Digital.CSIC. Repositorio Institucional del CSIC

oai:digital.csic.es:10261/339418

10 pages. -- Figure S1. Negative stain electron microscopy of purified ITV. -- Figure S2. c44H10 Fab targets an epitope largely conserved across major MHC Class II allele groups. -- Figure S3. Intramuscular ITV-TpD immunization elicits neutralizing antibody responses superior relative to subcutaneous administration. -- Figure S4. ITV-TpD is thermostable when stored at -20°C, 4°C or 40°C for up to 3 weeks. -- Figure S5. Bi-antigenic ITV-TpD elicits broad sarbecovirus-neutralizing antibody responses. -- Supplementary Table 1: Data collection and refinement statistics for the c44H10 Fab-MHC Class II (HLA-DRA*01:01, HLA-DRB1*04:01) complex (related to Figure 2). -- Supplementary Table 2: Table of contacts between the HLA-DR α chain and c44H10 Fab (Related to Figure 2). -- Supplementary Table 3: Table of contacts between the HLA-DR β chain and c44H10 Fab, Peer reviewed