BUSCADOR RECOLECTA

Cuadro de gran tamaño con una escena de la batalla de Clavijo. Tiene dos inscripciones: una (Inscripción 2) en el extremo inferior, en latín, con el pasaje de Josué 10:12-13, referido a la batalla de Israel contra los amorreos: el sol y la luna se detuvieron hasta que Israel se vengó de sus enemigos. Situación parecida, según la leyenda, se dio en la batalla de Clavijo, que es la que se representa en esta escena. La Virgen escuchó la súplica de los cristianos y detuvo por unas horas el Sol, consiguiendo con ello los cristianos ganar la batalla a los moros. Ésta es, precisamente, la otra inscripción (Inscripción 1) que encontramos en el cuadro, en una filacteria que ocupa el centro de la escena. En algunos lugares, se venera a la Virgen de Tentudía el mismo día que el apóstol Santiago. El cuadro se encuentra en la nave de la iglesia del Convento, en el lado de la epístola., CSIC. Proyecto intramural: “Epigrafía latina inédita de los siglos XV al XVIII en monumentos civiles y eclesiásticos de la provincia de Cuenca (2006-2007). Referencia: 2006 | 0| 011., Peer reviewed

Inscripción que forma parte de un escudo situado sobre el arco de la "Puerta del Agua". Únicamente contiene una fecha., CSIC. Proyecto intramural: “Epigrafía latina inédita de los siglos XV al XVIII en monumentos civiles y eclesiásticos de la provincia de Cuenca (2006-2007). Referencia: 2006 | 0| 011., Peer reviewed

Las inscripciones se encuentran en el lado interior de las dos puertas del relicario, que el Catálogo monumental de la Diócesis de Cuenca (p. 339) describe del siguiente modo: "En el Presbiterio, en su lado Norte, hay una alacena con doble puerta con versículos de la Sagrada Escritura alusivos a las reliquias, como marco de la misma, columnas y frontón de perfecta traza renacentista, pero de yeso". Son cuatro en letra negra sobre fondo blanco con algunos roleos como adorno en la parte inferior: puerta izquierda (A y B), y puerta derecha (C y D). Los textos en latín están tomados de la Biblia, de Salmos (A y B) y del Evangelio de Lucas (C y D). Inéditas., CSIC. Proyecto intramural: “Epigrafía latina inédita de los siglos XV al XVIII en monumentos civiles y eclesiásticos de la provincia de Cuenca (2006-2007). Referencia: 2006 | 0| 011., Peer reviewed

4 pages. -- Supplementary Figure 1. -- Supplementary Figure 2. -- Supplementary Figure 3. -- Supplementary Figure 4., Peer reviewed

27 pages. -- Content: SM 1.1. Reagents and stock solutions. -- SM 1.2. Samples processing and fogging treatment. -- SM 2. Laser treatment optimization on the graphene oxide film. -- SM 3. Optimization of the MNPs@rGO film fabrication. -- SM 4. Supplementary figures. -- SM 5. Supplementary tables. -- SM 6. Supplementary video, The combination of two-dimensional materials and metal nanoparticles (MNPs) allows the fabrication of novel nanocomposites with unique physical/chemical properties exploitable in high-performance smart devices and biosensing strategies. Current methods to obtain graphene-based films decorated with noble MNPs are cumbersome, poorly reproducible, and difficult to scale up. Herein, we propose a straightforward, versatile, surfactant-free, and single-step technique to produce reduced graphene oxide (rGO) conductive films integrating “naked” noble MNPs. This method relies on the instantaneous laser-induced co-reduction of graphene oxide and metal cations, resulting in highly exfoliated rGO nanosheets embedding gold, silver, and platinum NPs. The production procedure has been optimized, and the obtained nanomaterials are fully characterized; the hybrid nanosheets have been easily transferred onto lab-made screen-printed electrodes preserving their nanoarchitecture. The Au@rGO-, Ag@rGO-, and Pt@rGO-based electrodes have been challenged to detect caffeic acid, nitrite, and hydrogen peroxide in model solutions and real samples. The sensors yielded quantitative responses (R2 ≥ 0.997) with sub-micromolar limits of detections (LODs ≤ 0.6 μM) for all the analytes, allowing accurate quantification in samples (recoveries ≥ 90%; RSD ≤ 14.8%, n = 3). This single-step protocol which requires low cost and minimal equipment will allow the fabrication of free-standing, MNP-embedded rGO films integrable into a variety of scalable smart devices and biosensors., Peer reviewed

Video 1. rGO-based conductive film patterning, fabrication, and transferring onto flexible PET substrate, The combination of two-dimensional materials and metal nanoparticles (MNPs) allows the fabrication of novel nanocomposites with unique physical/chemical properties exploitable in high-performance smart devices and biosensing strategies. Current methods to obtain graphene-based films decorated with noble MNPs are cumbersome, poorly reproducible, and difficult to scale up. Herein, we propose a straightforward, versatile, surfactant-free, and single-step technique to produce reduced graphene oxide (rGO) conductive films integrating “naked” noble MNPs. This method relies on the instantaneous laser-induced co-reduction of graphene oxide and metal cations, resulting in highly exfoliated rGO nanosheets embedding gold, silver, and platinum NPs. The production procedure has been optimized, and the obtained nanomaterials are fully characterized; the hybrid nanosheets have been easily transferred onto lab-made screen-printed electrodes preserving their nanoarchitecture. The Au@rGO-, Ag@rGO-, and Pt@rGO-based electrodes have been challenged to detect caffeic acid, nitrite, and hydrogen peroxide in model solutions and real samples. The sensors yielded quantitative responses (R2 ≥ 0.997) with sub-micromolar limits of detections (LODs ≤ 0.6 μM) for all the analytes, allowing accurate quantification in samples (recoveries ≥ 90%; RSD ≤ 14.8%, n = 3). This single-step protocol which requires low cost and minimal equipment will allow the fabrication of free-standing, MNP-embedded rGO films integrable into a variety of scalable smart devices and biosensors., Peer reviewed

11 pages. -- Experimental and theoretical methods. -- Results., Peer reviewed

12 pages. -- Section S.1 Definitions of basic quantities of the IV model. -- Section S.2 Secondary IV effects included in the model. -- Section S.3 S.3 Thorough procedure for 1/f noise derivations. -- Section S.4 IV parameter extraction procedure. -- Section S.5 IV and 1/f noise plots of 2D-FETs. -- Section S.6 Tables with IV and 1/f noise model parameters., Peer reviewed

11 pages. -- Figure S1-S6. -- Table S1. XPS fitted data for Au-IrO2 NFs. -- Table S2. DLS and Z-potential measurements. -- Table S3. Equation parameters of all LFs systems for detection of HIgG in immunoglobulins depleted human serum samples. -- Extinction coefficient calculations. -- Table S4. Extinction coefficients of nanoparticles., As the current pandemic has shown, lateral flow assays (LFAs) are a prime example of point-of-care devices enabling quick testing at an affordable price. However, their ease of use undeniably affects their sensitivity, making them less sensitive than other multi-step and time-consuming diagnostic assays, such as polymerase chain reactions and enzyme-linked immunosorbent assays. A possible solution to overcome this lack of sensitivity is the exploitation of bottom-up approaches to synthesize nanomaterials with outstanding properties for use as colorimetric labels in LFAs, that is, using nanoparticles with better optical capabilities to improve the generation of the colorimetric signal and the overall sensitivity of LFAs. Following this strategy, we rationally optimized the synthesis of gold and iridium oxide nanoflowers (Au–IrO2 NFs) to enhance their physical–chemical properties as colorimetric labels in LFAs. Specifically, we were able to rationally control their size (from 155 to 53 nm in diameter) in order to guarantee an optimal flow along the different pads of a LFA. Moreover, thanks to their superior plasmonic behavior (compared to standard AuNPs), we could achieve an 8.5-fold lower limit of detection (down to 1.2 ng/mL) for human immunoglobulin G (HIgG) than standard LFAs (10.1 ng/mL). Therefore, due to their optical and redox properties, bioconjugation capabilities, and synergic combination of the individual components, Au–IrO2 NFs appear as potential candidates for the next generation of optical LFAs., Peer reviewed

Appendix A: Reagents and standards used for volatile analysis S1 Calculation of aroma vectors S2 Data analysis for the descriptions of groups formed in the sorting tasks S3 Appendix B: Table S1. Composition of aroma vectors, their generic and specific aroma descriptors in isolation S1 Table S2. Average concentration (±sd) of total aldehydes (expressed as µg L-1) present in Conventional and Natural wines (CW, NW) S2 Table S3. Average concentration (±sd) of major volatile compounds (expressed as mg L-1) present in Conventional and Natural wines (CW, NW) S3 Table S4. Average concentration (±sd) of minor volatile compounds (expressed as µg L-1) present in Conventional and Natural wines (CW, NW) S5 Table S5. Sensory vectors, average, range of occurrence, the ratio of maximal to minimal values of Odour Aroma Values and significance of aroma vectors (with minimal OAVmax of 1) of Conventional versus Natural wines S7, Peer reviewed