Dataset.

Image_5_CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression.pdf [Dataset]

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370227
Digital.CSIC. Repositorio Institucional del CSIC
  • Rodrigues, Cristiana
  • Laranjeira, Paula
  • Pinho, Aryane
  • Silva, Isabel
  • Silva, Sandra
  • Coucelo, Margarida
  • Oliveira, Ana C.
  • Simões, Ana Teresa
  • Damásio, Inês
  • Matos Silva, Helena
  • Urbano, Mafalda
  • Sarmento-Ribeiro, Ana Bela
  • Geraldes, Catarina
  • Domingues, M. Rosário
  • Almeida, Julia
  • Criado, Ignacio
  • Orfao, Alberto
  • Paiva, Artur
[Introduction]: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer., [Methods]: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease., [Results and discussion]: CD20+ T cells were more represented within the CD8+ T cell compartment and they showed a predominant memory Tc1 phenotype. CD20+ T cells were less represented in MBL and CLL patients vs healthy controls, particularly among those with unmutated IGVH gene. The expansion of malignant B cells was accompanied by phenotypic and functional changes in CD20+ T cells, including an increase in follicular helper CD4+ CD20+ T cells and CD20+ Tc1 cells, in addition to the expansion of the TCR Vβ 5.1 in CD4+ CD20+ T cells in CLL., Peer reviewed
 
DOI: http://hdl.handle.net/10261/370227
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370227

HANDLE: http://hdl.handle.net/10261/370227
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370227
 
Ver en: http://hdl.handle.net/10261/370227
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370227

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370227
Dataset. 2023

IMAGE_5_CD20+ T CELLS IN MONOCLONAL B CELL LYMPHOCYTOSIS AND CHRONIC LYMPHOCYTIC LEUKEMIA: FREQUENCY, PHENOTYPE AND ASSOCIATION WITH DISEASE PROGRESSION.PDF [DATASET]

Digital.CSIC. Repositorio Institucional del CSIC
  • Rodrigues, Cristiana
  • Laranjeira, Paula
  • Pinho, Aryane
  • Silva, Isabel
  • Silva, Sandra
  • Coucelo, Margarida
  • Oliveira, Ana C.
  • Simões, Ana Teresa
  • Damásio, Inês
  • Matos Silva, Helena
  • Urbano, Mafalda
  • Sarmento-Ribeiro, Ana Bela
  • Geraldes, Catarina
  • Domingues, M. Rosário
  • Almeida, Julia
  • Criado, Ignacio
  • Orfao, Alberto
  • Paiva, Artur
[Introduction]: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer., [Methods]: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease., [Results and discussion]: CD20+ T cells were more represented within the CD8+ T cell compartment and they showed a predominant memory Tc1 phenotype. CD20+ T cells were less represented in MBL and CLL patients vs healthy controls, particularly among those with unmutated IGVH gene. The expansion of malignant B cells was accompanied by phenotypic and functional changes in CD20+ T cells, including an increase in follicular helper CD4+ CD20+ T cells and CD20+ Tc1 cells, in addition to the expansion of the TCR Vβ 5.1 in CD4+ CD20+ T cells in CLL., Peer reviewed




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