Dataset.

Correlation of the kinetics of viral antigen and genomic RNA with restoration of normal cell homeostasis

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/285496
Digital.CSIC. Repositorio Institucional del CSIC
  • Castro, Victoria
  • Calvo, Gema
  • Gastaminza, Pablo
The main objective of the studies within COCID Work Package 6 is to understand basic mechanisms by which viral replication machineries are removed from cells after pharmacological interruption of viral replication using functional as well as imaging techniques, including soft X-ray tomography. In this document, we highlight the progress in establishing the HCV replication models (replicons), the antiviral treatment chosen to eliminate viral structures from the host cells and the correlation between elimination of the viral replication machinery and restoration of a normal host cell homeostasis, using markers of HCV-induced stress. These data are essential to frame the experimental setup chosen for the imaging process required in subsequent stps of the project., European Commission: CoCID - Compact Cell-Imaging Device to provide insight into the cellular origins of diseases and to aid in the development of novel therapeutics (101017116), Peer reviewed
 
DOI: http://hdl.handle.net/10261/285496
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/285496

HANDLE: http://hdl.handle.net/10261/285496
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/285496
 
Ver en: http://hdl.handle.net/10261/285496
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/285496

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/285496
Dataset. 2022

CORRELATION OF THE KINETICS OF VIRAL ANTIGEN AND GENOMIC RNA WITH RESTORATION OF NORMAL CELL HOMEOSTASIS

Digital.CSIC. Repositorio Institucional del CSIC
  • Castro, Victoria
  • Calvo, Gema
  • Gastaminza, Pablo
The main objective of the studies within COCID Work Package 6 is to understand basic mechanisms by which viral replication machineries are removed from cells after pharmacological interruption of viral replication using functional as well as imaging techniques, including soft X-ray tomography. In this document, we highlight the progress in establishing the HCV replication models (replicons), the antiviral treatment chosen to eliminate viral structures from the host cells and the correlation between elimination of the viral replication machinery and restoration of a normal host cell homeostasis, using markers of HCV-induced stress. These data are essential to frame the experimental setup chosen for the imaging process required in subsequent stps of the project., European Commission: CoCID - Compact Cell-Imaging Device to provide insight into the cellular origins of diseases and to aid in the development of novel therapeutics (101017116), Peer reviewed




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