Dataset.

Supplemental information for GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/313133
Digital.CSIC. Repositorio Institucional del CSIC
  • Bossi, Simon
  • Dhanasobhon, Dhanasak
  • Ellis-Davies, Graham C.R.
  • Frontera, Jimena
  • Brito Van Velze, Marcel de
  • Lourenço, Joana
  • Murillo, Alvaro
  • Luján, Rafael
  • Casado, Mariano
  • Pérez-Otaño, Isabel
  • Bacci, Alberto
  • Popa, Daniela
  • Paolitti, Pierre
  • Rebola, Nelson
Figure S1: Grin3a mRNA is abundantly expressed in vGlut2-positive neurons in the BLA and glycine-evoked currents display current-voltage relationship compatible with the activation of non-selective cationic channels. Related to Figures 1 and 2. Figure S2: Photolysis of CNI-Gly reliably activates inhibitory glycine receptors in dorsal horn spinal cord neurons and induces inward currents in SST-INs. Related to Figure 3. Figure S3: Photolysis of MNI-glutamate shows enrichment of ionotropic glutamatergic receptors in spines of BLA PNs. Related to Figure 3. Figure S4: Tonic activation and modulation of eGlyR in BLA neuronal populations. Related to Figure 4. Figure S5: Modulation of eGlyR activity in S1 SST-INs. Related to Figure 5. Figure S6: shGluN3A constructs effectively reduce functional expression of eGlyRs in SST-INs and BLA PNs. Related to Figure 6. Figure S7: Dopamine modulation of eGlyR activity; evaluation of cell types infected by AAV-shGluN3A constructs in the BLA and assessment of locomotion and anxiety-like behavior in shRNA treated mice. Related to Figure 7. Table S1: Passive and firing properties of S1 SST-INs in WT and GluN3A KO mice. Related to Figure5., Peer reviewed
 
DOI: http://hdl.handle.net/10261/313133
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/313133

HANDLE: http://hdl.handle.net/10261/313133
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/313133
 
Ver en: http://hdl.handle.net/10261/313133
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/313133

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/313133
Dataset. 2022

SUPPLEMENTAL INFORMATION FOR GLUN3A EXCITATORY GLYCINE RECEPTORS CONTROL ADULT CORTICAL AND AMYGDALAR CIRCUITS

Digital.CSIC. Repositorio Institucional del CSIC
  • Bossi, Simon
  • Dhanasobhon, Dhanasak
  • Ellis-Davies, Graham C.R.
  • Frontera, Jimena
  • Brito Van Velze, Marcel de
  • Lourenço, Joana
  • Murillo, Alvaro
  • Luján, Rafael
  • Casado, Mariano
  • Pérez-Otaño, Isabel
  • Bacci, Alberto
  • Popa, Daniela
  • Paolitti, Pierre
  • Rebola, Nelson
Figure S1: Grin3a mRNA is abundantly expressed in vGlut2-positive neurons in the BLA and glycine-evoked currents display current-voltage relationship compatible with the activation of non-selective cationic channels. Related to Figures 1 and 2. Figure S2: Photolysis of CNI-Gly reliably activates inhibitory glycine receptors in dorsal horn spinal cord neurons and induces inward currents in SST-INs. Related to Figure 3. Figure S3: Photolysis of MNI-glutamate shows enrichment of ionotropic glutamatergic receptors in spines of BLA PNs. Related to Figure 3. Figure S4: Tonic activation and modulation of eGlyR in BLA neuronal populations. Related to Figure 4. Figure S5: Modulation of eGlyR activity in S1 SST-INs. Related to Figure 5. Figure S6: shGluN3A constructs effectively reduce functional expression of eGlyRs in SST-INs and BLA PNs. Related to Figure 6. Figure S7: Dopamine modulation of eGlyR activity; evaluation of cell types infected by AAV-shGluN3A constructs in the BLA and assessment of locomotion and anxiety-like behavior in shRNA treated mice. Related to Figure 7. Table S1: Passive and firing properties of S1 SST-INs in WT and GluN3A KO mice. Related to Figure5., Peer reviewed




1106