Table of Content 1. Supplemental Figures 2. Supplemental Note a. Research electronic data capture (REDCap) b. Genetic risk score and multinomial regression on severity scale c. Evaluating the associations of leading SNPs in relation with comorbidities d. Measuring genome-specific effects on COVID-19 severity and hospitalization 3. Supplemental references 4. A full list of cohort members and affiliations a. SCOURGE cohort group b. HOSTAGE cohort group c. GR@ACE cohort group, Peer reviewed

SUPPLEMENTAL MATERIAL 1.- Description of genetic analyses performed in the IMCL-2015 study 2.- Treatment discontinuation events and relationship with IR combination 3.- Supplemental Table S1 . Histological review according to the tissue sample 4.- Supplemental Table S2. Clinical and biological features according to TP53 mutational status 5.- Supplemental Table S3. Clinical and biological features according to nnMCL or cMCL molecular subtypes 6.- Supplemental Table S4. Responses after 12 cycles of IR combination according to genomic complexity 7.- Supplemental Table S5. Molecular response in peripheral blood and bone marrow at 6,12, 18 and 24 months 8.- Supplemental Figure S1. PFS from the time of ibrutinib stop in patients in response and sustained undetectable MRD 9.- Supplemental Figure S2. PFS according to MRD status at PB (Cycle 12) 10.- Supplemental Figure S3. A) OS by MIPI and B) OS by TP53 mutational status 2 Supplemental Figure Legends Supplemental Figure S1. PFS from the time of ibrutinib stop in patients in response and sustained undetectable MRD PFS, progression-free survival; MRD, minimal residual disease Supplemental Figure S2. PFS according to MRD status at PB (Cycle 12) (P=.063) PFS, progression-free survival ;MRD, minimal residual disease; PB, peripheral blood Supplemental Figure S3. A) OS by MIPI (P= .007) and B) OS by TP53 mutational status (P= .0002) OS, overall survival; MIPI, Mantle cell lymphoma International Prognostic Index; wt, wild-type; mut, mutated, Peer reviewed

Supplementary_File_1_HP1_peaks Supplementary_File_2_HP1_gene_tissues Supplementary_File_3_Overlapping between HP1 bound genes with tissue-specific genes Supplementary_File_4_Overlapping between tissue-specific genes bound by HP1 proteins Supplemental Figures and Tables, Peer reviewed