BUSCADOR RECOLECTA

Supplementary Figures: Supplementary Figure 1. Short and long-term synaptic plasticity are preserved in the hippocampus of PD rats. (A) Pair pulse stimulation of the perforant pathway. Suprathreshold and equal intensity pairs of pulses (upper panel) are delivered at varying inter-stimulus time intervals (ISI). The results (lower panel) are expressed as the PS amplitude ratio (PS2/PS1). PS ratios below 1 indicate response depression and vice versa. Insets show pair pulse inhibition (left) and facilitation (right). (B) LTP of the perforant pathway. The upper panel shows the stimulation protocol used to induce LTP. Lower panel: synaptic potentiation in PD (orange) and control (black) rats quantified as the percentage increase of the PS amplitude after vs. before LTP induction. (C) Same as B but for the EPSP slope. (D) Evolution of the PS amplitude in response to perforant path stimulation before and 1 h after LTP induction. LTP protocol is applied at minute 6 (lasting 16 min) and PS amplitude is not tested until 1h later (grey shadow). The PS is normalized to pre-LTP measurements, and averaged across animals (n=5 per group). Data represents mean ± SEM. Supplementary Figure 2. Effect size of FA alterations in AUD patients analyzed with CSF correction (see Methods). Supplementary Figure 3. Effect size of FA alterations in a group of AUD patients chosen to avoid the age differences between groups. Supplementary Figure 4. Linear correlations between FA in the fimbria/fornix and cognitive variables: (A) NST, (B) TMT-A, (C) TMT-B, (D) number of perseverative errors in the WCST, (E) reaction times in the WCST, and (F) the Stroop test. (G) Correlation between FA in the fimbria/fornix and age. Supplementary Table 1. List of regions employed for the effect size analysis. Supplementary Table 2. List of cognitive test scores and age from AUD patients., Peer reviewed

This is the auxiliary online material to the research article: Brands et al. (2023): A global climate model performance atlas for the Southern Hemisphere extratropics based on regional atmospheric circulation patterns For further informaion, please see the README.txt file contained herein or contact Swen Brands, swen.brands@gmail.com, Peer reviewed

We initiate the study of a bulk-boundary eigenvalue problem for the Bilaplacian with a particular third order boundary condition that arises from the study of dynamical boundary conditions for the Cahn-Hilliard equation. First we consider continuity properties under parameter variation (in which the parameter also affects the domain of definition of the operator). Then we look at the ball and the annulus geometries (together with the punctured ball), obtaining the eigenvalues as solutions of a precise equation involving special functions. An interesting outcome of our analysis in the annulus case is the presence of a bifurcation from the zero eigenvalue depending on the size of the annulus., This work was initiated while C. Falcó was participating in the program “Introducción a la Investigación Severo Ochoa” grant at the Instituto de Ciencias Matemáticas (ICMAT). M.d.M. González acknowledges financial support from the Spanish Government, grant numbers MTM2017-85757-P, PID2020- 113596GB-I00; additionally, Grant RED2018-102650-T funded by MCIN/AEI/10.13039/501100011033, and the “Severo Ochoa Programme for Centers of Excellence in R&D” (CEX2019-000904-S)., With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000904-S)., No

Experimental chronogram: Figure S1: Chronogram of the glutathione manipulation. BSO = buthionine sulfoximine. From (Romero Haro and Alonso-Alvarez 2015). DNA extraction protocol. Supplementary statistical analyses. Supplementary Results: Table S1; Table S2; Table S3; Table S4; Table S5; Figure S2; Figure S3; Figure S4; Figure S5; Figure S6; Figure S7; Figure S8. Interaction between early glutathione levels and telomere length on longevity, Peer reviewed

Peer reviewed

Table S1: Nutritional composition of the red berries mixture, Table S2: Nutritional composition of cacao powder, Table S3: Demographics and characteristics of the participants at enrollment in each group, Table S4: Blood pressure and heart rate values in each group and by visit, Table S5: p-value from the comparison between diets at the baseline., Peer reviewed

Supplementary Table 1. Correlation coefficients between phenolic compounds and methylxanthines, and the radical scavenging, cytoprotective properties, and cellular antioxidant activity in the coffee pulp flour (CPF) and extract (CPE)., Peer reviewed

Supplementary material: Table S1. Alpha-diversity is expressed as Observed Species, Shannon, and Simpson indexes. Letters denote statistically significant differences between samples and times. Differences regarding the control that are statistically significant (p < 0.05) are marked in gray. Table S2. Genus level. Mean relative abundances (%) and standard deviation. Only genus with a mean relative abundance >0.5% and/or statistically significant were considered. Statistical differences (p-adjust < 0.05) regarding the control and PLAg/PLAm for each volunteer are highlighted, in gray if they appear only for one volunteer or in orange if they are common to at least two volunteers. Table S3. Concentration (µM) of short-chain fatty acids (SCFAs) at different colonic fermentation times. Table S4. Lactate concentration (µg/mL) at different colonic fermentation times. Table S5. Predicted bacterial pathways present in PLAm and PLAg samples from colonic fermentation simulations for the three volunteers. Only statistically different features comparing to control (q-value<0.05) and with a mean relative abundance >0.01% are shown. met. = metabolism. deg. = degradation. Table S6. Predicted bacterial genes (i.e., enzymes and proteins) present in PLAm and PLAg samples from colonic fermentation simulations for the three volunteers. Only statistically different features comparing to control (q-value<0.05). and with a mean relative abundance >0.01% are shown. Figure S1. Beta-diversity plots of the three volunteers (0, 24, 48, and 72 h) and the different conditions tested (control, PLAg, and PLAm)., Peer reviewed

This PDF file includes: Figs. S1 to S10 Legends for tables S1 to S6, Other Supplementary Material includes the following: Tables S1 to S6, Peer reviewed

Additional STM topographs and spectroscopy data and further results from DFT calculations., Peer reviewed