Resultados de investigación

Figure S1 Proteolytic activity of proteases (inactive zymogen proBFT-3, trypsin-activated BFT-3, and trypsin). Figure S2 Overview representation of all proBFT-3 structures determined. Figure S3 Close-up views of the inhibitor-binding exosite, the identified protein-ligand interaction network, and the proteolytic active site. Figure S4 Molecular representation of the identified BFT-3 exosite inhibitors. Figure S5 Ligand-omitted and bulk solvent-excluding mFo–DFc electron density maps of the identified exosite inhibitors. Figure S6 Size-exclusion chromatography (SEC) of proBFT-3 prior protein crystallization experiments. Table S1 Primary and secondary antibodies. Table S2 Crystallographic data. Table S3 Therapeutic information for the identified compounds. Table S4 Dissociation constants of the activated BFT-3-compound complexes obtained by ITC at 25°C and pH 7.4., Peer reviewed

S1 File. List of participating centers., Peer reviewed

This repository contains all the data (both raw and processed) used in the research paper: Sub-nanometer mapping of strain-induced band structure variations in planar nanowire core-shell heterostructures. In addition, the repository contains all the necessary code for reproducing, from the very raw data, all the results displayed in the paper, towards the best sake of reproducibility. Each folder contains the data as a fragmented zip file. Extract all the files inside each folder at once and a single folder will be generated. While the process is greatly tailored to the presented system of study (ZnSe@ZnTe core-shell nanowires on Al2O3 substrate) and so is the code for achieving it, its core and guidance is perfectly applicable for any translational invariant nanostructure, as detailed in the paper., Band gap mapping data.zip, Strain analysis micrographs.zip, Peer reviewed

S2 File. Definitions for main trial variables., Peer reviewed

Efficacy and safety of 7 versus 14 days of antibiotic treatment for Pseudomonas aeruginosa bacteraemia: a multicentre, randomized clinical trial (SHORTEN-2) with a DOOR/RADAR analysis., Peer reviewed

52 pages. -- Supplementary Note 1. Growth directions, plane interactions and associated mismatches. -- Supplementary Note 2. Intermediate cases (gradual bending). -- Supplementary Note 3. Strain tensor maps (𝜀ij). -- Supplementary Note 4. Atomic modelling on non-faceted cores. -- Supplementary Note 5. Additional details on strain relaxation mechanisms and shell rotation. -- Supplementary Note 6. Details on the Core-shell misfit dislocations. -- Supplementary Note 7. Simulations on VEEL spectra. -- Supplementary Note 8. Methodology for band gap mapping., Peer reviewed

S4 File. Results of the survey among participating centers regarding diagnostic and clinical routines for the management of BSI-PA, Peer reviewed

Efficacy and safety of 7 versus 14 days of antibiotic treatment for Pseudomonas aeruginosa bacteraemia: a multicentre, randomized clinical trial (SHORTEN-2) with a DOOR/RADAR analysis., Peer reviewed

22 pages. -- Table S1. Roughness data for samples shown in Figure 3. -- Figure S1. SEM images of a) a PS microsphere-lithography-fabricated honeycomb-shaped quasiinterdigitated back-contact electrode; defects present during the PS microsphere assembly process: b) vacancy (red dotted circle); c) dislocation (red dash line); d) secondary layer (red dotted circles). defects present in HQIDE: e) vacancy (red dotted circle); f) dislocation (red dash line); g) interconnecting circles (red dotted circles). -- Figure S2. Process for fabricating ML-BCE. -- Figure S3. Spectral response (external quantum efficiency – EQE, solid line) and the corresponding integrated short-circuit current density (J, dashed line) of champion BC-PSC based on ML-BCE (black) and PL-BCE (red). -- Figure S4. Statistic photovoltaic properties of BC-PSCs based on ML-BCE (black) and PL-BCE (red). -- Figure S5. Transient photovoltage (TPV) decay lifetime τ across a range of VOC for perovskites deposited on ML-BCE (black) and on PL-BCE (red). -- Figure S6. UV-visible spectroscopy of back-contact PSCs based on ML-BCE (black) and PL-BCE (red). -- Figure S7. Photovoltaic performance of p-i-n sandwich-type PSCs based on ITO/PTAA (black) and Ni/NiOx (red). -- Table S2. Photovoltaic parameters of champion p-i-n sandwich-type PSCs based on ITO/PTAA and Ni/NiOx substrates. -- Figure S8. a) J-V curves of PSCs based on ITO/PTAA measured from the glass side (black) and from the Au side (red); b) UV-visible transmittance spectra of glass (black), glass/40 nm Au (orange), glass/PCBM/BCP (blue) and glass/PCBM/BCP/Au (red) from 370 nm to 800 nm. a b. -- Table S3. Photovoltaic parameters of PSC based on ITO/PTAA measured from the glass side. -- Figure S9. a) Dark J-V of champion BC-PSCs based on ML-BCE (black) and PL-BCE (red) in forward scan direction; b) series resistance (Rseries) and c) shunt resistance (RSH) of BC-PSCs based on ML-BCE (black) and PL-BCE (red) fitted from the dark J-V curves and from the Au side. -- Figure S10. a) Bode (phase-frequency) plot and b) Nyquist plot of BC-PSCs based on ML-BCE and PL-BCE at a low applied bias at 0.6 V, 0.7 V and a high applied bias at 1.0 V, 1.1 V (c, d). e) Simplified equivalent AC circuit employed for the fitting of IS data. f) Fitted contact resistance at applied biases from 0.5 - 1.1 V. -- Figure S11. a) Resistances at 4 characteristic frequency ranges under various applied biases. b) J-V curves extracted during EIS measurement. c) R2 of devices based on ML-BCE and PL-BCE normalized by the pitch size (P) and gap size (G) of the corresponding electrode. -- Table S4. Radiative limit of back-contact PSCs. -- Table S5. Comparison of device PV parameters (reverse scan) with the radiative limit (with reflection optical loss). -- Figure S12. a) Photoluminescence decay of Cs0.05(FA0.83MA0.17)0.95Pb(I0.83Br0.17)3 perovskite on a PL-BCE (red) and a ML-BCE (black) at short-circuit condition. b) Photoluminescence emission spectra of perovskite film on glass (blue), a PL-BCE (red) and a ML-BCE (black). -- Table S6. Fitted parameters for photoluminescence decay measurements. -- Supplemental Experimental Procedures, Peer reviewed

Eficacia y seguridad de 7 versus 14 días de tratamiento antibiótico para la bacteriemia producida por Pseudomonas aeruginosa: un ensayo clínico multicéntrico, aleatorizado (SHORTEN-2) con un análisis DOOR/RADAR., Peer reviewed