Dataset.
Data from "Relationship between weight and dimensions of Bluefin tuna (Thunnus thynnus) following fattening on western Mediterranean farms"
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/312535
Digital.CSIC. Repositorio Institucional del CSIC
- Puig, V.
- Estruch, Vicente Domingo
- Espinosa, Víctor
- de-la-Gándara, Fernando
- Mèlich, B.
- Cort, José Luis
DOI: http://hdl.handle.net/10261/312535
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/312535
HANDLE: http://hdl.handle.net/10261/312535
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/312535
Ver en: http://hdl.handle.net/10261/312535
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/312535
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21 Documentos relacionados
21 Documentos relacionados
Recercat. Dipósit de la Recerca de Catalunya
oai:recercat.cat:2072/315385
Artículo científico (article).
DOES PET OWNERSHIP IN INFANCY LEAD TO ASTHMA OR ALLERGY AT SCHOOL AGE? POOLED ANALYSIS OF INDIVIDUAL PARTICIPANT DATA FROM 11 EUROPEAN BIRTH COHORTS
Recercat. Dipósit de la Recerca de Catalunya
- Lodrup Carlsen, Karin C
- Sunyer Deu, Jordi
- Puig, Carme
- Wickman, Magnus
Objective: To examine the associations between pet keeping in early childhood and asthma and allergies in children aged 6–10 years. Design: Pooled analysis of individual participant data of 11 prospective European birth cohorts that recruited a total of over 22,000 children in the 1990s. Exposure definition: Ownership of only cats, dogs, birds, rodents, or cats/dogs combined during the first 2 years of life. Outcome definition: Current asthma (primary outcome), allergic asthma, allergic rhinitis and allergic sensitization during 6–10 years of age. Data synthesis: Three-step approach: (i) Common definition of outcome and exposure variables across cohorts; (ii) calculation of adjusted effect estimates for each cohort; (iii) pooling of effect estimates by using random effects meta-analysis models.Results: We found no association between furry and feathered pet keeping early in life and asthma in school age. For example, the odds ratio for asthma comparing cat ownership with “no pets” (10 studies, 11489 participants) was 1.00 (95% confidence interval 0.78 to 1.28) (I2 = 9%; p = 0.36). The odds ratio for asthma comparing dog ownership with “no pets” (9 studies, 11433 participants) was 0.77 (0.58 to 1.03) (I2 = 0%, p = 0.89). Owning both cat(s) and dog(s) compared to “no pets” resulted in an odds ratio of 1.04 (0.59 to 1.84) (I2 = 33%, p = 0.18). Similarly, for allergic asthma and for allergic rhinitis we did not find associations regarding any type of pet ownership early in life. However, we found some evidence for an association between ownership of furry pets during the first 2 years of life and reduced likelihood of becoming sensitized to aero-allergens. Conclusions: Pet ownership in early life did not appear to either increase or reduce the risk of asthma or allergic rhinitis symptoms in children aged 6–10. Advice from health care practitioners to avoid or to specifically acquire pets for primary prevention of asthma or allergic rhinitis in children should not be given., This collaborative project was initiated, supported and funded by the Global Allergy and Asthma European Network (GA2LEN; www.ga2len.net) under the 6th framework programme of the European Commission (project no. FOOD-CT-2004-506378). Sources of funding of the individual birth cohort studies are described in their publications
Docusalut
oai:docusalut.com:20.500.13003/15721
Artículo científico (article). 2012
DOES PET OWNERSHIP IN INFANCY LEAD TO ASTHMA OR ALLERGY AT SCHOOL AGE? POOLED ANALYSIS OF INDIVIDUAL PARTICIPANT DATA FROM 11 EUROPEAN BIRTH COHORTS
Docusalut
- Carlsen, Karin C. Lodrup
- Roll, Stephanie
- Carlsen, Kai-Hakon
- Mowinckel, Petter
- Wijga, Alet H.
- Brunekreef, Bert
- Torrent Quetglas, Maties
- Roberts, Graham
- Arshad, S. Hasan
- Kull, Inger
- Kraemer, Ursula
- von Berg, Andrea
- Eller, Esben E.
- Host, Arne
- Kuehni, Claudia
- Spycher, Ben
- Sunyer, Jordi
- Chen, Chih-Mei
- Reich, Andreas
- Asarnoj, Anna
- Puig, Carmen
- Herbarth, Olf
- John, Jestinah M. Mahachie
- Van Steen, Kristel
- Willich, Stefan N.
- Wahn, Ulrich
- Lau, Susanne
- Keil, Thomas
- Birth Cohorts Working Grp
Objective: To examine the associations between pet keeping in early childhood and asthma and allergies in children aged 6-10 years. Design: Pooled analysis of individual participant data of 11 prospective European birth cohorts that recruited a total of over 22,000 children in the 1990s. Exposure definition: Ownership of only cats, dogs, birds, rodents, or cats/dogs combined during the first 2 years of life. Outcome definition: Current asthma (primary outcome), allergic asthma, allergic rhinitis and allergic sensitization during 610 years of age. Data synthesis: Three-step approach: (i) Common definition of outcome and exposure variables across cohorts; (ii) calculation of adjusted effect estimates for each cohort; (iii) pooling of effect estimates by using random effects meta-analysis models. Results: We found no association between furry and feathered pet keeping early in life and asthma in school age. For example, the odds ratio for asthma comparing cat ownership with no pets (10 studies, 11489 participants) was 1.00 (95% confidence interval 0.78 to 1.28) (I 2 = 9%; p = 0.36). The odds ratio for asthma comparing dog ownership with no pets (9 studies, 11433 participants) was 0.77 (0.58 to 1.03) (I-2 = 0%, p = 0.89). Owning both cat(s) and dog(s) compared to no pets resulted in an odds ratio of 1.04 (0.59 to 1.84) (I-2 = 33%, p = 0.18). Similarly, for allergic asthma and for allergic rhinitis we did not find associations regarding any type of pet ownership early in life. However, we found some evidence for an association between ownership of furry pets during the first 2 years of life and reduced likelihood of becoming sensitized to aero-allergens. Conclusions: Pet ownership in early life did not appear to either increase or reduce the risk of asthma or allergic rhinitis symptoms in children aged 6-10. Advice from health care practitioners to avoid or to specifically acquire pets for primary prevention of asthma or allergic rhinitis in children should not be given., This collaborative project was initiated, supported and funded by the Global Allergy and Asthma European Network (GA2LEN; www.ga2len.net) under the 6th framework programme of the European Commission (project no. FOOD-CT-2004-506378). Sources of funding of the individual birth cohort studies are described in their publications. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Acceda, Documentación científica de la ULPGC en abierto
oai:accedacris.ulpgc.es:10553/119493
Conferencia académica (lecture). 2022
CETACEANS AS SENTINEL FOR MARINE LITTER, DATA FROM THE CANARY ISLANDS (2000-2020)
Acceda, Documentación científica de la ULPGC en abierto
- Puig Lozano, Raquel Patricia
- Fernández Rodríguez, Antonio Jesús
- Bernaldo De Quirós Miranda, Yara
- Diaz Delgado, Josue
- García Álvarez, Natalia
- Sierra Pulpillo, Eva María
- Suarez Santana, Cristian Manuel
- Arregui Gil, Marina
- Rivero Santana, Miguel Antonio
- Arbelo Hernández, Manuel Antonio
Stranded cetaceans represent a significant opportunity to study the interaction of marine megafauna with plastic debris. In the Canary Islands, the major hotspot for cetacean biodiversity in European waters, 7.7% of stranded cetaceans ingest foreign bodies (FB), and almost 3% of studied cases die due to this lethal interaction (Puig-Lozano et al. 2018). In this study, we update the data on FB ingestion in stranded cetaceans from 2000 to 2020. We found a slightly lower prevalence of FB ingestion (6.7%;46/682) and deaths due to lesions produced by FB (2.05%;14/683). However, one more affected species was described (a total of 16 cetacean species), being deep divers more affected. As previously, plastics were the most prevalent item found (91.3%; 42/46), being classified as plastic bags and other domestic plastic debris (69%; 29/42), ropes (19%;8/42), nylon fishing line (9.5%; 4/42), packing (2.4%; 1/42) and net remains (2.4%; 1/42). Lesions varies due to severe ulcerative gastritis (28.3%; 13/46), gastric impactions (26%; 12/46), gastrointestinal perforations (0.04%; 2/46), stomatitis (0.04%; 2/46), glossitis (0.02%;1/46), cicatrized ulcers in stomach (0.02%;1/46), and absence of lesions or not possible to evaluate due to the advance decomposition of the carcasses (32.6%; 15/456). Also, metal filaments (4.3%; 2/46), clothes (2,2%; 1/46), and glass fragment (2,2%; 1/46) has been found. Eisfeld-Pierantoni et al. (2022) warned about the environmental consequences of the COVID-19 pandemic to marine plastic pollution, which is expected to produce serious consequences for marine life, including cetaceans. In fact, in March of this year, an adult female common dolphin (Delphinus delphis), stranded on Arico, Tenerife, presented an ingested facemask within other disposable plastics and nets on the forestomach, which may contribute to its death. Ongoing studies on FB ingestion in cetaceans are crucial to monitoring ocean health and future environmental conservation policies in this archipelago.
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/199978
Artículo científico (article). 2020
IMPACT OF FLUCONAZOLE SUSCEPTIBILITY ON THE OUTCOME OF PATIENTS WITH CANDIDAEMIA: DATA FROM A POPULATION-BASED SURVEILLANCE
Digital.CSIC. Repositorio Institucional del CSIC
- Fernández-Ruiz, Mario
- Guinea, J.
- Lora-Pablos, David
- Zaragoza, O.
- Puig-Asensio, M.
- Almirante, Benito
- Cuenca-Estrella, Manuel
- Aguado, José María
CANDIPOP Project: B. Padilla, P. Muñoz, J. Guinea, J. R. Paño Pardo, J. García-Rodríguez, C. G. Cerrada, J. Fortún, P. Martín, E. Gómez, P. Ryan, C. Campelo, I. de los Santos, Gil, V. Buendía, B. P. Gorricho, M. Alonso, F. S. Sanz, J. M. Aguado, P. Merino, F. González Romo, M. Gorgolas, I. Gadea, J. E. Losa, A. Delgado-Iribarren, A. Ramos, Y. Romero, I. S. Romero, O. Zaragoza, M. Cuenca-Estrella, J. Rodríguez-Baño, A. I. Suarez, A. Loza, A. I. Aller García, E. Martín-Mazuelos, M. R. Pérez de Pipaón, J. Garnacho, C. Ortiz, M. Chávez, F. L. Maroto, M. Salavert, J. Pemán, J. Blanquer, D. Navarro, J. J. Camarena, R. Zaragoza, V. Abril, C. Gimeno, S. Hernández, G. Ezpeleta, E. Bereciartua, J. L. Hernández Almaraz, M. Montejo, R. A. Rivas, R. Ayarza, A. M. Planes, I. R. Camps, B. Almirante, J. Mensa, M. Almela, M. Gurgui, F. Sánchez-Reus, J. Martínez-Montauti, M. Sierra, J. P. Horcajada, L.Sorli, J. Gómez, A. Gené, M. Urrea, A. Mularoni, M.Valerio, A. Díaz-Martín, F. Puchades., [Objectives] The clinical correlation of fluconazole antifungal susceptibility testing (AST) for Candida isolates and its integration with pharmacokinetics/pharmacodynamics (PK/PD) parameters is unclear. We analysed the impact of fluconazole minimum inhibitory concentration (MIC) values, 24-hour area under the concentration–time curve (AUC24) and AUC24/MIC ratio on the outcome of candidemic patients., [Methods] We included 257 episodes of candidaemia treated with fluconazole monotherapy for ≥72 hours from a population-based surveillance conducted in 29 hospitals (CANDIPOP Project). AST was centrally performed by European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Clinical and Laboratory Standards Institute (CLSI) microdilution methods. Primary outcome was clinical failure (30-day mortality and/or persistent candidaemia for ≥72 hours from initiation of therapy). Secondary outcomes included early (3–7 days) and late (3–30 days) mortality., [Results] Rates of clinical failure, early and late mortality among evaluable episodes were 32.3% (80/248), 3.1% (8/257) and 23.4% (59/248). There was no relationship between fluconazole MIC values or PK/PD parameters and clinical failure. Although MIC values ≥2 mg/L by EUCAST (positive predictive value 32.1%, negative predictive value 68.7%) and ≥0.5 mg/L by CLSI (positive predictive value 34.8%, negative predictive value 74.4%) appeared to be optimal for predicting clinical failure, no significant associations remained after multivariate adjustment (odds ratio 1.67; 95% confidence interval 0.48–5.79; p 0.423). Lack of association was consistent for alternative thresholds (including proposed clinical breakpoints). The only association found for secondary outcomes was between an AUC24/MIC ratio >400 h by CLSI and early mortality (odds ratio 0.18; 95% confidence interval 0.04–0.98; p 0.026)., [Conclusions] High fluconazole MIC values did not negatively impact outcome of patients with candidaemia treated with fluconazole. No effect of PK/PD targets on the risk of clinical failure was found., Supported in part by nonrestrictive research grants from Gilead, MSD, Astellas and Pfizer. This study was cofunded by Fundación SEIMC-GESIDA; the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (cofinanced by the European Development Regional Fund (ERDF) ‘A Way to Achieve Europe’); and the Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015).
MFR holds a ‘Juan Rodés’ clinical research contract (JR14/00036) and JG a ‘Miguel Servet’ contract (CPII15/00006), both from the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III. MFR has received honoraria for talks on behalf of Pfizer and Gilead Sciences. JG has received grant support from Astellas Pharma, MICOLAB, the Mutua Madrileña Foundation and the Spanish Health Research Fund (FIS). He has been paid for talks on behalf of Gilead Sciences, Merck Sharp & Dohme, Pfizer, Astellas Pharma, Hickma Pharmaceutica and United Medical. BA has received grant support from Gilead Sciences, Pfizer and the Instituto de Salud Carlos III. He has received honoraria for talks on behalf of Gilead Sciences, Merck Sharp & Dohme, Pfizer, Astellas Pharma and Novartis. BP has received honoraria for talks on behalf of Gilead Sciences, Merck Sharp & Dohme, Pfizer, Astellas Pharma and Novartis. MCE has received grant support from Astellas Pharma, bioMérieux, Gilead Sciences, Merck Sharp & Dohme, Pfizer, Schering Plough, Soria Melguizo SA, Ferrer International, the Europea Union, the ALBAN program, the Spanish Agency for International Cooperation, the Spanish Ministry of Culture and Education, the Spanish Health Research Fund, the Instituto de Salud Carlos III (Spanish Ministry of Economy and Competitiveness), the Ramon Areces Foundation and the Mutua Madrileña Foundation.
RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
oai:repositoriosalud.es:10668/18753
Artículo científico (article). 2017
IMPACT OF FLUCONAZOLE SUSCEPTIBILITY ON THE OUTCOME OF PATIENTS WITH CANDIDAEMIA: DATA FROM A POPULATION-BASED SURVEILLANCE
RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
- Fernandez-Ruiz, M.
- Guinea, J.
- Lora-Pablos, D.
- Zaragoza, O.
- Puig-Asensio, M.
- Almirante, B.
- Cuenca-Estrella, M.
- Aguado, J. M.
- CANDIPOP Project
- GEIH-GEMICOMED SEIMC
- REIPI
Objectives: The clinical correlation of fluconazole antifungal susceptibility testing (AST) for Candida isolates and its integration with pharmacokinetics/pharmacodynamics (PK/PD) parameters is unclear. We analysed the impact of fluconazole minimum inhibitory concentration (MIC) values, 24-hour area under the concentration-time curve (AUC24) and AUC24/MIC ratio on the outcome of candidemic patients.Methods: We included 257 episodes of candidaemia treated with fluconazole monotherapy for >= 72 hours from a population-based surveillance conducted in 29 hospitals (CANDIPOP Project). AST was centrally performed by European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Clinical and Laboratory Standards Institute (CLSI) microdilution methods. Primary outcome was clinical failure (30-day mortality and/or persistent candidaemia for >= 72 hours from initiation of therapy). Secondary outcomes included early (3-7 days) and late (3-30 days) mortality.Results: Rates of clinical failure, early and late mortality among evaluable episodes were 32.3% (80/248), 3.1% (8/257) and 23.4% (59/248). There was no relationship between fluconazole MIC values or PK/PD parameters and clinical failure. Although MIC values >= 2 mg/L by EUCAST (positive predictive value 32.1%, negative predictive value 68.7%) and >= 0.5 mg/L by CLSI (positive predictive value 34.8%, negative predictive value 74.4%) appeared to be optimal for predicting clinical failure, no significant associations remained after multivariate adjustment (odds ratio 1.67; 95% confidence interval 0.48-5.79; p 0.423). Lack of association was consistent for alternative thresholds (including proposed clinical breakpoints). The only association found for secondary outcomes was between an AUC24/MIC ratio >400 h by CLSI and early mortality (odds ratio 0.18; 95% confidence interval 0.04-0.98; p 0.026).Conclusions: High fluconazole MIC values did not negatively impact outcome of patients with candidaemia treated with fluconazole. No effect of PK/PD targets on the risk of clinical failure was found. (C) 2017 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
UPCommons. Portal del coneixement obert de la UPC
oai:upcommons.upc.edu:2117/383657
Artículo científico (article). 2023
EXPLORATORY ANALYSIS OF SCADA DATA FROM WIND URBINES USING THE K-MEANS CLUSTERING ALGORITHM FOR PREDICTIVE MAINTENANCE PURPOSES
UPCommons. Portal del coneixement obert de la UPC
- Cosa Rodríguez, Pablo
- Marti Puig, Pere
- Caiafa, Cesar F.
- Serra Serra, Moisès
- Cusidó Roura, Jordi|||0000-0002-1951-1498
- Sole Casals, Jordi
Product maintenance costs throughout the product’s lifetime can account for between 30–60% of total operating costs, making it necessary to implement maintenance strategies. This problem not only affects the economy but is also related to the impact on the environment, since breakdowns are also responsible for the delivery of greenhouse gases. Industrial maintenance is a set of measures of a technical-organizational nature whose purpose is to sustain the functionality of the equipment and guarantee an optimal state of the machines over time, with the aim of saving costs, extending the useful life of the machines, saving energy, maximising production and availability, ensuring the quality of the product obtained, providing job security for technicians, preserving the environment, and reducing emissions as much as possible. Machine learning techniques can be used to detect or predict faults in wind turbines. However, labelled data suffers from many problems in this application because alarms are usually not clearly associated with a specific fault, some labels are wrongly associated with a problem, and the imbalance between labels is evident. To avoid using labelled data, we investigate here the use of the clustering technique, more specifically K-means, and boxplot representations of the variables for a set of six different tests. Experimental results show that in some cases, the clustering and boxplot techniques allow us to determine outliers or identify erroneous behaviours of the wind turbines. These cases can then be investigated in detail by a specialist so that more efficient predictive maintenance can be carried out., Peer Reviewed, Objectius de Desenvolupament Sostenible::7 - Energia Assequible i No Contaminant, Objectius de Desenvolupament Sostenible::7 - Energia Assequible i No Contaminant::7.2 - Per a 2030, augmentar substancialment el percentatge d’energia renovable en el conjunt de fonts d’energia
O2, repositorio institucional de la UOC
oai:openaccess.uoc.edu:10609/151387
Artículo científico (article). 2023
EXPLORATORY ANALYSIS OF SCADA DATA FROM WIND TURBINES USING THE K-MEANS CLUSTERING ALGORITHM FOR PREDICTIVE MAINTENANCE PURPOSES
O2, repositorio institucional de la UOC
- Cosa Rodriguez, Pablo
- Marti-Puig, Pere
- Caiafa, Cesar F.
- Serra-Serra, Moisès
- Cusidó, Jordi
- Solé-Casals, Jordi
Product maintenance costs throughout the product’s lifetime can account for between
30–60% of total operating costs, making it necessary to implement maintenance strategies. This
problem not only affects the economy but is also related to the impact on the environment, since
breakdowns are also responsible for the delivery of greenhouse gases. Industrial maintenance is a set
of measures of a technical-organizational nature whose purpose is to sustain the functionality of the
equipment and guarantee an optimal state of the machines over time, with the aim of saving costs,
extending the useful life of the machines, saving energy, maximising production and availability,
ensuring the quality of the product obtained, providing job security for technicians, preserving the
environment, and reducing emissions as much as possible. Machine learning techniques can be used
to detect or predict faults in wind turbines. However, labelled data suffers from many problems in
this application because alarms are usually not clearly associated with a specific fault, some labels
are wrongly associated with a problem, and the imbalance between labels is evident. To avoid using
labelled data, we investigate here the use of the clustering technique, more specifically K-means,
and boxplot representations of the variables for a set of six different tests. Experimental results
show that in some cases, the clustering and boxplot techniques allow us to determine outliers or
identify erroneous behaviours of the wind turbines. These cases can then be investigated in detail by
a specialist so that more efficient predictive maintenance can be carried out
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
oai:repositoriosaludmadrid.es:20.500.12530/81642
Artículo científico (article). 2021
EVALUATION OF THE EFFECTIVENESS OF HELICOBACTER PYLORI ERADICATION REGIMENS IN LITHUANIA DURING THE YEARS 2013-2020: DATA FROM THE EUROPEAN REGISTRY ON HELICOBACTER PYLORI MANAGEMENT (HP-EUREG).
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
- Jonaitis, Paulius
- Kupcinskas, Juozas
- Nyssen, Olga P
- Puig, Ignasi
- Gisbert, Javier P
- Jonaitis, Laimas
Background and Objectives: The prevalence of H. pylori in Eastern Europe remains quite high; however, there is insufficient data on the eradication regimens and their effectiveness. Therefore, the objective of the study was to evaluate the diagnostic methods and treatment of H. pylori infection as well as their adherence to Maastricht V/Florence consensus during the years 2013-2020 in Lithuania. Materials and Methods: Sub-study of the "European Registry on H. pylori Management" (Hp-EuReg), international multicenter prospective non-interventional registry of the routine clinical practice. Lithuanian data from the years 2013-2020 were analyzed for effectiveness on a modified intention-to-treat (mITT) basis. 2000 adult patients, diagnosed with H. pylori infection, were included. Data were compared to the European Maastricht V guidelines. Results: Triple-therapy was used in 90% of the cases. In 91% of the first-line prescriptions, standard triple therapy (STT) was used. The most common second-line treatment was a combination of PPI, amoxicillin and levofloxacin (PPI+A+L) (47%). The overall effectiveness in 552 cases valid for analysis was 90% by mITT. In first-line treatment, the STT effectiveness was 90% and second-line treatment with PPI+A+L achieved 92% by mITT. Increasing overall H. pylori eradication rates were observed: from 72% in 2013 to more than 90% in 2018-2020, as well as a shift from 7 to 10-14 days treatments duration throughout 2013-2020. Conclusions: In Lithuania, the prescribed eradication regimens for H. pylori were in accordance with the international guidelines but diagnostic methods and treatment duration only partially met Maastricht V/Florence guidelines. The eradication effectiveness was improved progressively during the years 2018-2020, reaching ≥90% cure rates.
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
oai:fundanet.iislafe.san.gva.es:p13445
Otros (other). 2020
EFFICACY AND SAFETY OF BARICITINIB AND TOFACITINIB IN RHEUMATOID ARTHRITIS: DATA FROM REAL-WORLD
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
- Mazario, RG
- Fragio-Gil, J. J.
- Garcia, EG
- Navarro, MD
- Perales, CP
- Rodriguez, SL
- Cortes, JI
- Albuixech, RN
- Puig, LG
- Rodriguez, JEO
- Escandell, CA
- Bernabeu, EV
- Verdejo, IC
- Cordellat, IM
- Sanjuan, FMO
- Herranz, CN
- Olmos, IC
- Martinez, AJC
- Ivorra, JAR
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
oai:fundanet.iislafe.san.gva.es:p20528
Artículo científico (article). 2024
EFFECTIVENESS AND TOLERABILITY OF BRIVARACETAM IN PATIENTS WITH EPILEPSY STRATIFIED BY COMORBIDITIES AND ETIOLOGY IN THE REAL WORLD: 12-MONTH SUBGROUP DATA FROM THE INTERNATIONAL EXPERIENCE POOLED ANALYSIS.
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
- Szaflarski, Jerzy P
- Besson, Herve
- D'Souza, Wendyl
- Faught, Edward
- Klein, Pavel
- Reuber, Markus
- Rosenow, Felix
- Salas-Puig, Javier
- Soto Insuga, Victor
- Steinhoff, Bernhard J
- Strzelczyk, Adam
- Bourikas, Dimitrios
- Daniels, Tony
- Floricel, Florin
- Friesen, David
- Laloyaux, Cedric
- Villanueva, Vicente
OBJECTIVE: To assess the effectiveness and tolerability of brivaracetam
(BRV) in adults with epilepsy by specific comorbidities and epilepsy
etiologies.
METHODS: EXPERIENCE/EPD332 was a pooled analysis of individual patient
records from several non-interventional studies of patients with
epilepsy initiating BRV in clinical practice. Outcomes included=50%
reduction from baseline in seizure frequency, seizure freedom (no
seizures within prior 3months), continuous seizure freedom (no seizures
since baseline), BRV discontinuation, and treatment-emergent adverse
events (TEAEs) at 3, 6, and 12months. Analyses were performed for all
adult patients (=16years of age) and stratified by comorbidity and by
etiology at baseline (patients with cognitive/learning disability [CLD],
psychiatric comorbidity, post-stroke epilepsy, brain tumor-related
epilepsy [BTRE], and traumatic brain injury-related epilepsy [TBIE]).
RESULTS: At 12months,=50% seizure reduction was achieved in 35.6%
(n=264), 38.7% (n=310), 41.7% (n=24), 34.1% (n=41), and 50.0% (n=28) of
patients with CLD, psychiatric comorbidity, post-stroke epilepsy, BTRE,
and TBIE, respectively; and continuous seizure freedom was achieved in
5.7% (n=318), 13.7% (n=424), 29.4% (n=34), 11.4% (n=44), and 13.8%
(n=29), respectively. During the study follow-up, in patients with CLD,
psychiatric comorbidity, post-stroke epilepsy, BTRE, and TBIE, 37.1%
(n=403), 30.7% (n=605), 33.3% (n=51), 39.7% (n=68), and 27.1% (n=49) of
patients discontinued BRV, respectively; and TEAEs since prior visit at
12months were reported in 11.3% (n=283), 10.0% (n=410), 16.7% (n=36),
12.5% (n=48), and 3.0% (n=33), respectively.
CONCLUSIONS: BRV as prescribed in the real world is effective and well
tolerated among patients with CLD, psychiatric comorbidity, post-stroke
epilepsy, BTRE, and TBIE.
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2 Versiones
2 Versiones
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/269620
Dataset. 2017
DATA FROM: ANALYSIS OF THE PORCINE APOA2 GENE EXPRESSION IN LIVER, POLYMORPHISMS IDENTIFICATION AND ASSOCIATION WITH FATTY ACID COMPOSITION TRAITS
Digital.CSIC. Repositorio Institucional del CSIC
- Ballester, María
- Revilla, Manuel
- Puig-Oliveras, Anna
- Marchesi, J.A.P.
- Castelló, Anna
- Corominas, Jordi
- Fernández, Ana Isabel
- Folch, Josep María
Usage Notes
Porcine APOA2 gene expression in liver
Data from Analysis of the porcine APOA2 gene expression in liver, polymorphisms identification and association with fatty acid composition traits. Contains SNP genotypes for GWAS and eGWAS studies, mRNA expression of APOA2 in liver, and fatty acid composition in backfat and muscle, APOA2 is a protein implicated in triglyceride, fatty acid and glucose metabolism. In pigs, the APOA2 gene is located on pig chromosome 4 (SSC4) in a QTL region affecting fatty acid composition, fatness and growth traits. In this study, we evaluated APOA2 as a candidate gene for meat quality traits in an Iberian × Landrace backcross population. The APOA2:c.131T>A polymorphism, located in exon 3 of APOA2 and determining a missense mutation, was associated with the percentage of hexadecenoic acid [C16:1(n–9)], linoleic acid [C18:2(n–6)], α-linolenic acid [C18:3(n–3)], dihomo-gamma-linolenic acid [C20:3(n–6)] and polyunsaturated fatty acids (PUFAs) in backfat. Furthermore, this SNP was associated with the global mRNA expression levels of APOA2 in liver and was used as a marker to determine allelic expression imbalance by pyrosequencing. We determined an overexpression of the T allele in heterozygous samples with a mean ratio of 2.8 (T/A), observing a high variability in the allelic expression among individuals. This result suggests that complex regulatory mechanisms, beyond a single polymorphism (e.g. epigenetic effects or multiple cis-acting polymorphisms), may be regulating APOA2 gene expression., Peer reviewed
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/312535
Dataset. 2017
DATA FROM "RELATIONSHIP BETWEEN WEIGHT AND DIMENSIONS OF BLUEFIN TUNA (THUNNUS THYNNUS) FOLLOWING FATTENING ON WESTERN MEDITERRANEAN FARMS"
Digital.CSIC. Repositorio Institucional del CSIC
- Puig, V.
- Estruch, Vicente Domingo
- Espinosa, Víctor
- de-la-Gándara, Fernando
- Mèlich, B.
- Cort, José Luis
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