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-CD data; absorption and fluorescence spectra; and 1H NMR, 13C NMR, HPLC, and LC–MS spectra for final compounds (PDF)., -SMILES molecular formula strings (CSV)., Peer reviewed

This PDF file includes: Supplementary text; Figures S1 to S4; Tables S1 to S10; SI References., Peer reviewed

Supplementary material. Diversity of species, genera and families of trees observed in Municipal Garden and in Santa Catarina Park., Peer reviewed

DEPs identified in LINF 3323 (antimony resistant) vs control differential analysis (Table S1); DEPs identified in LINF 2126 (paromomycin resistant) vs control differential analysis) (Table S2); DEPs identified in LINF 5159 (miltefosine resistant) vs control differential analysis (Table S3); parameters associated with the three STRING networks generated with all the DEPs from the three resistant lines (Table S4); L. infantum DEGs from García-Hernández et al., 2022 (Table S5); GO′s obtained from the DEPs analysis for proteins-transcripts comparison (Table S6); STRING network generated with all the DEPs from the three resistant strains and their corresponding KEGGS pathways with the FDR value before network enrichment (Figure S1); Leishmania STRING network generated with all the DEPs from the three resistant strains and their corresponding GOs (Biological Process) and REACTOME pathways with the FDR value and the associated FDR after network enrichment (Figure S2); STRING network generated with all the DEPs from the three THP-1 Human proteomes infected with the resistant strains [Tagliazucchi et al.] (Figure S3); GOs (Biological Process) associated with the enriched STRING network in Figure 4, main text, with their corresponding statistics and significance (Table S7); REACTOME Pathways associated with the enriched STRING network in Figure 4, main text, with their corresponding statistics and significance) (Table S8); GOs (Biological Processes) emerged from the network represented in Figure 3, Supporting Information, with their associated statistical parameters (Table S9); REACTOME Pathways emerged from the network represented in Figure 3, Supporting Information, with their associated statistical parameters (Table S10); GOs terms emerged from Venn’s diagram generated by the intersection between GOs from Human and Parasitic biochemical pathways (Table S11); REACTOME Pathways terms emerged from the Venn diagram generated by intersection between GOs from Human and Parasitic biochemical pathways (Table S12); terms of the enriched STRING network generated with the DEPs that do not share the same GOs as the DEPs belonging to the THP-1 cells (Table S13); results from Level 1 SeqAPASS analysis for a novel antiparasitic drug (Table S14); boxplot describing SeqAPASS data illustrating the percent similarity of (A) all protein sequences across species compared to the primary amino acid sequences and (B) functional domain of L. infantum trypanothione Reductase (Figure S5); boxplot describing SeqAPASS data illustrating the percent similarity of (A) all protein sequences across species compared to the primary amino acid sequences and (B) functional domain of L. infantum ATP-Binding cassette protein (Figure S6); boxplot describing SeqAPASS data illustrating the percent similarity of (A) all protein sequences across species compared to the primary amino acid sequences, (B) functional domain of COG1196 Smc and (C) cd99121 MATH domain of L. infantum MATH-domain-containing protein (putative) (Figure S7); boxplot describing SeqAPASS data illustrating the percent similarity of (A) all protein sequence across species compared to the primary amino acid sequences and (B) functional domain of L. infantum Calpain-like cysteine peptidase (Figure S8) (PDF)., Sequence alignment to predict across species susceptibility (SeqAPASS) raw data (XLSX) id4c00185_si_001.pdf (0.98 MB)., Peer reviewed

Table S1: Data from the qualitative protein analysis in LES; Table S2: Data from the quantitative protein analysis in LES; Table S3: Specific data on peptides from the quantitative analysis of proteins in LES., Peer reviewed

Table S1: Fame fatty acid methyl esters (FAME) in milligrams per gram of carob flour; Table S2: Fame fatty acid methyl esters (FAME) in percentage., Peer reviewed

[Description of methods used for collection/generation of data] 1-s2.0-S0308814623022781-mmc1.xlsx, 1-s2.0-S0308814623022781-mmc2.xlsx and 1-s2.0-S0308814623022781-mmc3.xlsx. Carotenoid content and profile was determined according to Rodríguez-Suárez C, Requena-Ramírez MD, Hornero-Méndez D, Atienza SG (2022). Chapter 4. The breeder’s tool-box for enhancing the content of esterified carotenoids in wheat: From extraction and profiling of carotenoids to marker-assisted selection of candidate genes. En: Carotenoids: Carotenoid and apocarotenoid biosynthesis, metabolic engineering and synthetic biology. pp. 99-125. Editor. Eleanore T. Wurtzel. Book series: Methods in Enzymology. Editorial: Academic Press. Elsevier. Hardcover ISBN: 9780323913539., This research was funded by project PID2021-122152NB-I00 funded by MCIN/AEI/10.13039/501100011033/ and by ERDF “ERDF A way of making Europe”. M.D.R.-R. was supported by PRE2018-084037 funded by MCIN/AEI/10.13039/501100011033 and ESF “ESF investing in your future., 1-s2.0-S0308814623022781-mmc1.xlsx contains the changes in carotenoid content and profile in durum wheat grains during storage. 1-s2.0-S0308814623022781-mmc2.xlsx contains the carotenoid content and profile in durum wheat grains of the F2 population derived from the cros 'BGE047520 x Athoris' 1-s2.0-S0308814623022781-mmc3.xlsx contains the changes in carotenoid content and profile during storage of durum grains of selected individuals from the F2 population., Peer reviewed

[Description of methods used for collection/generation of data] foods-2286878-supplementary.xlsx. Carotenoid content and profile was determined according to Rodríguez-Suárez C, Requena-Ramírez MD, Hornero-Méndez D, Atienza SG (2022). Chapter 4. The breeder’s tool-box for enhancing the content of esterified carotenoids in wheat: From extraction and profiling of carotenoids to marker-assisted selection of candidate genes. En: Carotenoids: Carotenoid and apocarotenoid biosynthesis, metabolic engineering and synthetic biology. pp. 99-125. Editor. Eleanore T. Wurtzel. Book series: Methods in Enzymology. Editorial: Academic Press. Elsevier. Hardcover ISBN: 9780323913539., This research was financed by projects AGL2017-85368-P and PID2021-122152NB-I00 funded by MCIN/AEI/10.13039/501100011033/ and by ERDF “ERDF A way of making Europe”. M.D.R.-R. was supported by PRE2018-084037 funded by MCIN/AEI/10.13039/501100011033 and ESF “ESF investing in your future”., foods-2286878-supplementary contains Table S1 (Detailed carotenoid content of parental lines used in the work) and Table S2 (Detailed carotenoid content of bread wheat lines obtained)., Peer reviewed

Figure S1: HPLC-DAD chromatogram of betalains (at 480 and 535 nm) and phenolic compounds (at 280 and 370 nm) in Opuntia stricta var. dillenii from (a) whole fruit, (b) peel, (c) pulp and (d) bagasse. Numbers correspond to the identified compounds indicated in Table S1 according to Gómez-Lopez et al., Table S1: HPLC retention time (Rt), maximum absorption (λmax) and m/z of the identified major bioactive compounds from Opuntia stricta var. dillenii based on Gómez-Lopez et al., Table S2: Bioactive compounds content (mg/g dry weight) of the major betalains and polyphenols in peel, pulp and whole fruit and by-product (bagasse) from Opuntia stricta var. dillenii prickly pear based on Gómez-Lopez et al., Peer reviewed

Figure S1: Evolution of body weight and solid and liquid intake in rats of both sexes exposed to Instant Cascara (IC) beverage. Table S1. Vaginal smears in female rats before sacrifice. Figure S2: Longitudinal (LM) and circular (CM) muscle response to electrical field stimulation (EFS). Table S2. Longitudinal muscle (LM) and circular muscle (CM) response to electrical field stimulation (EFS)., Peer reviewed