BUSCADOR RECOLECTA

Table S1: Serologic results conducted on free-ranging pudu samples collected 2017–2023 in Chile; Table S2: Serum singles samples from captive pudus tested to determine the presence of livestock and zoonotic pathogens antibodies; Table S3: Serum samples from captive pudus tested to determine the presence of livestock and zoonotic pathogens antibodies in different years., Peer reviewed

(DREM³L) Drug REpurposing using Mechanistic Models of signal transduction and Machine Learning, The authors acknowledge Junta de Andalucía for the postdoctoral contract of Carlos Loucera (PAIDI2020- DOC_00350) co-funded by the European Social Fund (FSE) 2014-2020., Peer reviewed

Byte-by-byte Description of file: table1.dat -------------------------------------------------------------------------------- Bytes Format Units Label Explanations -------------------------------------------------------------------------------- 1- 3 I3 --- HCG [1/100] HCG number (Cat. VII/213) 5 I1 --- Nmemb [2/8] Number of galaxies in group 7- 15 F9.5 deg RAdeg Group right ascension (J2000) 17- 25 F9.5 deg DEdeg Group declination (J2000) 27- 31 I5 km/s HRV Group heliocentric radial velocity 33- 35 I3 Mpc Dist [0/160] Group distance (1) 37- 41 A5 --- VLAConfig VLA configuration(s) the group was observed with 43- 46 F4.1 km/s DVChan Channel width of reduced VLA HI observations 48- 51 F4.2 mJy/beam rms RMS noise in reduced VLA HI cube 53- 56 F4.1 arcsec beamMaj Major axis diameter of VLA synthesized beam 58- 61 F4.1 arcsec beamMin Minor axis diameter VLA synthesized beam 63- 66 F4.1 10+19cm-2 NHI 4-sigma HI column density sensitivity (over 20km/s) -------------------------------------------------------------------------------- Note (1): group distance calculated via the Cosmicflows-3 model (Tully et al., 2016AJ....152...50T, Cat. J/AJ/152/50; Kourkchi et al.. 2020AJ....159...67K), which have uncertainties of 3Mpc, -------------------------------------------------------------------------------- Byte-by-byte Description of file: table2.dat -------------------------------------------------------------------------------- Bytes Format Units Label Explanations -------------------------------------------------------------------------------- 1- 3 I3 --- HCG [2/100] HCG number (Cat. VII/213) 5 A1 --- l_logMHI-VLA [<] Upper limit flag for HI mass from VLA 7- 11 F5.2 [Msun] logMHI-VLA Logarithm of total group HI mass from VLA 13- 16 F4.2 [Msun] e_logMHI-VLA ?=- Uncertainty in HI mass from VLA 18- 22 F5.2 [Msun] logMHI-GBT ?=- Logarithm of total group HI mass from GBT observations (Borthakur et al., 2010ApJ...710..385B) 24- 28 F5.2 [Msun] logMHI-pred Logarithm of predicted total group HI mass based on B-band luminosity (Jones et al., 2016MNRAS.457.4393J) 30 A1 --- l_HIdef-VLA [>] Lower limit flag for HI deficiency from the VLA 32- 36 F5.2 --- HIdef-VLA HI deficiency of group from VLA HI mass 38- 42 F5.2 --- HIdef-GBT ?=- HI deficiency of group from GBT HI mass 44- 48 F5.2 [Msun] logMHI-gals ?=- Total HI mass in galaxies (VLA) 50- 53 F4.2 [Msun] logMHI-exfs ?=- Total HI mass in extended features (VLA) 55- 58 F4.2 --- fexfs ?=- Fraction of HI mass in extended features (VLA) 60- 61 A2 --- HIphase HI morphological phase (cf. Verdes-Montenegro et al., 2001A&A...377..812V) -------------------------------------------------------------------------------- Byte-by-byte Description of file: tablec1.dat -------------------------------------------------------------------------------- Bytes Format Units Label Explanations -------------------------------------------------------------------------------- 1- 3 I3 --- HCG [2/100] HCG number (Cat. VII/213) 5- 14 A10 --- Name Galaxy name 16- 24 F9.5 deg RAdeg Galaxy right ascension (J2000) 26- 34 F9.5 deg DEdeg Galaxy declination (J2000) 36- 39 A4 --- MType Galaxy morphological type (Hickson et al., 1989ApJS...70..687H, Cat. VII/213) 41- 49 A9 --- IRclass IR activity classification (Zucker et al., 2016ApJ...821..113Z, Cat. J/ApJ/821/113) 51- 55 I5 km/s HRV Galaxy heliocentric radial velocity (Hickson et al., 1992ApJ...399..353H, Cat. VII/213) 57- 61 F5.2 mag Bmag Galaxy B-band apparent magnitude (Hickson et al., 1989ApJS...70..687H, Cat. VII/213) 63- 66 F4.2 mag e_Bmag Uncertainty in B-band apparent magnitude 68- 72 F5.2 [Msun] logMHI-pred Logarithm of predicted HI mass (Jones et al., 2018A&A...609A..17J, Cat. J/A+A/609/A17) 74- 77 F4.2 [Msun] e_logMHI-pred Uncertainty in predicted HI mass 79- 83 F5.2 [Msun] logMHI ?=- Logarithm of HI mass (VLA) 85- 89 F5.2 --- HIdef ?=- Galaxy HI deficiency (VLA) -------------------------------------------------------------------------------- Byte-by-byte Description of file: list.dat -------------------------------------------------------------------------------- Bytes Format Units Label Explanations -------------------------------------------------------------------------------- 1- 3 I3 --- HCG [2/100] HCG number (Cat. VII/213) 5- 13 F9.5 deg RAdeg Right Ascension of center (J2000) 14- 22 F9.5 deg DEdeg Declination of center (J2000) 24- 27 I4 --- Nx Number of pixels along X-axis 29- 32 I4 --- Ny Number of pixels along Y-axis 34- 36 I3 --- Nz Number of pixels along Z-axis 38- 63 A26 "datime" Obs.date Observation date 65- 75 E11.6 m/s bVRAD Lower value of VRAD interval 77- 87 E11.6 m/s BVRAD Upper value of VRAD interval 89- 96 F8.2 m/s dVRAD VRAD resolution 98-103 I6 Kibyte size Size of FITS file 105-124 A20 --- FileName Name of FITS file, in subdirectory fits 126-149 A24 --- Title Title of the FITS file --------------------------------------------------------------------------------, Hickson compact groups (HCGs) are dense configurations of four to ten galaxies, whose HI morphology appears to follow an evolutionary sequence of three phases, with gas initially confined to galaxies, then significant amounts spread throughout the intra-group medium, and finally with almost no gas remaining in the galaxies themselves. It has also been suggested that several groups may harbour a diffuse HI component that is resolved out by interferometric observations. The HI deficiency of HCGs is expected to increase as the HI morphological phase progresses along the evolutionary sequence. If this is the case, HI deficiency would be a rough proxy for the age and evolutionary state of a HCG. We aim to test this hypothesis for the first time using a large sample of HCGs and to investigate the evidence for diffuse HI in HCGs. We performed a uniform reduction of all publicly available VLA HI observations (38 HCGs) with a purpose-built pipeline that also maximises the reproducibility of this study. The resulting HI data cubes were then analysed with the latest software tools to perform a manual separation of emission features into those belonging to galaxies and those extending into the intra-group medium. We thereby classified the HI morphological phase of each group as well as quantified their HI deficiency compared to galaxies in isolation. We find little evidence that HI deficiency can be used as a proxy for the evolutionary phase of a compact group in either of the first two phases, with the distribution of HI deficiency being consistent in both. However, for the final phase, the distribution clearly shifts to high HI deficiencies, with more than 90% of the expected HI content typically missing. Across all HCGs studied, we identify a few cases where there is strong evidence for a diffuse gas component in the intra-group medium, which might be detectable with improved observations. We also classify a new sub-phase where groups contain a lone HI-bearing galaxy, but are otherwise devoid of gas. The new morphological phase we have identified is likely the result of an evolved, gas-poor group acquiring a new, gas-rich member. The large spread of HI deficiencies in the first two morphological phases suggests that there is a broad range of initial HI content in HCGs, which is perhaps influenced by large-scale environment, and that the timescale for morphological changes is, in general, considerably shorter than the timescale for the destruction or consumption of neutral gas in these systems., Peer reviewed

Figure S1. Identification of flagellaless GR4flaAB-derivative transposants impaired in the response to volatile 2-tridecanone (2-TDC). Figure S2. Multiple sequence alignment by MUSCLE of DnaJ amino acid sequences from different bacterial species Figure S3. Growth of S. meliloti dnaJ mutants and their parental strains on solid and liquid media. Figure S4. Effect of H2O2 on S. meliloti GR4 and GR4flaAB cell survival. Figure S5. Appearance of alfalfa plants inoculated with S. meliloti dnaJ mutant strains at the end of the nodulation kinetics experiment. Figure S6. Complementation of the symbiotic phenotype of S. meliloti dnaJ mutants. Table S1. Bacterial strains and plasmids used in this study. Table S2. List of primers used in this study, Peer reviewed

S1 Table. List of primers employed by SybrGreen for real-time PCR., Peer reviewed

S2 Table. Kinases employed in this study., Cellular senescence and low-grade inflammation favor the acceleration of aging. The liver is an essential metabolic organ because changes related to its function are related to age-related diseases. The objective of this study was to evaluate the effects of maraviroc (MVC) and/or rapamycin (RAPA) on liver tissue in an experimental model of frailty syndrome in mice, since MVC and RAPA are two molecules able to decrease CCR5 expression, which is overexpressed in patients with frailty. Methods: Eighty male homozygous IL10KO mice were randomly assigned to one of 4 groups (n = 20): i) IL10KO group; ii) MVC group, iii) RAPA group, and iv) MVC-RAPA group. Liver samples were analyzed. Gene expression quantification and western blotting were also performed. The proinflammatory cytokines IL-6 and IL-18 were decreased in MVC and MVC/RAPA groups, IL-12 was decreased in RAPA and MVC/RAPA groups and TNF-α was decreased in all therapeutic groups. P21 was decreased in RAPA and MVC/RAPA groups, Galactosidase beta-1, was also significantly reduced in all therapeutic groups, as were NF-kB1, NF-kB2 and STAT3. In all groups, mTOR and CCL5 were significantly reduced. CCR5 expression was decreased in the MVC and MVC/RAPA groups. Conclusion: MVC and RAPA may protect against some factors involved in liver aging. More studies will be necessary to verify their clinical applications., Peer reviewed

S1 Fig. Original blots of the western blot analysis of Fig 3., Peer reviewed

Data_files_1: Final data frames containing 111 records with information on the individual ID of the birds (id), the aviary where they stayed during the experiment (aviary), and their corresponding sex (sex), reproductive status: bred vs not bred (reproductive), body weight before releasing in the aviaries ingrams (body.mass), malondialdehyde acid values in uM (mda), identification of laboratory analysis session (mda.lab.session), glutathione values in mM (glutathione), identification of laboratory analysis session (glutathione.lab.session), telomere length values in T/S ratio (telomere.length), strength of the pair relationship log transformed (pair.bond.strength.log), strength of the relationship with non-pair members log transformed (Non.pair.sociability.log), and strength of the relationships with all individuals in the avirary (overall.sociability.log). (Romero-Haro et al individuals ddbb.xlsx). This data was used for the analysis at the individual level to run the two linear mixed-effect models (one for males and one for females) that include pre-breeding pair bond strength the response variable, and the physiological variables (MDA, glutathione, and telomere length) as predictor variables. Data_files_2: Final data frames containing50 records with information on the individual ID of the females (female.ID) and the males (male.ID), the aviary where they stayed during the experiment (aviary), malondialdehyde acid values in uM for females (female.oxidative.damage.mda) and males (male.oxidative.damage.mda), identification of laboratory analysis session for the female (female.mda.session) and the male (male.mda.session) sample, glutathione values in mM for the female (female.glutathione) and the male (male.glutathione), identification of laboratory analysis session for the female (female.glutathione.session) and the male (male.glutatione.session), telomere length values in T/S ratio for the female (female.telomere.length) and the male (male.telomere.length), latency to breed in days (latency.to.breed), strength of the pair relationship log transformed (pair.bond.strength.log), strength of the relationship with non-pair members log transformed for the female (non.pair.sociability.female.log) and the males (non.pair.sociability.male.log) (Romero-Haro et al pair ddbb.xlsx). This data was used to run the analysis at the dyadic level on assortative mating and the pair-focused linear mixed-effects model that includes the bond strength of the pair as the response variable, and the levels of oxidative damage of the female and the male of the pair, and their interaction, as predictor variables., Peer reviewed

Appendix of Emerging Microbes & Infections 13: 2295389 (2024), Rat hepatitis E virus (ratHEV; species Rocahepevirus ratti) is considered a newly emerging cause of acute hepatitis of zoonotic origin. ratHEV infection of people living with HIV (PLWH) might portend a worse, as with hepatitis E virus (HEV; species Paslahepevirus balayani), and consequently this group may constitute a high-risk population. We aimed to evaluate the prevalence of ratHEV by measuring viral RNA and specific IgG antibodies in a large Spanish cohort of PLWH. Multicentre study conducted in Spain evaluating PLWHIV included in the Spanish AIDS Research Network (CoRIS). Patients were evaluated for ratHEV infection using PCR at baseline and anti-ratHEV IgG by dot blot analysis to evaluate exposure to ratHEV strains. Patients with detectable ratHEV RNA were followed-up to evaluate persistence of viremia and IgG seroconversion. Eight-hundred and forty-two individuals were tested. A total of 9 individuals showed specific IgG antibodies against ratHEV, supposing a prevalence of 1.1 (95% CI; 0.5%−2.1%). Of these, only one was reactive to HEV IgG antibodies by ELISA. One sample was positive for ratHEV RNA (prevalence of infection: 0.1%; 95% CI: 0.08%−0.7%). The case was a man who had sex with men exhibiting a slightly increased alanine transaminase level (49 IU/L) as only biochemical alteration. In the follow-up, the patients showed undetectable ratHEV RNA and seroconversion to specific ratHEV IgG antibodies. Our study shows that ratHEV is geographical broadly distributed in Spain, representing a potential zoonotic threat., This work was supported by the Andalusian General Secretariat for Research, Development, and Innovation in Health (PI-0287-2019), the Spanish Ministry of Health (RD12/0017/0012), co-financed by European Regional Development Fund (ERDF), and the Carlos III Health Institute (Research Project grant numbers: PI21/00793 and PI22/01098). Projects “PI21/00793” and “PI22/01098” were funded by Carlos III Health Institute (ISCIII) and co-funded by the European Union. ARJ is the recipient of a “Miguel Servet” Research Contract by the Spanish Ministry of Sciences (CP18/00111). JCG is supported by the CIBERINFEC (CB21/13/00083), Carlos III Health Institute, Spanish Ministry os Science and NextGenerationEU. MCJ is the recipient of a PFIS predoctoral grant (FI22/00180) from the Carlos III Health Institute and co-funded by the European Union. DCM is the recipient of a “Rio-Hortega” (CM22/00176) grant from the Carlos III Health Institute and co-funded by the European Union. PLL is the recipient of a “Margarita Salas” contract funded by NextGeneration EU. TGG is recipient of a “Ramon y Cajal” contract funded by MCIN/AEI/10.13039/501100011033 and NextGeneration EU/PRTR. The laboratory of R.G.U. is supported by DZIF Thematic Translational Unit (TTU) “Emerging Infections” (grant number 01.808; awarded to R.G.U.). The HIV BioBank is supported by Carlos III Health Institute (PT20/00138) and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN (CB22/01/00041). CoRIS cohort is supported by CIBER (CB21/13/00091), Carlos III Health Institute, Spanish Ministry of Sciences NextGenerationEU., Peer reviewed

Data from the paper "Optimization of the baiting strategy for the administration of oral vaccines to wild boar". These data are from experiments done in field work based on the baiting preference of different animal species., Peer reviewed