Resultados de investigación

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[Introduction] This study aimed to evaluate the predictive validity and discriminatory ability of clinical outcomes, inflammatory activity, oxidative and vascular damage, and metabolic mechanisms for detecting significant improve maximum heart rate after physical activity training in individuals with psychiatric disorders and obesity comorbid using a longitudinal design and transdiagnostic perspective., [Methods] Patients with major depressive disorder, bipolar disorder and, schizophrenia and with comorbid obesity (n = 29) were assigned to a 12-week structured physical exercise program. Peripheral blood biomarkers of inflammation, oxidative stress, vascular mechanisms, and metabolic activity, as well as neurocognitive and functional performance were assessed twice, before and after intervention. Maximum heart rate was considered a marker of effectiveness of physical activity. Mixed one-way analysis of variance and linear regression analyses were performed., [Results] Individuals with psychiatric disorders and comorbid obesity exhibited an improvement in cognition, mood symptoms and body mass index, increase anti-inflammatory activity together with enhancement of the oxidative and cardiovascular mechanisms after physical activity training (p<0.05 to 0.0001; d = 0.47 to 1.63). A better clinical outcomes along with regulation of inflammatory, oxidative, and cardiovascular mechanisms were critical for predicting significant maximum heart rate variation over time (χ2 = 32.2 to 39.0, p < 0.0001)., [Conclusions] The regulation of the anti-inflammatory mechanisms may be essential for maintained of healthy physical activity across psychiatric disorders and obesity. Likewise, inflammatory activity, oxidative stress, vascular and cardio-metabolic mechanisms may be a useful to identify individuals at greater risk of multi-comorbidity., Peer reviewed

Supplementary tables, Table 1. Effect of nutritional intervention on blood haematology before weaning. Table 2. Effect of nutritional intervention on blood haematology at 2 months post-weaning., Peer reviewed

Spanish Ministry of Science and University MICIU/AEI funded through the European Union NextGenerationEU/PRTR programme Comunidad de Madrid Comunidad de Madrid and the Spanish National Research Council (CSIC), Peer reviewed

Supplementary Material 1. Fig. S1 Location of the rice-growing regions in eastern Spain in Valencia and Ebro River delta. Soils used in this study, low fertility and high fertility soil, were harvested from rice fields located at the Ebro River delta site. Fig. S2 Experimental design followed to grow rice plants in the nursery for field experiments. Fig. S3 Experimental design used in field assays conducted in Valencia (2023 and 2024) and Ebro river delta (2023). Distribution of plots containing mock-inoculated or R. irregularis-inoculated plants of the rice varieties Albufera, Bomba and JSendra. Fig. S4 Pi content of rice plants that have been grown on soil collected from rice fields, low fertility soil or high fertility soil. Fig. S5 Typical symptoms of leaf blast, neck blast, node blast in field-grown rice plants., MICIU/AEI and European Union Next Generation EU/PRTR MICIU/AEI, Peer reviewed

This repository contains the raw data and metadata used in the study: A systematic review and meta-analysis on urban arthropod diversity, by Sanllorente et al. 2025, Peer reviewed

El dataset se puede consultar y descargar en el siguiente enlace: https://www.ebi.ac.uk/pride/archive/projects/PXD038980, We characterized genome expression at proteome level and correlated it with unbiased transcript expression data to obtain a dynamic view of early Arabidopsis flower development., Peer reviewed

During seedling deetiolation, plants adjust their development to expose photosynthetic tissues to sunlight, enabling the transition from heterotrophic to autotrophic growth. While various plant hormones are known to influence this process, the role of abscisic acid (ABA) remains unclear. Here, we reveal that ABA plays a major role in controlling the dynamics of cotyledon aperture during seedling deetiolation. In the dark, ABA accumulates in the cotyledons to effectively repress their opening. However, light exposure reverses this effect, allowing the cotyledons to open. Our findings indicate that ABA-mediated regulation of cotyledon dynamics is accompanied by genome-wide rearrangements in both transcriptional and splicing patterns. We demonstrate that ABA-dependent adjustments of cotyledon and splicing dynamics in response to light depend on the positive role of two splicing factors, RS40 and RS41. Moreover, we identify transcriptional and posttranscriptional mechanisms that control the activity of these proteins. Altogether, this work sheds light on the interplay between light and ABA, highlighting cotyledon opening as a new developmental outcome, and identifying alternative splicing as the underlying layer of gene regulation., MEC | Fundação para a Ciência e a Tecnologia (FCT): PTDC/ASP-PLA/2550/2021,UIDB/ 04551/2020 PTDC/BIA-BID/30608/2017 2023.06360.CEECIND/CP2836/CT0009 CEECIND/02655/2017/CP1428/CT0003 UIDP/04551/2020 Ministerio de Ciencia, Innovación y Universidades (MCIU): RYC2020-030160-I/AEI/10.13039/501100011033,PID2021-125223NA-I00/AEI/10.13039/501100011033/ FEDER,UE RYC2021-032539-I European Molecular Biology Organization (EMBO): ALTF 1576-2016 EC | Horizon Europe | Excellent Science | HORIZON EUROPE Marie Sklodowska-Curie Actions (MSCA): 750469 EC | H2020 | PRIORITY 'Excellent science' | H2020 Marie Skłodowska-Curie Actions (MSCA): 945043, Peer reviewed

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