ESTILOS DE VIDA Y CANCER DE MAMA - ENSAYO LIFEBREAST
PI18/00631
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Nombre agencia financiadora Instituto de Salud Carlos III
Acrónimo agencia financiadora ISCIII
Programa Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia
Subprograma Subprograma Estatal de Generación de Conocimiento
Convocatoria Proyectos de investigación en salud
Año convocatoria 2018
Unidad de gestión Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)
Centro beneficiario FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE NAVARRA
Centro realización FACULTAD DE MEDICINA DE PAMPLONA
Identificador persistente https://doi.org/10.13039/501100004587
Publicaciones
Found(s) 2 result(s)
Found(s) 1 page(s)
Found(s) 1 page(s)
Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- López-Herreros, J.
- Martínez González, Miguel Ángel
- Gea, A.
- Sánchez Villegas, María Almudena
- Dierssen Sotos, Trinidad
- Jiménez-Moleón, J. J.
- Ruiz Canela, Miguel
- Toledo, Estefanía
Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a
healthy middle-aged Mediterranean cohort.
Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university
graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36)
twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between
self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their
interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet).
Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent
vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model
with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend <
0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend =
0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with
repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these
associations.
Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the
Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous
comorbidities or adherence to the MedDiet., This project was made possible by funding from the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI18/00631, PI20/00564 and G03/140), from the Government of Navarra (27/2011, 45/2011, 122/2014), from the National Plan on Drugs (2020/021) as well as from the University of Navarra.
healthy middle-aged Mediterranean cohort.
Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university
graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36)
twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between
self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their
interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet).
Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent
vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model
with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend <
0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend =
0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with
repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these
associations.
Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the
Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous
comorbidities or adherence to the MedDiet., This project was made possible by funding from the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI18/00631, PI20/00564 and G03/140), from the Government of Navarra (27/2011, 45/2011, 122/2014), from the National Plan on Drugs (2020/021) as well as from the University of Navarra.
Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study
Dadun. Depósito Académico Digital de la Universidad de Navarra
- López-Herreros, J. (J.)
- Martinez-Gonzalez, M.A. (Miguel Ángel)
- Gea-Sánchez, A. (Alfredo)
- Sanchez-Villegas, A. (Almudena)
- Dierssen-Sotos, T. (T.)
- Jiménez-Moleón, J.J. (José Juan)
- Ruiz-Canela, M. (Miguel)
- Toledo, E. (Estefanía)
Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants -mean age 42.8 years at first HRQoL ascertainment, all university graduates-. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16-0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36-0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54-0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46-0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74-0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL -assessed as self-reported health, PCS-36 and MCS-36- obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet.