oai:digital.csic.es:10261/331178

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331180
Dataset. 2022

BIOACTIVE PEPTIDES FROM LUPIN (LUPINUS ANGUSTIFOLIUS) PREVENT THE EARLY STAGES OF ATHEROSCLEROSIS IN WESTERN DIET-FED APOE-/- MICE [DATASET]

  • Santos-Sánchez, Guillermo
  • Cruz-Chamorro, Iván
  • Álvarez-Ríos, Ana Isabel
  • Álvarez-Sánchez, Nuria
  • Rodríguez-Ortiz, Beatriz
  • Álvarez-López, Ana Isabel
  • Fernández-Pachón, María Soledad
  • Pedroche, Justo
  • Millán, Francisco
  • Millán-Linares, María del Carmen
  • Lardone, Patricia Judith
  • Bejarano, Ignacio
  • Carrillo-Vico, Antonio
Composition of experimental WD; sensitivity and inter/intra assay precision of the assays used in this study; primer sequences and qPCR conditions; flow cytometry antibodies characteristics; amino acid composition of LPH; raw data of antioxidant parameters; representative standard curve of the antioxidant assays used in this study; body weight monitored over time; and cell proliferation and cell viability., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331180
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331180
HANDLE: http://hdl.handle.net/10261/331180
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331180
PMID: http://hdl.handle.net/10261/331180
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331180
Ver en: http://hdl.handle.net/10261/331180
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oai:digital.csic.es:10261/331180

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331183
Dataset. 2022

SUPPLEMENTARY DATA OF THE ARTICLE ASSESSING THE COLONIZATION BY DAPHNIA MAGNA OF PESTICIDE-DISTURBED HABITATS (CHLORPYRIFOS, TERBUTHYLAZINE AND THEIR MIXTURES) AND THE BEHAVIORAL AND NEUROTOXIC EFFECTS

  • Vera-Herrera, Lucía
  • Araújo, Cristiano V. M.
  • Cordero, Andrea
  • Blasco, Julián
  • Picó, Yolanda
14 pages. -- Supplementary description of methods: 1.1. Chemical analysis of pesticides: extraction procedure and LC-MS/MS analysis; 1.2. Acetylcholinesterase (AChE) activity. -- Table S1. MRM conditions used in UPLC-MS/MS determination of pesticides selected. Two transitions (precursor ion →product ion) of each compound were analyzed. -- Table S2. Ranges of nominal and quantified concentrations in μg/L for the two pesticides used and the metabolite analyzed in the colonization assays. -- Table S3. Results of the Chi-square test to check statistically significant differences between the percentage of colonization achieved by the organisms in each chamber at 48h in the pesticide experiments and the expected value (100%). -- Table S4. Results of the within-group Kruskal-Wallis test to check statistically significant differences between chambers (source of variation) for the percentage of colonization of D. magna achieved at 48h in each pesticide experiment, together with the significant results of the pairwise post hoc test. -- Table S5. Results of the between-group Kruskal-Wallis test to check statistically significant differences between colonization experiments and chambers (sources of variation) for the percentage of colonization of D. magna at 48h, together with the significant results of the pairwise post hoc test. -- Table S6. Mean, standard error (SE), maximum and minimum values obtained for the mobility variables analyzed in D. magna after 48 h of exposure to the different study treatments. -- Table S7. Results of PERMANOVA ONE-WAY test to check statistically significant differences between study treatments for the mobility variables evaluated, together with the significant results of the pairwise post hoc test. -- Table S8. Results of Kruskal-Wallis test to check statistically significant differences between study treatments for the average vertical speed (study variable with non-normal distribution according to Shapiro-Wilk test), together with the significant results of the pairwise post hoc test and Dunn´s multiple comparisons test (specific comparisons with the control treatment). -- Table S9. One-way ANOVA test to check statistically significant differences among treatments for the remaining mobility variables evaluated, together with the significant results of the pairwise post hoc test and Dunnett´s multiple comparisons test (specific comparisons with the control treatment). -- Table S10. Mean, standard error (SE), maximum and minimum values obtained for the AChE activity in D. magna after 48 h of exposure to the different study treatments. -- Table S11. One-way ANOVA test to check statistically significant differences among treatments for the acetylcholinesterase (AChE) activity, together with the significant results of the pairwise post hoc test. -- Fig. S1. HeMHAS – Heterogeneous Multi-Habitat Assay System (version #3) used in the colonization experiments. -- Fig. S2. Detail of one of the compartments of the HeMHAS together with two gates that connect it to the adjacent chambers throughout a rotary locking system. -- Fig. S3. Picture of D. magna individually disposed in four wells of culture plates for analysis of horizontal swimming behavior. -- Fig. S4. Percentage of organisms (A) and colonization response (B) achieved in each chamber in the control test at 48h with ±SE of four replicates. -- Fig. S5. PCA analysis of the responses obtained for the mobility variables analysed in D. magna exposed to the different study treatments., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331183
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331183
HANDLE: http://hdl.handle.net/10261/331183
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331183
PMID: http://hdl.handle.net/10261/331183
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331183
Ver en: http://hdl.handle.net/10261/331183
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331183

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331185
Dataset. 2022

APPENDIX A. SUPPLEMENTARY DATA FOR POISONED CHALICE: USE OF TRANSFORMED LANDSCAPES ASSOCIATED WITH INCREASED PERSISTENT ORGANIC POLLUTANT CONCENTRATIONS AND POTENTIAL IMMUNE EFFECTS FOR AN ADAPTABLE CARNIVORE

  • Leighton, Gabriella R.M.
  • Bishop, Jacqueline M.
  • Camarero, Pablo R.
  • Mateo, Rafael
  • O'Riain, M. Justin
  • Serieys, Laurel E.K.
Table S1 Concentrations (ng/g) of organochlorine compounds in tissue (blood and adipose) of caracals in the Greater Cape Town area, South Africa in terms of wet weight (w.w.) and lipid weight (l.w.). Table S2 Spatial covariates considered for models of organochlorine exposure in caracal in the Greater Cape Town area, South Africa. Fig. S3 Boxplots (diamonds = means) of organochlorine compound concentrations (ng/g, logged) in whole blood and adipose of caracals in the Greater Cape Town area, South Africa. Table S4 Estimates (SE) of top linear mixed effects models (based on AICc) of whole blood organochlorine levels (ng/g, logged) and spatial predictors in caracal in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S5 Estimates (SE) of top linear mixed effects models (based on AICc) of adipose organochlorine levels (ng/g, logged) and spatial predictors in caracal in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S6 Diet proportions in several prey groupings for caracals around Cape Town, South Africa as determined by through integrating diet datasets from scat and prey remains found at GPS clusters. Table S7 Estimates (SE) for top models (based on AICc) of whole blood organochlorine levels (ng/g, logged) and diet (biomass) for broad taxonomic groups for caracals in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S8 Estimates (SE) for top models (based on AICc) of whole blood organochlorine levels (ng/g, logged) and diet (FO) for broad taxonomic groups for caracals in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S9 Estimates (SE) for top models (based on AICc) of whole blood organochlorine levels (ng/g, logged) and diet (biomass) for prey functional groups for caracals in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S10 Estimates (SE) for top models (based on AICc) of whole blood organochlorine levels (ng/g, logged) and diet (FO) for prey functional groups for caracals in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S11 Estimates (SE) for top models (based on AICc) of whole blood organochlorine levels (ng/g, logged) and diet (biomass) for prey foraging habitat for caracals in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S12 Estimates (SE) for top models (based on AICc) of whole blood organochlorine levels (ng/g, logged) and diet (FO) for prey foraging habitat for caracals in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S13 Estimates (SE) for top models (based on AICc) of whole blood organochlorine levels (ng/g, logged) and diet (biomass) for exotic prey groups for caracals in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S14 Estimates (SE) for top models (based on AICc) of whole blood organochlorine levels (ng/g, logged) and diet (FO) for exotic prey groups for caracals in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S15 Estimates (SE) for top models (based on AICc) of whole blood organochlorine levels (ng/g, logged) and blood cell count for caracals in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S16 Estimates (SE) for top models (based on AICc) of whole blood organochlorine levels (ng/g, logged) and serum biochemistry measures for caracals in the Greater Cape Town area, South Africa (*P < 0.1; **P < 0.05; ***P < 0.01). Table S17 Comparison of DDT concentrations (ng/g) ± SE in wild terrestrial mammalian predators from published studies. Where possible, like tissue was compared with like, but where not, serum/plasma was compared with caracal whole blood and liver/kidney was compared with caracal adipose. Table S18 Comparison of PCB concentrations (ng/g) ± SE in wild terrestrial mammalian predators from published studies. Where possible, like tissue was compared with like, but where not, serum/plasma was compared with caracal whole blood and liver/kidney was compared with caracal adipose., Peer reviewed

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DOI: http://hdl.handle.net/10261/331185
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331185
HANDLE: http://hdl.handle.net/10261/331185
Digital.CSIC. Repositorio Institucional del CSIC
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PMID: http://hdl.handle.net/10261/331185
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331185
Ver en: http://hdl.handle.net/10261/331185
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331185

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