Publicación
Artículo científico (article).
Blood Interferon Signatures Putatively Link Lack of Protection Conferred by the RTS,S Recombinant Malaria Vaccine to an Antigen-specific IgE Response
Recercat. Dipósit de la Recerca de Catalunya
oai:recercat.cat:2072/304097
Recercat. Dipósit de la Recerca de Catalunya
- Rinchai, Darawan
- Presnell, Scott
- Vidal, Marta
- Dutta, Sheetij
- Chauhan, Virander Singh
- Cavanagh, David
- Moncunill, Gemma
- Dobaño, Carlota, 1969-
- Chaussabel, Damien
Malaria remains a major cause of mortality and morbidity
worldwide. Progress has been made in recent years with the
development of vaccines that could pave the way towards
protection of hundreds of millions of exposed individuals. Here
we used a modular repertoire approach to re-analyze a publically
available microarray blood transcriptome dataset monitoring the
response to malaria vaccination. We report the seminal
identification of interferon signatures in the blood of subjects
on days 1, 3 and 14 following administration of the third dose
of the RTS,S recombinant malaria vaccine. These signatures at
day 1 correlate with protection, and at days 3 and 14 to
susceptibility to subsequent challenge of study subjects with
live parasites. In addition we putatively link the decreased
abundance of interferon-inducible transcripts observed at days 3
and 14 post-vaccination with the elicitation of an
antigen-specific IgE response in a subset of vaccine recipients
that failed to be protected by the RTS,S vaccine. Furthermore,
profiling of antigen-specific levels of IgE in a Mozambican
cohort of malaria-exposed children vaccinated with RTS,S
identified an association between elevated baseline IgE levels
and subsequent development of naturally acquired malaria
infection during follow up. Taken together these findings
warrant further investigation of the role of antigen-specific
IgE in conferring susceptibility to malaria infection.
DOI: http://hdl.handle.net/2445/119074
Recercat. Dipósit de la Recerca de Catalunya
oai:recercat.cat:2072/304097
HANDLE: http://hdl.handle.net/2445/119074
Recercat. Dipósit de la Recerca de Catalunya
oai:recercat.cat:2072/304097
Ver en: http://hdl.handle.net/2445/119074
Recercat. Dipósit de la Recerca de Catalunya
oai:recercat.cat:2072/304097