Resultados totales (Incluyendo duplicados): 34260
Encontrada(s) 3426 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331080
Dataset. 2022

ADDITIONAL FILE 1 OF ALTERED METHYLATION PATTERN IN EXOC4 IS ASSOCIATED WITH STROKE OUTCOME: AN EPIGENOME-WIDE ASSOCIATION STUDY

  • Cullell, Nàtalia
  • Soriano-Tárraga, Carolina
  • Gallego-Fabrega, Cristina
  • Cárcel-Márquez, Jara
  • Muiño, Elena
  • Llucià-Carol, Laia
  • Lledós, Miquel
  • Esteller, Manel
  • Moura, Manuel Castro de
  • Montaner, Joan
  • Rosell, Anna
  • Delgado, Pilar
  • Marti-Fabregas, Joan
  • Krupinski, Jerzy
  • Roquer, Jaume
  • Jiménez-Conde, Jordi
  • Fernández-Cadenas, Israel
1-Supplemental Materials and Methods. 2- Supplemental e-FIGURES. Figure I: Workflow for CpG-sites and sample QCs. Figure II: Batch effect evaluation with MDS and SVD plots. Figure III: Manhattan plots for DMCT. Figure IV: cg00039070 methylation correlation between blood and brain. Figure V: Blood–Brain Epigenetic Concordance (BECon) results for cg00039070. 3- Supplemental e-TABLES. Table I: Analysis of variables associated with ∆NIHSS in bivariate and regression analysis. Table II: Analysis of variables associated with mRS at 3 months in bivariate and regression analysis. Table III: Summary statistics for the discovery EWAS adjusted by batch. Table IV: Feature enrichment analysis. Table V: Differentially methylated region (DMR) results. Table VI: Differentially methylated block (DMB) results. Table VII: EWAS summary statistics in the meta-analyses for dichotomic ∆NIHSS. Table VIII: Demographic and clinical data for the subjects included in the analysis with SOMAscan. Table IX: eFORGE analysis. 4- Supplemental References., Boehringer Ingelheim España Instituto de Salud Carlos III Agència de Gestió d'Ajuts Universitaris i de Recerca FUNDACIÓ DOCÈNCIA I RECERCA MÚTUATERRASSA Bristol-Myers Squibb Eranet-Neuron Fundació la Marató de TV3., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331080
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331080
HANDLE: http://hdl.handle.net/10261/331080
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331080
PMID: http://hdl.handle.net/10261/331080
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331080
Ver en: http://hdl.handle.net/10261/331080
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331080

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331084
Dataset. 2022

A MULTI-CENTER, OPEN-LABEL, SINGLE-ARM TRIAL TO EVALUATE EFFICACY, PHARMACOKINETICS, AND SAFETY AND TOLERABILITY OF IGSC 20% IN SUBJECTS WITH PRIMARY IMMUNODEFICIENCY [DATASET]

  • Santamaría, Manuel
  • Neth, Olaf
  • Douglass, Jo A.
  • Krivan, Gergely
  • Kobbe, Robin
  • Bernatowska, Ewa
  • Grigoriadou, Sofia
  • Bethune, Claire
  • Chandra, Anita
  • Horneff, Gerd
  • Borte, Michael
  • Sonnenschein, Anja
  • Kralickova, Pavlina
  • Sánchez-Ramón, Silvia
  • Langguth, Daman
  • González-Granado, Luis
  • Alsina, Laia
  • Querolt, Montse
  • Griffin, Rhonda
  • Hames, Carrie
  • Mondou, Elsa
  • Price, Jeffrey
  • Sanz, Ana;
  • Lin, Jiang
Antibiotic usage in this study (GTI1503) was within the range reported for other subcutaneous immune globulin products approved for primary immunodeficiency syndromes in Europe and North America, as shown in the table below. Days of Antibiotic Use Per Subject-Year for Subcutaneous Immune Globulins., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331084
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331084
HANDLE: http://hdl.handle.net/10261/331084
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331084
PMID: http://hdl.handle.net/10261/331084
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331084
Ver en: http://hdl.handle.net/10261/331084
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331084

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331097
Dataset. 2022

ADDITIONAL FILE 3 OF AΒ OLIGOMERS TRIGGER NECROPTOSIS-MEDIATED NEURODEGENERATION VIA MICROGLIA ACTIVATION IN ALZHEIMER’S DISEASE

  • Salvadores, Natalia
  • Moreno-González, Inés
  • Gámez, Nazaret
  • Quiroz, Gabriel
  • Vegas-Gómez, Laura
  • Escandón, Marcela
  • Jiménez, Sebastián
  • Vitorica, Javier
  • Gutiérrez, Antonia
  • Soto, Claudio
  • Court, Felipe A.
Additional file 3: Fig. S3. Validation of the pMLKL antibody and assessment of cell specificity. Representative micrographs of (A) the dentate gyrus (DG) and (B) CA1 brain regions from wild-type and MLKL knockout mice subjected to intracerebral injection of Aβo, immunostained with anti-pMLKL antibody (scale bar, DG: 100 μm, CA1: 150 μm). (C, D) Representative images of the hilus of wild-type mice treated with Aβo, labeled with the indicated antibodies (scale bar, 50 μm and 25 μm for magnifications)., Fondecyt FONDAP ISCIII CIBERNED Junta de Andalucia Consejería de Economía y Conocimiento MICIN Ramon y Cajal Program National Institutes of Health., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331097
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331097
HANDLE: http://hdl.handle.net/10261/331097
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331097
PMID: http://hdl.handle.net/10261/331097
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331097
Ver en: http://hdl.handle.net/10261/331097
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331097

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331099
Dataset. 2022

ADDITIONAL FILE 4 OF AΒ OLIGOMERS TRIGGER NECROPTOSIS-MEDIATED NEURODEGENERATION VIA MICROGLIA ACTIVATION IN ALZHEIMER’S DISEASE

  • Salvadores, Natalia
  • Moreno-González, Inés
  • Gámez, Nazaret
  • Quiroz, Gabriel
  • Vegas-Gómez, Laura
  • Escandón, Marcela
  • Jiménez, Sebastián
  • Vitorica, Javier
  • Gutiérrez, Antonia
  • Soto, Claudio
  • Court, Felipe A.
Additional file 4: Fig. S4. Intracerebral administration of Aβo elicits neurodegeneration in wild-type mice. Representative micrographs of brain sections from wild-type mice treated as indicated in the images, stained with Fluoro-Jade C (scale bar, 150 μm)., Fondecyt FONDAP ISCIII CIBERNED Junta de Andalucia Consejería de Economía y Conocimiento MICIN Ramon y Cajal Program National Institutes of Health., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331099
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331099
HANDLE: http://hdl.handle.net/10261/331099
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331099
PMID: http://hdl.handle.net/10261/331099
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331099
Ver en: http://hdl.handle.net/10261/331099
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331099

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331101
Dataset. 2022

ADDITIONAL FILE 5 OF AΒ OLIGOMERS TRIGGER NECROPTOSIS-MEDIATED NEURODEGENERATION VIA MICROGLIA ACTIVATION IN ALZHEIMER’S DISEASE

  • Salvadores, Natalia
  • Moreno-González, Inés
  • Gámez, Nazaret
  • Quiroz, Gabriel
  • Vegas-Gómez, Laura
  • Escandón, Marcela
  • Jiménez, Sebastián
  • Vitorica, Javier
  • Gutiérrez, Antonia
  • Soto, Claudio
  • Court, Felipe A.
Additional file 5: Fig. S5. MLKL inhibition attenuates Aβo-induced microgliosis in mice. (A, B) Representative micrographs and quantitative analysis of brain sections from wild-type and Mlkl knockout mice treated as indicated in the images, immunostained with anti-Iba1 antibody (scale bar, 200 μm). The data are presented as mean ± S.E.M. and were analyzed by one-way ANOVA followed by Bonferroni post-test. *p < 0.05., Fondecyt FONDAP ISCIII CIBERNED Junta de Andalucia Consejería de Economía y Conocimiento MICIN Ramon y Cajal Program National Institutes of Health., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331101
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331101
HANDLE: http://hdl.handle.net/10261/331101
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331101
PMID: http://hdl.handle.net/10261/331101
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331101
Ver en: http://hdl.handle.net/10261/331101
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331101

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331102
Dataset. 2022

CONSTRAINING GALAXY-HALO CONNECTION WITH HIGH-ORDER STATISTICS [DATASET]

  • Zhang, Hanyu
  • Samushia, Lado
  • Gaztañaga, Enrique
Supplementary material to DESI's publication Constraining galaxy-halo connection with high-order statistics to comply with the data management plan. Including: Tabulated 2 point and 3 point counts of AbacusSummit highbase box at redshift 0.8, 1.1, and 1.4. HOD mock catalogs for LRGs at z=0.8, ELGs at z=0.8,1.1, QSOs at z=1.4 Jackknife Covariance from HOD mock catalogs MCMC chains., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331102
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331102
HANDLE: http://hdl.handle.net/10261/331102
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331102
PMID: http://hdl.handle.net/10261/331102
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331102
Ver en: http://hdl.handle.net/10261/331102
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331102

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331104
Dataset. 2022

TABLE_4_UNRAVELLING SOLUBLE IMMUNE CHECKPOINTS IN CHRONIC LYMPHOCYTIC LEUKEMIA: PHYSIOLOGICAL IMMUNOMODULATORS OR IMMUNE DYSFUNCTION.XLSX [DATASET]

  • Landeira-Viñuela, Alicia
  • Arias-Hidalgo, Carlota
  • Juanes-Velasco, Pablo
  • Alcoceba, Miguel
  • Navarro-Bailón, Almudena
  • Pedreira, C. E.
  • Lécrevisse, Quentin
  • Díaz-Muñoz, Laura
  • Sanchez-Santos, Jose Manuel
  • Hernández, Ángela-Patricia
  • García-Vaquero, Marina L.
  • Góngora, Rafael
  • De Las Rivas, Javier
  • González, Marcos
  • Orfao, Alberto
  • Fuentes, Manuel
Chronic lymphocytic leukemia (CLL) is a lymphoid neoplasm characterized by the accumulation of mature B cells. The diagnosis is established by the detection of monoclonal B lymphocytes in peripheral blood, even in early stages [monoclonal B-cell lymphocytosis (MBLhi)], and its clinical course is highly heterogeneous. In fact, there are well-characterized multiple prognostic factors that are also related to the observed genetic heterogenicity, such as immunoglobulin heavy chain variable region (IGHV) mutational status, del17p, and TP53 mutations, among others. Moreover, a dysregulation of the immune system (innate and adaptive immunity) has been observed in CLL patients, with strong impact on immune surveillance and consequently on the onset, evolution, and therapy response. In addition, the tumor microenvironment is highly complex and heterogeneous (i.e., matrix, fibroblast, endothelial cells, and immune cells), playing a critical role in the evolution of CLL. In this study, a quantitative profile of 103 proteins (cytokines, chemokines, growth/regulatory factors, immune checkpoints, and soluble receptors) in 67 serum samples (57 CLL and 10 MBLhi) has been systematically evaluated. Also, differential profiles of soluble immune factors that discriminate between MBLhi and CLL (sCD47, sCD27, sTIMD-4, sIL-2R, and sULBP-1), disease progression (sCD48, sCD27, sArginase-1, sLAG-3, IL-4, and sIL-2R), or among profiles correlated with other prognostic factors, such as IGHV mutational status (CXCL11/I-TAC, CXCL10/IP-10, sHEVM, and sLAG-3), were deciphered. These results pave the way to explore the role of soluble immune checkpoints as a promising source of biomarkers in CLL, to provide novel insights into the immune suppression process and/or dysfunction, mostly on T cells, in combination with cellular balance disruption and microenvironment polarization leading to tumor escape., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331104
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331104
HANDLE: http://hdl.handle.net/10261/331104
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331104
PMID: http://hdl.handle.net/10261/331104
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331104
Ver en: http://hdl.handle.net/10261/331104
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331104

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331106
Dataset. 2022

SUPPLEMENTAL MATERIAL FOR CONSTRAINTS ON DARK PHOTON DARK MATTER USING DATA FROM LIGO'S AND VIRGO'S THIRD OBSERVING RUN

  • Abbott, R.
  • Andrade, T.
  • Barneo, P.
  • Colleoni, Marta
  • Estellés, Héctor
  • García-Quirós, Cecilio
  • Guixé, G.
  • Husa, Sascha
  • Jaume, Rafel
  • Keitel, David
  • Kuroyanagi, S.
  • Mateu-Lucena, Maite
  • Sanuy, Andreu
  • Sintes, A. M.
  • Tenorio, Rodrigo
  • LIGO Scientific Collaboration
  • Virgo Collaboration
  • KAGRA Collaboration
Data from figures 1 and 3, and a juypter notebook for plotting this data., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331106
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331106
HANDLE: http://hdl.handle.net/10261/331106
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331106
PMID: http://hdl.handle.net/10261/331106
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331106
Ver en: http://hdl.handle.net/10261/331106
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331106

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331114
Dataset. 2022

TABLE_5_UNRAVELLING SOLUBLE IMMUNE CHECKPOINTS IN CHRONIC LYMPHOCYTIC LEUKEMIA PHYSIOLOGICAL IMMUNOMODULATORS OR IMMUNE DYSFUNCTION.XLSX [DATASET]

  • Landeira-Viñuela, Alicia
  • Arias-Hidalgo, Carlota
  • Juanes-Velasco, Pablo
  • Alcoceba, Miguel
  • Navarro-Bailón, Almudena
  • Pedreira, C. E.
  • Lécrevisse, Quentin
  • Díaz-Muñoz, Laura
  • Sanchez-Santos, Jose Manuel
  • Hernández, Ángela-Patricia
  • García-Vaquero, Marina L.
  • Góngora, Rafael
  • De Las Rivas, Javier
  • González, Marcos
  • Orfao, Alberto
  • Fuentes, Manuel
Chronic lymphocytic leukemia (CLL) is a lymphoid neoplasm characterized by the accumulation of mature B cells. The diagnosis is established by the detection of monoclonal B lymphocytes in peripheral blood, even in early stages [monoclonal B-cell lymphocytosis (MBLhi)], and its clinical course is highly heterogeneous. In fact, there are well-characterized multiple prognostic factors that are also related to the observed genetic heterogenicity, such as immunoglobulin heavy chain variable region (IGHV) mutational status, del17p, and TP53 mutations, among others. Moreover, a dysregulation of the immune system (innate and adaptive immunity) has been observed in CLL patients, with strong impact on immune surveillance and consequently on the onset, evolution, and therapy response. In addition, the tumor microenvironment is highly complex and heterogeneous (i.e., matrix, fibroblast, endothelial cells, and immune cells), playing a critical role in the evolution of CLL. In this study, a quantitative profile of 103 proteins (cytokines, chemokines, growth/regulatory factors, immune checkpoints, and soluble receptors) in 67 serum samples (57 CLL and 10 MBLhi) has been systematically evaluated. Also, differential profiles of soluble immune factors that discriminate between MBLhi and CLL (sCD47, sCD27, sTIMD-4, sIL-2R, and sULBP-1), disease progression (sCD48, sCD27, sArginase-1, sLAG-3, IL-4, and sIL-2R), or among profiles correlated with other prognostic factors, such as IGHV mutational status (CXCL11/I-TAC, CXCL10/IP-10, sHEVM, and sLAG-3), were deciphered. These results pave the way to explore the role of soluble immune checkpoints as a promising source of biomarkers in CLL, to provide novel insights into the immune suppression process and/or dysfunction, mostly on T cells, in combination with cellular balance disruption and microenvironment polarization leading to tumor escape., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331114
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331114
HANDLE: http://hdl.handle.net/10261/331114
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331114
PMID: http://hdl.handle.net/10261/331114
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331114
Ver en: http://hdl.handle.net/10261/331114
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331114

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331117
Dataset. 2022

SUPPLEMENTARY MATERIAL FOR ENHANCING CONTROL SYSTEMS OF HIGHER PLANT CULTURE CHAMBERS VIA MULTILEVEL STRUCTURAL MECHANISTIC MODELLING

  • Ciurans, Carles
  • Guerrero, Josep M.
  • Martínez-Mongue, Ivan
  • Dussap, Claude-Gilles
  • Marin de Mas, Igor
  • Gòdia, Francesc
Table_1_Enhancing control systems of higher plant culture chambers via multilevel structural mechanistic modelling. Table_2_Enhancing control systems of higher plant culture chambers via multilevel structural mechanistic modelling. Table_3_Enhancing control systems of higher plant culture chambers via multilevel structural mechanistic modelling. Table_4_Enhancing control systems of higher plant culture chambers via multilevel structural mechanistic modelling. Table_5_Enhancing control systems of higher plant culture chambers via multilevel structural mechanistic modelling. Table_6_Enhancing control systems of higher plant culture chambers via multilevel structural mechanistic modelling., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331117
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331117
HANDLE: http://hdl.handle.net/10261/331117
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331117
PMID: http://hdl.handle.net/10261/331117
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331117
Ver en: http://hdl.handle.net/10261/331117
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331117

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