BUSCADOR RECOLECTA

Figure S1. Representative standard curve of the Melatonin (A) and 6-SMT (B) assays. Figure S2. Representative standard curve of the antioxidative assays used in this study (TAC, FRAP, ORAC)., Peer reviewed

Classification probabilities obtained for the Dark Energy Survey 5-year photometrically identified SN Ia. Probabilities were obtained with SuperNNova (Möller et al. 2020) using multi-band light-curves and host galaxy redshifts. The classification models were trained to disentangle type Ia vs. non Ia supernovae., Peer reviewed

Supplementary material to DESI's publication "The DESI N-body Simulation Project II: Suppressing Sample Variance with Fast Simulations" to comply with the data management plan., We collect all the data and code needed to produce the figures in the paper. The data set mainly consists of halo two-point correlation function (CF), power spectra (Pk) and bispectra (Bk) from the AbacusSummit and FastPM simulations. For Pk, we include results from the base cosmology (c000), the secondary cosmology c002 and c004, respectively. For Pk and CF, we separate results with different halo mass cut 10^11 and 10^13 Msun/h. We provide python jupyter notebooks for the plotting routines. The subfolder "output" in each directory contains all the necessary data for the plots., ZD and YY were supported by the National Key Basic Research and Development Program of China (No. 2018YFA0404504) and the National Science Foundation of China (grant Nos. 11621303, 1189069, 111773048)., Peer reviewed

1-Supplemental Materials and Methods. 2- Supplemental e-FIGURES. Figure I: Workflow for CpG-sites and sample QCs. Figure II: Batch effect evaluation with MDS and SVD plots. Figure III: Manhattan plots for DMCT. Figure IV: cg00039070 methylation correlation between blood and brain. Figure V: Blood–Brain Epigenetic Concordance (BECon) results for cg00039070. 3- Supplemental e-TABLES. Table I: Analysis of variables associated with ∆NIHSS in bivariate and regression analysis. Table II: Analysis of variables associated with mRS at 3 months in bivariate and regression analysis. Table III: Summary statistics for the discovery EWAS adjusted by batch. Table IV: Feature enrichment analysis. Table V: Differentially methylated region (DMR) results. Table VI: Differentially methylated block (DMB) results. Table VII: EWAS summary statistics in the meta-analyses for dichotomic ∆NIHSS. Table VIII: Demographic and clinical data for the subjects included in the analysis with SOMAscan. Table IX: eFORGE analysis. 4- Supplemental References., Boehringer Ingelheim España Instituto de Salud Carlos III Agència de Gestió d'Ajuts Universitaris i de Recerca FUNDACIÓ DOCÈNCIA I RECERCA MÚTUATERRASSA Bristol-Myers Squibb Eranet-Neuron Fundació la Marató de TV3., Peer reviewed

Antibiotic usage in this study (GTI1503) was within the range reported for other subcutaneous immune globulin products approved for primary immunodeficiency syndromes in Europe and North America, as shown in the table below. Days of Antibiotic Use Per Subject-Year for Subcutaneous Immune Globulins., Peer reviewed

Additional file 1: Fig. S1. Validation of the pMLKL immunoreactivity by DAB staining. Representative micrographs of hippocampal brain areas of AD patients (n = 3) immunostained with anti-pMLKL antibody. Orange arrows indicate pMLKL-positive neurons, and green arrows show pMLKL-positive microglia. Magnification, 20X., Fondecyt, FONDAP, ISCIII, CIBERNED, Junta de Andalucia Consejería de Economía y Conocimiento, MICIN Ramon y Cajal Program National Institutes of Health., Peer reviewed

Additional file 2: Fig. S2. Coefficient of variation of the dot-blot assays. The coefficient of variation (CV) was calculated using triplicates of Braak V-VI samples. A CV of 11.63% and 15.06% was determined for OC and A11, respectively., Fondecyt FONDAP ISCIII CIBERNED Junta de Andalucia Consejería de Economía y Conocimiento MICIN Ramon y Cajal Program National Institutes of Health., Peer reviewed

Additional file 3: Fig. S3. Validation of the pMLKL antibody and assessment of cell specificity. Representative micrographs of (A) the dentate gyrus (DG) and (B) CA1 brain regions from wild-type and MLKL knockout mice subjected to intracerebral injection of Aβo, immunostained with anti-pMLKL antibody (scale bar, DG: 100 μm, CA1: 150 μm). (C, D) Representative images of the hilus of wild-type mice treated with Aβo, labeled with the indicated antibodies (scale bar, 50 μm and 25 μm for magnifications)., Fondecyt FONDAP ISCIII CIBERNED Junta de Andalucia Consejería de Economía y Conocimiento MICIN Ramon y Cajal Program National Institutes of Health., Peer reviewed

Additional file 4: Fig. S4. Intracerebral administration of Aβo elicits neurodegeneration in wild-type mice. Representative micrographs of brain sections from wild-type mice treated as indicated in the images, stained with Fluoro-Jade C (scale bar, 150 μm)., Fondecyt FONDAP ISCIII CIBERNED Junta de Andalucia Consejería de Economía y Conocimiento MICIN Ramon y Cajal Program National Institutes of Health., Peer reviewed

Additional file 5: Fig. S5. MLKL inhibition attenuates Aβo-induced microgliosis in mice. (A, B) Representative micrographs and quantitative analysis of brain sections from wild-type and Mlkl knockout mice treated as indicated in the images, immunostained with anti-Iba1 antibody (scale bar, 200 μm). The data are presented as mean ± S.E.M. and were analyzed by one-way ANOVA followed by Bonferroni post-test. *p < 0.05., Fondecyt FONDAP ISCIII CIBERNED Junta de Andalucia Consejería de Economía y Conocimiento MICIN Ramon y Cajal Program National Institutes of Health., Peer reviewed