Dataset.
Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance [Dataset]
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/360617
Digital.CSIC. Repositorio Institucional del CSIC
- Zeng, Qingmin
- Liu, Chang-Hai
- Ampuero, Javier
- Wu, Dongbo
- Jiang, Wei
- Zhou, Lingyun
- Li, Hong
- Bai, Lang
- Romero-Gómez, Manuel
- Tang, Hong
Supplementary Table 1. The intersecting circRNAs from current published data via a Venn map.-- Supplementary Figure 1. Dysregulated circRNAs in NAFLD from 7 published studies. (A) The nomenclature of circRNAs was converted to gene names, which is the most commonly used method in circRNAs publications (the complete data set of differentially expressed circRNAs was used if available in the original article or supplementary information; otherwise, the top circRNAs expression profiles in the original article was used); (B) Aligent data from original data.-- Supplementary Figure 2. CircRNAs predicted solely through bioinformatics analysis, but the underlying mechanism were not verified by in vitro or in vivo experiment. NAFLD, nonalcoholic fatty liver disease; UCP2, uncoupling protein 2; SLC1A5 (ASCT2), solute carrier family 1 member 5; PLP2, proteolipid protein 2; CPEB1, CPE-binding protein1; LPIN1, Lipin 1; SIRT1, sirtuin 1; PEG10, paternally expressed gene 10., Nonalcoholic fatty liver disease (NAFLD), which affects approximately 25% of the global population, is an urgent health issue leading to various metabolic comorbidities. Circular RNAs (circRNAs), covalently closed RNA molecules, are characterized by ubiquity, diversity, stability, and conservatism. Indeed, they participate in various biological processes via distinct mechanisms that could modify the natural history of NAFLD. In this review, we briefly introduce the biogenesis, characteristics, and biological functions of circRNAs. Furthermore, we summarize circRNAs expression profiles in NAFLD by intersecting seven sequencing data sets and describe the cellular roles of circRNAs and their potential advantages as biomarkers of NAFLD. In addition, we emphatically discuss the exosomal non-coding RNA sorting mechanisms and possible functions in recipient cells. Finally, we extensively discuss the potential application of targeting disease-related circRNAs and competing endogenous RNA networks through gain-of-function and loss-of-function approaches in targeted therapy of NAFLD., This work was supported by the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (No. ZYGD20009); Sichuan Science and Technological Program (No. 2022YFS0338); Post-Doctor Research Project of West China Hospital of Sichuan University (2020HXBH079); Chengdu Science and Technology innovation project (2021-YF05-00800-SN); National Natural Science Foundation of China (No. 81900512 and No. 81802468)., Peer reviewed
DOI: http://hdl.handle.net/10261/360617
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/360617
HANDLE: http://hdl.handle.net/10261/360617
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/360617
Ver en: http://hdl.handle.net/10261/360617
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/360617
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1 Documentos relacionados
1 Documentos relacionados
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/360614
. 2024
CIRCULAR RNAS IN NON-ALCOHOLIC FATTY LIVER DISEASE: FUNCTIONS AND CLINICAL SIGNIFICANCE
Digital.CSIC. Repositorio Institucional del CSIC
- Zeng, Qingmin
- Liu, Chang-Hai
- Ampuero, Javier
- Wu, Dongbo
- Jiang, Wei
- Zhou, Lingyun
- Li, Hong
- Bai, Lang
- Romero-Gómez, Manuel
- Tang, Hong
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permitsunrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow theposting of the Accepted Manuscript in a repository by the author(s) or with their consent., Nonalcoholic fatty liver disease (NAFLD), which affects approximately 25% of the global population, is an urgent health issue leading to various metabolic comorbidities. Circular RNAs (circRNAs), covalently closed RNA molecules, are characterized by ubiquity, diversity, stability, and conservatism. Indeed, they participate in various biological processes via distinct mechanisms that could modify the natural history of NAFLD. In this review, we briefly introduce the biogenesis, characteristics, and biological functions of circRNAs. Furthermore, we summarize circRNAs expression profiles in NAFLD by intersecting seven sequencing data sets and describe the cellular roles of circRNAs and their potential advantages as biomarkers of NAFLD. In addition, we emphatically discuss the exosomal non-coding RNA sorting mechanisms and possible functions in recipient cells. Finally, we extensively discuss the potential application of targeting disease-related circRNAs and competing endogenous RNA networks through gain-of-function and loss-of-function approaches in targeted therapy of NAFLD., This work was supported by the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (No. ZYGD20009); Sichuan Science and Technological Program (No. 2022YFS0338); Post-Doctor Research Project of West China Hospital of Sichuan University (2020HXBH079); Chengdu Science and Technology innovation project (2021-YF05-00800-SN); National Natural Science Foundation of China (No. 81900512 and No. 81802468)., Peer reviewed
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1 Versiones
1 Versiones
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/360617
Dataset. 2023
CIRCULAR RNAS IN NON-ALCOHOLIC FATTY LIVER DISEASE: FUNCTIONS AND CLINICAL SIGNIFICANCE [DATASET]
Digital.CSIC. Repositorio Institucional del CSIC
- Zeng, Qingmin
- Liu, Chang-Hai
- Ampuero, Javier
- Wu, Dongbo
- Jiang, Wei
- Zhou, Lingyun
- Li, Hong
- Bai, Lang
- Romero-Gómez, Manuel
- Tang, Hong
Supplementary Table 1. The intersecting circRNAs from current published data via a Venn map.-- Supplementary Figure 1. Dysregulated circRNAs in NAFLD from 7 published studies. (A) The nomenclature of circRNAs was converted to gene names, which is the most commonly used method in circRNAs publications (the complete data set of differentially expressed circRNAs was used if available in the original article or supplementary information; otherwise, the top circRNAs expression profiles in the original article was used); (B) Aligent data from original data.-- Supplementary Figure 2. CircRNAs predicted solely through bioinformatics analysis, but the underlying mechanism were not verified by in vitro or in vivo experiment. NAFLD, nonalcoholic fatty liver disease; UCP2, uncoupling protein 2; SLC1A5 (ASCT2), solute carrier family 1 member 5; PLP2, proteolipid protein 2; CPEB1, CPE-binding protein1; LPIN1, Lipin 1; SIRT1, sirtuin 1; PEG10, paternally expressed gene 10., Nonalcoholic fatty liver disease (NAFLD), which affects approximately 25% of the global population, is an urgent health issue leading to various metabolic comorbidities. Circular RNAs (circRNAs), covalently closed RNA molecules, are characterized by ubiquity, diversity, stability, and conservatism. Indeed, they participate in various biological processes via distinct mechanisms that could modify the natural history of NAFLD. In this review, we briefly introduce the biogenesis, characteristics, and biological functions of circRNAs. Furthermore, we summarize circRNAs expression profiles in NAFLD by intersecting seven sequencing data sets and describe the cellular roles of circRNAs and their potential advantages as biomarkers of NAFLD. In addition, we emphatically discuss the exosomal non-coding RNA sorting mechanisms and possible functions in recipient cells. Finally, we extensively discuss the potential application of targeting disease-related circRNAs and competing endogenous RNA networks through gain-of-function and loss-of-function approaches in targeted therapy of NAFLD., This work was supported by the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (No. ZYGD20009); Sichuan Science and Technological Program (No. 2022YFS0338); Post-Doctor Research Project of West China Hospital of Sichuan University (2020HXBH079); Chengdu Science and Technology innovation project (2021-YF05-00800-SN); National Natural Science Foundation of China (No. 81900512 and No. 81802468)., Peer reviewed
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