Dataset.

Supporting Information: Experimental and in Silico Analysis of TEM β-Lactamase Adaptive Evolution

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330796
Digital.CSIC. Repositorio Institucional del CSIC
  • Standley, Melissa
  • Blay, Vincent
  • Beleva Guthrie, Violeta
  • Kim, Jay
  • Lyman, Audrey
  • Moya, Andrés
  • Karchin, Rachel
  • Camps, Manel
Mutations in CCED database (Figure S1), dose–response fitting (Figure S2), IC50 for all variants (Table S1), epistatic interactions identified (Table S2), previously reported interactions (Table S3), structural model of TEM-1 (Figure S3), relationship between ampicillin and cefotaxime epistasis (Figure S4), virtual alanine scanning (Figure S5), FoldX results (Figure S6), destabilizing effects in CCED (Figure S7), and molecular dynamics results (Figure S8) (PDF) SI01.xlsx, CCED raw data (XLSX) SI02.xlsx, experimental raw data (XLSX) SI03.xlsx, epistatic analysis of experimental data (XLSX) SI04.xlsx, epistatic analysis of CCED data (XLSX), Peer reviewed
 
DOI: http://hdl.handle.net/10261/330796
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330796

HANDLE: http://hdl.handle.net/10261/330796
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330796
 
Ver en: http://hdl.handle.net/10261/330796
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330796

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/330796
Dataset. 2022

SUPPORTING INFORMATION: EXPERIMENTAL AND IN SILICO ANALYSIS OF TEM Β-LACTAMASE ADAPTIVE EVOLUTION

Digital.CSIC. Repositorio Institucional del CSIC
  • Standley, Melissa
  • Blay, Vincent
  • Beleva Guthrie, Violeta
  • Kim, Jay
  • Lyman, Audrey
  • Moya, Andrés
  • Karchin, Rachel
  • Camps, Manel
Mutations in CCED database (Figure S1), dose–response fitting (Figure S2), IC50 for all variants (Table S1), epistatic interactions identified (Table S2), previously reported interactions (Table S3), structural model of TEM-1 (Figure S3), relationship between ampicillin and cefotaxime epistasis (Figure S4), virtual alanine scanning (Figure S5), FoldX results (Figure S6), destabilizing effects in CCED (Figure S7), and molecular dynamics results (Figure S8) (PDF) SI01.xlsx, CCED raw data (XLSX) SI02.xlsx, experimental raw data (XLSX) SI03.xlsx, epistatic analysis of experimental data (XLSX) SI04.xlsx, epistatic analysis of CCED data (XLSX), Peer reviewed




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