Dataset.
Tumour-infiltrated cortex participates in large-scale cognitive circuits. Supplementary Materials
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370640
Digital.CSIC. Repositorio Institucional del CSIC
- Mandal, Ayan S.
- Wiener, Chemda
- Assem, Moataz
- Romero García, Rafael
- Coelho, Pedro
- McDonald, Alexa
- Woodberry, Emma
- Morris, Robert C.
- Price, Stephen J.
- Duncan, John
- Santarius, Thomas
- Suckling, John
- Hart, Michael G.
- Erez, Yaara
Supplementary Figure 1. Placement of electrodes within tumour-infiltrated tissue. Electrode locations are represented in red. The outline of each tumour mask is coloured green., Supplementary Figure 2. Time course of high gamma power modulations in tumour-infiltrated tissue for the hard vs. easy contrast. Average time course across all electrodes that showed significant change in power for this contrast, smoothed by a 1000 ms Gaussian kernel (SD=200 ms). Data is average across all trials, cropped to the shortest trial duration. Shaded area indicates SEM., Supplementary Figure 3. The relationship between tumour-DAN connectivity and performance on the Hearts Cancellation task stratified by glioma subtype. Scatterplots of the relationship between overall accuracy on the Hearts Cancellation Task and tumour-DAN connectivity at the preop and latest follow up timepoints, as well as the difference between the follow up and preoperative scores stratified by glioma subtypes indicated in Table 1. The preoperative and follow-up Heart Cancellation Scores were Z-score normalized using descriptive statistics from healthy participants., Supplementary Table 1. Relationship between functional network connectivity and power modulations for hard>easy contrast across different frequency bands. The relationships between functional network connectivity and power modulations were assessed using linear mixed-effects models. Chi-square test statistics are displayed with the corresponding P-values in parentheses. In certain cases, a P-value could not be accurately calculated because of a poorly fit model, indicated in the table as “NA”., Supplementary Table 2. Results of multiple linear regression models predicting Tumour-DAN Connectivity and long-term outcomes on the Heart Cancellation task, excluding participants without a Month 3 or greater follow-up assessment., Peer reviewed
DOI: http://hdl.handle.net/10261/370640
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370640
HANDLE: http://hdl.handle.net/10261/370640
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370640
Ver en: http://hdl.handle.net/10261/370640
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370640
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1 Documentos relacionados
1 Documentos relacionados
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370639
Artículo científico (article). 2024
TUMOUR-INFILTRATED CORTEX PARTICIPATES IN LARGE-SCALE COGNITIVE CIRCUITS
Digital.CSIC. Repositorio Institucional del CSIC
- Mandal, Ayan S.
- Wiener, Chemda
- Assem, Moataz
- Romero García, Rafael
- Coelho, Pedro
- McDonald, Alexa
- Woodberry, Emma
- Morris, Robert C.
- Price, Stephen J.
- Duncan, John
- Santarius, Thomas
- Suckling, John
- Hart, Michael G.
- Erez, Yaara
The extent to which tumour-infiltrated brain tissue contributes to cognitive function remains unclear. We tested the hypothesis that cortical tissue infiltrated by diffuse gliomas participates in large-scale cognitive circuits using a unique combination of intracranial electrocorticography (ECoG) and resting-state functional magnetic resonance (fMRI) imaging in four patients. We also assessed the relationship between functional connectivity with tumour-infiltrated tissue and long-term cognitive outcomes in a larger, overlapping cohort of 17 patients. We observed significant task-related high gamma (70-250 Hz) power modulations in tumour-infiltrated cortex in response to increased cognitive effort (i.e., switch counting compared to simple counting), implying preserved functionality of neoplastic tissue for complex tasks probing executive function. We found that tumour locations corresponding to task-responsive electrodes exhibited functional connectivity patterns that significantly co-localised with canonical brain networks implicated in executive function. Specifically, we discovered that tumour-infiltrated cortex with larger task-related high gamma power modulations tended to be more functionally connected to the dorsal attention network (DAN). Finally, we demonstrated that tumour-DAN connectivity is evident across a larger cohort of patients with gliomas and that it relates to long-term postsurgical outcomes in goal-directed attention. Overall, this study contributes convergent fMRI-ECoG evidence that tumour-infiltrated cortex participates in large-scale neurocognitive circuits that support executive function in health. These findings underscore the potential clinical utility of mapping large-scale connectivity of tumour-infiltrated tissue in the care of patients with diffuse gliomas., The Gates Cambridge Trust provided financial support in the form of a Gates Cambridge Scholarship to ASM (OPP1144). The Royal Society provided financial support in the form of a Royal Society Dorothy Hodgkin Research Fellowship to YE (DH130100). The Applebaum Foundation provided financial support in the form of a grant award to YE. Cambridge Commonwealth European and International Trust provided financial support in the form of a Yousef Jameel scholarship to MA. Guarantors of Brain provided financial support in the form of a Post-Doctoral Fellowship award to RRG. The National Institute for Health Research (NIHR, UK) provided financial support in the form of a Clinician Scientist Award 35 to SJP (ref: NIHR/CS/009/011). The Brain Tumour Charity provided financial support in the form of a grant award to MGH, YE and TS (ref: RG86218). JD was funded by a Medical Research Council grant (SUAG/045.G101400)., Peer reviewed
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1 Versiones
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Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/370640
Dataset. 2024
TUMOUR-INFILTRATED CORTEX PARTICIPATES IN LARGE-SCALE COGNITIVE CIRCUITS. SUPPLEMENTARY MATERIALS
Digital.CSIC. Repositorio Institucional del CSIC
- Mandal, Ayan S.
- Wiener, Chemda
- Assem, Moataz
- Romero García, Rafael
- Coelho, Pedro
- McDonald, Alexa
- Woodberry, Emma
- Morris, Robert C.
- Price, Stephen J.
- Duncan, John
- Santarius, Thomas
- Suckling, John
- Hart, Michael G.
- Erez, Yaara
Supplementary Figure 1. Placement of electrodes within tumour-infiltrated tissue. Electrode locations are represented in red. The outline of each tumour mask is coloured green., Supplementary Figure 2. Time course of high gamma power modulations in tumour-infiltrated tissue for the hard vs. easy contrast. Average time course across all electrodes that showed significant change in power for this contrast, smoothed by a 1000 ms Gaussian kernel (SD=200 ms). Data is average across all trials, cropped to the shortest trial duration. Shaded area indicates SEM., Supplementary Figure 3. The relationship between tumour-DAN connectivity and performance on the Hearts Cancellation task stratified by glioma subtype. Scatterplots of the relationship between overall accuracy on the Hearts Cancellation Task and tumour-DAN connectivity at the preop and latest follow up timepoints, as well as the difference between the follow up and preoperative scores stratified by glioma subtypes indicated in Table 1. The preoperative and follow-up Heart Cancellation Scores were Z-score normalized using descriptive statistics from healthy participants., Supplementary Table 1. Relationship between functional network connectivity and power modulations for hard>easy contrast across different frequency bands. The relationships between functional network connectivity and power modulations were assessed using linear mixed-effects models. Chi-square test statistics are displayed with the corresponding P-values in parentheses. In certain cases, a P-value could not be accurately calculated because of a poorly fit model, indicated in the table as “NA”., Supplementary Table 2. Results of multiple linear regression models predicting Tumour-DAN Connectivity and long-term outcomes on the Heart Cancellation task, excluding participants without a Month 3 or greater follow-up assessment., Peer reviewed
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