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Data: Ciprofloxacin Release and Corrosion Behaviour of a Hybrid PEO/PCL Coating on Mg3Zn0.4Ca Alloy

Docta Complutense
oai:docta.ucm.es:20.500.14352/118490
Docta Complutense
  • Moreno, Lara
  • Wang, Cheng
  • Lamaka, Sviatlana V.
  • Zheludkevich, Mikhail L.
  • Rodríguez Hernández, Juan
  • Arrabal Durán, Raúl
  • Matykina, Endzhe
In the present work, a hybrid hierarchical coating (HHC) system comprising a plasma electrolytic oxidation (PEO) coating and a homogeneously porous structured polycaprolactone (PCL) top-coat layer, loaded with ciprofloxacin (CIP), was developed on Mg3Zn0.4Ca alloy. According to the findings, the HHC system avoided burst release and ensured gradual drug elution (64% over 240 h). The multi-level protection of the magnesium alloy is achieved through sealing of the PEO coating pores by the polymer layer and the inhibiting effect of CIP (up to 74%). The corrosion inhibition effect of HHC and the eluted drug is associated with the formation of insoluble CIP-Me (Mg/Ca) chelates that repair the defects in the HHC and impede the access of corrosive species as corroborated by FTIR spectra, EIS and SEM images after 24 h of immersion. Therefore, CIP participates in an active protection mechanism by interacting with cations coming through the damaged coating.
 
DOI: https://hdl.handle.net/20.500.14352/118490
Docta Complutense
oai:docta.ucm.es:20.500.14352/118490

HANDLE: https://hdl.handle.net/20.500.14352/118490
Docta Complutense
oai:docta.ucm.es:20.500.14352/118490
 
Ver en: https://hdl.handle.net/20.500.14352/118490
Docta Complutense
oai:docta.ucm.es:20.500.14352/118490
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Docta Complutense
oai:docta.ucm.es:20.500.14352/118490
Set de datos (Dataset). 2023

DATA: CIPROFLOXACIN RELEASE AND CORROSION BEHAVIOUR OF A HYBRID PEO/PCL COATING ON MG3ZN0.4CA ALLOY

Docta Complutense
  • Moreno, Lara
  • Wang, Cheng
  • Lamaka, Sviatlana V.
  • Zheludkevich, Mikhail L.
  • Rodríguez Hernández, Juan
  • Arrabal Durán, Raúl
  • Matykina, Endzhe
In the present work, a hybrid hierarchical coating (HHC) system comprising a plasma electrolytic oxidation (PEO) coating and a homogeneously porous structured polycaprolactone (PCL) top-coat layer, loaded with ciprofloxacin (CIP), was developed on Mg3Zn0.4Ca alloy. According to the findings, the HHC system avoided burst release and ensured gradual drug elution (64% over 240 h). The multi-level protection of the magnesium alloy is achieved through sealing of the PEO coating pores by the polymer layer and the inhibiting effect of CIP (up to 74%). The corrosion inhibition effect of HHC and the eluted drug is associated with the formation of insoluble CIP-Me (Mg/Ca) chelates that repair the defects in the HHC and impede the access of corrosive species as corroborated by FTIR spectra, EIS and SEM images after 24 h of immersion. Therefore, CIP participates in an active protection mechanism by interacting with cations coming through the damaged coating.

HANDLE: https://hdl.handle.net/20.500.14352/118490


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