Dataset.
Supplementary Materials: Remote-controlled activation of the release through drug-loaded magnetic electrospun fibers
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/371128
Digital.CSIC. Repositorio Institucional del CSIC
- Ziegler, Richard; Ilyas, Shaista; Mathur, Sanjay; Goya, Gerardo F. CSIC ORCID; Fuentes-García, J. A.
Figure S1. Morphological, magnetic and compositional analysis of the elaborated MNPs. (a) quasi-spherical shape and size of 21 ± 4 nm according to TEM images; (b) hysteresis loop showing saturation magnetization of 54 emu/g and 12 Oe of coercive field; and (c) EDS analysis showing Fe2.9Mn0.1O4 stoichiometry; Figure S2. Characterization of MSNs. (a) typical TEM image from elaborated MSNs; (b) size of 33.3 ± 4.2 nm; (c) FTIR spectrum; and (d) N2 adsorption isotherm for BET analysis; Figure S3. ATR-FTIR spectra of unloaded (black), curcumin-loaded (blue) and ketorolac-loaded (red) MSNs with the characteristic silica bands marked in black and two bands characteristic for ketorolac tromethamine at 2970 cm−1 and 2360 cm−1 marked in red. Most of the loaded drug is inside the pores and thus not visible in ATR-FTIR; Figure S4: Cumulative drug release of curcumin from MSNs at pH 7.4 and 5.5 and 37 °C. Curcumin shows a higher release at more acidic pH, with a maximum of 2.2% after 12 days; Figure S5: Cumulative drug release of ketorolac tromethamine from MSNs at pH 7.4 and 5.5 and 37 °C. Ketorolac showed a higher release at pH 7.4, up to 11.4% after 12 days, compared to 8.7% at pH 5.5; Figure S6. Contact angle measurement of CurPAN. With a contact angle of 143.6°, the curcumin-loaded fibers are very hydrophobic; Figure S7. Images from electrospun mats, (a) ENFs-KET, (b) ENFs-@MSNs-KET, (c) ENFs-CUR, (d) ENFs-@MSNs-CUR., Peer reviewed
DOI: http://hdl.handle.net/10261/371128
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/371128
HANDLE: http://hdl.handle.net/10261/371128
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/371128
Ver en: http://hdl.handle.net/10261/371128
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/371128
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Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/371128
Dataset. 2024
SUPPLEMENTARY MATERIALS: REMOTE-CONTROLLED ACTIVATION OF THE RELEASE THROUGH DRUG-LOADED MAGNETIC ELECTROSPUN FIBERS
Digital.CSIC. Repositorio Institucional del CSIC
- Ziegler, Richard; Ilyas, Shaista; Mathur, Sanjay; Goya, Gerardo F. CSIC ORCID; Fuentes-García, J. A.
Figure S1. Morphological, magnetic and compositional analysis of the elaborated MNPs. (a) quasi-spherical shape and size of 21 ± 4 nm according to TEM images; (b) hysteresis loop showing saturation magnetization of 54 emu/g and 12 Oe of coercive field; and (c) EDS analysis showing Fe2.9Mn0.1O4 stoichiometry; Figure S2. Characterization of MSNs. (a) typical TEM image from elaborated MSNs; (b) size of 33.3 ± 4.2 nm; (c) FTIR spectrum; and (d) N2 adsorption isotherm for BET analysis; Figure S3. ATR-FTIR spectra of unloaded (black), curcumin-loaded (blue) and ketorolac-loaded (red) MSNs with the characteristic silica bands marked in black and two bands characteristic for ketorolac tromethamine at 2970 cm−1 and 2360 cm−1 marked in red. Most of the loaded drug is inside the pores and thus not visible in ATR-FTIR; Figure S4: Cumulative drug release of curcumin from MSNs at pH 7.4 and 5.5 and 37 °C. Curcumin shows a higher release at more acidic pH, with a maximum of 2.2% after 12 days; Figure S5: Cumulative drug release of ketorolac tromethamine from MSNs at pH 7.4 and 5.5 and 37 °C. Ketorolac showed a higher release at pH 7.4, up to 11.4% after 12 days, compared to 8.7% at pH 5.5; Figure S6. Contact angle measurement of CurPAN. With a contact angle of 143.6°, the curcumin-loaded fibers are very hydrophobic; Figure S7. Images from electrospun mats, (a) ENFs-KET, (b) ENFs-@MSNs-KET, (c) ENFs-CUR, (d) ENFs-@MSNs-CUR., Peer reviewed
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