Dataset.
Image_5_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370227
Digital.CSIC. Repositorio Institucional del CSIC
- Rodrigues, Cristiana
- Laranjeira, Paula
- Pinho, Aryane
- Silva, Isabel
- Silva, Sandra
- Coucelo, Margarida
- Oliveira, Ana C.
- Simões, Ana Teresa
- Damásio, Inês
- Matos Silva, Helena
- Urbano, Mafalda
- Sarmento-Ribeiro, Ana Bela
- Geraldes, Catarina
- Domingues, M. Rosário
- Almeida, Julia
- Criado, Ignacio
- Orfao, Alberto
- Paiva, Artur
[Introduction]: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer., [Methods]: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease., [Results and discussion]: CD20+ T cells were more represented within the CD8+ T cell compartment and they showed a predominant memory Tc1 phenotype. CD20+ T cells were less represented in MBL and CLL patients vs healthy controls, particularly among those with unmutated IGVH gene. The expansion of malignant B cells was accompanied by phenotypic and functional changes in CD20+ T cells, including an increase in follicular helper CD4+ CD20+ T cells and CD20+ Tc1 cells, in addition to the expansion of the TCR Vβ 5.1 in CD4+ CD20+ T cells in CLL., Peer reviewed
DOI: http://hdl.handle.net/10261/370227
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370227
HANDLE: http://hdl.handle.net/10261/370227
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370227
Ver en: http://hdl.handle.net/10261/370227
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370227
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Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370227
Dataset. 2023
IMAGE_5_CD20+ T CELLS IN MONOCLONAL B CELL LYMPHOCYTOSIS AND CHRONIC LYMPHOCYTIC LEUKEMIA: FREQUENCY, PHENOTYPE AND ASSOCIATION WITH DISEASE PROGRESSION.PDF [DATASET]
Digital.CSIC. Repositorio Institucional del CSIC
- Rodrigues, Cristiana
- Laranjeira, Paula
- Pinho, Aryane
- Silva, Isabel
- Silva, Sandra
- Coucelo, Margarida
- Oliveira, Ana C.
- Simões, Ana Teresa
- Damásio, Inês
- Matos Silva, Helena
- Urbano, Mafalda
- Sarmento-Ribeiro, Ana Bela
- Geraldes, Catarina
- Domingues, M. Rosário
- Almeida, Julia
- Criado, Ignacio
- Orfao, Alberto
- Paiva, Artur
[Introduction]: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer., [Methods]: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease., [Results and discussion]: CD20+ T cells were more represented within the CD8+ T cell compartment and they showed a predominant memory Tc1 phenotype. CD20+ T cells were less represented in MBL and CLL patients vs healthy controls, particularly among those with unmutated IGVH gene. The expansion of malignant B cells was accompanied by phenotypic and functional changes in CD20+ T cells, including an increase in follicular helper CD4+ CD20+ T cells and CD20+ Tc1 cells, in addition to the expansion of the TCR Vβ 5.1 in CD4+ CD20+ T cells in CLL., Peer reviewed
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