Efectos de un programa de ejercicio físico sobre la grasa hepática en niños y niñas con sobrepeso

PI13/01335

Nombre agencia financiadora Ministerio de Economía y Competitividad
Acrónimo agencia financiadora MINECO
Programa Programa Estatal de I+D+I Orientada a los Retos de la Sociedad
Subprograma Salud, cambio demográfico y bienestar
Convocatoria Proyectos de investigación en salud (AE en Salud)
Año convocatoria 2013
Unidad de gestión Instituto de Salud Carlos III (ISCIII)
Centro beneficiario UNIVERSIDAD DEL PAIS VASCO EUSKAL HERRIKO UNIBERTSITATEA
Centro realización FACULTAD DE FARMACIA DE VITORIA
Identificador persistente http://dx.doi.org/10.13039/501100003329

Publicaciones

Found(s) 2 result(s)
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The effect of a multicomponent intervention on steatosis is partially mediated by the reduction of intermuscular abdominal adipose tissue in children with overweight or obesity: the EFIGRO Project

Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
  • 0000-0002-4513-9108
  • Idoate, Fernando
  • 0000-0001-7999-1182
  • 0000-0001-9822-2530
  • Rodríguez Vigil, Beatriz
  • 0000-0001-7048-642X
  • 0000-0001-7815-7583
  • Ortega, Francisco B.
  • Ruiz, Jonatan R.
  • 0000-0002-4334-3287
OBJECTIVE: In adults, there is evidence that improvement of metabolic-associated fatty liver disease (MAFLD) depends on the reduction of myosteatosis. In children, in whom the prevalence of MAFLD is alarming, this muscle-liver crosstalk has not been tested. Therefore, we aimed to explore whether the effects of a multicomponent intervention on hepatic fat is mediated by changes in intermuscular abdominal adipose tissue (IMAAT) in children with overweight/obesity. RESEARCH DESIGN AND METHODS: A total of 116 children with overweight/obesity were allocated to a 22-week family-based lifestyle and psychoeducational intervention (control group, n = 57) or the same intervention plus supervised exercise (exercise group, n = 59). Hepatic fat percentage and IMAAT were acquired by MRI at baseline and at the end of the intervention. RESULTS: Changes in IMAAT explained 20.7% of the improvements in hepatic steatosis (P < 0.05). Only children who meaningfully reduced their IMAAT (i.e., responders) had improved hepatic steatosis at the end of the intervention (within-group analysis: responders -20% [P = 0.005] vs. nonresponders -1.5% [P = 0.803]). Between-group analysis showed greater reductions in favor of IMAAT responders compared with nonresponders (18.3% vs. 0.6%, P = 0.018), regardless of overall abdominal fat loss. CONCLUSIONS: The reduction of IMAAT plays a relevant role in the improvement of hepatic steatosis after a multicomponent intervention in children with overweight/obesity. Indeed, only children who achieved a meaningful reduction in IMAAT at the end of the intervention had a reduced percentage of hepatic fat independent of abdominal fat loss. Our findings suggest that abdominal muscle fat infiltration could be a therapeutic target for the treatment of MAFLD in childhood., This project was funded by the Spanish Ministry of Health's Fondos de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01335), the Spanish Ministry of the Economy Industry and Competitiveness (DEP2016-78377-R), and by European Regional Development Funds (ERDF): Una Manera de Hacer Europa. Support was also provided by the Regional Government of Navarra's Department of Economic Development (0011-1365-2019-000152 & 0011-1365-2020-000243), co-funded by European Regional Development Funds (ERDF 2014-2020 for Navarra). CC-S is supported by the Spanish Ministry of Science and Innovation (FJC2018-037925-I). MM is supported by Junta de Andalucía and European Union (SNGJ Ref-8025). MO is supported by the Spanish Ministry of Economy and Competitiveness (BES-2017-080770). This study was supported by the University of Granada Plan Propio de Investigación 2021 -Excellence actions: Unit of Excellence on Exercise, Nutrition and Health (UCEENS)- and the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, European Regional Development Funds (ref. SOMM17/6107/UGR).




Effects of a family-based lifestyle intervention plus supervised exercise training on abdominal fat depots in children with overweight or obesity: a secondary analysis of a nonrandomized clinical trial

Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
  • 0000-0002-4513-9108
  • 0000-0001-7999-1182
  • Idoate, Fernando
  • 0000-0001-7815-7583
  • 0000-0001-7048-642X
  • 0000-0001-9822-2530
  • 0000-0003-0200-1077
  • Sanz Muñoz, Aritz
  • Ortega, Francisco B.
  • Ruiz, Jonatan R.
  • 0000-0002-4334-3287
Importance Excess abdominal fat is a major determinant in the development of insulin resistance and other metabolic disorders. Increased visceral adipose tissue (VAT) seems to precede the development of insulin resistance and is therefore a prime target of childhood lifestyle interventions aimed at preventing diabetes. OBJECTIVES To examine the effect of added exercise to a family-based lifestyle intervention program designed to reduce VAT plus subcutaneous (ASAT), intermuscular (IMAAT), and pancreatic (PAT) adipose tissue in children with overweight or obesity and to explore the effect of changes in VAT on insulin resistance. DESIGN, SETTING, AND PARTICIPANTS This 2-group, parallel-design clinical trial was conducted in Vitoria-Gasteiz, Spain. A total of 116 children with overweight or obesity participated and were assigned to a 22-week family-based lifestyle program (control group [n = 57]) or the same program plus an exercise intervention (exercise group [n = 59]). Data were collected between September 1, 2014, and June 30, 2017, and imaging processing for fat depot assessments and data analysis were performed between May 1, 2019, and February 12, 2021. INTERVENTIONS The compared interventions consisted of a family-based lifestyle and psychoeducation program (two 90-minute sessions per month) and the same program plus supervised exercise (three 90-minute sessions per week). MAIN OUTCOMES AND MEASURES The primary outcome of this study was the change in VAT between baseline and 22 weeks as estimated by magnetic resonance imaging. The secondary outcomes were changes in ASAT, IMAAT, and PAT. The effect of changes in VAT area on insulin resistance was also recorded. RESULTS The 116 participants included in the analysis (62 girls [53.4%]) had a mean (SD) age of 10.6 (1.1) years, and 67 (57.8%) presented with obesity. Significantly greater reductions were recorded for the exercise group in terms of reduction in VAT (−18.1% vs −8.5% for the control group; P = .004), ASAT (−9.9% vs −3.0%; P = .001), and IMAAT (−6.0% vs −2.6%; P = .02) fat fractions compared with the control group. Changes in VAT explained 87.6% of the improvement seen in insulin resistance (β = −0.102 [95% CI, −0.230 to −0.002]). CONCLUSIONS AND RELEVANCE These findings suggest that the addition of exercise to a lifestyle intervention program substantially enhanced the positive effects on abdominal fat depots in children with overweight or obesity. In addition, the reduction in VAT seemed to largely mediate the improvement of insulin sensitivity. These results highlight the importance of including exercise as part of lifestyle therapies aimed at treating childhood obesity and preventing the development of type 2 diabetes., This study was supported by grant PI13/01335 from the Spanish Ministry of Health’s Fondos de Investigación Sanitaria del Instituto de Salud Carlos III; by grant DEP2016-78377 from the Spanish Ministry of the Economy Industry and Competitiveness; by European Regional Development Funds (ERDF) Una Manera de Hacer Europa; by grant 0011-1365-2019-000085 from the Regional Government of Navarra’s Department of Economic Development (cofunded by ERDF 2014-2020 for Navarra); by grant 47/2021 from the Government of Navarra’s Department of Health; by grant FJC2018-037925-I from the Spanish Ministry of Science and Innovation (Dr Cadenas-Sanchez); by Marie Sklodowska Curie grant agreement 101028929 from the European Union’s Horizon 2020 Research and Innovation Programme (Dr Cadenas-Sanchez); by grant BES-2017-080770 from the Spanish Ministry of the Economy Industry and Competitiveness (Dr Osés); by grants PRE_2016_1_0057, PRE_2017_2_0224, PRE_2018_2_0057, and PRE_2019_2_0004 from the Education Department of the Government of the Basque Country (Dr Arenaza); and by grant SOMM17/6107/UGR from the University of Granada Plan Propio de Investigación 2021 Excellence actions: Unit of Excellence on Exercise, Nutrition and Health and the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, ERDF.