Resultados totales (Incluyendo duplicados): 45302
Encontrada(s) 4531 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329658
Dataset. 2022

SUPPORTING INFORMATION FOR TEXTURE, NANOTEXTURE, AND STRUCTURE OF CARBON NANOTUBE-SUPPORTED CARBON CONES

  • Paredes, Germercy
  • Wang, Rongrong
  • Puech, Pascal
  • Seine, Grégory
  • Leyssale, Jean-Marc
  • Arenal, Raúl
  • Masseboeuf, Aurélien
  • Piazza, Fabrice
  • Monthioux, Marc
Procedure for tapering Au wires; additional HRTEM image; details of the calculation for the possible dimensions of a coherent domain enabled by large radii of curvature of concentric graphenes; tentative growth scenario for the cone parts; further data on modeling., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329658
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329658
HANDLE: http://hdl.handle.net/10261/329658
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329658
PMID: http://hdl.handle.net/10261/329658
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329658
Ver en: http://hdl.handle.net/10261/329658
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329658

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329660
Dataset. 2022

SUPPLEMENTARY FILES OF THE ARTICLE IBRUTINIB PLUS RITUXIMAB VERSUS PLACEBO PLUS RITUXIMAB FOR WALDENSTRÖM’S MACROGLOBULINEMIA: FINAL ANALYSIS FROM THE RANDOMIZED PHASE III INNOVATE STUDY [DATASET]

  • Buske, Christian
  • Tedeschi, Alessandra
  • Trotman, Judith
  • García-Sanz, Ramón
  • MacDonald, David
  • Leblond, Véronique
  • Mahe, Beatrice
  • Herbaux, Charles
  • Matous, Jeffrey V.
  • Tam, Constantine S.
  • Heffner, Leonard T.
  • Varettoni, Marzia
  • Palomba, M. Lia
  • Shustik, Chaim
  • Kastritis, Efstathios
  • Treon, Steven P.
  • Ping, Jerry
  • Hauns, Bernhard
  • Arango-Hisijara, Israel
  • Dimopoulos, Meletios A.
Figure S1. CONSORT diagram. aCrossed over to receive single-agent ibrutinib after PD (n = 35). bOf the 29 patients in the placebo-rituximab arm who discontinued treatment due to investigator decision, 24 patients discontinued due to study unblinding per Data Monitoring Committee recommendation. cDiscontinued rituximab before the completion of 8 infusions. Figure S2. Progression-free survival benefit across prespecified subgroups by prior treatment status. CI, confidence interval; IgG, immunoglobulin G; Hgb, hemoglobin; HR, hazard ratio; RTX, rituximab; IPSSWM, International Prognostic Scoring System for Waldenström’s Macroglobulinemia. Figure S3. Serum immunoglobulin M (IgM) improvement over time. Figure S4. Overall survival. Not censored at crossover. aCounterfactual survival times in crossover patients (n = 35) were calculated using the two-stage Accelerated Failure Time model (Latimer NR, et al: Med Decis Mak. 2014;34(3):387-402). CI, confidence interval; HR, hazard ratio. TABLE S1. Baseline Demographics and Clinical Characteristics by Genotype TABLE S2. Reasons for Ibrutinib Discontinuation. TABLE S3. Key Concomitant Medications of Interest TABLE S4. Adverse events leading to ibrutinib dose reductions., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329660
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329660
HANDLE: http://hdl.handle.net/10261/329660
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329660
PMID: http://hdl.handle.net/10261/329660
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329660
Ver en: http://hdl.handle.net/10261/329660
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329660

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329664
Dataset. 2022

SUPPORTING INFORMATION FOR TUNABLE CONTROL OF THE STRUCTURAL FEATURES AND RELATED PHYSICAL PROPERTIES OF MNXFE3- XO4 NANOPARTICLES: IMPLICATION ON THEIR HEATING PERFORMANCE BY MAGNETIC HYPERTHERMIA

  • Del Sol-Fernández, Susel
  • Odio, Oscar F.
  • Crespo, Paula M.
  • Obed Pérez, E.
  • Salas, Gorka
  • Gutiérrez, Lucía
  • Morales, M. P.
  • Reguera, Edilso
Normalized calculation for SAR values and magnetization relative to the (Fe + Mn) content of the ferrite; FT-IR spectra for S2 and NF NPs, high-resolution XPS spectra and table with the peak position of the Mn 3s orbital for S1, S2, and NF NPs, table with the Mössbauer parameters derived from the spectra recorded at 5 and 270 K, respectively, for the samples under study, and table with AC data fitted to the Arrhenius model; and heating curves of temperature increase as a function of time for the four samples at different frequencies (100 kHz up to 300 kHz) and 16 kA/m., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329664
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329664
HANDLE: http://hdl.handle.net/10261/329664
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329664
PMID: http://hdl.handle.net/10261/329664
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329664
Ver en: http://hdl.handle.net/10261/329664
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329664

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329665
Dataset. 2022

TABLE_1_EFFECTS OF IMPAIRED STERYL ESTER BIOSYNTHESIS ON TOMATO GROWTH AND DEVELOPMENTAL PROCESSES.DOC

  • Burciaga-Monge, Alma
  • López-Tubau, Joan Manel
  • Laibach, Natalie
  • Deng, Cuiyun
  • Ferrer, Albert
  • Altabella, Teresa
Supplementary Table 1: Primers used in this work., Steryl esters (SE) are stored in cytoplasmic lipid droplets and serve as a reservoir of sterols that helps to maintain free sterols (FS) homeostasis in cell membranes throughout plant growth and development, and provides the FS needed to meet the high demand of these key plasma membrane components during rapid plant organ growth and expansion. SE are also involved in the recycling of sterols and fatty acids released from membranes during plant tissues senescence. SE are synthesized by sterol acyltransferases, which catalyze the transfer of long-chain fatty acid groups to the hydroxyl group at C3 position of FS. Depending on the donor substrate, these enzymes are called acyl-CoA:sterol acyltransferases (ASAT), when the substrate is a long-chain acyl-CoA, and phospholipid:sterol acyltransferases (PSAT), which use a phospholipid as a donor substrate. We have recently identified and preliminary characterized the tomato (Solanum lycopersicum cv. Micro-Tom) SlASAT1 and SlPSAT1 enzymes. To gain further insight into the biological role of these enzymes and SE biosynthesis in tomato, we generated and characterized CRISPR/Cas9 single knock-out mutants lacking SlPSAT1 (slpsat1) and SlASAT1 (slasat1), as well as the double mutant slpsat1 x slasat1. Analysis of FS and SE profiles in seeds and leaves of the single and double mutants revealed a strong depletion of SE in slpsat1, that was even more pronounced in the slpsat1 x slasat1 mutant, while an increase of SE levels was observed in slasat1. Moreover, SlPSAT1 and SlASAT1 inactivation affected in different ways several important cellular and physiological processes, like leaf lipid bo1dies formation, seed germination speed, leaf senescence, and the plant size. Altogether, our results indicate that SlPSAT1 has a predominant role in tomato SE biosynthesis while SlASAT1 would mainly regulate the flux of the sterol pathway. It is also worth to mention that some of the metabolic and physiological responses in the tomato mutants lacking functional SlPSAT1 or SlASAT1 are different from those previously reported in Arabidopsis, being remarkable the synergistic effect of SlASAT1 inactivation in the absence of a functional SlPSAT1 on the early germination and premature senescence phenotypes., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329665
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329665
HANDLE: http://hdl.handle.net/10261/329665
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329665
PMID: http://hdl.handle.net/10261/329665
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329665
Ver en: http://hdl.handle.net/10261/329665
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329665

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329666
Dataset. 2022

SUPPLEMENTARY DATA DISTINCT ROLES FOR PARP-1 AND PARP-2 IN C-MYC-DRIVEN B-CELL LYMPHOMA IN MICE

PARP-1 AND PARP-2 IN C-MYC-DRIVEN LYMPHOMA

  • Galindo-Campos, M. A.
  • Lutfi, Nuria
  • Bonnin, Sarah
  • Martínez, Carlos
  • Velasco-Hernández, Talia
  • García-Hernández, V.
  • Martín Caballero, Juan
  • Ampurdanés, Coral
  • Gimeno, Ramón
  • Colomo, Lluis
  • Roué, Gaël
  • Guilbaud, G.
  • Dantzer, Françoise
  • Navarro Medrano, Pilar
  • Murga, Matilde
  • Fernández-Capetillo, Óscar
  • Bigas, Anna
  • Menéndez, Pablo
  • Sale; J. E.
Resources available on the publisher's site: http://dx.doi.org/10.1182/blood.2021012805, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329666
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329666
HANDLE: http://hdl.handle.net/10261/329666
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329666
PMID: http://hdl.handle.net/10261/329666
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329666
Ver en: http://hdl.handle.net/10261/329666
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329666

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329667
Dataset. 2023

CIENCIA PARA LAS POLÍTICAS

INFORME DE TRANSFERENCIA DE CONOCIMIENTO

  • Presidencia del CSIC
Ciencia para las Políticas Públicas - Science 4 Policy.-- Coordinado por: Vincenzo Pavone, Jordi Molas, Jordi Brandts, Rafael Serrano., Los informes Ciencia para las Políticas Públicas (Science For Policy) forman parte de un proyecto estratégico impulsado desde la presidencia del organismo para contribuir a la definición de políticas basadas en la evidencia científica. Elaborados por equipos de investigadores del CSIC, estos documentos abordan los principales retos científicos y sociales como la resistencia de las bacterias a los antibióticos, los incendios, las sequías, la generación de energía, la producción alimentaria y el tratamiento de plásticos. Su objetivo es servir de puente entre los centros de investigación y los decisores políticos para contribuir a la definición de políticas públicas basadas en la evidencia científica., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329667
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329667
HANDLE: http://hdl.handle.net/10261/329667
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329667
PMID: http://hdl.handle.net/10261/329667
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329667
Ver en: http://hdl.handle.net/10261/329667
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329667

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329668
Dataset. 2022

SUPPORTING INFORMATION FOR MOLYBDENUM DISELENIDE-MANGANESE PORPHYRIN BIFUNCTIONAL ELECTROCATALYST FOR THE HYDROGEN EVOLUTION REACTION AND SELECTIVE HYDROGEN PEROXIDE PRODUCTION

  • Kagkoura, Antonia
  • Stangel, Christina
  • Arenal, Raúl
  • Tagmatarchis, Nikos
Experimental section including preparation of MoSe2, f-MoSe2, PorMn, and MoSe2–MnP, high-magnification HAADF-STEM images, UV–vis spectra, and electrochemical data., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329668
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329668
HANDLE: http://hdl.handle.net/10261/329668
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329668
PMID: http://hdl.handle.net/10261/329668
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329668
Ver en: http://hdl.handle.net/10261/329668
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329668

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329669
Dataset. 2022

TABLE_2_EFFECTS OF IMPAIRED STERYL ESTER BIOSYNTHESIS ON TOMATO GROWTH AND DEVELOPMENTAL PROCESSES.DOCX

  • Burciaga-Monge, Alma
  • López-Tubau, Joan Manel
  • Laibach, Natalie
  • Deng, Cuiyun
  • Ferrer, Albert
  • Altabella, Teresa
Table S2. FS and SE quantification in seeds of wt, slasat1, slpsat1 and slpsat1 x slasat1 mutants. Data are shown as average values from three biological replicates with SEM in parentheses. n.d. stands for not detected. Significant changes compared to wild-type (WT) seeds are indicated by asterisks (*P<0.05; **P<0.01; ***P<0.005)., Steryl esters (SE) are stored in cytoplasmic lipid droplets and serve as a reservoir of sterols that helps to maintain free sterols (FS) homeostasis in cell membranes throughout plant growth and development, and provides the FS needed to meet the high demand of these key plasma membrane components during rapid plant organ growth and expansion. SE are also involved in the recycling of sterols and fatty acids released from membranes during plant tissues senescence. SE are synthesized by sterol acyltransferases, which catalyze the transfer of long-chain fatty acid groups to the hydroxyl group at C3 position of FS. Depending on the donor substrate, these enzymes are called acyl-CoA:sterol acyltransferases (ASAT), when the substrate is a long-chain acyl-CoA, and phospholipid:sterol acyltransferases (PSAT), which use a phospholipid as a donor substrate. We have recently identified and preliminary characterized the tomato (Solanum lycopersicum cv. Micro-Tom) SlASAT1 and SlPSAT1 enzymes. To gain further insight into the biological role of these enzymes and SE biosynthesis in tomato, we generated and characterized CRISPR/Cas9 single knock-out mutants lacking SlPSAT1 (slpsat1) and SlASAT1 (slasat1), as well as the double mutant slpsat1 x slasat1. Analysis of FS and SE profiles in seeds and leaves of the single and double mutants revealed a strong depletion of SE in slpsat1, that was even more pronounced in the slpsat1 x slasat1 mutant, while an increase of SE levels was observed in slasat1. Moreover, SlPSAT1 and SlASAT1 inactivation affected in different ways several important cellular and physiological processes, like leaf lipid bo1dies formation, seed germination speed, leaf senescence, and the plant size. Altogether, our results indicate that SlPSAT1 has a predominant role in tomato SE biosynthesis while SlASAT1 would mainly regulate the flux of the sterol pathway. It is also worth to mention that some of the metabolic and physiological responses in the tomato mutants lacking functional SlPSAT1 or SlASAT1 are different from those previously reported in Arabidopsis, being remarkable the synergistic effect of SlASAT1 inactivation in the absence of a functional SlPSAT1 on the early germination and premature senescence phenotypes., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329669
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329669
HANDLE: http://hdl.handle.net/10261/329669
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329669
PMID: http://hdl.handle.net/10261/329669
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329669
Ver en: http://hdl.handle.net/10261/329669
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329669

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329671
Dataset. 2022

TABLE_3_EFFECTS OF IMPAIRED STERYL ESTER BIOSYNTHESIS ON TOMATO GROWTH AND DEVELOPMENTAL PROCESSES.DOCX

  • Burciaga-Monge, Alma
  • López-Tubau, Joan Manel
  • Laibach, Natalie
  • Deng, Cuiyun
  • Ferrer, Albert
  • Altabella, Teresa
Table S3. FS and SE quantification in leaves of wt, slasat1, slpsat1 and slpsat1 x slasat1 mutants. Data are shown as average values from four biological replicates with SEM in parentheses. n.d. stands for not detected. Significant changes compared to wild-type leaves are indicated by asterisks (*P<0.05; **P<0.01; ***P<0.005)., Steryl esters (SE) are stored in cytoplasmic lipid droplets and serve as a reservoir of sterols that helps to maintain free sterols (FS) homeostasis in cell membranes throughout plant growth and development, and provides the FS needed to meet the high demand of these key plasma membrane components during rapid plant organ growth and expansion. SE are also involved in the recycling of sterols and fatty acids released from membranes during plant tissues senescence. SE are synthesized by sterol acyltransferases, which catalyze the transfer of long-chain fatty acid groups to the hydroxyl group at C3 position of FS. Depending on the donor substrate, these enzymes are called acyl-CoA:sterol acyltransferases (ASAT), when the substrate is a long-chain acyl-CoA, and phospholipid:sterol acyltransferases (PSAT), which use a phospholipid as a donor substrate. We have recently identified and preliminary characterized the tomato (Solanum lycopersicum cv. Micro-Tom) SlASAT1 and SlPSAT1 enzymes. To gain further insight into the biological role of these enzymes and SE biosynthesis in tomato, we generated and characterized CRISPR/Cas9 single knock-out mutants lacking SlPSAT1 (slpsat1) and SlASAT1 (slasat1), as well as the double mutant slpsat1 x slasat1. Analysis of FS and SE profiles in seeds and leaves of the single and double mutants revealed a strong depletion of SE in slpsat1, that was even more pronounced in the slpsat1 x slasat1 mutant, while an increase of SE levels was observed in slasat1. Moreover, SlPSAT1 and SlASAT1 inactivation affected in different ways several important cellular and physiological processes, like leaf lipid bo1dies formation, seed germination speed, leaf senescence, and the plant size. Altogether, our results indicate that SlPSAT1 has a predominant role in tomato SE biosynthesis while SlASAT1 would mainly regulate the flux of the sterol pathway. It is also worth to mention that some of the metabolic and physiological responses in the tomato mutants lacking functional SlPSAT1 or SlASAT1 are different from those previously reported in Arabidopsis, being remarkable the synergistic effect of SlASAT1 inactivation in the absence of a functional SlPSAT1 on the early germination and premature senescence phenotypes., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329671
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329671
HANDLE: http://hdl.handle.net/10261/329671
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329671
PMID: http://hdl.handle.net/10261/329671
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329671
Ver en: http://hdl.handle.net/10261/329671
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329671

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329672
Dataset. 2022

SUPPORTING INFORMATION FOR &QUOT;SYNTHESIS AND CRYSTAL GROWTH MECHANISM OF PST-2: AN ALUMINOSILICATE SBS/SBT ZEOLITE INTERGROWTH&QUOT;

  • Lee, Hwajun
  • Zeng, Jinjin
  • Mayoral, Álvaro
  • Hong, Suk Bong
Detailed experimental procedures; MAS NMR spectra of OSDAs and as-synthesized PST-2; TGA/DTA curves of TEA-rho, TEA-ZK-5, and a series of TEA-PST-2 products for different times; FE-SEM images; Raman spectra; relative crystallinities and yields; and chemical composition data of TEA-PST-2., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329672
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329672
HANDLE: http://hdl.handle.net/10261/329672
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329672
PMID: http://hdl.handle.net/10261/329672
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329672
Ver en: http://hdl.handle.net/10261/329672
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329672

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