Dataset.
Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks: Supplementary data
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311659
Digital.CSIC. Repositorio Institucional del CSIC
- Medalla, Maria
- Chang, Wayne
- Ibáñez, Sara
- Guillamón-Vivancos, Teresa
- Nittmann, Mathias
- Kapitonava, Anastasia
- Busch, Silas E.
- Moore, Tara L.
- Rosene, Douglas L.
- Luebke, Jennifer I.
Supplementary data:
Table S2. Electrophysiological Properties of ACC PMd-targeting and AMY-targeting pyramidal neurons.
Supplementary Figure S1. Dendritic reconstructions of tracer-labeled neurons. Representative 3D reconstructions of AMY-targeting and PMd -targeting projection neurons in layers 3 and 5.
Supplementary Figure S2. Effects of firing frequency adaption to synchrony of distinct ACC networks.
Supplementary Figure S3. Representative plots of simulated low and high stochastic drive (IsFigure S4. Simulated output of networks with and without inhibition and recurrent excitation to pyramidal neurons. Ctoch)., Peer reviewed
DOI: http://hdl.handle.net/10261/311659
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311659
HANDLE: http://hdl.handle.net/10261/311659
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311659
Ver en: http://hdl.handle.net/10261/311659
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311659
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1 Documentos relacionados
1 Documentos relacionados
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/286260
Artículo científico (article). 2022
LAYER-SPECIFIC PYRAMIDAL NEURON PROPERTIES UNDERLIE DIVERSE ANTERIOR CINGULATE CORTICAL MOTOR AND LIMBIC NETWORKS
Digital.CSIC. Repositorio Institucional del CSIC
- Medalla, Maria
- Chang, Wayne
- Ibáñez, Sara
- Guillamón-Vivancos, Teresa
- Nittmann, Mathias
- Kapitonava, Anastasia
- Busch, Silas E.
- Moore, Tara L.
- Rosene, Douglas L.
- Luebke, Jennifer I.
The laminar cellular and circuit mechanisms by which the anterior cingulate cortex (ACC) exerts flexible control of motor and affective information for goal-directed behavior have not been elucidated. Using multimodal tract-tracing, in vitro patch-clamp recording and computational approaches in rhesus monkeys (M. mulatta), we provide evidence that specialized motor and affective network dynamics can be conferred by layer-specific biophysical and structural properties of ACC pyramidal neurons targeting two key downstream structures —the dorsal premotor cortex (PMd) and the amygdala (AMY). AMY-targeting neurons exhibited significant laminar differences, with L5 more excitable (higher input resistance and action potential firing rates) than L3 neurons. Between-pathway differences were found within L5, with AMY-targeting neurons exhibiting greater excitability, apical dendritic complexity, spine densities, and diversity of inhibitory inputs than PMd-targeting neurons. Simulations using a pyramidal-interneuron network model predict that these layer- and pathway-specific single-cell differences contribute to distinct network oscillatory dynamics. L5 AMY-targeting networks are more tuned to slow oscillations well-suited for affective and contextual processing timescales, while PMd-targeting networks showed strong beta/gamma synchrony implicated in rapid sensorimotor processing. These findings are fundamental to our broad understanding of how layer-specific cellular and circuit properties can drive diverse laminar activity found in flexible behavior., This work was supported by the National Institutes of Health NIH/NIMH K99/R00MH101234, R01 MH116008 (PI: M. Medalla); NIH/NIA: R01-AG059028 (MPIs: J. I. Luebke and P. Hof), and RF1-AG043640 (PI: D. L. Rosene)., Peer reviewed
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1 Versiones
1 Versiones
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/311659
Dataset. 2022
LAYER-SPECIFIC PYRAMIDAL NEURON PROPERTIES UNDERLIE DIVERSE ANTERIOR CINGULATE CORTICAL MOTOR AND LIMBIC NETWORKS: SUPPLEMENTARY DATA
Digital.CSIC. Repositorio Institucional del CSIC
- Medalla, Maria
- Chang, Wayne
- Ibáñez, Sara
- Guillamón-Vivancos, Teresa
- Nittmann, Mathias
- Kapitonava, Anastasia
- Busch, Silas E.
- Moore, Tara L.
- Rosene, Douglas L.
- Luebke, Jennifer I.
Supplementary data:
Table S2. Electrophysiological Properties of ACC PMd-targeting and AMY-targeting pyramidal neurons.
Supplementary Figure S1. Dendritic reconstructions of tracer-labeled neurons. Representative 3D reconstructions of AMY-targeting and PMd -targeting projection neurons in layers 3 and 5.
Supplementary Figure S2. Effects of firing frequency adaption to synchrony of distinct ACC networks.
Supplementary Figure S3. Representative plots of simulated low and high stochastic drive (IsFigure S4. Simulated output of networks with and without inhibition and recurrent excitation to pyramidal neurons. Ctoch)., Peer reviewed
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